PT97301A - Processo para a preparacao de novos alquil-3-carboxi-carbapenems 2-substituidos uteis como antibioticos - Google Patents

Processo para a preparacao de novos alquil-3-carboxi-carbapenems 2-substituidos uteis como antibioticos

Info

Publication number
PT97301A
PT97301A PT97301A PT9730191A PT97301A PT 97301 A PT97301 A PT 97301A PT 97301 A PT97301 A PT 97301A PT 9730191 A PT9730191 A PT 9730191A PT 97301 A PT97301 A PT 97301A
Authority
PT
Portugal
Prior art keywords
carbxenems
antibiotics
carboxy
preparation
substituted alkyl
Prior art date
Application number
PT97301A
Other languages
English (en)
Other versions
PT97301B (pt
Inventor
Carl B Ziegler Jr
William V Curran
Gregg Feigelson
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of PT97301A publication Critical patent/PT97301A/pt
Publication of PT97301B publication Critical patent/PT97301B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT97301A 1990-04-10 1991-04-09 Processo para a preparacao de novos alquil-3-carboxi-carbapenems 2-substituidos uteis como antibioticos PT97301B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/507,271 US5068232A (en) 1990-04-10 1990-04-10 Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them

Publications (2)

Publication Number Publication Date
PT97301A true PT97301A (pt) 1992-01-31
PT97301B PT97301B (pt) 1998-08-31

Family

ID=24017956

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97301A PT97301B (pt) 1990-04-10 1991-04-09 Processo para a preparacao de novos alquil-3-carboxi-carbapenems 2-substituidos uteis como antibioticos

Country Status (20)

Country Link
US (3) US5068232A (pt)
EP (1) EP0478874A3 (pt)
JP (1) JPH04234885A (pt)
KR (1) KR0183020B1 (pt)
CN (3) CN1034332C (pt)
AU (1) AU634876B2 (pt)
CA (1) CA2039968A1 (pt)
CZ (1) CZ280808B6 (pt)
FI (1) FI95256C (pt)
HU (1) HU215606B (pt)
IE (1) IE910676A1 (pt)
IL (1) IL97275A (pt)
NO (1) NO178624C (pt)
NZ (1) NZ237610A (pt)
PH (1) PH27462A (pt)
PL (3) PL166336B1 (pt)
PT (1) PT97301B (pt)
SK (1) SK278900B6 (pt)
TW (1) TW229209B (pt)
ZA (1) ZA912629B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
US5189158A (en) * 1991-03-20 1993-02-23 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US5607928A (en) * 1994-08-05 1997-03-04 Zeneca Limited Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives
EP0695753A1 (en) * 1994-08-05 1996-02-07 Zeneca Limited Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use
US6204260B1 (en) 1996-02-23 2001-03-20 Eli Lilly And Company Non-peptidyl vasopressin V1a antagonists
HRP970146A2 (en) * 1997-03-13 1998-10-31 Mice Kovacevic Epoxi-azetidines, preparation and use
JP2004537032A (ja) * 2001-02-16 2004-12-09 ペプスキャン　システムズ　ベー．フェー． ピクセルアレイ
WO2005123066A1 (en) * 2004-06-10 2005-12-29 Fob Synthesis, Inc. Carbapenem antibacterials with gram-negative activity and processes for their preparation
WO2006040893A1 (ja) * 2004-10-08 2006-04-20 Dainippon Sumitomo Pharma Co., Ltd. 新規な抗菌性医薬
CN105884663B (zh) * 2016-04-27 2017-12-15 湖南科技学院 一种(z)‑磺酰基烯酸酯的制备方法
CN105906537B (zh) * 2016-04-27 2017-12-15 湖南科技学院 （z）式磺酰基烯酸酯化合物的一锅合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122379A (en) * 1980-03-03 1981-09-25 Sankyo Co Ltd 1-carba-2-penem-3-carboxylic acid derivative
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
CA1179675A (en) * 1981-01-30 1984-12-18 Erwin Gotschi 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-derivatives
JPS58103388A (ja) * 1981-12-11 1983-06-20 Sankyo Co Ltd カルバペネム誘導体
EP0171064B1 (en) * 1984-08-06 1995-07-12 Fujisawa Pharmaceutical Co., Ltd. Azetidinone derivative and processes for production thereof
EP0184844A1 (en) * 1984-12-13 1986-06-18 Merck & Co. Inc. 1-Methylcarbapenems having a 2-position substituent joined through an alkylenethio bridge
US4882429A (en) * 1986-03-03 1989-11-21 Schering Corporation Stereospecific preparation of (3S,4R,5R)-3-(1-hydroxyethyl)-4-benzoyloxy-azeridinones from L-(-)-theonine
IT1197873B (it) * 1986-10-15 1988-12-21 Erba Farmitalia Procedimento per la preparazione di azetidinoni
DE3779856T2 (de) * 1986-10-16 1993-03-25 Merck & Co Inc Antibakterielle, 2-substituierte alkyl-carbapeneme.
US5021565A (en) * 1986-10-16 1991-06-04 Merck & Co., Inc. Novel 2-substituted alkyl carbapenem antibacterials
JPS63218659A (ja) * 1987-03-06 1988-09-12 Yasumitsu Tamura β−ラクタム化合物およびその製造法
JPH0193586A (ja) * 1987-10-05 1989-04-12 Yasumitsu Tamura カルバベネム化合物およびその製造法
US4960879A (en) * 1988-03-23 1990-10-02 Shionogi & Co., Ltd. Process for carbapenem intermediates
JPH0642853Y2 (ja) * 1988-10-28 1994-11-09 新王子製紙株式会社 プリンター
JPH03120280A (ja) * 1989-10-03 1991-05-22 Shionogi & Co Ltd ハロメチルカルバペネム化合物の製法

