PT1246814E - Compostos e metodos para a modulacao de receptores de estrgenio - Google Patents

Compostos e metodos para a modulacao de receptores de estrgenio

Info

Publication number: PT1246814E
Authority: PT; Portugal
Prior art keywords: compounds; methods; disclosed; beta; same
Prior art date: 1999-12-30

Application number

PT00990966T

Other languages

English (en)

Inventor

Shripad S Bhagwat

Sak Khammungkhune

Jeffrey A Mckie

Original Assignee

Signal Pharm Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-30

Filing date

2000-12-29

Publication date

2005-07-29

2000-01-27 Priority claimed from US09/492,939 external-priority patent/US6291456B1/en

2000-07-06 Priority claimed from US09/611,156 external-priority patent/US6331562B1/en

2000-12-29 Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc

2005-07-29 Publication of PT1246814E publication Critical patent/PT1246814E/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 3
102000015694 estrogen receptors Human genes 0.000 abstract 2
108010038795 estrogen receptors Proteins 0.000 abstract 2
201000004384 Alopecia Diseases 0.000 abstract 1
208000000044 Amnesia Diseases 0.000 abstract 1
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
206010006187 Breast cancer Diseases 0.000 abstract 1
208000026310 Breast neoplasm Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
208000002177 Cataract Diseases 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
208000033830 Hot Flashes Diseases 0.000 abstract 1
206010060800 Hot flush Diseases 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
206010027951 Mood swings Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
206010060862 Prostate cancer Diseases 0.000 abstract 1
208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
208000024313 Testicular Neoplasms Diseases 0.000 abstract 1
206010057644 Testis cancer Diseases 0.000 abstract 1
206010046543 Urinary incontinence Diseases 0.000 abstract 1
230000002411 adverse Effects 0.000 abstract 1
230000002500 effect on skin Effects 0.000 abstract 1
239000003256 environmental substance Substances 0.000 abstract 1
229940011871 estrogen Drugs 0.000 abstract 1
239000000262 estrogen Substances 0.000 abstract 1
230000014509 gene expression Effects 0.000 abstract 1
208000024963 hair loss Diseases 0.000 abstract 1
230000003676 hair loss Effects 0.000 abstract 1
230000003054 hormonal effect Effects 0.000 abstract 1
230000006984 memory degeneration Effects 0.000 abstract 1
208000023060 memory loss Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000004240 prostatic hypertrophy Diseases 0.000 abstract 1
230000001850 reproductive effect Effects 0.000 abstract 1
201000003120 testicular cancer Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Obesity (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT00990966T 1999-12-30 2000-12-29 Compostos e metodos para a modulacao de receptores de estrgenio PT1246814E (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US47577699A	1999-12-30	1999-12-30
US09/492,939 US6291456B1 (en)	1998-12-30	2000-01-27	Compounds and methods for modulation of estrogen receptors
US09/611,156 US6331562B1 (en)	1998-12-30	2000-07-06	Compounds and methods for modulation of estrogen receptors

Publications (1)

Publication Number	Publication Date
PT1246814E true PT1246814E (pt)	2005-07-29

Family

ID=27413348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT00990966T PT1246814E (pt)	1999-12-30	2000-12-29	Compostos e metodos para a modulacao de receptores de estrgenio

Country Status (13)

