PT88648A - Process for the preparation of new androstane 17-carboxylic acid esters and a pharmaceutical composition containing same - Google Patents

Process for the preparation of new androstane 17-carboxylic acid esters and a pharmaceutical composition containing same

Info

Publication number: PT88648A
Authority: PT; Portugal
Prior art keywords: group; image; carbon atoms; hydroxy; carboxylic acid
Prior art date: 1987-10-02

Application number

PT88648A

Other languages

English (en)

Other versions

PT88648B (pt

Original Assignee

Nativelle Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-02

Filing date

1988-09-30

Publication date

1988-10-01

1988-09-30 Application filed by Nativelle Lab filed Critical Nativelle Lab

1988-10-01 Publication of PT88648A publication Critical patent/PT88648A/pt

1992-12-31 Publication of PT88648B publication Critical patent/PT88648B/pt

Links

PBXJGQQGODZSQR-HUWVKCSISA-N (5R,8R,9S,10S,13S,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid Chemical class [C@@H]12CCC([C@@]1(C)CC[C@H]1[C@H]2CC[C@H]2CCCC[C@]12C)C(=O)O PBXJGQQGODZSQR-HUWVKCSISA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
206010019280 Heart failures Diseases 0.000 abstract 1
125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002345 steroid group Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Photoreceptors In Electrophotography (AREA)

PT88648A 1987-10-02 1988-09-30 Processo para a preparacao de novos esteres de acido androstano 17-carboxilico, e de composicao farmaceutica que os contem PT88648B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8713658A FR2621316B1 (fr)	1987-10-02	1987-10-02	Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant

Publications (2)

Publication Number	Publication Date
PT88648A true PT88648A (pt)	1988-10-01
PT88648B PT88648B (pt)	1992-12-31

Family

ID=9355472

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88648A PT88648B (pt)	1987-10-02	1988-09-30	Processo para a preparacao de novos esteres de acido androstano 17-carboxilico, e de composicao farmaceutica que os contem

Country Status (22)

