PT950657E - Carbazoles substituidos, processo para a sua preparacao, e sua utilizacao como inibidores de spla2 - Google Patents

Carbazoles substituidos, processo para a sua preparacao, e sua utilizacao como inibidores de spla2

Info

Publication number: PT950657E
Authority: PT; Portugal
Prior art keywords: preparation; spla2 inhibitors; substituted carbazoles; carbazoles; substituted
Prior art date: 1998-04-17

Application number

PT99302967T

Other languages

English (en)

Portuguese (pt)

Inventor

Gary Alan Hite

Daniel Jon Sall

Nicholas James Bach

Robert Theodore Vasileff

Michael Dean Kinnick

John Michael Morin Jr

Jolie Anne Bastian

Edward David Mihelich

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-17

Filing date

1999-04-16

Publication date

2004-11-30

1999-04-16 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2004-11-30 Publication of PT950657E publication Critical patent/PT950657E/pt

Links

150000001716 carbazoles Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT99302967T 1998-04-17 1999-04-16 Carbazoles substituidos, processo para a sua preparacao, e sua utilizacao como inibidores de spla2 PT950657E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6232898A	1998-04-17	1998-04-17

Publications (1)

Publication Number	Publication Date
PT950657E true PT950657E (pt)	2004-11-30

Family

ID=22041763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99302967T PT950657E (pt)	1998-04-17	1999-04-16	Carbazoles substituidos, processo para a sua preparacao, e sua utilizacao como inibidores de spla2

Country Status (30)