Country	Link
EP (1)	EP1246814B1 (pt)
JP (1)	JP2003519219A (pt)
KR (1)	KR20020075388A (pt)
CN (1)	CN1281598C (pt)
AT (1)	ATE289300T1 (pt)
AU (1)	AU781282B2 (pt)
CA (1)	CA2396059A1 (pt)
DE (1)	DE60018215T2 (pt)
DK (1)	DK1246814T3 (pt)
ES (1)	ES2238034T3 (pt)
IL (1)	IL150463A0 (pt)
PT (1)	PT1246814E (pt)
WO (1)	WO2001049673A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CO5271709A1 (es) *	2000-01-12	2003-04-30	Pfizer Prod Inc	Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos
EP1177787A3 (en) *	2000-07-28	2003-09-10	Pfizer Products Inc.	Use of an estrogen agonist/antagonist for treating cataracts
EP1281710A1 (en) *	2001-08-03	2003-02-05	CHIESI FARMACEUTICI S.p.A.	2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
US7148252B2 (en) *	2001-10-03	2006-12-12	Signal Pharmaceuticals, Llc	Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis
EA007382B1 (ru)	2001-11-19	2006-10-27	Эли Лилли Энд Компани	Замещенные бензопираны в качестве селективных агонистов бета-рецептора эстрогена
AU2005202072B2 (en) *	2001-11-29	2008-10-23	Gtx, Inc.	Prevention and treatment of androgen-deprivation induced conditions
EP1666033B1 (en) *	2001-11-29	2008-12-31	GTX, Inc.	Prevention and treatment of androgen-deprivation induced osteoporosis
US7524866B2 (en)	2001-11-29	2009-04-28	Gtx, Inc.	Prevention and treatment of androgen—deprivation induced osteoporosis
EP1497277A1 (en) *	2002-04-19	2005-01-19	Signal Pharmaceuticals, Inc.	Benzopyranone compounds, compositions thereof, and methods of treatment therewith
US7091235B2 (en)	2002-10-15	2006-08-15	Signal Pharmaceuticals, Llc	Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer
US7674783B2 (en) *	2002-11-22	2010-03-09	Dimera Inc.	Estrogen beta receptor agonists to prevent or reduce the severity of cardiovascular disease
ATE457308T1 (de)	2003-04-21	2010-02-15	Lilly Co Eli	Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
CN100374444C (zh)	2003-04-21	2008-03-12	伊莱利利公司	作为选择性β-雌激素受体激动剂的取代的苯并吡喃化合物
US7098340B2 (en) *	2003-05-14	2006-08-29	Warner Lambert Company Llc	Benzyl sulfonamide derivatives
AU2004274445A1 (en) *	2003-09-15	2005-03-31	Novartis Ag	Benzopyranone compounds, compositions thereof, and methods of treatment therewith
CA2595472A1 (en) *	2005-01-21	2006-07-27	Janssen Pharmaceutica N.V.	Novel coumarin derivatives as ion channel openers
ES2436028T3 (es) *	2006-06-23	2013-12-26	Radius Health, Inc.	Tratamiento de síntomas vasomotores con moduladores selectivos de receptores de estrógeno
PT2568806T (pt)	2010-05-12	2016-08-05	Radius Health Inc	Regimes terapêuticos
ES2550319T3 (es)	2010-09-28	2015-11-06	Radius Health, Inc	Moduladores selectivos del receptor de andrógenos
US9421264B2 (en)	2014-03-28	2016-08-23	Duke University	Method of treating cancer using selective estrogen receptor modulators
RS67458B1 (sr)	2014-03-28	2025-12-31	Univ Duke	Lečenje kancera dojke pozitivnog na receptor estrogena upotrebom selektivnih modulatora receptora estrogena
CN105801544A (zh) *	2016-04-18	2016-07-27	中国药科大学	3-芳基-4-芳香胺-香豆素衍生物及其制备方法和医药用途
CN105801543B (zh) *	2016-04-18	2019-08-02	中国药科大学	4-芳香胺-香豆素衍生物及其制备方法和医药用途
RS63311B1 (sr)	2016-06-22	2022-07-29	Ellipses Pharma Ltd	Ar+ metode lečenja raka dojke
CN106492204A (zh) *	2016-12-27	2017-03-15	郑州郑先医药科技有限公司	一种治疗白内障的药物组合物
CN106727637A (zh) *	2016-12-27	2017-05-31	郑州郑先医药科技有限公司	一种治疗白内障的西药组合物及其用途
KR102881465B1 (ko)	2017-01-05	2025-11-04	래디어스 파마슈티컬스, 인코포레이티드	Rad1901-2hcl의 다형 형태

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5726202A (en) *	1996-01-11	1998-03-10	Novo Nordisk A/S	Benign prostatic hypertrophy
AU1367297A (en) *	1996-01-11	1997-08-01	Novo Nordisk A/S	Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical comp osition for the treatment or prophylaxis of menopausal symptoms
US5883118A (en) *	1996-01-11	1999-03-16	Nova Nordisk A/S	Prostatic carcinoma
JP2002533456A (ja) *	1998-12-30	2002-10-08	シグナルファーマシューティカルズ，インコーポレイテッド	エストロゲン受容体のモジュレートを行うための化合物および方法

