PT93082A - Processo de producao de um derivado de activador de plaminogenio tissular, de plasmideo de expressao e de medicamento contendo o referido derivado - Google Patents

Processo de producao de um derivado de activador de plaminogenio tissular, de plasmideo de expressao e de medicamento contendo o referido derivado

Info

Publication number: PT93082A
Authority: PT; Portugal
Prior art keywords: pct; protein; plasmide; expression; production process
Prior art date: 1989-02-07

Application number

PT93082A

Other languages

English (en)

Other versions

PT93082B (pt

Inventor

Stephan Fischer

Anne Stern

Ulrich Kohnert

Rainer Rudolph

Ulrich Martin

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-07

Filing date

1990-02-07

Publication date

1990-08-31

1990-02-07 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1990-08-31 Publication of PT93082A publication Critical patent/PT93082A/pt

1996-03-29 Publication of PT93082B publication Critical patent/PT93082B/pt

Links

239000012190 activator Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
102000004169 proteins and genes Human genes 0.000 abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
125000003275 alpha amino acid group Chemical group 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
230000002349 favourable effect Effects 0.000 abstract 1
102000035122 glycosylated proteins Human genes 0.000 abstract 1
108091005608 glycosylated proteins Proteins 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Analytical Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Public Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Luminescent Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

PT93082A 1989-02-07 1990-02-07 Processo de producao de um derivado de activador de plaminogenio tissular, de plasmideo de expressao e de medicamento contendo o referido derivado PT93082B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3903581A DE3903581A1 (de)	1989-02-07	1989-02-07	Gewebs-plasminogenaktivator-derivat

Publications (2)

Publication Number	Publication Date
PT93082A true PT93082A (pt)	1990-08-31
PT93082B PT93082B (pt)	1996-03-29

Family

ID=6373566

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT93082A PT93082B (pt)	1989-02-07	1990-02-07	Processo de producao de um derivado de activador de plaminogenio tissular, de plasmideo de expressao e de medicamento contendo o referido derivado

Country Status (29)

