SE8102194L - Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna - Google Patents

Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna

Info

Publication number
SE8102194L
SE8102194L SE8102194A SE8102194A SE8102194L SE 8102194 L SE8102194 L SE 8102194L SE 8102194 A SE8102194 A SE 8102194A SE 8102194 A SE8102194 A SE 8102194A SE 8102194 L SE8102194 L SE 8102194L
Authority
SE
Sweden
Prior art keywords
compound
bound
active organic
pharmaceutical preparation
carbon atom
Prior art date
Application number
SE8102194A
Other languages
Unknown language ( )
English (en)
Swedish (sv)
Inventor
R E A V Axen
J P E Carlsson
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Priority to SE8102194A priority Critical patent/SE8102194L/
Priority to DE8282850072T priority patent/DE3271990D1/de
Priority to JP57501193A priority patent/JPS58500482A/ja
Priority to EP82850072A priority patent/EP0063109B1/fr
Priority to PCT/SE1982/000110 priority patent/WO1982003394A1/fr
Publication of SE8102194L publication Critical patent/SE8102194L/
Priority to US06/594,981 priority patent/US4711951A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
SE8102194A 1981-04-06 1981-04-06 Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna SE8102194L (sv)

Priority Applications (6)

Application Number Priority Date Filing Date Title
SE8102194A SE8102194L (sv) 1981-04-06 1981-04-06 Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
DE8282850072T DE3271990D1 (en) 1981-04-06 1982-04-05 Therapeutically active compound and pharmaceutical composition containing the same
JP57501193A JPS58500482A (ja) 1981-04-06 1982-04-05 治療上活性な化合物およびそれを含有する薬学的組成物
EP82850072A EP0063109B1 (fr) 1981-04-06 1982-04-05 Composés à activité thérapeutique et les compositions pharmaceutiques les contenant
PCT/SE1982/000110 WO1982003394A1 (fr) 1981-04-06 1982-04-05 Compose therapeutiquement actif et composition pharmaceutique le contenant
US06/594,981 US4711951A (en) 1981-04-06 1984-03-29 Therapeutically active compound and pharmaceutical composition containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8102194A SE8102194L (sv) 1981-04-06 1981-04-06 Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna

Publications (1)

Publication Number Publication Date
SE8102194L true SE8102194L (sv) 1982-10-07

Family

ID=20343535

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8102194A SE8102194L (sv) 1981-04-06 1981-04-06 Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna

Country Status (6)

Country Link
US (1) US4711951A (fr)
EP (1) EP0063109B1 (fr)
JP (1) JPS58500482A (fr)
DE (1) DE3271990D1 (fr)
SE (1) SE8102194L (fr)
WO (1) WO1982003394A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8302758L (sv) * 1983-05-17 1984-11-18 Pharmacia Ab Sett for uppspjelkning av disulfidbindningar och derigenom erhallen forening
DE3604868A1 (de) * 1986-02-15 1987-08-20 Behringwerke Ag Insulinderivate, verfahren zu ihrer herstellung und ihre verwendung
US5134071A (en) * 1989-02-06 1992-07-28 State University Of New York Polymerization and copolymerization of proteins
SE9004047L (sv) * 1990-12-19 1992-06-20 Francisco Batista Metod foer immobilisering av tiolfoereningar via aktivering av polymerer, aktiverade polymerer, och produkter erhaallna med metoden
US5516703A (en) * 1993-08-20 1996-05-14 The University Of Utah Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands
US6284503B1 (en) 1993-08-20 2001-09-04 University Of Utah Research Foundation Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
ES2266258T3 (es) * 2000-09-15 2007-03-01 Vertex Pharmaceuticals Incorporated Compuestos de pirazol utiles como inhibidores de proteina cinasas.
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
EP1345925B1 (fr) * 2000-12-21 2006-05-17 Vertex Pharmaceuticals Incorporated Composes de pyrazole presentant une grande utilite comme inhibiteurs de proteine kinase
RU2004126671A (ru) * 2002-02-06 2005-04-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Гетероарилсоединения, полезные в качестве ингибиторов gsk-3
EP1485380B1 (fr) * 2002-03-15 2010-05-19 Vertex Pharmaceuticals Incorporated Azolylaminoazines inhibitrices des proteines kinases
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
ES2273043T3 (es) * 2002-08-02 2007-05-01 Vertex Pharmaceuticals Incorporated Composiciones de pirazol utiles como inhibidores de gsk-3.
WO2004037310A2 (fr) 2002-10-21 2004-05-06 Allvivo, Inc. Revetement de surface comprenant un compose bioactif
WO2004072029A2 (fr) * 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Compositions utiles en tant qu'inhibiteurs de proteine kinases
US7858108B2 (en) 2003-10-21 2010-12-28 Richard Nagler Elutable surface coating
US7592340B2 (en) * 2003-12-04 2009-09-22 Vertex Pharmaceuticals Incorporated Quinoxalines useful as inhibitors of protein kinases
CA2619517A1 (fr) * 2005-08-18 2007-02-22 Michael Mortimore Inhibiteurs de pyrazine kinases
WO2007056163A2 (fr) * 2005-11-03 2007-05-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines utiles en tant qu'inhibiteurs de kinases
MX2009004807A (es) * 2006-11-02 2009-06-15 Vertex Pharma Aminopiridinas y aminopirimidinas utiles como inhibidores de proteina cinasa.
JP2010513567A (ja) * 2006-12-19 2010-04-30 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼの阻害剤として有用なアミノピリミジン
WO2008112646A1 (fr) * 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Utilisation des aminopyridines comme inhibiteurs de protéines kinases
ATE526328T1 (de) * 2007-03-09 2011-10-15 Vertex Pharma Als inhibitoren von proteinkinasen geeignete aminopyrimidine
WO2008112642A1 (fr) * 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines utiles en tant qu'inhibiteurs des protéines kinases
CA2683785A1 (fr) 2007-04-13 2008-10-23 Vertex Pharmaceuticals Incorporated Aminopyrimidines utilisees en tant qu'inhibiteurs de kinases
MX2009011811A (es) * 2007-05-02 2010-01-14 Vertex Pharma Aminopirimidinas utiles como inhibidores de cinasa.
MX2009011812A (es) * 2007-05-02 2010-01-14 Vertex Pharma Aminopirimidinas utiles como inhibidores de cinasa.
CA2685876A1 (fr) 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Thiazoles et pyrazoles qui s'utilisent comme inhibiteurs de kinase
CN101687852A (zh) * 2007-05-24 2010-03-31 沃泰克斯药物股份有限公司 可用作激酶抑制剂的噻唑类和吡唑类化合物
AR067762A1 (es) * 2007-07-31 2009-10-21 Vertex Pharma Proceso para preparar 5-fluoro-1h-pirazolo (3,4-b) piridin-3-amina y derivados de la misma
KR20110050549A (ko) * 2008-09-03 2011-05-13 버텍스 파마슈티칼스 인코포레이티드 공-결정 및 이를 포함하는 제약 제제