Country	Link
EP (2)	EP0950657B1 (de)
JP (2)	JPH11322713A (de)
KR (2)	KR19990083232A (de)
CN (1)	CN1149193C (de)
AR (2)	AR018186A1 (de)
AT (2)	ATE271037T1 (de)
AU (2)	AU753436B2 (de)
BR (2)	BR9901279A (de)
CA (2)	CA2269262A1 (de)
CO (2)	CO5031247A1 (de)
CZ (2)	CZ136999A3 (de)
DE (2)	DE69917833T2 (de)
DK (1)	DK0950657T3 (de)
DZ (1)	DZ2769A1 (de)
EA (2)	EA002816B1 (de)
ES (2)	ES2226286T3 (de)
HU (2)	HUP9901221A3 (de)
ID (2)	ID23287A (de)
IL (2)	IL129483A0 (de)
NO (2)	NO314400B1 (de)
NZ (3)	NZ335253A (de)
PE (2)	PE20000432A1 (de)
PL (2)	PL332565A1 (de)
PT (1)	PT950657E (de)
SG (2)	SG81977A1 (de)
SI (1)	SI0950657T1 (de)
TR (2)	TR199900843A2 (de)
TW (1)	TWI238160B (de)
YU (2)	YU19199A (de)
ZA (2)	ZA992771B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999009978A1 (en) *	1997-08-28	1999-03-04	Eli Lilly And Company	Method for treatment of non-rheumatoid athritis
DZ2769A1 (fr) *	1998-04-17	2003-12-01	Lilly Co Eli	Composés tricycliques substitués.
AU1940800A (en) *	1998-12-21	2000-07-12	Eli Lilly And Company	Combination therapy for the treatment of sepsis
US6706752B1 (en)	1999-07-19	2004-03-16	Eli Lilly And Company	sPLA2 inhibitors
JP2003505372A (ja) *	1999-07-19	2003-02-12	イーライ・リリー・アンド・カンパニー	ｓＰＬＡ２インヒビター
ES2294003T3 (es) *	2000-06-29	2008-04-01	Anthera Pharmaceuticals, Inc.	Remedios contra el cancer.
WO2002000257A1 (en) *	2000-06-29	2002-01-03	Shionogi & Co., Ltd.	Remedies for alzheimer's disease
AU2001267825A1 (en) *	2000-06-29	2002-01-08	Shionogi And Co., Ltd.	Remedies for cirrhosis
WO2002005796A2 (en) *	2000-07-14	2002-01-24	Eli Lilly And Company	Use of a spla2 inhibitor for the treatment of sepsis
WO2002050034A2 (en) *	2000-12-18	2002-06-27	Eli Lilly And Company	Tetracyclic carbazole derivates and their use as spla2 inhibitors
DE60218155D1 (de)	2001-03-28	2007-03-29	Lilly Co Eli	Substituierte carbazole als inhibitoren von spla2
AUPS282602A0 (en)	2002-06-07	2002-06-27	Garvan Institute Of Medical Research	Method of inhibiting cell proliferation
DE10249055A1 (de)	2002-10-22	2004-05-06	Bayer Cropscience Ag	2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar)	2006-10-10	2020-07-05	Infinity Discovery Inc	الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (de) *	2007-04-27	2008-11-05	AEterna Zentaris GmbH	Neue Tetrahydrocarbazolderivate als Liganden von G-Protein-gekoppelten Rezeptoren
WO2009119534A1 (ja)	2008-03-26	2009-10-01	第一三共株式会社	新規テトラヒドロイソキノリン誘導体
EP2282742A1 (de)	2008-04-09	2011-02-16	Infinity Pharmaceuticals, Inc.	Inhibitoren von fettsäureamidhydrolase
US8580795B2 (en)	2009-01-22	2013-11-12	Orchid Chemicals & Pharmaceuticals Limited	Heterocyclic compounds as phosphodiesterase inhibitors
US8541581B2 (en)	2009-04-07	2013-09-24	Infinity Pharmaceuticals, Inc.	Inhibitors of fatty acid amide hydrolase
US8546564B2 (en)	2009-04-07	2013-10-01	Infinity Pharmaceuticals, Inc.	Inhibitors of fatty acid amide hydrolase
MX361692B (es)	2010-02-03	2018-12-13	Infinity Pharmaceuticals Inc	Inhibidores de amida hidrolasa de ácido graso.
AR088377A1 (es)	2011-10-20	2014-05-28	Siena Biotech Spa	Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) *	2012-08-20	2015-06-03	东南大学	咔唑衍生物及其制备方法与用途
WO2014083113A1 (en)	2012-11-30	2014-06-05	Ge Healthcare Limited	Crystallization process of tricyclic indole derivatives
CN104797559A (zh) *	2012-11-30	2015-07-22	通用电气健康护理有限公司	卤化锌介导的环化过程得到三环吲哚
WO2016116527A1 (de) *	2015-01-20	2016-07-28	Cynora Gmbh	Organische moleküle, insbesondere zur verwendung in optoelektronischen bauelementen
CN108707104A (zh) *	2018-08-07	2018-10-26	北京恒信卓元科技有限公司	2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3579534A (en) *	1969-05-09	1971-05-18	American Cyanamid Co	Tetrahydrocarbazolecarboxylates
US3979391A (en) *	1972-11-22	1976-09-07	Sterling Drug Inc.	1,2,3,4-Tetrahydrocarbazoles
US3939177A (en) *	1972-11-22	1976-02-17	Sterling Drug Inc.	4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US5420289A (en) *	1989-10-27	1995-05-30	American Home Products Corporation	Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
PT95692A (pt) *	1989-10-27	1991-09-13	American Home Prod	Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
WO1993001169A2 (en) *	1991-07-05	1993-01-21	Merck Sharp & Dohme Limited	Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) *	1991-08-12	1998-03-31	Ciba Geigy Ag	1-acylpiperindine compounds.
IL109309A (en) *	1993-04-16	2000-06-29	Lilly Co Eli	1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) *	1993-04-16	1994-07-31	Lilly Co Eli	1H-indole-3-acetamide sPla2 inhibitors
DE69610793T2 (de) *	1995-06-23	2001-05-03	Eli Lilly And Co., Indianapolis	6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
EP0779271B1 (de) *	1995-12-13	2001-08-01	Eli Lilly And Company	Naphthyl-Acetamide als sPLA2-Inhibitoren
PL332896A1 (en) *	1996-10-30	1999-10-25	Lilly Co Eli	Substituted tricyclic compounds
CA2304482A1 (en) *	1997-09-26	1999-04-08	Eli Lilly And Company	Method for the treatment of cystic fibrosis
CA2310250A1 (en) *	1997-11-14	1999-05-27	August Masaru Watanabe	Treatment for alzheimer's disease
DZ2769A1 (fr) *	1998-04-17	2003-12-01	Lilly Co Eli	Composés tricycliques substitués.