Country	Link
US (1)	US5223256A (pt)
EP (1)	EP0382174B1 (pt)
JP (1)	JP2559538B2 (pt)
KR (1)	KR970008485B1 (pt)
AT (1)	ATE126270T1 (pt)
AU (1)	AU623228B2 (pt)
CA (1)	CA2025900C (pt)
CZ (1)	CZ281836B6 (pt)
DD (1)	DD291779A5 (pt)
DE (2)	DE3903581A1 (pt)
DK (1)	DK0382174T3 (pt)
ES (1)	ES2031804T3 (pt)
FI (1)	FI100244B (pt)
GR (2)	GR900300140T1 (pt)
HK (1)	HK153396A (pt)
HU (1)	HU218092B (pt)
IE (1)	IE61077B1 (pt)
IL (1)	IL93280A (pt)
LU (1)	LU90025I2 (pt)
LV (1)	LV10302B (pt)
NL (1)	NL970008I2 (pt)
NO (2)	NO306563B1 (pt)
NZ (1)	NZ232337A (pt)
PT (1)	PT93082B (pt)
RU (1)	RU2107094C1 (pt)
SK (1)	SK279029B6 (pt)
UA (1)	UA27111A1 (pt)
WO (1)	WO1990009437A1 (pt)
ZA (1)	ZA90861B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4634007A (en) *	1985-12-02	1987-01-06	Adolph Coors Company	Carton blank with perforated tear line
US5676947A (en) *	1989-02-07	1997-10-14	Boehringer Manneheim Gmbh	Method for treating thromboembolic conditions using thrombolytically active proteins
DE3923339A1 (de) *	1989-05-31	1990-12-06	Boehringer Mannheim Gmbh	Gewebs-plasminogen-aktivator-derivat
GB9019120D0 (en) *	1990-09-01	1990-10-17	Beecham Group Plc	Novel compounds
DE4037196A1 (de) *	1990-11-22	1992-05-27	Boehringer Mannheim Gmbh	Verfahren zur reaktivierung von denaturiertem protein
DE4123845A1 (de) *	1991-07-18	1993-01-21	Boehringer Mannheim Gmbh	Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe
JPH06506459A (ja) *	1991-04-16	1994-07-21	ロシュダイアグノスティックスゲーエムベーハー	プラスミノーゲン活性化剤を含有する多重ボーラス投与用医薬パッケージユニット
US5510330A (en) *	1994-03-25	1996-04-23	Boehringer Mannheim Gmbh	Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
DE4423574A1 (de) *	1994-07-05	1996-01-11	Boehringer Mannheim Gmbh	Nicht-glykosylierte Plasminogenaktivator-Derivate und ihre Verwendung bei erhöhtem Blutungsrisiko
WO1996017928A1 (en) *	1994-12-06	1996-06-13	Boehringer Mannheim Gmbh	Use of the protease domain of human plasminogen activator for the treatment of thromboembolic diseases
US5723122A (en) *	1995-06-01	1998-03-03	Boehringer Mannheim Gmbh	Use of the protease domain of human plasminogen activator for the treatment of thromboembolic diseases
AU2660397A (en) *	1996-04-05	1997-10-29	Board Of Regents, The University Of Texas System	Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6083715A (en) *	1997-06-09	2000-07-04	Board Of Regents, The University Of Texas System	Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
AU729489B2 (en)	1997-07-23	2001-02-01	Roche Diagnostics Gmbh	Production of human mutated proteins in human cells by means of homologous recombination
AU8864398A (en) *	1997-08-13	1999-03-08	Boehringer Mannheim Gmbh	Plasminogen activator with enhanced zymogenic power and reduced fibrin linking
AU9162198A (en) *	1997-08-13	1999-03-08	Boehringer Mannheim Gmbh	Plasminogen activator with improved zymogenity
DE10105912A1 (de) *	2001-02-09	2002-08-14	Roche Diagnostics Gmbh	Rekombinante Proteinase K
DE10153601A1 (de) *	2001-11-02	2003-05-22	Paion Gmbh	DSPA zur Behandlung von Schlaganfall
RU2323001C1 (ru) *	2007-05-30	2008-04-27	Общество с ограниченной ответственностью "Научно-производственное предприятие "Техноген"	Фармацевтическая композиция, обладающая фибринолитическим действием
AR068914A1 (es) *	2007-10-18	2009-12-16	Paion Deutschland Gmbh	Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
EP2289542A1 (en)	2009-08-31	2011-03-02	PAION Deutschland GmbH	Treatment of neurological or neurodegenerative disorders
EP2289541A1 (en)	2009-08-31	2011-03-02	PAION Deutschland GmbH	Treatment of neurological or neurodegenerative disorders
TWI866194B (zh)	2017-02-03	2024-12-11	法商艾提寇生物技術公司	使用抗人類ｇｐｖｉ抗體抑制血小板凝集
EP3624832B1 (en)	2017-05-16	2025-08-20	Institut National de la Santé et de la Recherche Médicale	Methods and pharmaceutical compositions for the treatment of acute ischemic stroke
EP3806833A1 (en)	2018-06-15	2021-04-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity
WO2021148439A1 (en)	2020-01-21	2021-07-29	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for stimulating cerebrovascular function
EP4161579A1 (en)	2020-06-09	2023-04-12	Institut National de la Santé et de la Recherche Médicale (INSERM)	Fucoidan-functionalized polysaccharide particles with t-pa for targeted thrombolytic therapy
WO2023156683A1 (en)	2022-02-21	2023-08-24	Acticor Biotech	Treatment of cardiovascular diseases using anti-human gpvi antibodies
EP4556492A1 (en)	2023-11-14	2025-05-21	Acticor Biotech	Treatment of cardiovascular diseases using anti-human gpvi antibodies in subpopulations of subjects

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4766075A (en) *	1982-07-14	1988-08-23	Genentech, Inc.	Human tissue plasminogen activator
EP0112122B1 (en) *	1982-12-14	1991-08-28	South African Inventions Development Corporation	Plasminogen activator
US4511502A (en) *	1982-12-22	1985-04-16	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
US4620948A (en) *	1982-12-22	1986-11-04	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
US4753879A (en) *	1984-08-27	1988-06-28	Biogen N.V.	Modified tissue plasminogen activators
US5073494A (en) *	1985-04-22	1991-12-17	Genentech, Inc.	Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
JPH0672105B2 (ja) *	1985-10-02	1994-09-14	持田製薬株式会社	血栓溶解剤及びその製法
DE3537708A1 (de) *	1985-10-23	1987-04-23	Boehringer Mannheim Gmbh	Verfahren zur aktivierung von t-pa nach expression in prokaryonten
US4777043A (en) *	1985-12-17	1988-10-11	Genentech, Inc.	Stabilized human tissue plasminogen activator compositions
US5034225A (en) *	1985-12-17	1991-07-23	Genentech Inc.	Stabilized human tissue plasminogen activator compositions
DE3611817A1 (de) *	1986-04-08	1987-10-15	Boehringer Mannheim Gmbh	Verfahren zur renaturierung von proteinen
DE3643158A1 (de) *	1986-04-21	1987-11-19	Boehringer Mannheim Gmbh	Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
US4898825A (en) *	1986-05-07	1990-02-06	Mitsui Toatsu Chemicals, Incorporated	Methods for purification of single-chain and double-chain tissue plasminogen activator
JPH0779692B2 (ja) *	1986-05-07	1995-08-30	三井東圧化学株式会社	一本鎖ｔ−ＰＡと二本鎖ｔ−ＰＡを分離する方法
JPS6463378A (en) *	1986-08-11	1989-03-09	Mitsui Toatsu Chemicals	Separation of single stranded tpa and double standard tpa
SE8702562L (sv) *	1987-06-18	1988-12-19	Kabigen Ab	Nya fibrinolytiska enzymer
US4935237A (en) *	1988-03-21	1990-06-19	Genentech, Inc.	Processes for the preparation of t-PA mutants
IL87276A (en) *	1987-08-03	1995-07-31	Fujisawa Pharmaceutical Co	Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
US4963357A (en) *	1987-10-09	1990-10-16	Monsanto Company	Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5037752A (en) *	1987-10-09	1991-08-06	Monsanto Company	Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277

