PT95566A - Metodo para a utilizacao de derivados de 2-oxindole substituidos na posicao 3 como inibidores da biossintese de interleuquina-1 - Google Patents

Metodo para a utilizacao de derivados de 2-oxindole substituidos na posicao 3 como inibidores da biossintese de interleuquina-1

Info

Publication number: PT95566A
Authority: PT; Portugal
Prior art keywords: interleuquin; biosafety; inhibitors; oxindole derivatives; derivatives substituted
Prior art date: 1989-10-13

Application number

PT95566A

Other languages

English (en)

Other versions

PT95566B (pt

Inventor

Gary Richard Schulte

Carl Joseph Goddard

Douglas Charles Hanson

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-13

Filing date

1990-10-11

Publication date

1991-08-14

1990-10-11 Application filed by Pfizer filed Critical Pfizer

1991-08-14 Publication of PT95566A publication Critical patent/PT95566A/pt

1997-11-28 Publication of PT95566B publication Critical patent/PT95566B/pt

Links

JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical group C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
102000000589 Interleukin-1 Human genes 0.000 abstract 2
108010002352 Interleukin-1 Proteins 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
-1 3-substituted-2-oxindole Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
210000002808 connective tissue Anatomy 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT95566A 1989-10-13 1990-10-11 Metodo para a utilizacao de derivados de 2-oxindole substituidos na posicao 3 como inibidores da biossintese de interleuquina-1 PT95566B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42144589A	1989-10-13	1989-10-13
US52905090A	1990-05-25	1990-05-25

Publications (2)

Publication Number	Publication Date
PT95566A true PT95566A (pt)	1991-08-14
PT95566B PT95566B (pt)	1997-11-28

Family

ID=27025248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95566A PT95566B (pt)	1989-10-13	1990-10-11	Metodo para a utilizacao de derivados de 2-oxindole substituidos na posicao 3 como inibidores da biossintese de interleuquina-1

Country Status (14)

Country	Link
US (1)	US5192790A (pt)
EP (1)	EP0425109B1 (pt)
JP (1)	JPH0684300B2 (pt)
KR (1)	KR910007526A (pt)
AT (1)	ATE109349T1 (pt)
AU (1)	AU624739B2 (pt)
CA (1)	CA2027394C (pt)
DE (1)	DE69011272T2 (pt)
DK (1)	DK0425109T3 (pt)
HU (2)	HUT59004A (pt)
IE (1)	IE63140B1 (pt)
IL (1)	IL95880A (pt)
MY (1)	MY106834A (pt)
PT (1)	PT95566B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL110296A (en) *	1993-07-16	1999-12-31	Smithkline Beecham Corp	Imidazole compounds process for their preparation and pharmaceutical compositions containing them
US6266485B1 (en)	1998-02-19	2001-07-24	Emerson Electric Co.	One-piece plastic tank and temperature control system for a hot water dispenser
US6673816B1 (en)	1998-09-30	2004-01-06	Angelika Esswein	Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
US20020077276A1 (en) *	1999-04-27	2002-06-20	Fredeking Terry M.	Compositions and methods for treating hemorrhagic virus infections and other disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN162090B (pt) *	1984-03-19	1988-03-26	Pfizer
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
IN161509B (pt) *	1984-05-04	1987-12-19	Pfizer
US4569942A (en) *	1984-05-04	1986-02-11	Pfizer Inc.	N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4678802A (en) *	1985-07-09	1987-07-07	Pfizer Inc.	1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8517958D0 (en) *	1985-07-16	1985-08-21	Cellena Cell Eng Ag	Compositions containing melatonin/homologues
JPH01501705A (ja) *	1986-01-30	1989-06-15	ユニバ−シテイ・オブ・ユタ	骨損失の治療
US4677132A (en) *	1986-03-12	1987-06-30	American Home Products Corporation	Inhibition of bone resorption by etodolac
US4861794A (en) *	1988-04-13	1989-08-29	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US5047554A (en) *	1989-04-18	1991-09-10	Pfizer Inc.	3-substituted-2-oxindole derivatives

