PT89123A - Metodo para a utilizacao de d1-5-{(2-benzil-3,4-di-hidro-2h-benzopiran-6-il)metil}tiazolidino-2,4-diona como agente anti-aterosclerose - Google Patents

Metodo para a utilizacao de d1-5-{(2-benzil-3,4-di-hidro-2h-benzopiran-6-il)metil}tiazolidino-2,4-diona como agente anti-aterosclerose

Info

Publication number: PT89123A
Authority: PT; Portugal
Prior art keywords: thiazolidine; benzopyran; dihydro; benzyl; methyl
Prior art date: 1987-12-02

Application number

PT89123A

Other languages

English (en)

Other versions

PT89123B (pt

Inventor

Michael Norman Krupp

Archie Calhoun Swindell

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-02

Filing date

1988-11-30

Publication date

1989-12-29

1988-11-30 Application filed by Pfizer filed Critical Pfizer

1989-12-29 Publication of PT89123A publication Critical patent/PT89123A/pt

1993-09-30 Publication of PT89123B publication Critical patent/PT89123B/pt

Links

-1 2-BENZYL-3,4-DIHYDRO-2H-BENZOPYRAN-6-YL Chemical class 0.000 title abstract 3
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 3
125000002091 cationic group Chemical group 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
200000000007 Arterial disease Diseases 0.000 abstract 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
230000000979 retarding effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

PT89123A 1987-12-02 1988-11-30 Metodo para a utilizacao de d1-5-{(2-benzil-3,4-di-hidro-2h-benzopiran-6-il)metil}tiazolidino-2,4-diona como agente anti-aterosclerose PT89123B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/127,858 US4798835A (en)	1987-12-02	1987-12-02	dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidine-2,4-dione as an anti-atherosclerosis agent

Publications (2)

Publication Number	Publication Date
PT89123A true PT89123A (pt)	1989-12-29
PT89123B PT89123B (pt)	1993-09-30

Family

ID=22432331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT89123A PT89123B (pt)	1987-12-02	1988-11-30	Metodo para a utilizacao de d1-5-{(2-benzil-3,4-di-hidro-2h-benzopiran-6-il)metil}tiazolidino-2,4-diona como agente anti-aterosclerose

Country Status (16)

Country	Link
US (1)	US4798835A (pt)
EP (1)	EP0319288B1 (pt)
JP (1)	JPH01186883A (pt)
KR (1)	KR900006993B1 (pt)
AT (1)	ATE81456T1 (pt)
AU (1)	AU604176B2 (pt)
CA (1)	CA1313139C (pt)
DE (1)	DE3875324T2 (pt)
DK (1)	DK670988A (pt)
HU (1)	HU204433B (pt)
IE (1)	IE883600L (pt)
IL (1)	IL88513A (pt)
MY (1)	MY103498A (pt)
PH (1)	PH24873A (pt)
PT (1)	PT89123B (pt)
ZA (1)	ZA888968B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5053420A (en) *	1989-10-13	1991-10-01	Pershadsingh Harrihar A	Thiazolidine derivatives for the treatment of hypertension
DK0494405T3 (da) *	1991-01-10	1996-11-18	Transcend Therapeutics Inc	Anvendelse af thiazolidin-4-carboxylatderivater til behandling af lungesygdomme
US5747459A (en) *	1991-02-04	1998-05-05	Nestec, Ltd.	Method for insuring adequate intracellular glutathione in tissue
US5866595A (en) *	1991-09-26	1999-02-02	The Regents Of The University Of California	Calcium antagonists for treatment of vascular restenosis
US5430045A (en) *	1992-04-23	1995-07-04	Free Radical Sciences, Inc.	Method of reducing or preventing bone marrow hypoplasia
US5306724A (en) *	1992-08-17	1994-04-26	Clintec Nutrition Company	Method for preventing and treating atherosclerosis
US5447712A (en) *	1993-12-09	1995-09-05	Free Radical Sciences	Method of reducing cyclophosphamide induced hemorrhagic cystitis
GB9611947D0 (en) *	1996-06-07	1996-08-07	Glaxo Group Ltd	Medicaments