Country	Link
US (1)	US4885280A (pt)
EP (1)	EP0310519B1 (pt)
JP (1)	JP2783560B2 (pt)
KR (1)	KR970002642B1 (pt)
AT (1)	ATE79630T1 (pt)
AU (1)	AU607100B2 (pt)
CA (1)	CA1306248C (pt)
DE (1)	DE3873870T2 (pt)
DK (1)	DK165595C (pt)
EG (1)	EG19114A (pt)
ES (1)	ES2052761T3 (pt)
FI (1)	FI89055C (pt)
FR (1)	FR2621316B1 (pt)
GR (1)	GR3005968T3 (pt)
HK (1)	HK60297A (pt)
IE (1)	IE61941B1 (pt)
IL (1)	IL87894A (pt)
MY (1)	MY103635A (pt)
NO (1)	NO173011C (pt)
NZ (1)	NZ226433A (pt)
PT (1)	PT88648B (pt)
ZA (1)	ZA887396B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5209926A (en) *	1990-06-12	1993-05-11	Insite Vision Incorporated	Aminosteroids for ophthalmic use
US5124154A (en) *	1990-06-12	1992-06-23	Insite Vision Incorporated	Aminosteroids for ophthalmic use
US5256408A (en) *	1990-06-12	1993-10-26	Insite Vision Incorporated	Aminosteroids for ophthalmic use
US5252319A (en) *	1990-06-12	1993-10-12	Insite Vision Incorporated	Aminosteroids for ophthalmic use
WO1993005790A1 (en) *	1991-09-27	1993-04-01	Procter & Gamble Pharmaceuticals, Inc.	Use of 14-aminosteroids for the manufacture of a medicament to slow the rate of progression of myocardial structural damages characteristic of congestive heart failure
CZ331094A3 (en) *	1992-06-26	1995-09-13	Pfizer	Steroidal glycosides and their use for treating hypercholesterolemia and atherosclerosis
AU700131B2 (en) *	1993-09-24	1998-12-24	Procter & Gamble Company, The	Novel deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds
CZ86796A3 (en) *	1993-09-24	1996-10-16	Procter & Gamble	Novel deoxy and on oxygen substituted sugar derivatives of aminosteroidal compounds
BR9407612A (pt) *	1993-09-24	1997-01-14	Procter & Gamble	Novos compostos de 14-aminoesteróides contendo oligossacarideos e nova química de processo de aminoesteróide diastereosseletivo
US5922703A (en) *	1993-09-24	1999-07-13	The Procter & Gamble Company	Urethane-containing aminosteroid compounds
BR9709835A (pt) *	1996-06-17	1999-08-10	Procter & Gamble	Compostos 14-aminoesteróides contendo açúcar substituído com deóxi e oxigênio para uso como um antiarrítmico
ATE473759T1 (de)	1998-05-22	2010-07-15	Univ Leland Stanford Junior	Bifunktionelle moleküle sowie darauf basierende therapien.
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
EP2398500B1 (en)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Glutathione-based drug delivery system
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
GB201112402D0 (en)	2011-07-19	2011-08-31	British American Tobacco Co	Cellulose acetate compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3449381A (en) *	1962-06-12	1969-06-10	Syntex Corp	19-oxo- and 19-lower alkyl-19-oxoandrostane derivatives
US3634409A (en) *	1966-04-26	1972-01-11	Syntex Corp	3beta-tetrahydrofuran-2'-yloxy-delta**4-steroids of the androstane and estrane series
FR2464270A1 (fr) *	1979-08-31	1981-03-06	Nativelle Sa Ets	Nouveaux derives d'amino-14 steroides, et procede pour leur preparation
NZ205293A (en) *	1982-08-20	1986-12-05	Nativelle Sa Ets	14-aminosteroids and pharmaceutical compositions
ES524796A0 (es) *	1982-08-20	1984-05-01	Nativelle Sa Ets	Procedimiento de preparacion de nuevos derivos de amino-14 esteroides