Also Published As

Publication number Publication date
EP0478874A3 (en) 1993-03-24
CS92991A3 (en) 1992-04-15
HU911141D0 (en) 1991-10-28
PH27462A (en) 1993-07-09
PL166336B1 (pl) 1995-05-31
AU634876B2 (en) 1993-03-04
US5068232A (en) 1991-11-26
CA2039968A1 (en) 1991-10-11
CN1034329C (zh) 1997-03-26
CN1108649A (zh) 1995-09-20
TW229209B (pt) 1994-09-01
US5369102A (en) 1994-11-29
PL289814A1 (en) 1992-08-10
ZA912629B (en) 1992-01-29
US5480987A (en) 1996-01-02
FI95256B (fi) 1995-09-29
HU215606B (hu) 1999-01-28
NZ237610A (en) 1995-02-24
FI911701A0 (fi) 1991-04-09
EP0478874A2 (en) 1992-04-08
PL165952B1 (pl) 1995-03-31
PL165937B1 (pl) 1995-03-31
AU7424891A (en) 1991-10-17
IE910676A1 (en) 1991-10-23
FI911701L (fi) 1991-10-11
NO178624C (no) 1996-05-02
IL97275A0 (en) 1992-05-25
PT97301B (pt) 1998-08-31
NO911368D0 (no) 1991-04-09
HUT57770A (en) 1991-12-30
CN1034332C (zh) 1997-03-26
FI95256C (fi) 1996-01-10
CN1108648A (zh) 1995-09-20
SK278900B6 (sk) 1998-04-08
PL294071A1 (pt) 1993-02-08
NO178624B (no) 1996-01-22
KR0183020B1 (ko) 1999-05-01
CN1056878A (zh) 1991-12-11
NO911368L (no) 1991-10-11
CN1037177C (zh) 1998-01-28
JPH04234885A (ja) 1992-08-24
CZ280808B6 (cs) 1996-04-17
IL97275A (en) 1996-01-31
KR910018384A (ko) 1991-11-30

Similar Documents

Publication Publication Date Title
PT98638A (pt) Processo para a preparacao de derivados de borsolina
PT97433A (pt) Processo para a preparacao de sacarose-6-ester
PT82794B (pt) Processo para a preparacao de derivados de 3-fenil-4-cianopirrole uteis como microbicidas
PT96871A (pt) Processo para a preparacao de compostos 3-arilcarbonil-1h-indol uteis como agentes terapeuticos
PT80231B (pt) Processo para a preparacao de derivados de nitrometileno com efeito insecticida
PT94059A (pt) Processo para a preparacao de copolimetros hidrossoluveis, de n-vinilamidas
PT98491A (pt) Processo para a preparacao de um poliactideo
PT81463B (pt) Processo para a preparacao de novos derivados 5-amino-4-hidroxivalerilo
PT82989B (pt) Processo para a preparacao de antibioticos beta-lactamicos
PT97416A (pt) Processo para a preparacao de novos compostos quinolona-tio-ureia antimicrobianos
PT83389B (pt) Processo para a preparacao de derivados de sulfonilureia uteis como agentes anti-tumurais
BR8506910A (pt) Processo para preparacao de poliais polimericos
PT99984A (pt) Processo para a preparacao de compostos 1-carba-(1-destia) cefem uteis como agentes antibacterianos
PT88180A (pt) Processo para a preparacao de derivados alquilaminoalcoxifenilo
BR8702112A (pt) Processo para a preparacao de um derivado de pirazol pirimidina
PT94008A (pt) Processo para a preparacao de novos derivados de tieno-triazolo-diazepina
BR8202216A (pt) Processo para a preparacao de sulferetos organicos
PT97828A (pt) Processo para a preparacao de fenil-triazinas
PT95119A (pt) Processo para a preparacao de carbamatos benzazaciclicos, uteis como inibidores de colinesterase
PT98729A (pt) Processo para a preparacao de compostos azatri-hetero ciclicos
ES530337A0 (es) Un procedimiento para la preparacion de un derivado carbapenem.
PT89809A (pt) Processo para a preparacao de pirimidinas substituidas
BR8700457A (pt) Processo para a preparacao de um derivado de alquileno-diamina
PT99268A (pt) Processo para a preparacao de derivados da 8-cloroquinolona
PT85608A (pt) Processo para a preparacao de derivados de fenil-etanolamina

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910912

FG3A Patent granted, date of granting

Effective date: 19980504

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991130