SE512663C2 - Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer - Google Patents
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymerInfo
- Publication number
- SE512663C2 SE512663C2 SE9703874A SE9703874A SE512663C2 SE 512663 C2 SE512663 C2 SE 512663C2 SE 9703874 A SE9703874 A SE 9703874A SE 9703874 A SE9703874 A SE 9703874A SE 512663 C2 SE512663 C2 SE 512663C2
- Authority
- SE
- Sweden
- Prior art keywords
- active substance
- process according
- biodegradable polymer
- aqueous
- polyethylene glycol
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
- B01J13/18—In situ polymerisation with all reactants being present in the same phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Formation And Processing Of Food Products (AREA)
- Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
- Glass Compositions (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
- Surgical Instruments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703874A SE512663C2 (sv) | 1997-10-23 | 1997-10-23 | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
| EP98948005A EP1033973B1 (en) | 1997-10-23 | 1998-09-24 | Encapsulation method |
| PT98948005T PT1033973E (pt) | 1997-10-23 | 1998-09-24 | Metodo de encapsulacao |
| US09/529,442 US6861064B1 (en) | 1997-10-23 | 1998-09-24 | Encapsulation method |
| JP2000516653A JP2001520186A (ja) | 1997-10-23 | 1998-09-24 | カプセル封入方法 |
| DK98948005T DK1033973T3 (da) | 1997-10-23 | 1998-09-24 | Fremgangsmåde til indkapsling |
| HK01100785.8A HK1029931B (en) | 1997-10-23 | 1998-09-24 | Encapsulation method |
| ES98948005T ES2205551T3 (es) | 1997-10-23 | 1998-09-24 | Metodo de encapsulacion. |
| IL13573398A IL135733A (en) | 1997-10-23 | 1998-09-24 | Encapsulation method |
| AT98948005T ATE249813T1 (de) | 1997-10-23 | 1998-09-24 | Einhüllungssverfahren |
| DE69818295T DE69818295T2 (de) | 1997-10-23 | 1998-09-24 | Einhüllungssverfahren |
| PCT/SE1998/001717 WO1999020253A1 (en) | 1997-10-23 | 1998-09-24 | Encapsulation method |
| HU0004732A HU224008B1 (hu) | 1997-10-23 | 1998-09-24 | Kapszulázási eljárás |
| KR1020007004276A KR100572711B1 (ko) | 1997-10-23 | 1998-09-24 | 캡슐화 방법 |
| CZ20001352A CZ299100B6 (cs) | 1997-10-23 | 1998-09-24 | Zpusob zapouzdrování aktivní látky v biologicky odstranitelném polymeru |
| AU94670/98A AU732891B2 (en) | 1997-10-23 | 1998-09-24 | Encapsulation method |
| CA002306824A CA2306824C (en) | 1997-10-23 | 1998-09-24 | Encapsulation method |
| ZA989199A ZA989199B (en) | 1997-10-23 | 1998-10-08 | Encapsulation method |
| NO20002039A NO310177B1 (no) | 1997-10-23 | 2000-04-18 | Fremgangsmåte for å innkapsle en aktiv substans samt vedvarende frigivelsesmikro- eller nanopartikler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703874A SE512663C2 (sv) | 1997-10-23 | 1997-10-23 | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE9703874D0 SE9703874D0 (sv) | 1997-10-23 |
| SE9703874L SE9703874L (sv) | 1999-04-24 |
| SE512663C2 true SE512663C2 (sv) | 2000-04-17 |
Family
ID=20408722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9703874A SE512663C2 (sv) | 1997-10-23 | 1997-10-23 | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6861064B1 (no) |
| EP (1) | EP1033973B1 (no) |
| JP (1) | JP2001520186A (no) |
| KR (1) | KR100572711B1 (no) |
| AT (1) | ATE249813T1 (no) |
| AU (1) | AU732891B2 (no) |
| CA (1) | CA2306824C (no) |