1999
- 1999-04-14 DZ DZ990069A patent/DZ2769A1/xx active
- 1999-04-15 IL IL12948399A patent/IL129483A0/xx unknown
- 1999-04-15 IL IL12948599A patent/IL129485A0/xx unknown
- 1999-04-15 ID IDP990340D patent/ID23287A/id unknown
- 1999-04-15 ID IDP990341D patent/ID23761A/id unknown
- 1999-04-16 ES ES99302967T patent/ES2226286T3/es not_active Expired - Lifetime
- 1999-04-16 KR KR1019990013436A patent/KR19990083232A/ko not_active Withdrawn
- 1999-04-16 EA EA199900303A patent/EA002816B1/ru not_active IP Right Cessation
- 1999-04-16 ZA ZA9902771A patent/ZA992771B/xx unknown
- 1999-04-16 NZ NZ335253A patent/NZ335253A/xx unknown
- 1999-04-16 YU YU19199A patent/YU19199A/sh unknown
- 1999-04-16 JP JP11109629A patent/JPH11322713A/ja not_active Withdrawn
- 1999-04-16 JP JP15240099A patent/JP4435330B2/ja not_active Expired - Fee Related
- 1999-04-16 EP EP99302967A patent/EP0950657B1/de not_active Expired - Lifetime
- 1999-04-16 NO NO19991821A patent/NO314400B1/no not_active IP Right Cessation
- 1999-04-16 DE DE69917833T patent/DE69917833T2/de not_active Expired - Lifetime
- 1999-04-16 AT AT99302967T patent/ATE271037T1/de active
- 1999-04-16 AU AU23817/99A patent/AU753436B2/en not_active Ceased
- 1999-04-16 NO NO19991822A patent/NO312240B1/no not_active IP Right Cessation
- 1999-04-16 HU HU9901221A patent/HUP9901221A3/hu unknown
- 1999-04-16 EA EA199900301A patent/EA002347B1/ru not_active IP Right Cessation
- 1999-04-16 AU AU23819/99A patent/AU753547B2/en not_active Ceased
- 1999-04-16 CN CNB991079574A patent/CN1149193C/zh not_active Expired - Fee Related
- 1999-04-16 CZ CZ991369A patent/CZ136999A3/cs unknown
- 1999-04-16 DE DE69918590T patent/DE69918590T2/de not_active Expired - Lifetime
- 1999-04-16 BR BR9901279-0A patent/BR9901279A/pt not_active IP Right Cessation
- 1999-04-16 AT AT99302941T patent/ATE268756T1/de not_active IP Right Cessation
- 1999-04-16 BR BR9902365-2A patent/BR9902365A/pt not_active IP Right Cessation
- 1999-04-16 PE PE1999000314A patent/PE20000432A1/es not_active Application Discontinuation
- 1999-04-16 CO CO99022884A patent/CO5031247A1/es unknown
- 1999-04-16 KR KR1019990013438A patent/KR100586761B1/ko not_active Expired - Fee Related
- 1999-04-16 CZ CZ991370A patent/CZ137099A3/cs unknown
- 1999-04-16 TR TR1999/00843A patent/TR199900843A2/xx unknown
- 1999-04-16 CA CA002269262A patent/CA2269262A1/en not_active Abandoned
- 1999-04-16 EP EP99302941A patent/EP0952149B1/de not_active Expired - Lifetime
- 1999-04-16 NZ NZ335251A patent/NZ335251A/xx unknown
- 1999-04-16 AR ARP990101770A patent/AR018186A1/es not_active Application Discontinuation
- 1999-04-16 CO CO99022897A patent/CO5011054A1/es unknown
- 1999-04-16 TR TR1999/00853A patent/TR199900853A3/tr unknown
- 1999-04-16 TW TW088106130A patent/TWI238160B/zh not_active IP Right Cessation
- 1999-04-16 NZ NZ507564A patent/NZ507564A/xx unknown
- 1999-04-16 HU HU9901220A patent/HUP9901220A3/hu unknown
- 1999-04-16 SI SI9930650T patent/SI0950657T1/xx unknown
- 1999-04-16 ES ES99302941T patent/ES2222663T3/es not_active Expired - Lifetime
- 1999-04-16 PL PL99332565A patent/PL332565A1/xx not_active Application Discontinuation
- 1999-04-16 SG SG9901869A patent/SG81977A1/en unknown
- 1999-04-16 AR ARP990101771A patent/AR018593A1/es active IP Right Grant
- 1999-04-16 DK DK99302967T patent/DK0950657T3/da active
- 1999-04-16 CA CA002269246A patent/CA2269246C/en not_active Expired - Fee Related
- 1999-04-16 ZA ZA9902772A patent/ZA992772B/xx unknown
- 1999-04-16 PE PE1999000320A patent/PE20000476A1/es not_active Application Discontinuation
- 1999-04-16 PL PL99332566A patent/PL332566A1/xx not_active Application Discontinuation
- 1999-04-16 SG SG9901681A patent/SG81976A1/en unknown
- 1999-04-16 PT PT99302967T patent/PT950657E/pt unknown
- 1999-04-16 YU YU18999A patent/YU18999A/sh unknown

