PT2848258T - Tratamento da febre mediterrânica familiar com anticorpos anti il-1b - Google Patents

Tratamento da febre mediterrânica familiar com anticorpos anti il-1b

Info

Publication number: PT2848258T
Authority: PT; Portugal
Prior art keywords: antibodies; treatment; mediterranean fever; family mediterranean; family
Prior art date: 2005-10-26

Application number

PT141915827T

Other languages

English (en)

Inventor

Wright Timothy

Lowe Phil

Gram Hermann

Jung Thomas

Mundel Trevor

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-26

Filing date

2006-10-24

Publication date

2018-03-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37806690&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2848258(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-10-24 Application filed by Novartis Ag filed Critical Novartis Ag

2018-03-20 Publication of PT2848258T publication Critical patent/PT2848258T/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/246—IL-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Mycology (AREA)
Endocrinology (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Zoology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)

PT141915827T 2005-10-26 2006-10-24 Tratamento da febre mediterrânica familiar com anticorpos anti il-1b PT2848258T (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73043505P	2005-10-26	2005-10-26
US74212505P	2005-12-02	2005-12-02

Publications (1)

Publication Number	Publication Date
PT2848258T true PT2848258T (pt)	2018-03-20

Family

ID=37806690

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT06826560T PT1940465E (pt)	2005-10-26	2006-10-24	Nova utilização para compostos de il-1 beta
PT141915827T PT2848258T (pt)	2005-10-26	2006-10-24	Tratamento da febre mediterrânica familiar com anticorpos anti il-1b

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT06826560T PT1940465E (pt)	2005-10-26	2006-10-24	Nova utilização para compostos de il-1 beta

Country Status (28)

Country	Link
US (8)	US8105587B2 (pt)
EP (5)	EP1940465B1 (pt)
JP (4)	JP2009513645A (pt)
KR (3)	KR101749388B1 (pt)
CN (2)	CN102861332A (pt)
AU (1)	AU2006306280B2 (pt)
BR (1)	BRPI0617830B8 (pt)
CA (3)	CA2898369C (pt)
CY (4)	CY1113378T1 (pt)
DK (2)	DK2848258T3 (pt)
ES (3)	ES2389110T3 (pt)
HU (2)	HUE036973T2 (pt)
IL (4)	IL190545A (pt)
JO (2)	JO2826B1 (pt)
LT (3)	LT2848258T (pt)
LU (2)	LU92326I2 (pt)
MA (1)	MA29919B1 (pt)
NO (2)	NO345888B1 (pt)
NZ (1)	NZ567222A (pt)
PH (2)	PH12013501287B1 (pt)
PL (2)	PL1940465T3 (pt)
PT (2)	PT1940465E (pt)
RU (2)	RU2468817C2 (pt)
SI (2)	SI2848258T1 (pt)
TN (1)	TNSN08189A1 (pt)
TR (1)	TR201802449T4 (pt)
TW (3)	TWI388335B (pt)
WO (1)	WO2007050607A2 (pt)

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PL1940465T3 (pl)	2005-10-26	2013-01-31	Novartis Ag	Nowe zastosowanie przeciwciał anty-IL-1beta
CN104873972A (zh) *	2007-05-29	2015-09-02	诺华股份有限公司	抗IL-1β治疗的新适应症
AU2012203932B2 (en) *	2007-05-29	2014-04-24	Novartis Ag	New indications for anti-IL-I-beta therapy
CA2727171A1 (en) *	2008-06-06	2009-12-10	Xoma Technology Ltd.	Methods for the treatment of rheumatoid arthritis
EP2196476A1 (en)	2008-12-10	2010-06-16	Novartis Ag	Antibody formulation
CA2774326C (en)	2009-09-14	2023-11-07	Donald Bellgrau	Modulation of yeast-based immunotherapy products and responses
KR20120104542A (ko) *	2009-10-15	2012-09-21	아보트 러보러터리즈	Ｉｌ?１ 결합 단백질
AR081246A1 (es) *	2010-05-14	2012-07-18	Abbott Lab	Proteinas de union a il-1
PE20141060A1 (es) *	2010-12-21	2014-09-26	Abbvie Inc	Inmunoglobulinas de dominio variable dual biespecificas de il-1 alfa y beta y su uso
AU2012253422B2 (en)	2011-05-10	2015-08-13	Société des Produits Nestlé S.A.	Methods of disease activity profiling for personalized therapy management
EP3426775A1 (en)	2016-03-10	2019-01-16	Novartis AG	Chemically modified messenger rna's
EP3612843A1 (en)	2017-05-31	2020-02-26	Prometheus Biosciences, Inc.	Methods for assessing mucosal healing in crohn's disease patients
UY37758A (es)	2017-06-12	2019-01-31	Novartis Ag	Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
CA3061874A1 (en)	2017-06-22	2018-12-27	Novartis Ag	Il-1beta binding antibodies for use in treating cancer
WO2019215484A1 (en)	2018-05-09	2019-11-14	Novartis Ag	Use of canakinumab
US20220025036A1 (en)	2018-12-21	2022-01-27	Novartis Ag	Use of il-1beta binding antibodies
WO2020128637A1 (en)	2018-12-21	2020-06-25	Novartis Ag	Use of il-1 binding antibodies in the treatment of a msi-h cancer
KR20210107730A (ko)	2018-12-21	2021-09-01	노파르티스 아게	골수 형성이상 증후군의 치료 또는 예방에서의 il-1 베타 항체의 용도
JP2022514087A (ja)	2018-12-21	2022-02-09	ノバルティスアーゲー	ＩＬ－１β結合抗体の使用
TWI793503B (zh) *	2020-01-20	2023-02-21	美商美國禮來大藥廠	抗IL-1β抗體
US20250099548A1 (en) *	2022-01-10	2025-03-27	Gi Innovation, Inc.	Pharmaceutical composition for preventing or treating degenerative brain diseases, containing glucagon-like peptide-1 and interleukin-1 receptor antagonist

