RU2220719C2 - Противоопухолевые экстракты какао, способы их получения и использование - Google Patents
Противоопухолевые экстракты какао, способы их получения и использование Download PDFInfo
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- RU2220719C2 RU2220719C2 RU97106832/15A RU97106832A RU2220719C2 RU 2220719 C2 RU2220719 C2 RU 2220719C2 RU 97106832/15 A RU97106832/15 A RU 97106832/15A RU 97106832 A RU97106832 A RU 97106832A RU 2220719 C2 RU2220719 C2 RU 2220719C2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/577—Malvaceae (Mallow family)
- A61K36/5777—Theobroma, e.g. cocao or cocoa
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
- C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
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- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Coloring Foods And Improving Nutritive Qualities (AREA)
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Abstract
Изобретение относится к экстрактам из бобов какао, таким как полифенолы, предпочтительно полифенолы, обогащенные процианидинами. Экстракт какао получают предпочтительно способом, предусматривающим измельчение какао-бобов до образования порошка, обезжиривание полученного порошка и экстрагирование из этого порошка активных соединений. Изобретение также относится к использованию экстрактов какао в основном в противоопухолевых композициях, в ингибирующих топоизомеразу композициях и в качестве антиоксидантов. Технический результат изобретения заключается в указанном назначении композиций на основе экстрактов какао. 15 с. и 15 з.п. ф-лы, 20 ил., 8 табл.
Description
Текст описания в факсимильном виде (см. графический материал)р
Claims (30)
1. Экстракт какао, содержащий полифенолы какао, полученный способом, который включает измельчение неферментированных или частично ферментированных какао-бобов в порошок; обезжиривание порошка; экстрагирование полифенолов какао из порошка методом экстракции растворителем и очистку полученного таким образом экстракта какао.
2. Экстракт какао по п.1, где способ включает очистку экстракта методом гельпроникающей хроматографии и/или высокоэффективной жидкостной хроматографии (ВЭЖХ).
3. Экстракт какао по п.1 или 2, который содержит по меньшей мере один процианидин какао, выбранный из (-)-эпикатехина, процианидина В-2, олигомеров 4-12 процианидина, процианидина В-5, процианидина А-2 и процианидина С-1.
4. Экстракт какао, содержащий полифенолы какао, который включает по меньшей мере один из димеров, тримеров, тетрамеров, пентамеров, гексамеров, гептамеров, октамеров, нонамеров, декамеров, ундекамеров и додекамеров процианидина какао.
5. Экстракт какао, содержащий полифенолы какао и не содержащий ксантиновые алкалоиды, полученный способом, который включает измельчение какао-бобов в порошок; обезжиривание порошка; экстрагирование полифенолов какао из порошка методом экстракции растворителем и удаление ксантиновых алкалоидов из экстракта с получением подфракции, не содержащей ксантиновые алкалоиды.
6. Экстракт какао по любому из пп.1-3 или 5, где способ измельчения какао-бобов в порошок включает сушку сублимацией бобов и мякоти; удаление мякоти из массы, подвергнутой сушке сублимацией; шелушение какао-бобов, подвергнутых сушке сублимацией, и измельчение очищенных от кожуры бобов.
7. Экстракт какао по любому из пп.1-6 в лиофилизованном виде.
8. Твердая композиция, подходящая для орального введения, которая содержит подходящий носитель и экстракт какао, содержащий по меньшей мере один из олигомеров 4-12 процианидина какао.
9. Твердая композиция, подходящая для орального введения, включающая подходящий носитель и экстракт неферментированных или частично ферментированных какао-бобов, где указанный экстракт содержит по меньшей мере один процианидин какао, выбранный из эпикатехина, процианидина В-2, олигомеров 2-12 процианидина, процианидина В-5, процианидина А-2 и процианидина С-1.
10. Твердая композиция по п.8 или 9, где указанный экстракт ферментативно окислен.
