ATE81456T1 - Dl-5-((2-benzyl-3,4-dihydro-2h-benzopyran-6yl)methyl>thiazolidin-2,4-dion als antiatherosklerosemittel. - Google Patents

Dl-5-((2-benzyl-3,4-dihydro-2h-benzopyran-6yl)methyl>thiazolidin-2,4-dion als antiatherosklerosemittel.

Info

Publication number: ATE81456T1
Authority: AT; Austria
Prior art keywords: dione; benzopyran; dihydro; benzyl; methyl
Prior art date: 1987-12-02

Application number

AT88311378T

Other languages

English (en)

Inventor

Michael Norman Krupp

Archie Calhoum Swindell

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-02

Filing date

1988-12-01

Publication date

1992-10-15

1988-12-01 Application filed by Pfizer filed Critical Pfizer

1992-10-15 Application granted granted Critical

1992-10-15 Publication of ATE81456T1 publication Critical patent/ATE81456T1/de

Links

ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 title abstract 4
230000000879 anti-atherosclerotic effect Effects 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 3
-1 2-benzyl-3,4-dihydro-2H-benzopyran-6-yl Chemical group 0.000 abstract 2
125000002091 cationic group Chemical group 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
200000000007 Arterial disease Diseases 0.000 abstract 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
230000000979 retarding effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT88311378T 1987-12-02 1988-12-01 Dl-5-((2-benzyl-3,4-dihydro-2h-benzopyran-6yl)methyl>thiazolidin-2,4-dion als antiatherosklerosemittel. ATE81456T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/127,858 US4798835A (en)	1987-12-02	1987-12-02	dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidine-2,4-dione as an anti-atherosclerosis agent
EP88311378A EP0319288B1 (de)	1987-12-02	1988-12-01	dl-5-[(2-Benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidin-2,4-dion als Antiatherosklerosemittel

Publications (1)

Publication Number	Publication Date
ATE81456T1 true ATE81456T1 (de)	1992-10-15

Family

ID=22432331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88311378T ATE81456T1 (de)	1987-12-02	1988-12-01	Dl-5-((2-benzyl-3,4-dihydro-2h-benzopyran-6yl)methyl>thiazolidin-2,4-dion als antiatherosklerosemittel.

Country Status (16)

Country	Link
US (1)	US4798835A (de)
EP (1)	EP0319288B1 (de)
JP (1)	JPH01186883A (de)
KR (1)	KR900006993B1 (de)
AT (1)	ATE81456T1 (de)
AU (1)	AU604176B2 (de)
CA (1)	CA1313139C (de)
DE (1)	DE3875324T2 (de)
DK (1)	DK670988A (de)
HU (1)	HU204433B (de)
IE (1)	IE883600L (de)
IL (1)	IL88513A (de)
MY (1)	MY103498A (de)
PH (1)	PH24873A (de)
PT (1)	PT89123B (de)
ZA (1)	ZA888968B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5053420A (en) *	1989-10-13	1991-10-01	Pershadsingh Harrihar A	Thiazolidine derivatives for the treatment of hypertension
ES2092539T3 (es) *	1991-01-10	1996-12-01	Transcend Therapeutics Inc	Uso de derivados de la tiazolidina-4-carboxilato para el tratamiento de enfermedades pulmonares.
US5747459A (en) *	1991-02-04	1998-05-05	Nestec, Ltd.	Method for insuring adequate intracellular glutathione in tissue
US5866595A (en) *	1991-09-26	1999-02-02	The Regents Of The University Of California	Calcium antagonists for treatment of vascular restenosis
US5430045A (en) *	1992-04-23	1995-07-04	Free Radical Sciences, Inc.	Method of reducing or preventing bone marrow hypoplasia
US5306724A (en) *	1992-08-17	1994-04-26	Clintec Nutrition Company	Method for preventing and treating atherosclerosis
US5447712A (en) *	1993-12-09	1995-09-05	Free Radical Sciences	Method of reducing cyclophosphamide induced hemorrhagic cystitis
GB9611947D0 (en) *	1996-06-07	1996-08-07	Glaxo Group Ltd	Medicaments

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en) *	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
JPS58118577A (ja) *	1982-01-07	1983-07-14	Takeda Chem Ind Ltd	チアゾリジン誘導体
US4617312A (en) *	1983-01-17	1986-10-14	Pfizer Inc.	Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
JPS6051189A (ja) *	1983-08-30	1985-03-22	Sankyo Co Ltd	チアゾリジン誘導体およびその製造法
AR240698A1 (es) *	1985-01-19	1990-09-28	Takeda Chemical Industries Ltd	Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
HU210339B (en) *	1985-05-21	1995-03-28	Pfizer	Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect
JPH06779B2 (ja) *	1985-06-10	1994-01-05	武田薬品工業株式会社	チアゾリジオン誘導体およびそれを含んでなる医薬組成物