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US8003779B2 (en)	2005-01-20	2011-08-23	University Of Rochester	Compositions and methods for studying and treating inflammatory diseases and disorders
CN103589650A (zh)	2005-03-18	2014-02-19	米克罗比亚公司	产油酵母和真菌中类胡萝卜素的产生
HUE029021T2 (en)	2005-06-21	2017-02-28	Xoma (Us) Llc	IL-1beta-binding antibodies and fragments thereof
PL1940465T3 (pl)	2005-10-26	2013-01-31	Novartis Ag	Nowe zastosowanie przeciwciał anty-IL-1beta

2006
- 2006-10-24 PL PL06826560T patent/PL1940465T3/pl unknown
- 2006-10-24 EP EP06826560A patent/EP1940465B1/en active Active
- 2006-10-24 TR TR2018/02449T patent/TR201802449T4/tr unknown
- 2006-10-24 CA CA2898369A patent/CA2898369C/en active Active
- 2006-10-24 US US12/090,490 patent/US8105587B2/en active Active
- 2006-10-24 HU HUE14191582A patent/HUE036973T2/hu unknown
- 2006-10-24 EP EP14191582.7A patent/EP2848258B1/en active Active
- 2006-10-24 KR KR1020147035512A patent/KR101749388B1/ko active Active
- 2006-10-24 AU AU2006306280A patent/AU2006306280B2/en active Active
- 2006-10-24 NO NO20200810A patent/NO345888B1/no unknown
- 2006-10-24 CN CN2012102904088A patent/CN102861332A/zh active Pending
- 2006-10-24 EP EP23155348.8A patent/EP4218815A3/en active Pending
- 2006-10-24 ES ES06826560T patent/ES2389110T3/es active Active
- 2006-10-24 PL PL14191582T patent/PL2848258T3/pl unknown
- 2006-10-24 RU RU2008120625/15A patent/RU2468817C2/ru active
- 2006-10-24 PT PT06826560T patent/PT1940465E/pt unknown
- 2006-10-24 BR BRPI0617830A patent/BRPI0617830B8/pt active IP Right Grant
- 2006-10-24 EP EP10181100A patent/EP2332577A1/en not_active Withdrawn
- 2006-10-24 CN CN200680039395XA patent/CN101291693B/zh active Active
- 2006-10-24 DK DK14191582.7T patent/DK2848258T3/en active
- 2006-10-24 KR KR1020177008682A patent/KR20170038131A/ko not_active Ceased
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2011
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2012
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2013
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2014
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2015
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2016
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2017
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2018
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Also Published As