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US471617A (en) * 1892-03-29 Apparatus for treating refractory ores
US3481917A (en) * 1967-03-06 1969-12-02 American Home Prod N - mercaptosuccinoylinsulin and n - (lower)alkanoylmercaptosuccinoylinsulin
IL36587A (en) * 1970-05-05 1977-10-31 Grassetti D Compositions containing pyridine derivatives and their use in a method of modifying cellular surface reactions
SE399880B (sv) 1973-05-24 1978-03-06 Ciba Geigy Ag Sett att framstella peptider, som innehaller mer en en disulfidbindning
DE2619451A1 (de) * 1976-05-03 1977-11-24 Bayer Ag Verfahren zur bindung von hoch- und niedermolekularen liganden an polymere traeger
SE427505B (sv) * 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
SE430062B (sv) * 1977-03-04 1983-10-17 Pharmacia Fine Chemicals Ab Kopplings- eller tioleringsreagens
SE404553B (sv) * 1977-03-04 1978-10-09 Pharmacia Diagnostics Ab Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner
US4220722A (en) * 1978-02-10 1980-09-02 Syva Company Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby
SE448631B (sv) * 1978-04-28 1987-03-09 Toyo Jozo Kk Disulfidforening av en berare med s-s-utbytesreaktivitet
US4258193A (en) * 1978-07-13 1981-03-24 Toyo Jozo Kabushiki Kaisha Disulfide derivatives having S--S exchange reactivity
JPS6058232B2 (ja) * 1978-07-13 1985-12-19 東洋醸造株式会社 新規なジスルフイド誘導体
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
FR2437213A1 (fr) * 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
SE446184B (sv) * 1979-01-12 1986-08-18 Toyo Jozo Kk Polyfunktionell disulfidforening anvendbar som tverbindande medel
JPS55133382A (en) * 1979-04-05 1980-10-17 Toyo Jozo Co Ltd Novel polyfunctional compound
JPS6052745B2 (ja) * 1979-01-12 1985-11-21 東洋醸造株式会社 新規な化合物
JPS55136235A (en) * 1979-04-09 1980-10-23 Teijin Ltd Antitumor protein complex and its preparation
JPS55136261A (en) * 1979-04-12 1980-10-23 Toyo Jozo Co Ltd Novel compound and kit comprising it
DE2923787A1 (de) * 1979-06-12 1980-12-18 Max Planck Gesellschaft Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
JPS5616417A (en) * 1979-07-19 1981-02-17 Teijin Ltd Antitumor protein complex and its preparation
JPS5616418A (en) * 1979-07-20 1981-02-17 Teijin Ltd Antitumor protein complex and its preparation
FR2470187A1 (fr) * 1979-11-19 1981-05-29 Martel Catala & Cie Ets Perfectionnements aux toiles de formage double couche pour machines a papier
JPS5686121A (en) * 1979-12-14 1981-07-13 Teijin Ltd Antitumor proten complex and its preparation
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives

Also Published As

Publication number Publication date
JPS58500482A (ja) 1983-03-31
EP0063109B1 (fr) 1986-07-16
WO1982003394A1 (fr) 1982-10-14
EP0063109A3 (en) 1983-01-26
EP0063109A2 (fr) 1982-10-20
DE3271990D1 (en) 1986-08-21
US4711951A (en) 1987-12-08

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