1987
- 1987-12-02 US US07/127,858 patent/US4798835A/en not_active Expired - Lifetime
1988
- 1988-11-26 MY MYPI88001364A patent/MY103498A/en unknown
- 1988-11-28 IL IL8851388A patent/IL88513A/en unknown
- 1988-11-29 JP JP63302127A patent/JPH01186883A/ja active Granted
- 1988-11-30 PT PT89123A patent/PT89123B/pt not_active IP Right Cessation
- 1988-11-30 ZA ZA888968A patent/ZA888968B/xx unknown
- 1988-11-30 CA CA000584530A patent/CA1313139C/en not_active Expired - Fee Related
- 1988-12-01 EP EP88311378A patent/EP0319288B1/de not_active Expired - Lifetime
- 1988-12-01 DK DK670988A patent/DK670988A/da not_active Application Discontinuation
- 1988-12-01 HU HU886143A patent/HU204433B/hu not_active IP Right Cessation
- 1988-12-01 AT AT88311378T patent/ATE81456T1/de not_active IP Right Cessation
- 1988-12-01 AU AU26471/88A patent/AU604176B2/en not_active Ceased
- 1988-12-01 IE IE883600A patent/IE883600L/xx unknown
- 1988-12-01 DE DE8888311378T patent/DE3875324T2/de not_active Expired - Fee Related
- 1988-12-01 KR KR1019880015992A patent/KR900006993B1/ko not_active Expired
- 1988-12-02 PH PH37884A patent/PH24873A/en unknown

Also Published As

Publication number	Publication date
IL88513A0 (en)	1989-06-30
PT89123A (pt)	1989-12-29
IE883600L (en)	1989-06-02
US4798835A (en)	1989-01-17
DE3875324T2 (de)	1993-02-25
AU604176B2 (en)	1990-12-06
HUT54045A (en)	1991-01-28
AU2647188A (en)	1989-06-08
CA1313139C (en)	1993-01-26
PT89123B (pt)	1993-09-30
DK670988D0 (da)	1988-12-01
EP0319288A3 (en)	1990-12-27
JPH01186883A (ja)	1989-07-26
ZA888968B (en)	1990-07-25
DK670988A (da)	1989-07-24
JPH0460582B2 (de)	1992-09-28
DE3875324D1 (de)	1992-11-19
EP0319288A2 (de)	1989-06-07
PH24873A (en)	1990-12-26
IL88513A (en)	1994-04-12
MY103498A (en)	1993-06-30
EP0319288B1 (de)	1992-10-14
HU204433B (en)	1992-01-28
KR900006993B1 (ko)	1990-09-25
KR890009922A (ko)	1989-08-04

Legal Events

Date	Code	Title	Description
1993-03-15	UEP	Publication of translation of european patent specification
1994-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK233586A (da)	1986-11-22	5-substituerede 1,3-thiazolidon-2,4-dion forbindelser og farmaceutiske praeparater indeholdende disse
NO922380L (no)	1992-06-17	Substituerte 4-fenyl-4-piperidinkarboksamider med baade lokal anestetisk og analgetisk effekt samt fremgangsmaater for deres fremstilling
ATE81456T1 (de)	1992-10-15	Dl-5-((2-benzyl-3,4-dihydro-2h-benzopyran-6yl)methyl>thiazolidin-2,4-dion als antiatherosklerosemittel.
DK165982C (da)	1993-07-26	Imidazolylguanidinderivater og laegemidler, der indeholder disse forbindelser
KR910004191A (ko)	1991-03-28	신질환치료제
DZ2430A1 (fr)	2003-01-11	Procédé pour la préparation de dérivés de thiazolidinedione substitués.
EP0292352A3 (de)	1988-12-28	Makrolid-Derivate, Verfahren zu ihrer Herstellung und ihre pharmazeutischen Zusammensetzungen
NO166400C (no)	1991-07-17	Anodning ved delvis nedsenkbar plattform.
DK520787A (da)	1988-04-07	Terapeutisk middel indeholdende propentofyllin eller derivater deraf til brug ved behandling af peptisk ulcus
ATE34661T1 (de)	1988-06-15	Verbindungen zur verminderung des lipidspiegels.
ATE120447T1 (de)	1995-04-15	Polyamin-derivate als antineoplastische mittel.
ATE175673T1 (de)	1999-01-15	Alkylidenanaloge von 1'-aminospiro-(isochinolin- 4(1h), 3'-pyrrolidin>-1,2',3,5'(2h)-tetronen, verwendbar als aldose reduktase-inhibitoren in vivo
KR910002818A (ko)	1991-02-26	4,5,6,7-사치환된 벤즈옥사졸론
ATE45574T1 (de)	1989-09-15	Aldosereduktasehemmende 5-(2alkoxyphenyl)thiazolidinedione.
DK69889D0 (da)	1989-02-15	2-substituerede carbonylimidazol(4,5-c)-quinoliner
HUP0002727A2 (hu)	2001-08-28	Eljárás fibrinogén csökkentésére benzotiofénszármazékok felhasználásával
ATE81005T1 (de)	1992-10-15	Ponalrestat enthaltendes hyperurikaemie-mittel.
ATE81983T1 (de)	1992-11-15	Absorptionsverbesserer fuer proteine.
DK175787A (da)	1987-10-08	Stabile, injicerbare antiemetiske praeparater
FI892577A0 (fi)	1989-05-26	Vattenhaltig framkallarkomposition foer med loesningsmedel framkallbara fotoresistbelaeggningar.
IL83214A (en)	1991-07-18	5-substituted thiazolidine-2,4-diones as hyperglycemic agents
KR890011593A (ko)	1989-08-21	쇼크 치료에 사용하기 위한 2-(페닐아미노)이미디졸린-(2)의 용도
NO911497L (no)	1989-02-08	Bi-heterosyklisk forbindelse til bruk ved framstilling avterapeutisk aktive beta-lactamforbindelser.