Publication number	Publication date
US20210147533A1 (en)	2021-05-20
CY1113378T1 (el)	2015-11-04
LUC00078I2 (fr)	2018-08-14
NZ567222A (en)	2011-07-29
TW201302220A (zh)	2013-01-16
IL258983B (en)	2020-10-29
PL2848258T3 (pl)	2018-06-29
JP2017206552A (ja)	2017-11-24
LTC2848258I2 (lt)	2019-08-12
HK1121041A1 (en)	2009-04-17
JP6286403B2 (ja)	2018-02-28
TR201802449T4 (tr)	2018-03-21
TWI537003B (zh)	2016-06-11
RU2012133522A (ru)	2014-02-20
IL190545A (en)	2016-09-29
NO345888B1 (no)	2021-09-27
RU2571563C2 (ru)	2015-12-20
RU2008120625A (ru)	2010-01-20
CN102861332A (zh)	2013-01-09
PH12013501287A1 (en)	2016-02-01
LTC1940465I2 (lt)	2017-12-11
EP3332807A2 (en)	2018-06-13
LTPA2018506I1 (lt)	2018-06-25
CA2898369C (en)	2017-06-20
ES2944067T3 (es)	2023-06-19
CY2013046I1 (el)	2015-11-04
PH12020500559A1 (en)	2021-06-14
MA29919B1 (fr)	2008-11-03
JP2016020377A (ja)	2016-02-04
WO2007050607A2 (en)	2007-05-03
EP1940465A2 (en)	2008-07-09
JP2009513645A (ja)	2009-04-02
AU2006306280B2 (en)	2010-06-17
KR20150013834A (ko)	2015-02-05
HUS1800025I1 (hu)	2018-07-30
EP2848258A1 (en)	2015-03-18
IL258983A (en)	2018-06-28
ES2389110T3 (es)	2012-10-23
CY2013046I2 (el)	2015-11-04
JP6061747B2 (ja)	2017-01-18
NO20082344L (no)	2008-07-22
EP2848258B1 (en)	2017-12-13
RU2468817C2 (ru)	2012-12-10
PT1940465E (pt)	2012-10-03
CA2626214A1 (en)	2007-05-03
SI2848258T1 (en)	2018-03-30
LT2848258T (lt)	2018-02-26
AU2006306280A1 (en)	2007-05-03
EP3332807B1 (en)	2023-02-22
US20150322148A1 (en)	2015-11-12
IL277406A (en)	2020-11-30
ES2662420T3 (es)	2018-04-06
TWI388335B (zh)	2013-03-11
KR20170038131A (ko)	2017-04-05
US20240083997A1 (en)	2024-03-14
BRPI0617830B1 (pt)	2020-10-20
TWI626056B (zh)	2018-06-11
DK2848258T3 (en)	2018-03-19
CY2018018I1 (el)	2018-12-12
KR101518064B1 (ko)	2015-05-06
SI1940465T1 (sl)	2012-10-30
EP3332807A3 (en)	2018-06-20
EP4218815A3 (en)	2024-03-27
HK1204767A1 (en)	2015-12-04
EP4218815A2 (en)	2023-08-02
TW201617097A (zh)	2016-05-16
US8409576B2 (en)	2013-04-02
EP1940465B1 (en)	2012-08-01
US20120039910A1 (en)	2012-02-16
HUE036973T2 (hu)	2018-08-28
CY1120018T1 (el)	2018-12-12
IL245387B (en)	2019-09-26
JP2013166757A (ja)	2013-08-29
CA2963828A1 (en)	2007-05-03
CA2626214C (en)	2016-06-21
IL245387A0 (en)	2016-06-30
DK1940465T3 (da)	2012-10-22
EP2332577A1 (en)	2011-06-15
CN101291693A (zh)	2008-10-22
US8105587B2 (en)	2012-01-31
CN101291693B (zh)	2012-10-03
KR101749388B1 (ko)	2017-06-20
LU92326I2 (fr)	2014-02-05
CA2898369A1 (en)	2007-05-03
TNSN08189A1 (en)	2009-10-30
PL1940465T3 (pl)	2013-01-31
BRPI0617830A2 (pt)	2011-08-09
JO2826B1 (en)	2014-09-15
NO20200810A1 (no)	2008-07-22
BRPI0617830B8 (pt)	2021-05-25
CY2018018I2 (el)	2018-12-12
US20130171167A1 (en)	2013-07-04
JOP20140120B1 (ar)	2021-08-17
TW200803898A (en)	2008-01-16
WO2007050607A3 (en)	2007-06-28
US20080286266A1 (en)	2008-11-20
KR20080059598A (ko)	2008-06-30
IL190545A0 (en)	2008-11-03
LU92326I9 (pt)	2019-01-16
NO345140B1 (no)	2020-10-12
US9649377B2 (en)	2017-05-16
US20180201674A1 (en)	2018-07-19
HK1252316A1 (en)	2019-05-24
PH12013501287B1 (en)	2016-02-01
US20170218063A1 (en)	2017-08-03

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