ATE109349T1 - 3-substituierte-2-oxindolderivate als interleukin-biosynthesehemmer. - Google Patents

3-substituierte-2-oxindolderivate als interleukin-biosynthesehemmer.

Info

Publication number: ATE109349T1
Authority: AT; Austria
Prior art keywords: interleukin; substituted; biosynthesis inhibitors; derivatives; oxindol derivatives
Prior art date: 1989-10-13

Application number

AT90310806T

Other languages

English (en)

Inventor

Carl Joseph Goddard

Douglas Charles Hanson

Gary Richard Schulte

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-13

Filing date

1990-10-03

Publication date

1994-08-15

1990-10-03 Application filed by Pfizer filed Critical Pfizer

1994-08-15 Application granted granted Critical

1994-08-15 Publication of ATE109349T1 publication Critical patent/ATE109349T1/de

Links

-1 3-SUBSTITUTED-2-OXINDOL Chemical class 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title abstract 2
102000015696 Interleukins Human genes 0.000 title 1
108010063738 Interleukins Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
102000000589 Interleukin-1 Human genes 0.000 abstract 2
108010002352 Interleukin-1 Proteins 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
210000000988 bone and bone Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
210000002808 connective tissue Anatomy 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90310806T 1989-10-13 1990-10-03 3-substituierte-2-oxindolderivate als interleukin-biosynthesehemmer. ATE109349T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42144589A	1989-10-13	1989-10-13
US52905090A	1990-05-25	1990-05-25

Publications (1)

Publication Number	Publication Date
ATE109349T1 true ATE109349T1 (de)	1994-08-15

Family

ID=27025248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90310806T ATE109349T1 (de)	1989-10-13	1990-10-03	3-substituierte-2-oxindolderivate als interleukin-biosynthesehemmer.

Country Status (14)

Country	Link
US (1)	US5192790A (de)
EP (1)	EP0425109B1 (de)
JP (1)	JPH0684300B2 (de)
KR (1)	KR910007526A (de)
AT (1)	ATE109349T1 (de)
AU (1)	AU624739B2 (de)
CA (1)	CA2027394C (de)
DE (1)	DE69011272T2 (de)
DK (1)	DK0425109T3 (de)
HU (2)	HUT59004A (de)
IE (1)	IE63140B1 (de)
IL (1)	IL95880A (de)
MY (1)	MY106834A (de)
PT (1)	PT95566B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL110296A (en) *	1993-07-16	1999-12-31	Smithkline Beecham Corp	Imidazole compounds process for their preparation and pharmaceutical compositions containing them
US6266485B1 (en)	1998-02-19	2001-07-24	Emerson Electric Co.	One-piece plastic tank and temperature control system for a hot water dispenser
AU6330799A (en) *	1998-09-30	2000-04-17	Roche Diagnostics Gmbh	Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
US20020077276A1 (en) *	1999-04-27	2002-06-20	Fredeking Terry M.	Compositions and methods for treating hemorrhagic virus infections and other disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN162090B (de) *	1984-03-19	1988-03-26	Pfizer
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
IN161509B (de) *	1984-05-04	1987-12-19	Pfizer
US4569942A (en) *	1984-05-04	1986-02-11	Pfizer Inc.	N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4678802A (en) *	1985-07-09	1987-07-07	Pfizer Inc.	1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8517958D0 (en) *	1985-07-16	1985-08-21	Cellena Cell Eng Ag	Compositions containing melatonin/homologues
EP0284612B1 (de) *	1986-01-30	1991-07-24	University of Utah	Behandlung von knochenschwund
US4677132A (en) *	1986-03-12	1987-06-30	American Home Products Corporation	Inhibition of bone resorption by etodolac
US4861794A (en) *	1988-04-13	1989-08-29	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US5047554A (en) *	1989-04-18	1991-09-10	Pfizer Inc.	3-substituted-2-oxindole derivatives