1987
- 1987-10-02 FR FR8713658A patent/FR2621316B1/fr not_active Expired - Fee Related
1988
- 1988-09-29 CA CA000578812A patent/CA1306248C/en not_active Expired - Lifetime
- 1988-09-30 ES ES88402476T patent/ES2052761T3/es not_active Expired - Lifetime
- 1988-09-30 IL IL8789488A patent/IL87894A/en not_active IP Right Cessation
- 1988-09-30 DK DK549388A patent/DK165595C/da not_active IP Right Cessation
- 1988-09-30 PT PT88648A patent/PT88648B/pt not_active IP Right Cessation
- 1988-09-30 AT AT88402476T patent/ATE79630T1/de not_active IP Right Cessation
- 1988-09-30 EP EP88402476A patent/EP0310519B1/fr not_active Expired - Lifetime
- 1988-09-30 US US07/252,240 patent/US4885280A/en not_active Expired - Fee Related
- 1988-09-30 NO NO884344A patent/NO173011C/no not_active IP Right Cessation
- 1988-09-30 DE DE8888402476T patent/DE3873870T2/de not_active Expired - Fee Related
- 1988-09-30 FI FI884511A patent/FI89055C/fi not_active IP Right Cessation
- 1988-10-02 EG EG50588A patent/EG19114A/xx active
- 1988-10-03 AU AU22935/88A patent/AU607100B2/en not_active Ceased
- 1988-10-03 IE IE299188A patent/IE61941B1/en not_active IP Right Cessation
- 1988-10-03 ZA ZA887396A patent/ZA887396B/xx unknown
- 1988-10-03 NZ NZ226433A patent/NZ226433A/en unknown
- 1988-10-03 JP JP63249708A patent/JP2783560B2/ja not_active Expired - Lifetime
- 1988-10-04 KR KR1019880012904A patent/KR970002642B1/ko not_active Expired - Fee Related
- 1988-11-07 MY MYPI88001276A patent/MY103635A/en unknown
1992
- 1992-10-12 GR GR920402291T patent/GR3005968T3/el unknown
1997
- 1997-05-08 HK HK60297A patent/HK60297A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2783560B2 (ja)	1998-08-06
JPH01156995A (ja)	1989-06-20
AU607100B2 (en)	1991-02-21
KR970002642B1 (ko)	1997-03-07
AU2293588A (en)	1989-04-06
IE882991L (en)	1989-04-02
GR3005968T3 (pt)	1993-06-07
FI89055B (fi)	1993-04-30
NO173011C (no)	1993-10-13
KR890006667A (ko)	1989-06-15
DK165595C (da)	1993-05-03
DK549388D0 (da)	1988-09-30
FR2621316B1 (fr)	1991-06-21
DK549388A (da)	1989-04-03
NZ226433A (en)	1991-06-25
IL87894A0 (en)	1989-03-31
DE3873870T2 (de)	1993-02-18
PT88648B (pt)	1992-12-31
NO173011B (no)	1993-07-05
IL87894A (en)	1994-02-27
EG19114A (fr)	1994-07-30
DE3873870D1 (de)	1992-09-24
EP0310519B1 (fr)	1992-08-19
EP0310519A1 (fr)	1989-04-05
DK165595B (da)	1992-12-21
CA1306248C (en)	1992-08-11
ES2052761T3 (es)	1994-07-16
FI884511A7 (fi)	1989-04-03
NO884344D0 (no)	1988-09-30
ATE79630T1 (de)	1992-09-15
NO884344L (no)	1989-04-03
FR2621316A1 (fr)	1989-04-07
IE61941B1 (en)	1994-11-30
MY103635A (en)	1993-08-28
HK60297A (en)	1997-05-16
FI884511A0 (fi)	1988-09-30
US4885280A (en)	1989-12-05
FI89055C (fi)	1993-08-10
ZA887396B (en)	1991-11-27

Legal Events

Date

Code

Title

Description

1992-12-31

FG3A

Patent granted, date of granting

Effective date: 19920616

2002-04-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20011231

Publication	Publication Date	Title
IL87894A0 (en)	1989-03-31	Androstane 17-carboxylic acid esters,their preparation and pharmaceutical compositions containing them
EP0393494A3 (en)	1992-05-20	Bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
ES8404694A1 (es)	1984-05-01	Procedimiento de preparacion de nuevos derivos de amino-14 esteroides
IL72330A (en)	1987-02-27	3-alkyl-7-pyridyl-1h-triazolo(3,4-a)pyrimidine-5-one derivatives,their preparation and pharmaceutical compositions containing them
AU608643B2 (en)	1991-04-11	Novel derivatives of the oxime of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde, the process for their preparation, their use as medicaments and the compositions containing them
DK163055C (da)	1992-06-15	Analogifremgangsmaade til fremstilling af 2-dipropylamino-(5 eller 7)-formylamino-6-hydroxy-1,2,3,4-tetrahydronaphthalen og farmakologisk acceptable syreadditionssalte deraf
DE69306513D1 (de)	1997-01-23	Neue kardioaktive Zyklopentaperhydrophenanthrene-17-beta-(hydroxy oder alkoxy)-17-alpha-(aryl oder heterozyklyl)-3-beta Derivate, ein Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon
AU617849B2 (en)	1991-12-05	New benzopyrrolidinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
PT75900A (de)	1982-12-01	Neue oxyme von 3'''-dehydro-cardenolid-trididitoxosiden verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ES8303405A1 (es)	1983-02-16	Procedimiento de preparacion de derivados de quinidina.
JPS568400A (en)	1981-01-28	Novel 122dehydrodigoxinnoxime* its manufacture and heart failure drug containing same
GB826362A (en)	1960-01-06	Steroid compounds and therapeutic compositions containing them