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en) *	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
JPS58118577A (ja) *	1982-01-07	1983-07-14	Takeda Chem Ind Ltd	チアゾリジン誘導体
US4617312A (en) *	1983-01-17	1986-10-14	Pfizer Inc.	Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
JPS6051189A (ja) *	1983-08-30	1985-03-22	Sankyo Co Ltd	チアゾリジン誘導体およびその製造法
AR240698A1 (es) *	1985-01-19	1990-09-28	Takeda Chemical Industries Ltd	Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
WO1986007056A1 (en) *	1985-05-21	1986-12-04	Pfizer Inc.	Hypoglycemic thiazolidinediones
JPH06779B2 (ja) *	1985-06-10	1994-01-05	武田薬品工業株式会社	チアゾリジオン誘導体およびそれを含んでなる医薬組成物

1987
- 1987-12-02 US US07/127,858 patent/US4798835A/en not_active Expired - Lifetime
1988
- 1988-11-26 MY MYPI88001364A patent/MY103498A/en unknown
- 1988-11-28 IL IL8851388A patent/IL88513A/en unknown
- 1988-11-29 JP JP63302127A patent/JPH01186883A/ja active Granted
- 1988-11-30 ZA ZA888968A patent/ZA888968B/xx unknown
- 1988-11-30 CA CA000584530A patent/CA1313139C/en not_active Expired - Fee Related
- 1988-11-30 PT PT89123A patent/PT89123B/pt not_active IP Right Cessation
- 1988-12-01 DK DK670988A patent/DK670988A/da not_active Application Discontinuation
- 1988-12-01 AT AT88311378T patent/ATE81456T1/de not_active IP Right Cessation
- 1988-12-01 DE DE8888311378T patent/DE3875324T2/de not_active Expired - Fee Related
- 1988-12-01 AU AU26471/88A patent/AU604176B2/en not_active Ceased
- 1988-12-01 KR KR1019880015992A patent/KR900006993B1/ko not_active Expired
- 1988-12-01 IE IE883600A patent/IE883600L/xx unknown
- 1988-12-01 EP EP88311378A patent/EP0319288B1/en not_active Expired - Lifetime
- 1988-12-01 HU HU886143A patent/HU204433B/hu not_active IP Right Cessation
- 1988-12-02 PH PH37884A patent/PH24873A/en unknown

Also Published As

Publication number	Publication date
ZA888968B (en)	1990-07-25
HUT54045A (en)	1991-01-28
EP0319288A3 (en)	1990-12-27
EP0319288A2 (en)	1989-06-07
IL88513A0 (en)	1989-06-30
DE3875324T2 (de)	1993-02-25
DK670988A (da)	1989-07-24
EP0319288B1 (en)	1992-10-14
HU204433B (en)	1992-01-28
AU2647188A (en)	1989-06-08
PH24873A (en)	1990-12-26
MY103498A (en)	1993-06-30
JPH0460582B2 (pt)	1992-09-28
IL88513A (en)	1994-04-12
ATE81456T1 (de)	1992-10-15
CA1313139C (en)	1993-01-26
PT89123B (pt)	1993-09-30
AU604176B2 (en)	1990-12-06
US4798835A (en)	1989-01-17
DK670988D0 (da)	1988-12-01
KR900006993B1 (ko)	1990-09-25
JPH01186883A (ja)	1989-07-26
KR890009922A (ko)	1989-08-04
IE883600L (en)	1989-06-02
DE3875324D1 (de)	1992-11-19

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Legal Events

Date

Code

Title

Description

1993-09-30

FG3A

Patent granted, date of granting

Effective date: 19930305

1995-03-01

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19940930