Also Published As

Publication number	Publication date
KR100586761B1 (ko)	2006-06-08
SG81976A1 (en)	2001-07-24
AR018593A1 (es)	2001-11-28
NO314400B1 (no)	2003-03-17
DE69918590T2 (de)	2005-07-21
KR19990083233A (ko)	1999-11-25
NO991821L (no)	1999-10-18
NO991822L (no)	1999-10-18
PL332565A1 (en)	1999-10-25
HU9901220D0 (en)	1999-06-28
TR199900843A2 (xx)	2000-02-21
SG81977A1 (en)	2001-07-24
CO5011054A1 (es)	2001-02-28
CZ137099A3 (cs)	1999-11-17
HU9901221A (hu)	2000-04-28
CZ136999A3 (cs)	1999-11-17
EA199900303A2 (ru)	1999-10-28
KR19990083232A (ko)	1999-11-25
IL129485A0 (en)	2000-02-29
NZ507564A (en)	2002-10-25
IL129483A0 (en)	2000-02-29
NO991822D0 (no)	1999-04-16
HU9901221D0 (en)	1999-06-28
ATE268756T1 (de)	2004-06-15
EP0950657A3 (de)	2001-08-16
HUP9901220A3 (en)	2001-11-28
CA2269246C (en)	2009-08-25
JP2000026416A (ja)	2000-01-25
ID23287A (id)	2000-04-05
ATE271037T1 (de)	2004-07-15
JPH11322713A (ja)	1999-11-24
PE20000432A1 (es)	2000-05-23
HU9901220A (hu)	2000-04-28
CN1253948A (zh)	2000-05-24
NO312240B1 (no)	2002-04-15
TR199900853A2 (xx)	1999-11-22
YU19199A (sh)	2002-08-12
DK0950657T3 (da)	2004-11-22
DE69917833D1 (de)	2004-07-15
EA002347B1 (ru)	2002-04-25
PE20000476A1 (es)	2000-06-02
EA199900301A2 (ru)	1999-10-28
BR9901279A (pt)	2000-05-02
AU753547B2 (en)	2002-10-24
BR9902365A (pt)	2001-04-24
CA2269262A1 (en)	1999-10-17
JP4435330B2 (ja)	2010-03-17
HUP9901221A3 (en)	2001-11-28
EA199900303A3 (ru)	2000-04-24
AU753436B2 (en)	2002-10-17
NZ335253A (en)	2000-11-24
EP0952149A2 (de)	1999-10-27
NZ335251A (en)	2000-11-24
ZA992772B (en)	2002-07-16
TWI238160B (en)	2005-08-21
EA002816B1 (ru)	2002-10-31
EA199900301A3 (ru)	2000-04-24
TR199900853A3 (tr)	1999-11-22
CN1149193C (zh)	2004-05-12
YU18999A (sh)	2002-08-12
EP0952149A3 (de)	2001-08-16
NO991821D0 (no)	1999-04-16
DE69918590D1 (de)	2004-08-19
EP0950657B1 (de)	2004-07-14
ZA992771B (en)	2002-04-18
PL332566A1 (en)	1999-10-25
DZ2769A1 (fr)	2003-12-01
AR018186A1 (es)	2001-10-31
SI0950657T1 (en)	2005-02-28
CO5031247A1 (es)	2001-04-27
CA2269246A1 (en)	1999-10-17
ES2222663T3 (es)	2005-02-01
ES2226286T3 (es)	2005-03-16
AU2381999A (en)	1999-10-28
EP0950657A2 (de)	1999-10-20
AU2381799A (en)	1999-10-28
EP0952149B1 (de)	2004-06-09
ID23761A (id)	2000-05-11
DE69917833T2 (de)	2005-07-14

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