11. Твердая композиция, подходящая для орального введения, которая включает подходящий носитель и синтетический олигомер 2-12 процианидина какао, или его гликозид, или сложный эфир.
12. Твердая композиция по п.11, где указанный сложный эфир представляет собой сложный эфир галловой кислоты.
13. Твердая композиция по любому из пп.8-12 в виде жевательной твердой композиции.
14. Твердая композиция по любому из пп.8-13 в виде твердой композиции, ароматизированной какао или шоколадом.
15. Жидкий состав, подходящий для орального введения, включающий подходящий носитель и экстракт какао, содержащий по меньшей мере один олигомер 4-12 процианидина какао.
16. Жидкий состав, подходящий для орального введения, включающий подходящий носитель и экстракт неферментированных или частично ферментированных какао-бобов, где указанный экстракт содержит по меньшей мере один процианидин какао, выбранный из эпикатехина, процианидина В-2, олигомеров 2-12 процианидина, процианидина В-5, процианидина А-2 и процианидина С-1.
17. Жидкий состав по пп.15 и 16, где экстракт ферментативно окислен.
18. Жидкий состав, подходящий для орального введения, включающий подходящий носитель и синтетический олигомер 2-12 процианидина какао, или его гликозид, или сложный эфир.
19. Жидкий состав по п.18, включающий подходящий носитель и синтетический олигомер 2-5 процианидина какао, или его гликозид, или сложный эфир.
20. Жидкий состав по п.18 или 19, где указанный сложный эфир представляет собой сложный эфир галловой кислоты.
21. Жидкий состав по любому из пп.15-20 в виде суспензии, сиропа или эликсира.
22. Таблетка, капсула или пилюля, включающая подходящий носитель и экстракт какао, содержащий олигомер 2-12 процианидина какао.
23. Таблетка, капсула или пилюля по п.22, где экстракт ферментативно окислен.
24. Таблетка, капсула или пилюля, включающая подходящий носитель и синтетический олигомер 2-12 процианидина какао, или его гликозид, или сложный эфир.
25. Таблетка, капсула или пилюля по п.24, где указанный сложный эфир представляет собой сложный эфир галловой кислоты.
26. Антинеопластическая композиция, включающая экстракт какао, содержащий по меньшей мере один олигомер 5-12 процианидина какао.
27. Антинеопластическая композиция, которая содержит синтетический олигомер процианидина какао, или его гликозид, или сложный эфир.
28. Антинеопластическая композиция по п.26 или 27, используемая для лечения рака молочной железы, рака носоглотки, рака почек, лейкемии Т-клеток, рака простаты или шейного рака.
29. Ингибирующая топоизомеразу композиция, включающая экстракт какао, содержащий по меньшей мере один олигомер 5-12 процианидина какао.