2000
- 2000-12-29 AT AT00990966T patent/ATE289300T1/de not_active IP Right Cessation
- 2000-12-29 AU AU30771/01A patent/AU781282B2/en not_active Ceased
- 2000-12-29 DK DK00990966T patent/DK1246814T3/da active
- 2000-12-29 CN CNB008192227A patent/CN1281598C/zh not_active Expired - Fee Related
- 2000-12-29 EP EP00990966A patent/EP1246814B1/en not_active Expired - Lifetime
- 2000-12-29 DE DE60018215T patent/DE60018215T2/de not_active Expired - Fee Related
- 2000-12-29 ES ES00990966T patent/ES2238034T3/es not_active Expired - Lifetime
- 2000-12-29 IL IL15046300A patent/IL150463A0/xx unknown
- 2000-12-29 PT PT00990966T patent/PT1246814E/pt unknown
- 2000-12-29 CA CA002396059A patent/CA2396059A1/en not_active Abandoned
- 2000-12-29 WO PCT/US2000/035671 patent/WO2001049673A2/en not_active Ceased
- 2000-12-29 JP JP2001550213A patent/JP2003519219A/ja active Pending
- 2000-12-29 KR KR1020027008569A patent/KR20020075388A/ko not_active Abandoned

Also Published As

Publication number	Publication date
IL150463A0 (en)	2002-12-01
ES2238034T3 (es)	2005-08-16
WO2001049673A2 (en)	2001-07-12
CN1437591A (zh)	2003-08-20
EP1246814A2 (en)	2002-10-09
DE60018215T2 (de)	2006-02-09
AU781282B2 (en)	2005-05-12
AU3077101A (en)	2001-07-16
JP2003519219A (ja)	2003-06-17
HK1058521A1 (en)	2004-05-21
CA2396059A1 (en)	2001-07-12
EP1246814B1 (en)	2005-02-16
KR20020075388A (ko)	2002-10-04
WO2001049673A3 (en)	2001-12-06
CN1281598C (zh)	2006-10-25
ATE289300T1 (de)	2005-03-15
DK1246814T3 (da)	2005-05-30
DE60018215D1 (de)	2005-03-24

Publication	Publication Date	Title
IL150463A0 (en)	2002-12-01	Compounds and methods for modulation of estrogen receptors
WO2000055137A8 (en)	2001-07-05	Compounds and methods for modulation of estrogen receptors
PT1140889E (pt)	2004-01-30	Compostos e metodos para modulacao de receptores de estrogenio
MY115784A (en)	2003-09-30	Estrogen agonists/antagonists
BR0010215A (pt)	2002-02-13	Derivados de indolina como antagonistas de progesterona
MX9505249A (es)	1997-01-31	Agonistas de estrogeno.
EA200300474A1 (ru)	2003-10-30	Модуляторы рецепторов эстрогена
CY1115317T1 (el)	2017-01-04	Εκλεκτικος ρυθμιστης οιστρογονικου υποδοχεα σε συνδυασμο με δεϋδροεπιανδροστερονη (dhea) ή αναλογα
ATE397125T1 (de)	2008-06-15	Geschwollene stärke-latex-zusammensetzungen zur anwendung bei der papierherstellung
AU2002367060A8 (en)	2003-07-30	Heterocyclic modulators of nuclear receptors
BR0312024A (pt)	2005-03-22	Uso de derivados de ciclotiocarbamato no tratamento de condições relacionadas com hormÈnios
CR7657A (es)	2005-07-13	Moduladores selectivos de receptores de estrogenos que contienen un grupo de fenilsulfonilo
BRPI0409831A (pt)	2006-04-25	composição de condicionamento de tecidos, e, uso de um material não iÈnico
ATE292468T1 (de)	2005-04-15	Verwendung von biogenen estrogensulfamaten zur hormonsubstitutionstherapie
TW200731969A (en)	2007-09-01	Use of progesterone receptor modulators
NZ515353A (en)	2004-03-26	Cyclothiocarbamate derivatives as progesterone receptor modulators
ATE254122T1 (de)	2003-11-15	Indolderivate als 5-ht1b und 5-ht1d agonisten
DE69828207D1 (de)	2005-01-20	Mit Thiophen substituierte Piperazine für die Behandlung von benigner Prostatahyperplasie
LT2002031A (en)	2003-02-25	Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
Friedman	2005	The Estradiol-Dihydrotestosterone model of prostate cancer
DK1196428T3 (da)	2005-01-24	11-beta-aryl-17,17-spirothiolan-substituerede steroider
DK0898708T3 (da)	2002-03-04	Interaktion af cyclin D1 og estrogenreceptor og anvendelse deraf i assays
Meyers	1984	The role of hormone receptors in estrogen activity is questionable
Charnock-Jones et al.	1998	Vascular endothelial growth factor and corpus luteum angiogenesis
MY137604A (en)	2009-02-27	Benzopyranone compounds, compositions thereof, and methods of treatment therewith