PT98006B - Processo para a preparacao de novos derivados peptidicos - Google Patents

Processo para a preparacao de novos derivados peptidicos Download PDF

Info

Publication number: PT98006B
Authority: PT; Portugal
Prior art keywords: ppm; group; general formula; radical; isomer
Prior art date: 1990-06-18

Application number

PT98006A

Other languages

English (en)

Portuguese (pt)

Other versions

PT98006A (pt

Inventor

Jean Lepagnol

Michel Vincent

Georges Remond

Bernard Portevin

Yolande Herve

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-18

Filing date

1991-06-17

Publication date

1998-11-30

1991-06-17 Application filed by Adir filed Critical Adir

1992-03-31 Publication of PT98006A publication Critical patent/PT98006A/pt

1998-11-30 Publication of PT98006B publication Critical patent/PT98006B/pt

Links

238000004519 manufacturing process Methods 0.000 title 1
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239000002253 acid Substances 0.000 claims abstract description 16
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 14
150000003839 salts Chemical class 0.000 claims abstract description 12
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HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 9
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238000000926 separation method Methods 0.000 claims description 23
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230000003000 nontoxic effect Effects 0.000 description 1
229960002748 norepinephrine Drugs 0.000 description 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000002953 preparative HPLC Methods 0.000 description 1
238000004262 preparative liquid chromatography Methods 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000000829 suppository Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
230000008733 trauma Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
229960000317 yohimbine Drugs 0.000 description 1
AADVZSXPNRLYLV-UHFFFAOYSA-N yohimbine carboxylic acid Natural products C1=CC=C2C(CCN3CC4CCC(C(C4CC33)C(O)=O)O)=C3NC2=C1 AADVZSXPNRLYLV-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Psychiatry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT98006A 1990-06-18 1991-06-17 Processo para a preparacao de novos derivados peptidicos PT98006B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9007559A FR2663336B1 (fr)	1990-06-18	1990-06-18	Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number	Publication Date
PT98006A PT98006A (pt)	1992-03-31
PT98006B true PT98006B (pt)	1998-11-30

Family

ID=9397708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98006A PT98006B (pt)	1990-06-18	1991-06-17	Processo para a preparacao de novos derivados peptidicos

Country Status (15)

Country	Link
US (1)	US5190923A (de)
EP (1)	EP0462884B1 (de)
JP (1)	JPH04253995A (de)
AT (1)	ATE90688T1 (de)
AU (1)	AU631068B2 (de)
CA (1)	CA2044736A1 (de)
DE (1)	DE69100128T2 (de)
DK (1)	DK0462884T3 (de)
ES (1)	ES2059079T3 (de)
FR (1)	FR2663336B1 (de)
IE (1)	IE65543B1 (de)
NZ (1)	NZ238574A (de)
OA (1)	OA09368A (de)
PT (1)	PT98006B (de)
ZA (1)	ZA914662B (de)

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US8476261B2 (en)	2007-09-12	2013-07-02	Kyorin Pharmaceutical Co., Ltd.	Spirocyclic aminoquinolones as GSK-3 inhibitors
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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2575753B1 (fr) *	1985-01-07	1987-02-20	Adir	Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2585709B1 (fr) *	1985-08-05	1987-10-02	Adir	Nouveaux derives peptidiques a structure lactonique ou cycloamidique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2610934B1 (fr) *	1987-02-13	1989-05-05	Adir	Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2616663B1 (fr) *	1987-06-16	1989-08-18	Adir	Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2649110B1 (fr) *	1989-06-29	1994-10-21	Adir	Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

1990
- 1990-06-18 FR FR9007559A patent/FR2663336B1/fr not_active Expired - Lifetime
1991
- 1991-06-04 US US07/710,283 patent/US5190923A/en not_active Expired - Fee Related
- 1991-06-17 IE IE205291A patent/IE65543B1/en not_active IP Right Cessation
- 1991-06-17 CA CA002044736A patent/CA2044736A1/fr not_active Abandoned
- 1991-06-17 NZ NZ238574A patent/NZ238574A/xx unknown
- 1991-06-17 PT PT98006A patent/PT98006B/pt not_active IP Right Cessation
- 1991-06-17 AU AU78447/91A patent/AU631068B2/en not_active Ceased
- 1991-06-18 OA OA60022A patent/OA09368A/xx unknown
- 1991-06-18 DK DK91401624.1T patent/DK0462884T3/da active
- 1991-06-18 EP EP91401624A patent/EP0462884B1/de not_active Expired - Lifetime
- 1991-06-18 ZA ZA914662A patent/ZA914662B/xx unknown
- 1991-06-18 AT AT91401624T patent/ATE90688T1/de not_active IP Right Cessation
- 1991-06-18 JP JP3145935A patent/JPH04253995A/ja active Pending
- 1991-06-18 DE DE91401624T patent/DE69100128T2/de not_active Expired - Fee Related
- 1991-06-18 ES ES91401624T patent/ES2059079T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IE912052A1 (en)	1991-12-18
FR2663336B1 (fr)	1992-09-04
ATE90688T1 (de)	1993-07-15
IE65543B1 (en)	1995-11-01
DE69100128D1 (de)	1993-07-22
DE69100128T2 (de)	1994-01-13
JPH04253995A (ja)	1992-09-09
US5190923A (en)	1993-03-02
OA09368A (fr)	1992-09-15
AU7844791A (en)	1991-12-19
AU631068B2 (en)	1992-11-12
NZ238574A (en)	1993-03-26
EP0462884A1 (de)	1991-12-27
ZA914662B (en)	1992-03-25
FR2663336A1 (fr)	1991-12-20
EP0462884B1 (de)	1993-06-16
PT98006A (pt)	1992-03-31
DK0462884T3 (da)	1993-08-23
CA2044736A1 (fr)	1991-12-19
ES2059079T3 (es)	1994-11-01

Legal Events

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1992-03-31

BB1A

Laying open of patent application

Effective date: 19911114

1998-11-30

FG3A

Patent granted, date of granting

Effective date: 19980807

2000-06-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000229

Publication	Publication Date	Title
US5190923A (en)	1993-03-02	Peptide compounds containing a cyclic amide structure
EP0148133B1 (de)	1989-03-22	Tripeptid-Verbindungen enthaltend Pyroglutaminsäure und Tryptophan, deren Herstellungsverfahren und therapeutische Verwendung
IE913423A1 (en)	1992-04-08	Tripeptide antithrombotic agents
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JPS61236770A (ja)	1986-10-22	新規なアミノ酸誘導体
JPH0342271B2 (de)	1991-06-26
JPS6340199B2 (de)	1988-08-10
US5098888A (en)	1992-03-24	New heterocyclic tripeptide compounds
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