PT99051A - Processo para a preparacao de formoterol e de compostos com ele relacionados e seus derivados - Google Patents

Processo para a preparacao de formoterol e de compostos com ele relacionados e seus derivados

Info

Publication number: PT99051A
Authority: PT; Portugal
Prior art keywords: formoterol; related compounds; derivatives; preparation; directed
Prior art date: 1990-09-26

Application number

PT99051A

Other languages

English (en)

Other versions

PT99051B (pt

Inventor

Edib Jakupovic

Jan William Trofast

Lena Katarina Mansson

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-26

Filing date

1991-09-25

Publication date

1992-08-31

1991-09-25 Application filed by Astra Ab filed Critical Astra Ab

1992-08-31 Publication of PT99051A publication Critical patent/PT99051A/pt

1999-02-26 Publication of PT99051B publication Critical patent/PT99051B/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 3
BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 title abstract 3
229960002848 formoterol Drugs 0.000 title abstract 3
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Pyrrole Compounds (AREA)
Steroid Compounds (AREA)

PT99051A 1990-09-26 1991-09-25 Processo para a preparacao de formoterol e de compostos com ele relacionados e seus derivados PT99051B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9003057A SE9003057D0 (sv)	1990-09-26	1990-09-26	New process

Publications (2)

Publication Number	Publication Date
PT99051A true PT99051A (pt)	1992-08-31
PT99051B PT99051B (pt)	1999-02-26

Family

ID=20380456

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99051A PT99051B (pt)	1990-09-26	1991-09-25	Processo para a preparacao de formoterol e de compostos com ele relacionados e seus derivados

Country Status (28)

Country	Link
EP (1)	EP0550612B1 (pt)
JP (1)	JP2801401B2 (pt)
KR (1)	KR0179639B1 (pt)
AT (1)	ATE134990T1 (pt)
AU (1)	AU652386B2 (pt)
BG (1)	BG61605B1 (pt)
CA (1)	CA2091343C (pt)
CZ (1)	CZ284256B6 (pt)
DE (1)	DE69117768T2 (pt)
DK (1)	DK0550612T3 (pt)
EE (1)	EE02979B1 (pt)
ES (1)	ES2084831T3 (pt)
FI (1)	FI111714B (pt)
GR (1)	GR3020134T3 (pt)
HK (1)	HK52297A (pt)
HU (1)	HU214054B (pt)
IE (1)	IE74387B1 (pt)
IS (1)	IS1684B (pt)
LT (1)	LT3813B (pt)
LV (1)	LV10770B (pt)
NO (1)	NO301709B1 (pt)
PL (1)	PL166434B1 (pt)
PT (1)	PT99051B (pt)
RU (1)	RU2079486C1 (pt)
SE (1)	SE9003057D0 (pt)
SG (1)	SG43150A1 (pt)
SK (1)	SK22793A3 (pt)
WO (1)	WO1992005147A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6299863B1 (en)	1992-04-03	2001-10-09	Sepracor Inc.	Aerosol formulations containing micronized optically pure (R,R) formoterol for bronchodilating therapy
US5795564A (en) *	1991-04-05	1998-08-18	Sepracor, Inc.	Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
US6866839B2 (en)	1991-04-05	2005-03-15	Sepracor Inc.	Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
US5629200A (en) *	1993-11-18	1997-05-13	Daicel Chemical Industries, Ltd.	Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation
SE9404080L (sv) *	1993-12-28	1995-06-29	Ciba Geigy Ag	Förfarande för framställning av en optiskt ren enantiomer av formoterol
US6040344A (en)	1996-11-11	2000-03-21	Sepracor Inc.	Formoterol process
EP0938467B1 (en) *	1996-11-11	2002-06-12	Sepracor, Inc.	Process for the preparation of optically pure isomers of formoterol
US6303145B2 (en)	1999-05-10	2001-10-16	Sepracor Inc.	(S,R) formoterol methods and compositions
AR028948A1 (es)	2000-06-20	2003-05-28	Astrazeneca Ab	Compuestos novedosos
WO2002066021A2 (de) *	2001-02-22	2002-08-29	Universitätsklinikum Charite Medizinische Fakultät Der Humboldt-Universität Zu Berlin	Inhibitoren der protein kinase d und der protein kinase 2 als mittel zur hemmung von tumorzellen und zur stimulierung der angiogehese
US6472563B1 (en)	2001-11-09	2002-10-29	Sepracor Inc.	Formoterol tartrate process and polymorph
TWI359675B (en)	2003-07-10	2012-03-11	Dey L P	Bronchodilating β-agonist compositions
TW200738634A (en)	2005-08-02	2007-10-16	Astrazeneca Ab	New salt
WO2008035380A2 (en) *	2006-09-19	2008-03-27	Natco Pharma Limited	An improved process for the preparation of high purity formoterol and its pharmaceutically acceptable salts
TW200825084A (en)	2006-11-14	2008-06-16	Astrazeneca Ab	New compounds 521
EP2205966A2 (en) *	2007-10-29	2010-07-14	Generics Ýuk¨Limited	Novel chromatography methods
NZ589091A (en)	2008-05-13	2011-07-29	Astrazeneca Ab	Quinuclidine derivatives as muscarinic m3 receptor antagonists
CN101921200B (zh) *	2009-06-16	2014-01-15	上海医药工业研究院	一种n-苄基-1-(4-甲氧基苯基)-2-丙胺的制备方法
WO2011061527A1 (en)	2009-11-17	2011-05-26	Astrazeneca Ab	Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
CN115368250B (zh) *	2022-09-02	2024-07-26	博诺康源(北京)药业科技有限公司	拆分福莫特罗手性中间体的方法
CN117682969A (zh) *	2023-07-31	2024-03-12	浙江理工大学	一种福莫特罗中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2305092A1 (de)	1972-02-05	1973-08-16	Yamanouchi Pharma Co Ltd	Alpha-aminomethylbenzylalkoholderivate
GB1468156A (en) *	1973-07-19	1977-03-23	Ici Ltd	Phenylethylamine derivatives
ES2005492A6 (es)	1987-12-23	1989-03-01	Lasa Lab	Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i).

