SE7907455L - Nytt forfarande for framstellning av vissa cefemforeningar - Google Patents
Nytt forfarande for framstellning av vissa cefemforeningarInfo
- Publication number
- SE7907455L SE7907455L SE7907455A SE7907455A SE7907455L SE 7907455 L SE7907455 L SE 7907455L SE 7907455 A SE7907455 A SE 7907455A SE 7907455 A SE7907455 A SE 7907455A SE 7907455 L SE7907455 L SE 7907455L
- Authority
- SE
- Sweden
- Prior art keywords
- slier
- ken
- cefem
- associations
- vats
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 125000001539 acetonyl group Chemical group [H]C([H])([H])C(=O)C([H])([H])* 0.000 claims abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 2
- 230000000269 nucleophilic effect Effects 0.000 claims abstract 2
- 101100366940 Mus musculus Stom gene Proteins 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 239000003245 coal Substances 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
Claims (1)
1. rbrferande &Sr framstallning AV en f8rening eked formeln i vilken Ri betecknar vate slier en aaylerupp oak R2 betecknar en rest av en nukleofil fdrening, eller ett salt dkrav, k Innetecknat av att en Mr-ening med forneln vilken W betecknar acetonyl slier en grope representerad av -X-COOH slier -X-ON War X Ir en tvAvard kolkedja, sem ken bil- 0 00 0 .0 da en fem- Slier sexledad ring med -0-0-0- slier -C-0-C-0-, corn ken innefatta en dubbelbindning slier sAdan(a) stom(ar) gm Byre, kvtive slier evavel, och till vats kolkedja(a) substituent(er) ken vats bundna) eller ett salt darav, omgAttes med en nukleofil f5rening. TOTH 000W COOS
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2315875A JPS5837316B2 (ja) | 1975-02-24 | 1975-02-24 | セフアロスポリンカゴウブツノ セイゾウホウ |
| JP3375975A JPS5951553B2 (ja) | 1975-03-20 | 1975-03-20 | セフアロスポリン化合物の製造法 |
| JP3471475A JPS5951554B2 (ja) | 1975-03-21 | 1975-03-21 | セフアロスポリン化合物の製造法 |
| JP127476A JPS5283869A (en) | 1976-01-01 | 1976-01-01 | Cephalosporin compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7907455L true SE7907455L (sv) | 1979-09-07 |
| SE435182B SE435182B (sv) | 1984-09-10 |
Family
ID=27453366
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7907455A SE435182B (sv) | 1975-02-24 | 1979-09-07 | Nytt forfarande for framstellning av cefalosporinderivat |
| SE7907454A SE435183B (sv) | 1975-02-24 | 1979-09-07 | Nya 7-amino cefalosporinderivat till anvendning som mellanprodukt for framstellning av cefalosporinderivat |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7907454A SE435183B (sv) | 1975-02-24 | 1979-09-07 | Nya 7-amino cefalosporinderivat till anvendning som mellanprodukt for framstellning av cefalosporinderivat |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4245088A (sv) |
| AT (1) | AT346486B (sv) |
| AU (1) | AU496914B2 (sv) |
| BE (1) | BE838833A (sv) |
| CA (1) | CA1092095A (sv) |
| CH (1) | CH625245A5 (sv) |
| DE (1) | DE2607064C2 (sv) |
| DK (3) | DK159154C (sv) |
| ES (2) | ES445348A1 (sv) |
| FR (1) | FR2301528A1 (sv) |
| GB (1) | GB1544103A (sv) |
| HK (1) | HK2482A (sv) |
| HU (2) | HU179070B (sv) |
| MX (1) | MX3635E (sv) |
| NL (1) | NL187166C (sv) |
| NO (1) | NO760590L (sv) |
| PH (1) | PH16245A (sv) |
| SE (2) | SE435182B (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323676A (en) * | 1975-02-24 | 1982-04-06 | Takeda Chemical Industries, Ltd. | Process for preparing cephalosporins |
| BE878433A (fr) * | 1978-08-31 | 1980-02-25 | Fujisawa Pharmaceutical Co | Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne |
| GR70261B (sv) * | 1977-12-12 | 1982-09-02 | Takeda Chemical Industries Ltd | |
| JPS5823698A (ja) * | 1981-07-17 | 1983-02-12 | グラクソ・グル−プ・リミテツド | セフアロスポリン化合物 |
| US4584371A (en) * | 1984-03-01 | 1986-04-22 | The Upjohn Company | Catalytic process for preparing 3-ester-methyl cephalosporins from desacetyl-7-aminocephalosporanic acid |
| JP2867438B2 (ja) * | 1988-08-10 | 1999-03-08 | 武田薬品工業株式会社 | セファロスポリン化合物の製造法 |
| US5552542A (en) * | 1995-05-10 | 1996-09-03 | Bristol-Myers Squibb Company | Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carboxylic acids |
| US8198434B2 (en) * | 2008-05-07 | 2012-06-12 | Idexx Laboratories, Inc. | Process for preparing cefsulodin sodium |
| CN103601737B (zh) * | 2013-12-04 | 2016-02-03 | 哈药集团制药总厂 | 一种盐酸头孢替安的制备方法 |
| WO2017153824A1 (en) * | 2016-03-07 | 2017-09-14 | Dhanuka Laboratories Ltd. | A process for alkylating the hydroxymethyl group at position -3 of cephalosporins |