30. Ингибирующая топоизомеразу композиция, включающая синтетический олигомер 2-12 процианидина какао.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/317,226 US5554645A (en) | 1994-10-03 | 1994-10-03 | Antineoplastic cocoa extracts and methods for making and using the same |
| US317,226 | 1994-10-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97106832A RU97106832A (ru) | 1999-05-10 |
| RU2220719C2 true RU2220719C2 (ru) | 2004-01-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97106832/15A RU2220719C2 (ru) | 1994-10-03 | 1995-10-03 | Противоопухолевые экстракты какао, способы их получения и использование |
Country Status (26)
| Country | Link |
|---|---|
| US (13) | US5554645A (ru) |
| EP (2) | EP0789568B1 (ru) |
| JP (2) | JPH10506903A (ru) |
| CN (2) | CN1134255C (ru) |
| AP (1) | AP9700952A0 (ru) |
| AT (1) | ATE346599T1 (ru) |
| AU (1) | AU696050B2 (ru) |
| BG (1) | BG101446A (ru) |
| CA (1) | CA2201310C (ru) |
| CZ (1) | CZ99197A3 (ru) |
| DE (1) | DE69535318T2 (ru) |
| DK (1) | DK0789568T3 (ru) |
| EE (1) | EE9700074A (ru) |
| FI (1) | FI971354A7 (ru) |
| HU (1) | HUT77366A (ru) |
| IS (1) | IS4456A (ru) |
| LT (1) | LT4322B (ru) |
| LV (1) | LV11819B (ru) |
| MD (1) | MD970165A (ru) |
| MX (1) | MX9702415A (ru) |
| NO (1) | NO971485L (ru) |
| OA (1) | OA10604A (ru) |
| PL (1) | PL187819B1 (ru) |
| RU (1) | RU2220719C2 (ru) |
| SK (1) | SK43497A3 (ru) |
| WO (1) | WO1996010404A1 (ru) |
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| CA2250792C (en) * | 1996-04-02 | 2011-09-13 | Mars, Incorporated | Cocoa extract compounds and methods for making and using the same |
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| US6297273B1 (en) * | 1996-04-02 | 2001-10-02 | Mars, Inc. | Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions |
| US6423743B1 (en) | 1996-04-02 | 2002-07-23 | Mars Incorporated | Cocoa extract compounds and methods for making and using the same |
| US6696485B1 (en) | 1996-04-02 | 2004-02-24 | Mars, Incorporated | Procyanidin and cyclo-oxygenase modulator compositions |
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| US6312753B1 (en) * | 1996-09-06 | 2001-11-06 | Mars, Incorporated | Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses |
| US6558713B2 (en) * | 1996-09-06 | 2003-05-06 | Mars, Incorporated | Health of a mammal by administering a composition containing at least one cocoa polyphenol ingredient |
| US7968140B2 (en) * | 1997-09-08 | 2011-06-28 | Mars, Incorporated | Chocolates and chocolate liquor having an enhanced polyphenol content |
| CZ97399A3 (cs) * | 1996-09-20 | 1999-08-11 | The Howard Foundation | Potravinový doplněk s obsahem flavonolu |
| US6238673B1 (en) | 1996-09-20 | 2001-05-29 | The Howard Foundation | Method of producing high flavonol content polyphenol compositions |
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| US6066350A (en) * | 1997-02-07 | 2000-05-23 | Cargill Incorporated | Method and arrangement for processing cocoa mass |
| JP2001513505A (ja) * | 1997-08-08 | 2001-09-04 | エイティーエイジェイジェイイー インコーポレーテッド | タンニン酸及びタンニン複合体により癌を治療する組成物及び方法 |
| US6207842B1 (en) | 1997-10-09 | 2001-03-27 | Mars Incorporated | Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives |
| ATE372972T1 (de) * | 1998-03-12 | 2007-09-15 | Mars Inc | Produkte enthaltend polyphenol(e) und l-arginin zur stimulierung der stickstoffoxidproduktion |
| US8507018B2 (en) * | 1998-03-12 | 2013-08-13 | Mars, Incorporated | Products containing polyphenol(s) and L-arginine and methods of use thereof |
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| RU2286778C2 (ru) * | 2000-03-22 | 2006-11-10 | Марс, Инк. | Применение процианидинов какао в сочетании с ацетилсалициловой кислотой как противотромбоцитного терапевтического средства |
| IT1317035B1 (it) | 2000-05-30 | 2003-05-26 | Sigma Tau Healthscience Spa | Integratore ad attivita' antiossidante comprendente unaalcanoilcarnitina ed una associazione di polifenoli estratti dal |