1989
- 1989-02-07 DE DE3903581A patent/DE3903581A1/de not_active Withdrawn
1990
- 1990-01-30 IE IE34390A patent/IE61077B1/en not_active IP Right Cessation
- 1990-02-01 NZ NZ232337A patent/NZ232337A/xx unknown
- 1990-02-02 DD DD90337557A patent/DD291779A5/de not_active IP Right Cessation
- 1990-02-05 IL IL9328090A patent/IL93280A/en not_active IP Right Cessation
- 1990-02-06 WO PCT/EP1990/000194 patent/WO1990009437A1/de not_active Ceased
- 1990-02-06 SK SK558-90A patent/SK279029B6/sk not_active IP Right Cessation
- 1990-02-06 JP JP2502957A patent/JP2559538B2/ja not_active Expired - Lifetime
- 1990-02-06 ES ES90102329T patent/ES2031804T3/es not_active Expired - Lifetime
- 1990-02-06 EP EP90102329A patent/EP0382174B1/de not_active Expired - Lifetime
- 1990-02-06 RU SU4831496A patent/RU2107094C1/ru active
- 1990-02-06 LU LU90025C patent/LU90025I2/fr unknown
- 1990-02-06 HU HU644/90A patent/HU218092B/hu unknown
- 1990-02-06 KR KR1019900702203A patent/KR970008485B1/ko not_active Expired - Lifetime
- 1990-02-06 AU AU50470/90A patent/AU623228B2/en not_active Expired
- 1990-02-06 US US07/585,129 patent/US5223256A/en not_active Expired - Lifetime
- 1990-02-06 CA CA002025900A patent/CA2025900C/en not_active Expired - Lifetime
- 1990-02-06 AT AT90102329T patent/ATE126270T1/de active
- 1990-02-06 CZ CS90558A patent/CZ281836B6/cs not_active IP Right Cessation
- 1990-02-06 DK DK90102329.1T patent/DK0382174T3/da active
- 1990-02-06 UA UA4831496A patent/UA27111A1/uk unknown
- 1990-02-06 DE DE59009487T patent/DE59009487D1/de not_active Expired - Lifetime
- 1990-02-06 ZA ZA90861A patent/ZA90861B/xx unknown
- 1990-02-07 PT PT93082A patent/PT93082B/pt not_active IP Right Cessation
- 1990-09-27 NO NO904211A patent/NO306563B1/no not_active IP Right Cessation
- 1990-10-08 FI FI904951A patent/FI100244B/fi active IP Right Grant
1991
- 1991-09-27 GR GR90300140T patent/GR900300140T1/el unknown
1993
- 1993-06-01 LV LVP-93-448A patent/LV10302B/xx unknown
1995
- 1995-08-10 GR GR950402065T patent/GR3017099T3/el unknown
1996
- 1996-08-08 HK HK153396A patent/HK153396A/xx not_active IP Right Cessation
1997
- 1997-02-17 NL NL970008C patent/NL970008I2/nl unknown
2000
- 2000-05-19 NO NO2000002C patent/NO2000002I1/no unknown