| NL2022854B1 (en) * | 2019-04-03 | 2020-10-08 | Univ Leiden | Prodrug inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1141293A (en) | 1964-12-23 | 1969-01-29 | Glaxo Lab Ltd | Cephemoic acids and derivatives thereof |
| GB1241657A (en) * | 1967-08-21 | 1971-08-04 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin compounds |
| GB1333905A (en) | 1971-05-07 | 1973-10-17 | Smith Kline French Lab | Method for o-acylating 7-acylaminocephalosporadesic acids and o-acyl-7-acylaminocephalosporadesic acids |
| US4007178A (en) * | 1972-04-10 | 1977-02-08 | Smithkline Corporation | O-acyl-7-acylaminocephalosporadesic acids |
-
1976
- 1976-02-03 DK DK044076A patent/DK159154C/da not_active IP Right Cessation
- 1976-02-18 HU HU76TA1387A patent/HU179070B/hu not_active IP Right Cessation
- 1976-02-18 HU HU76TA1512A patent/HU179598B/hu not_active IP Right Cessation
- 1976-02-20 ES ES445348A patent/ES445348A1/es not_active Expired
- 1976-02-20 FR FR7604820A patent/FR2301528A1/fr active Granted
- 1976-02-21 DE DE2607064A patent/DE2607064C2/de not_active Expired
- 1976-02-23 NO NO760590A patent/NO760590L/no unknown
- 1976-02-23 AT AT126476A patent/AT346486B/de not_active IP Right Cessation
- 1976-02-23 AU AU11349/76A patent/AU496914B2/en not_active Expired
- 1976-02-23 BE BE164543A patent/BE838833A/xx not_active IP Right Cessation
- 1976-02-23 GB GB7009/76A patent/GB1544103A/en not_active Expired
- 1976-02-23 MX MX768U patent/MX3635E/es unknown
- 1976-02-23 PH PH18130A patent/PH16245A/en unknown
- 1976-02-23 CH CH218276A patent/CH625245A5/de not_active IP Right Cessation
- 1976-02-23 CA CA246,307A patent/CA1092095A/en not_active Expired
- 1976-02-24 NL NLAANVRAGE7601902,A patent/NL187166C/xx not_active IP Right Cessation
-
1977
- 1977-05-28 ES ES459261A patent/ES459261A1/es not_active Expired
-
1979
- 1979-06-08 US US06/046,708 patent/US4245088A/en not_active Expired - Lifetime
- 1979-09-07 SE SE7907455A patent/SE435182B/sv not_active IP Right Cessation
- 1979-09-07 SE SE7907454A patent/SE435183B/sv not_active IP Right Cessation
-
1982
- 1982-02-14 HK HK24/82A patent/HK2482A/xx unknown
-
1990
- 1990-03-12 DK DK063990A patent/DK160313C/da not_active IP Right Cessation
- 1990-03-23 DK DK076190A patent/DK161201C/da not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE7907811L (sv) | Azetidinylforening for framstellning av cefemforeningar och forfarande for dess framstellning | |
| ES427859A1 (es) | Un procedimiento para la preparacion de compuestos de cefa-losporina. | |
| IE41528L (en) | Furfuryl-benzomorphane derivatives. | |
| SE7509861L (sv) | Forfarande for framstellning av n-acylamino-alfa-arylacetamido-cefalosporiner | |
| US3450705A (en) | 1a- and/or 7-substituted derivatives of mitomycin | |
| IE43519L (en) | Benzimidazole-2-carbamates | |
| AU556922B2 (en) | Pyridobenzodiazepinone derivatives | |
| ES445348A1 (es) | Un procedimiento para preparar compuestos de 3-aciloximetil-cefem. | |
| SE7603951L (sv) | Forfarande for framstellning av 7-alfa-(4-hydroci-1,5-nafthydrin-3karbonamido)alfa-fenylacetamido-cefalosporinderivat | |
| ES486023A1 (es) | Un procedimiento para la preparacion de antibioticos de ce- falosporina | |
| GB1066347A (en) | New derivatives of 7-amino-cephalosporamic acid and process for their manufacture | |
| GR80832B (en) | Cyclic ethers | |
| IE792069L (en) | Cephalosporin derivatives. | |
| GB1557423A (en) | Cephalosporins | |
| ES447615A1 (es) | Un procedimiento para obtener compuesto de cefalosporina. | |
| IE42705L (en) | Cephalosporin compounds. | |
| GB1529434A (en) | Acyl derivatives of clavulanic acid methods for their preparation and compositions containing them | |
| SE8003311L (sv) | Maleinsyrasalt av 2-fenyl-6-(1-hydroxi-2-t-butyl-aminoetyl-4h-pyrido(3,2-d)-1,3-dioxin | |
| JPS5283363A (en) | Synthesis of novel isoindoline derivative pigment | |
| GB727481A (en) | Improvements in or relating to the preparation of esters and amides of penicillin g and penicillin x | |
| JPS56135489A (en) | Preparative method of cephalosporanic acid derivative | |
| JPS51113890A (en) | Method for preparing novel cephalosporins | |
| JPS5610193A (en) | Preparation of rifamycin derivative | |
| JPS55138396A (en) | Production of cephalosporin analogs | |
| GB824625A (en) | Substituted trioxohexahydropyridazines and process for their preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7907455-5 Effective date: 19920904 Format of ref document f/p: F |