| US6627232B1 (en) * | 2000-06-09 | 2003-09-30 | Mars Incorporated | Method for extracting cocoa procyanidins |
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1994
- 1994-10-03 US US08/317,226 patent/US5554645A/en not_active Expired - Lifetime
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1995
- 1995-10-03 EP EP95938189A patent/EP0789568B1/en not_active Revoked
- 1995-10-03 DK DK95938189T patent/DK0789568T3/da active
- 1995-10-03 EP EP06024499A patent/EP1759696A1/en not_active Withdrawn
- 1995-10-03 AT AT95938189T patent/ATE346599T1/de active
- 1995-10-03 CN CNB951965956A patent/CN1134255C/zh not_active Expired - Lifetime
- 1995-10-03 RU RU97106832/15A patent/RU2220719C2/ru active
- 1995-10-03 AP APAP/P/1997/000952A patent/AP9700952A0/en unknown
- 1995-10-03 WO PCT/US1995/012963 patent/WO1996010404A1/en not_active Ceased
- 1995-10-03 MX MX9702415A patent/MX9702415A/es not_active Application Discontinuation
- 1995-10-03 AU AU38916/95A patent/AU696050B2/en not_active Ceased
- 1995-10-03 EE EE9700074A patent/EE9700074A/xx unknown
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- 1995-10-03 CN CNB2003101015256A patent/CN100357287C/zh not_active Expired - Lifetime
- 1995-10-03 SK SK434-97A patent/SK43497A3/sk unknown
- 1995-10-03 FI FI971354A patent/FI971354A7/fi not_active Application Discontinuation
- 1995-10-03 JP JP8512152A patent/JPH10506903A/ja active Pending
- 1995-10-03 HU HU9702279A patent/HUT77366A/hu unknown
- 1995-10-03 PL PL95319756A patent/PL187819B1/pl unknown
- 1995-10-03 MD MD97-0165A patent/MD970165A/ru unknown
- 1995-10-03 CZ CZ97991A patent/CZ99197A3/cs unknown
- 1995-10-03 DE DE69535318T patent/DE69535318T2/de not_active Expired - Lifetime
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1996
- 1996-07-26 US US08/687,885 patent/US5712305A/en not_active Expired - Lifetime
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1997
- 1997-04-02 IS IS4456A patent/IS4456A/is unknown
- 1997-04-02 NO NO971485A patent/NO971485L/no unknown
- 1997-04-03 OA OA60986A patent/OA10604A/en unknown
- 1997-04-14 US US08/839,446 patent/US5891905A/en not_active Expired - Lifetime
- 1997-04-14 US US08/834,637 patent/US5877206A/en not_active Expired - Lifetime
- 1997-04-22 US US08/837,803 patent/US6479539B1/en not_active Expired - Lifetime
- 1997-04-25 BG BG101446A patent/BG101446A/xx unknown
- 1997-04-29 LT LT97-077A patent/LT4322B/lt not_active IP Right Cessation
- 1997-05-02 LV LVP-97-85A patent/LV11819B/xx unknown
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1998
- 1998-10-15 US US09/172,873 patent/US6225338B1/en not_active Expired - Lifetime
- 1998-11-23 US US09/198,551 patent/US6156791A/en not_active Expired - Fee Related
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2001
- 2001-01-24 US US09/768,473 patent/US6562863B2/en not_active Expired - Lifetime
- 2001-10-11 US US09/975,242 patent/US6517841B2/en not_active Expired - Lifetime
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2003
- 2003-01-15 US US10/342,772 patent/US6790966B2/en not_active Expired - Fee Related
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2004
- 2004-03-01 US US10/790,268 patent/US20040175448A1/en not_active Abandoned
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2007
- 2007-05-08 US US11/745,698 patent/US7820713B2/en not_active Expired - Fee Related
- 2007-10-29 US US11/926,919 patent/US20080269320A1/en not_active Abandoned
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2009
- 2009-09-03 JP JP2009203541A patent/JP2009286796A/ja active Pending
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| US4797421A (en) * | 1984-07-03 | 1989-01-10 | Kikkoman Corporation | Antioxidant comprising proanthocyanidin as principal component |
| US4704292A (en) * | 1984-12-10 | 1987-11-03 | Cacaofabriek De Zaan B.V. | Cocoa |
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