1990
- 1990-10-02 IL IL9588090A patent/IL95880A/en not_active IP Right Cessation
- 1990-10-03 DK DK90310806.6T patent/DK0425109T3/da active
- 1990-10-03 DE DE69011272T patent/DE69011272T2/de not_active Expired - Fee Related
- 1990-10-03 EP EP90310806A patent/EP0425109B1/de not_active Expired - Lifetime
- 1990-10-03 AT AT90310806T patent/ATE109349T1/de not_active IP Right Cessation
- 1990-10-11 MY MYPI90001771A patent/MY106834A/en unknown
- 1990-10-11 PT PT95566A patent/PT95566B/pt not_active IP Right Cessation
- 1990-10-11 JP JP2273150A patent/JPH0684300B2/ja not_active Expired - Lifetime
- 1990-10-11 CA CA002027394A patent/CA2027394C/en not_active Expired - Fee Related
- 1990-10-12 AU AU64582/90A patent/AU624739B2/en not_active Ceased
- 1990-10-12 HU HU906436A patent/HUT59004A/hu unknown
- 1990-10-12 KR KR1019900016153A patent/KR910007526A/ko not_active Ceased
- 1990-10-12 IE IE364890A patent/IE63140B1/en not_active IP Right Cessation
1991
- 1991-12-17 US US07/808,491 patent/US5192790A/en not_active Expired - Fee Related
1995
- 1995-05-11 HU HU95P/P00128P patent/HU210902A9/hu unknown

Also Published As

Publication number	Publication date
HU210902A9 (en)	1995-09-28
DE69011272D1 (de)	1994-09-08
DK0425109T3 (da)	1994-11-21
IL95880A (en)	1995-12-31
AU624739B2 (en)	1992-06-18
DE69011272T2 (de)	1994-11-24
HU906436D0 (en)	1991-04-29
HUT59004A (en)	1992-04-28
PT95566B (pt)	1997-11-28
EP0425109A3 (en)	1992-01-15
PT95566A (pt)	1991-08-14
CA2027394C (en)	1995-01-03
AU6458290A (en)	1991-04-18
KR910007526A (ko)	1991-05-30
MY106834A (en)	1995-07-31
JPH03133929A (ja)	1991-06-07
EP0425109B1 (de)	1994-08-03
CA2027394A1 (en)	1991-04-14
IE903648A1 (en)	1991-04-24
JPH0684300B2 (ja)	1994-10-26
IE63140B1 (en)	1995-03-22
US5192790A (en)	1993-03-09
EP0425109A2 (de)	1991-05-02

Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2001-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69435086D1 (de)	2008-04-24	Phenylacetate und Derivate, allein oder in Kombination mit anderen Verbindungen, zur Behandlung von neoplastischen und anderen Erkrankungen
EP1042305A4 (de)	2003-05-14	HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN
DK0513702T3 (da)	1996-12-30	Melatoninderivater til anvendelse til behandling af søvnlidelser og til præ-anæstetisk medicinering
PL398445A1 (pl)	2012-06-04	Kompozycje farmaceutyczne zawierające dekstrometorfan i chininę do leczenia zaburzeń neurologicznych
IL125282A (en)	2003-06-24	Substituted imidazole compounds, process for their preparation, pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating cytokine mediated diseases
DE58902712D1 (de)	1992-12-17	N-acetylglucosamin-zubereitungen zur buccalen anwendung.
DE3480053D1 (en)	1989-11-16	A kit or device and method for administering gangliosides and derivatives thereof of inhalation and pharmaceutical compositions suitable therefor
DK174389A (da)	1989-10-16	Anvendelse af 3-substituerede 2-oxindol-1-carboxamid-forbindelser til fremstilling af farmaceutiske praeparater til inhibering af interleukin-1-biosyntese
AU624739B2 (en)	1992-06-18	3-substituted-2-oxindole derivatives as inhibitors of interleukin-1 biosynthesis
IL111580A (en)	1999-10-28	Use of melatonin derivatives in the preparation of pharmaceutical compositions for use in treating sleep disorders
IT9020968A0 (it)	1990-07-18	Metodi e composizioni farmaceutiche per il trattamento di malattie oftalmiche
ATE208402T1 (de)	2001-11-15	Pharmazeutische zusammensetzung enthaltend interferon-gamma inhibitoren
SE8403659L (sv)	1985-01-12	Synergistiska farmaceutiska kompositioner
ITMI931174A0 (it)	1993-06-04	Composizioni farmaceutiche per la cura della talassemia
DK0608648T3 (da)	1997-06-16	Højdoserede vitamin A-præparater
ATE136776T1 (de)	1996-05-15	Verwendung von heptastigmin zur behandlung der zerebralen ictus