1990
- 1990-10-02 IL IL9588090A patent/IL95880A/en not_active IP Right Cessation
- 1990-10-03 DK DK90310806.6T patent/DK0425109T3/da active
- 1990-10-03 EP EP90310806A patent/EP0425109B1/en not_active Expired - Lifetime
- 1990-10-03 AT AT90310806T patent/ATE109349T1/de not_active IP Right Cessation
- 1990-10-03 DE DE69011272T patent/DE69011272T2/de not_active Expired - Fee Related
- 1990-10-11 MY MYPI90001771A patent/MY106834A/en unknown
- 1990-10-11 PT PT95566A patent/PT95566B/pt not_active IP Right Cessation
- 1990-10-11 CA CA002027394A patent/CA2027394C/en not_active Expired - Fee Related
- 1990-10-11 JP JP2273150A patent/JPH0684300B2/ja not_active Expired - Lifetime
- 1990-10-12 HU HU906436A patent/HUT59004A/hu unknown
- 1990-10-12 KR KR1019900016153A patent/KR910007526A/ko not_active Ceased
- 1990-10-12 IE IE364890A patent/IE63140B1/en not_active IP Right Cessation
- 1990-10-12 AU AU64582/90A patent/AU624739B2/en not_active Ceased
1991
- 1991-12-17 US US07/808,491 patent/US5192790A/en not_active Expired - Fee Related
1995
- 1995-05-11 HU HU95P/P00128P patent/HU210902A9/hu unknown

Also Published As

Publication number	Publication date
IL95880A (en)	1995-12-31
EP0425109B1 (en)	1994-08-03
AU624739B2 (en)	1992-06-18
MY106834A (en)	1995-07-31
HU906436D0 (en)	1991-04-29
HUT59004A (en)	1992-04-28
PT95566B (pt)	1997-11-28
IE903648A1 (en)	1991-04-24
JPH0684300B2 (ja)	1994-10-26
DE69011272D1 (de)	1994-09-08
IE63140B1 (en)	1995-03-22
EP0425109A2 (en)	1991-05-02
JPH03133929A (ja)	1991-06-07
CA2027394C (en)	1995-01-03
HU210902A9 (en)	1995-09-28
DK0425109T3 (da)	1994-11-21
ATE109349T1 (de)	1994-08-15
CA2027394A1 (en)	1991-04-14
US5192790A (en)	1993-03-09
EP0425109A3 (en)	1992-01-15
DE69011272T2 (de)	1994-11-24
KR910007526A (ko)	1991-05-30
AU6458290A (en)	1991-04-18

Legal Events

Date

Code

Title

Description

1991-08-14

BB1A

Laying open of patent application

Effective date: 19910320

1997-11-28

FG3A

Patent granted, date of granting

Effective date: 19970829

2001-06-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20010228

Publication	Publication Date	Title
SE9803710D0 (sv)	1998-10-29	Use of certain drugs for treating nerve root injury
IT1212896B (it)	1989-11-30	Metodo di somministrazione per via inalatoria di gangliosidi e derivati, e composizioni farmaceutiche relative
PH25130A (en)	1991-02-19	4-acylphenoxy derivatives as anti-inflammatory agents
DE58902712D1 (de)	1992-12-17	N-acetylglucosamin-zubereitungen zur buccalen anwendung.
PT90248A (pt)	1989-11-10	Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas como inibidores da biossintese da interleucina-1
PT655243E (pt)	2002-11-29	Derivados da melatonina para utilizacao no tratamento de disturbios do sono
PT656209E (pt)	2003-09-30	Derivados de melatonina para uso no tratamento de perturbacoes de dessincronizacao
DK0425109T3 (da)	1994-11-21	3-substitueret-2-oxindolderivater som inhibitorer for interleukin-1-biosyntese
HUT70757A (en)	1995-10-30	Pharmaceutical compositions for treating skin disorders
GB2204488B (en)	1991-02-06	Pharmaceutical compositions for the treatment or prophylaxis of skin disorders
DK0415321T3 (da)	1995-12-27	Oligodendrocyt-cytotoksisk faktor
PT950053E (pt)	2003-10-31	Novos derivados de benzoilalquil-1,2,3,6-tetra-hidropiridinas