1990
- 1990-09-26 SE SE9003057A patent/SE9003057D0/xx unknown
1991
- 1991-09-25 JP JP3516242A patent/JP2801401B2/ja not_active Expired - Lifetime
- 1991-09-25 KR KR1019930700901A patent/KR0179639B1/ko not_active Expired - Lifetime
- 1991-09-25 IS IS3756A patent/IS1684B/is unknown
- 1991-09-25 HU HU9300867A patent/HU214054B/hu unknown
- 1991-09-25 DE DE69117768T patent/DE69117768T2/de not_active Expired - Lifetime
- 1991-09-25 ES ES91917624T patent/ES2084831T3/es not_active Expired - Lifetime
- 1991-09-25 RU RU9193005269A patent/RU2079486C1/ru active
- 1991-09-25 SG SG1996004479A patent/SG43150A1/en unknown
- 1991-09-25 SK SK22793A patent/SK22793A3/sk unknown
- 1991-09-25 WO PCT/SE1991/000643 patent/WO1992005147A1/en not_active Ceased
- 1991-09-25 EP EP91917624A patent/EP0550612B1/en not_active Expired - Lifetime
- 1991-09-25 CZ CZ93442A patent/CZ284256B6/cs not_active IP Right Cessation
- 1991-09-25 PL PL91298237A patent/PL166434B1/pl unknown
- 1991-09-25 CA CA002091343A patent/CA2091343C/en not_active Expired - Lifetime
- 1991-09-25 PT PT99051A patent/PT99051B/pt not_active IP Right Cessation
- 1991-09-25 DK DK91917624.8T patent/DK0550612T3/da active
- 1991-09-25 AU AU86520/91A patent/AU652386B2/en not_active Expired
- 1991-09-25 AT AT91917624T patent/ATE134990T1/de not_active IP Right Cessation
- 1991-09-26 IE IE337391A patent/IE74387B1/en not_active IP Right Cessation
1993
- 1993-03-23 NO NO931058A patent/NO301709B1/no not_active IP Right Cessation
- 1993-03-24 BG BG97576A patent/BG61605B1/bg unknown
- 1993-03-25 FI FI931333A patent/FI111714B/fi not_active IP Right Cessation
- 1993-08-10 LV LVP-93-1025A patent/LV10770B/en unknown
- 1993-12-30 LT LTIP1715A patent/LT3813B/lt not_active IP Right Cessation
1994
- 1994-11-23 EE EE9400425A patent/EE02979B1/xx unknown
1996
- 1996-05-31 GR GR960401514T patent/GR3020134T3/el unknown
1997
- 1997-04-24 HK HK52297A patent/HK52297A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
LV10770A (lv)	1995-08-20
LV10770B (en)	1996-04-20
LT3813B (en)	1996-03-25
HU214054B (en)	1997-12-29
ATE134990T1 (de)	1996-03-15
KR0179639B1 (ko)	1999-05-15
SK22793A3 (en)	1993-07-07
SE9003057D0 (sv)	1990-09-26
CA2091343A1 (en)	1992-03-27
AU652386B2 (en)	1994-08-25
BG97576A (bg)	1994-03-31
LTIP1715A (en)	1995-07-25
NO931058L (no)	1993-03-23
EP0550612A1 (en)	1993-07-14
IS1684B (is)	1998-02-24
DE69117768D1 (de)	1996-04-11
HK52297A (en)	1997-05-02
AU8652091A (en)	1992-04-15
BG61605B1 (bg)	1998-01-30
WO1992005147A1 (en)	1992-04-02
IE74387B1 (en)	1997-07-30
CZ284256B6 (cs)	1998-10-14
DE69117768T2 (de)	1996-08-29
NO301709B1 (no)	1997-12-01
DK0550612T3 (da)	1996-07-22
PT99051B (pt)	1999-02-26
RU2079486C1 (ru)	1997-05-20
SG43150A1 (en)	1997-10-17
FI111714B (fi)	2003-09-15
CA2091343C (en)	2002-07-09
ES2084831T3 (es)	1996-05-16
JPH06501262A (ja)	1994-02-10
EP0550612B1 (en)	1996-03-06
HUT65912A (en)	1994-07-28
IS3756A7 (is)	1992-03-27
FI931333L (fi)	1993-04-22
HU9300867D0 (en)	1993-06-28
CZ44293A3 (en)	1994-01-19
GR3020134T3 (en)	1996-08-31
JP2801401B2 (ja)	1998-09-21
EE02979B1 (et)	1997-04-15
NO931058D0 (no)	1993-03-23
FI931333A0 (fi)	1993-03-25
PL166434B1 (pl)	1995-05-31
IE913373A1 (en)	1992-04-08