Also Published As

Publication number	Publication date
HU218092B (hu)	2000-05-28
ZA90861B (en)	1990-11-28
NZ232337A (en)	1991-09-25
LV10302A (lv)	1994-10-20
US5223256A (en)	1993-06-29
GR3017099T3 (en)	1995-11-30
AU5047090A (en)	1990-09-05
FI100244B (fi)	1997-10-31
HUT58813A (en)	1992-03-30
IE61077B1 (en)	1994-09-21
JP2559538B2 (ja)	1996-12-04
NL970008I1 (nl)	1997-04-01
DK0382174T3 (da)	1996-01-02
SK55890A3 (en)	1998-05-06
JPH03500724A (ja)	1991-02-21
PT93082B (pt)	1996-03-29
RU2107094C1 (ru)	1998-03-20
HK153396A (en)	1996-08-16
ES2031804T1 (es)	1993-01-01
UA27111A1 (uk)	2000-02-28
NO2000002I1 (no)	2000-05-19
NL970008I2 (nl)	1997-07-01
DD291779A5 (de)	1991-07-11
NO306563B1 (no)	1999-11-22
DE59009487D1 (de)	1995-09-14
CZ281836B6 (cs)	1997-02-12
ES2031804T3 (es)	1995-11-01
CA2025900C (en)	1999-01-19
EP0382174B1 (de)	1995-08-09
KR910700336A (ko)	1991-03-14
ATE126270T1 (de)	1995-08-15
EP0382174A1 (de)	1990-08-16
IL93280A (en)	1995-08-31
LV10302B (en)	1995-04-20
IE900343L (en)	1990-08-07
KR970008485B1 (ko)	1997-05-24
LU90025I2 (fr)	1997-04-22
CZ55890A3 (en)	1996-10-16
AU623228B2 (en)	1992-05-07
NO904211D0 (no)	1990-09-27
GR900300140T1 (en)	1991-09-27
HU901644D0 (en)	1991-04-29
SK279029B6 (sk)	1998-05-06
WO1990009437A1 (de)	1990-08-23
DE3903581A1 (de)	1990-08-16
CA2025900A1 (en)	1990-08-08
FI904951A0 (fi)	1990-10-08
IL93280A0 (en)	1990-11-29
NO904211L (no)	1990-09-27

Legal Events

Date

Code

Title

Description

1996-03-29

FG3A

Patent granted, date of granting

Effective date: 19951228

2009-07-16

PC4A

Transfer of assignment

Owner name: ACTAVIS GROUP PTC EHF., IS

Effective date: 20090213

2011-01-05

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20101228

Publication	Publication Date	Title
PT93082A (pt)	1990-08-31	Processo de producao de um derivado de activador de plaminogenio tissular, de plasmideo de expressao e de medicamento contendo o referido derivado
BR0109494A (pt)	2002-12-10	Produção de fatores recombinantes de coagulação do sangue em linhas celulares humanas
FI875533A0 (fi)	1987-12-16	Insulinpreparat foer non-parenteral dosering.
DK288183D0 (da)	1983-06-22	Fremgangsmade til fremstilling af et oligonucleotidt terapeutisk middel
HUP0100928A2 (hu)	2001-08-28	Humán inzulin B láncának részletét tartalmazó peptidanalógok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
DK610888D0 (da)	1988-11-02	Cardiodilatinfragmentet, fremgangsmaade til fremstilling deraf samt dets anvendelse
BR9007115A (pt)	1991-11-26	Novo trombolitico
ES2108694T3 (es)	1998-01-01	Inhibidor de proteasa.
BR9708388A (pt)	2000-01-04	Solução aquosa de hemoglobina polimerizada piridoxilada e processo de sua preparação.
ATE111525T1 (de)	1994-09-15	Plasminogenaktivator-varianten und verfahren zu ihrer herstellung.
KR890006815A (ko)	1989-06-16	산성 섬유아세포 생장인자의 돌연변이체
DE69002946D1 (de)	1993-09-30	Paracetamol enthaltende arzneizubereitung.
PT88913A (pt)	1988-12-01	Processo para a preparacao da proteina pp4-x anticoagulante
EP0303538A3 (en)	1989-03-29	Protein with a vascular activity, derived from monocytes and their analogues, process for its use as a therapeutic agent and the preparation of antibodies
DK0423326T3 (da)	1999-05-25	Hidtil ukendt fysiologisk aktivt peptid og calcium-metabolisme-regulerende middel, der omfatter peptidet som effektiv besta
DE69008859D1 (de)	1994-06-16	Modifizierte menschliche anti-rh(d)-antikörper.
KR910016339A (ko)	1991-11-05	Pp4-델타, 이의 제조방법 및 용도
ES2015772A6 (es)	1990-09-01	Procedimiento e obtencion de nuevos derivados del 5-fluorouracilo, concretamente los n1-acil-sustituidos-n3-orto-toluil-5-fluorouracilo.