| CZ (1) | CZ299100B6 (no) |
| DE (1) | DE69818295T2 (no) |
| DK (1) | DK1033973T3 (no) |
| ES (1) | ES2205551T3 (no) |
| HU (1) | HU224008B1 (no) |
| IL (1) | IL135733A (no) |
| NO (1) | NO310177B1 (no) |
| PT (1) | PT1033973E (no) |
| SE (1) | SE512663C2 (no) |
| WO (1) | WO1999020253A1 (no) |
| ZA (1) | ZA989199B (no) |
Families Citing this family (342)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE288270T1 (de) | 1993-11-19 | 2005-02-15 | Janssen Pharmaceutica Nv | Mikroverkapselte 1,2-benzazole |
| DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
| KR20010002589A (ko) * | 1999-06-16 | 2001-01-15 | 김윤 | 생리활성물질 함유 생분해성 고분자 마이크로스피어의 제조방법 |
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1997
- 1997-10-23 SE SE9703874A patent/SE512663C2/sv not_active IP Right Cessation
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1998
- 1998-09-24 DK DK98948005T patent/DK1033973T3/da active
- 1998-09-24 KR KR1020007004276A patent/KR100572711B1/ko not_active Expired - Fee Related
- 1998-09-24 HU HU0004732A patent/HU224008B1/hu active IP Right Grant
- 1998-09-24 CA CA002306824A patent/CA2306824C/en not_active Expired - Fee Related
- 1998-09-24 ES ES98948005T patent/ES2205551T3/es not_active Expired - Lifetime
- 1998-09-24 US US09/529,442 patent/US6861064B1/en not_active Expired - Fee Related
- 1998-09-24 WO PCT/SE1998/001717 patent/WO1999020253A1/en not_active Ceased
- 1998-09-24 EP EP98948005A patent/EP1033973B1/en not_active Expired - Lifetime
- 1998-09-24 DE DE69818295T patent/DE69818295T2/de not_active Expired - Fee Related
- 1998-09-24 AT AT98948005T patent/ATE249813T1/de not_active IP Right Cessation
- 1998-09-24 JP JP2000516653A patent/JP2001520186A/ja active Pending
- 1998-09-24 PT PT98948005T patent/PT1033973E/pt unknown
- 1998-09-24 CZ CZ20001352A patent/CZ299100B6/cs not_active IP Right Cessation
- 1998-09-24 AU AU94670/98A patent/AU732891B2/en not_active Ceased
- 1998-09-24 IL IL13573398A patent/IL135733A/xx not_active IP Right Cessation
- 1998-10-08 ZA ZA989199A patent/ZA989199B/xx unknown
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2000
- 2000-04-18 NO NO20002039A patent/NO310177B1/no unknown
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| AU9467098A (en) | 1999-05-10 |
| SE9703874L (sv) | 1999-04-24 |
| NO310177B1 (no) | 2001-06-05 |
| WO1999020253A1 (en) | 1999-04-29 |
| EP1033973A1 (en) | 2000-09-13 |
| SE9703874D0 (sv) | 1997-10-23 |
| DE69818295D1 (de) | 2003-10-23 |
| KR100572711B1 (ko) | 2006-04-24 |
| EP1033973B1 (en) | 2003-09-17 |
| DE69818295T2 (de) | 2004-07-08 |
| ATE249813T1 (de) | 2003-10-15 |
| DK1033973T3 (da) | 2004-02-02 |
| NO20002039D0 (no) | 2000-04-18 |
| PT1033973E (pt) | 2004-02-27 |
| KR20010031289A (ko) | 2001-04-16 |
| AU732891B2 (en) | 2001-05-03 |
| HK1029931A1 (en) | 2001-04-20 |
| US6861064B1 (en) | 2005-03-01 |
| CA2306824A1 (en) | 1999-04-29 |
| IL135733A (en) | 2005-11-20 |
| NO20002039L (no) | 2000-06-13 |
| CA2306824C (en) | 2008-01-08 |
| JP2001520186A (ja) | 2001-10-30 |
| HUP0004732A3 (en) | 2001-12-28 |
| HUP0004732A2 (hu) | 2001-05-28 |
| ES2205551T3 (es) | 2004-05-01 |
| CZ299100B6 (cs) | 2008-04-23 |
| CZ20001352A3 (cs) | 2000-10-11 |
| HU224008B1 (hu) | 2005-04-28 |
| ZA989199B (en) | 1999-04-15 |
| IL135733A0 (en) | 2001-05-20 |
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