PT3000808T - Derivados de ácido 3-hidroxipiridino-2-il-carbonilamino]alcanóico 5-arilo ou 5-heteroarilo substituído, e seus sais bem como sua preparação a partir dos respectivos derivados de ácido 3-hidroxi-picolínico - Google Patents

Derivados de ácido 3-hidroxipiridino-2-il-carbonilamino]alcanóico 5-arilo ou 5-heteroarilo substituído, e seus sais bem como sua preparação a partir dos respectivos derivados de ácido 3-hidroxi-picolínico

Info

Publication number
PT3000808T
PT3000808T PT151898228T PT15189822T PT3000808T PT 3000808 T PT3000808 T PT 3000808T PT 151898228 T PT151898228 T PT 151898228T PT 15189822 T PT15189822 T PT 15189822T PT 3000808 T PT3000808 T PT 3000808T
Authority
PT
Portugal
Prior art keywords
halophenyl
carbonylamino
pyridin
intermediates
amides
Prior art date
Application number
PT151898228T
Other languages
English (en)
Inventor
M Lanthier Christopher
Michael Janusz John
Gorin Boris
Oudenes Jan
Edwar Ddixon Craig
Qingbo Lu Alan
Densmore Copp James
Original Assignee
Akebia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akebia Therapeutics Inc filed Critical Akebia Therapeutics Inc
Publication of PT3000808T publication Critical patent/PT3000808T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
PT151898228T 2011-06-06 2012-06-05 Derivados de ácido 3-hidroxipiridino-2-il-carbonilamino]alcanóico 5-arilo ou 5-heteroarilo substituído, e seus sais bem como sua preparação a partir dos respectivos derivados de ácido 3-hidroxi-picolínico PT3000808T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161493536P 2011-06-06 2011-06-06

Publications (1)

Publication Number Publication Date
PT3000808T true PT3000808T (pt) 2017-11-23

Family

ID=47262177

Family Applications (4)

Application Number Title Priority Date Filing Date
PT171913627T PT3290404T (pt) 2011-06-06 2012-06-05 Derivados de 5-((halogenofenil)-3-halogeno-piridin-2-il)-nitrilo como intermediários na preparação de derivados de ácido [(5-(halogenofenil)-3-hidroxipiridin-2-carbonil)-amino]alcanóico
PT192144053T PT3683209T (pt) 2011-06-06 2012-06-05 Processo para preparar ácido [(5-(3-clorofenil)-3-hidroxipiridina-2-carbonil)-amino]acético a partir de 5-((3-clorofenil)-3-cloro-piridin-2-il)-nitrilo e processo para preparar derivados 5-((halogenofenil)-3-halogenopiridin-2-il)-nitrilo
PT127963742T PT2718265E (pt) 2011-06-06 2012-06-05 Processo para a preparação de ácidos, ésteres e amidas [(3-hidroxipiridino-2-carbonil)amino]alcanóicos
PT151898228T PT3000808T (pt) 2011-06-06 2012-06-05 Derivados de ácido 3-hidroxipiridino-2-il-carbonilamino]alcanóico 5-arilo ou 5-heteroarilo substituído, e seus sais bem como sua preparação a partir dos respectivos derivados de ácido 3-hidroxi-picolínico

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PT171913627T PT3290404T (pt) 2011-06-06 2012-06-05 Derivados de 5-((halogenofenil)-3-halogeno-piridin-2-il)-nitrilo como intermediários na preparação de derivados de ácido [(5-(halogenofenil)-3-hidroxipiridin-2-carbonil)-amino]alcanóico
PT192144053T PT3683209T (pt) 2011-06-06 2012-06-05 Processo para preparar ácido [(5-(3-clorofenil)-3-hidroxipiridina-2-carbonil)-amino]acético a partir de 5-((3-clorofenil)-3-cloro-piridin-2-il)-nitrilo e processo para preparar derivados 5-((halogenofenil)-3-halogenopiridin-2-il)-nitrilo
PT127963742T PT2718265E (pt) 2011-06-06 2012-06-05 Processo para a preparação de ácidos, ésteres e amidas [(3-hidroxipiridino-2-carbonil)amino]alcanóicos

Country Status (23)

Country Link
US (6) US9145366B2 (pt)
EP (5) EP3290404B1 (pt)
JP (6) JP6290781B2 (pt)
KR (5) KR102000485B1 (pt)
CN (1) CN106518759B (pt)
AU (4) AU2012268426B2 (pt)
CA (2) CA2838194C (pt)
CY (4) CY1117177T1 (pt)
DK (4) DK3683209T3 (pt)
ES (4) ES2900572T3 (pt)
HR (4) HRP20151416T1 (pt)
HU (4) HUE034975T2 (pt)
IL (1) IL229775A (pt)
LT (3) LT3000808T (pt)
MX (2) MX337216B (pt)
NO (1) NO2686520T3 (pt)
PL (4) PL3290404T3 (pt)
PT (4) PT3290404T (pt)
RS (3) RS54517B1 (pt)
RU (2) RU2602083C2 (pt)
SI (4) SI2718265T1 (pt)
SM (3) SMT202000061T1 (pt)
WO (1) WO2012170377A1 (pt)

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NO2686520T3 (pt) 2011-06-06 2018-03-17
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EP3578546A1 (en) 2013-11-15 2019-12-11 Akebia Therapeutics Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
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EP3270922A4 (en) * 2015-03-20 2018-08-01 Akebia Therapeutics Inc. Deuterium-enriched hypoxia-inducible factor prolyl hydroxylase enzyme inhibitors
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