Legal Events

Date	Code	Title	Description
1992-08-31	BB1A	Laying open of patent application	Effective date: 19920504
1999-02-26	FG3A	Patent granted, date of granting	Effective date: 19981112
1999-05-31	PD3A	Change of proprietorship	Owner name: ASTRA AKTIEBOLAG Effective date: 19990209
2013-11-19	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20131112

Publication	Publication Date	Title
EE02979B1 (et)	1997-04-15	Formoterool ja tema ühendid ning nende valmistamise meetod
FI914905L (fi)	1992-04-19	Menetelmä uusien terapeuttisesti käyttökelpoisten merkaptoasetyyliamidopyrrolo- ja -pyridobentsatsepiinijohdannaisten valmistamiseksi
NO914667D0 (no)	1991-11-27	Fremgangsmaate for fremstilling av terapeutisk aktive arylderivater
FI923527L (fi)	1992-08-05	Menetelmä terapeuttisesti käyttökelpoisten 3-piperidino-4-hydroksikromaanijohdannaisten valmistamiseksi
RU93005269A (ru)	1996-04-27	Способ получения формотерола и родственных соединений
FI930723L (fi)	1993-02-18	Menetelmä terapeuttisesti aktiivisten tiatsolidiinijohdannaisten valmistamiseksi
FI925871L (fi)	1992-12-23	Menetelmä terapeuttisesti aktiivisten fenyyliguanidiinijohdannaisten valmistamiseksi
FI906408L (fi)	1991-06-29	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
ES2071303T3 (es)	1995-06-16	Compuestos homologados de vitamina d2 y los derivados hidroxilados en 1alfa correspondientes.
FI904838A7 (fi)	1991-04-04	Menetelmä farmaseuttisesti aktiivisten karboksitetrahydroisokinoliinien ja niiden johdannaisten valmistamiseksi
FI911080A7 (fi)	1991-09-09	Menetelmä 1,5-bentsotiatsepiinijohdannaisten valmistamiseksi
FI903835A7 (fi)	1991-02-03	Menetelmä farmaseuttisesti käyttökelpoisten 4-(N-substituoitu amino)-2-butynyyli-1-ureoiden ja -tioureoiden ja niiden johdannaisten valmistamiseksi
PT99249A (pt)	1992-08-31	Processo para a preparacao de derivados de piperazina
EE03027B1 (et)	1997-08-15	Meetod 8-klorokinolooni derivaatide valmistamiseks
NO179205C (no)	1996-08-28	Analogifremgangsmåte for fremstilling av terapeutisk aktive 1-piperidinylalkanoylarylsulfonamidderivater
FI903834A7 (fi)	1991-02-03	Menetelmä farmaseuttisesti käyttökelpoisten 4-(N-substituoitu amino)-2-butynyyli-1-karbamaattien ja -tiokarbamaattien ja niiden johdannaisten valmistamiseksi
FI922835L (fi)	1992-06-17	Menetelmä terapeuttisesti aktiivisten piperidiinijohdannaisten valmistamiseksi
MA22200A1 (fr)	1992-04-01	Procede de preparation de derives d'aminodiols
PT90262A (pt)	1989-11-10	Processo para a preparacao de novos derivados trienicos com estrutura cromenica
ES2089176T3 (es)	1996-10-01	Procedimiento para la preparacion de carboditioatos de piperidina fluorometil-sustituidos.
PT98186A (pt)	1992-05-29	Processo para a preparacao de purinil- e de pirimidinil-tetra-hidrofuranos e de composicoes farmaceuticas que os contem
FI912733L (fi)	1991-12-08	Menetelmä terapeuttisesti käyttökelpoisten /(1-aryylipyrrolidin-2-yyli)metyyli/piperatsiinijohdannaisten valmistamiseksi
NO914452L (no)	1992-05-15	Fremgangsmaate for fremstilling av isokinolinderivater
ES531141A0 (es)	1985-09-01	Un procedimiento para preparar derivados de tropona
FI913656A7 (fi)	1992-02-01	Menetelmä alkyyli-6-pyridatsiinijohdannaisten valmistamiseksi