SG11201401007SA - Compositions and methods for toxigenicity testing - Google Patents

Compositions and methods for toxigenicity testing

Info

Publication number
SG11201401007SA
SG11201401007SA SG11201401007SA SG11201401007SA SG11201401007SA SG 11201401007S A SG11201401007S A SG 11201401007SA SG 11201401007S A SG11201401007S A SG 11201401007SA SG 11201401007S A SG11201401007S A SG 11201401007SA SG 11201401007S A SG11201401007S A SG 11201401007SA
Authority
SG
Singapore
Prior art keywords
compositions
methods
toxigenicity
testing
toxigenicity testing
Prior art date
Application number
SG11201401007SA
Other languages
English (en)
Inventor
Eric Arthur Johnson
Sabine Pellett
Regina Clare Meyer Whitemarsh
William Howard Tepp
Original Assignee
Cellsnap Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellsnap Llc filed Critical Cellsnap Llc
Publication of SG11201401007SA publication Critical patent/SG11201401007SA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073Stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SG11201401007SA 2011-09-29 2012-09-28 Compositions and methods for toxigenicity testing SG11201401007SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161540693P 2011-09-29 2011-09-29
PCT/US2012/057825 WO2013049508A1 (en) 2011-09-29 2012-09-28 Compositions and methods for toxigenicity testing

Publications (1)

Publication Number Publication Date
SG11201401007SA true SG11201401007SA (en) 2014-04-28

Family

ID=47996425

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201401007SA SG11201401007SA (en) 2011-09-29 2012-09-28 Compositions and methods for toxigenicity testing

Country Status (19)

Country Link
US (1) US9217172B2 (pl)
EP (1) EP2761065B1 (pl)
JP (1) JP5877617B2 (pl)
KR (1) KR101640694B1 (pl)
CN (1) CN103958747B (pl)
AU (1) AU2012315783B2 (pl)
BR (1) BR112014007717B1 (pl)
CA (1) CA2850531C (pl)
ES (1) ES2653249T3 (pl)
HR (1) HRP20171937T1 (pl)
HU (1) HUE037509T2 (pl)
IL (1) IL231768B (pl)
LT (1) LT2761065T (pl)
MX (1) MX348188B (pl)
PL (1) PL2761065T3 (pl)
RU (1) RU2616281C2 (pl)
SG (1) SG11201401007SA (pl)
SI (1) SI2761065T1 (pl)
WO (1) WO2013049508A1 (pl)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014301116B2 (en) 2013-06-28 2019-11-14 Merz Pharma Gmbh & Co. Kgaa Means and methods for the determination of the biological activity of Neurotoxin polypeptides in cells
LT3030905T (lt) 2013-08-09 2018-01-25 Biomadison, Inc. Padidinto jautrumo botulino toksino tyrimas
ES2642916T3 (es) 2014-06-06 2017-11-20 Galit KLEINER-FISMAN Toxina botulínica para su uso en el tratamiento de la paratonia
EP3590500B1 (en) 2014-12-23 2025-06-25 Merz Pharma GmbH & Co. KGaA Botulinum toxin prefilled container
WO2017063743A1 (en) 2015-10-14 2017-04-20 Merz Pharma Gmbh & Co. Kgaa Improvements to ultrasound-based therapy of photoaged tissue
CN108463242A (zh) 2016-03-02 2018-08-28 梅尔兹制药公司 包含肉毒杆菌毒素的组合物
PL3463432T3 (pl) 2016-05-27 2021-04-19 Ipsen Biopharm Limited Ciekła formulacja neurotoksyny stabilizowana tryptofanem lub tyrozyną
TWI737742B (zh) 2016-06-22 2021-09-01 德商梅茲製藥有限兩合公司 肉毒桿菌毒素的預填充式注射器系統、具有其之套組以及其之使用
EP3290437A1 (en) 2016-08-31 2018-03-07 Merz Pharma GmbH & Co. KGaA Novel recombinant clostridial neurotoxins with decreased duration of effect
EP3312290A1 (en) * 2016-10-18 2018-04-25 Ipsen Biopharm Limited Cellular vamp cleavage assay
EP3312193A1 (en) 2016-10-19 2018-04-25 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum neurotoxins with accelerated onset of effect
US10751394B2 (en) * 2016-10-25 2020-08-25 Cellsnap Llc Neurotoxins and uses thereof
EP3333179A1 (en) 2016-12-07 2018-06-13 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum toxin with accelarated onset of effect
EP3335719A1 (en) 2016-12-14 2018-06-20 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum neurotoxins with a stabilized light chain
AU2018237799B2 (en) 2017-03-24 2024-11-14 Merz Pharma Gmbh & Co. Kgaa Improved use of botulinum neurotoxin in the treatment of sialorrhea
WO2018233813A1 (en) 2017-06-20 2018-12-27 Merz Pharma Gmbh & Co. Kgaa NOVEL RECOMBINANT BOTULINUM TOXINS WITH INCREASED DURATION
EP3649143B1 (en) 2017-07-06 2022-08-31 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum neurotoxins with increased duration of effect
US20210008156A1 (en) 2017-10-26 2021-01-14 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum neurotoxins with increased duration of effect
US20200354706A1 (en) 2017-11-22 2020-11-12 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum toxin with increased duration of effect
CA3111674A1 (en) * 2018-09-28 2020-04-02 Ipsen Biopharm Limited Cell-based clostridal neurotoxin assays
EP3860640A1 (en) 2018-10-02 2021-08-11 Merz Pharma GmbH & Co. KGaA Novel uses of botulinum neurotoxin for treating lipoedema
US12171717B2 (en) 2018-10-08 2024-12-24 Merz Pharma Gmbh & Co. Kgaa Neurotoxin prefilled vial
KR20210130711A (ko) 2019-02-21 2021-11-01 메르츠 파마 게엠베하 운트 코. 카가아 진전의 치료를 위한 보툴리눔 신경독의 신규 용도
KR102297991B1 (ko) * 2019-10-11 2021-09-07 주식회사 하울바이오 SNARE 복합체를 억제하는 항-Syntaxin 1A 항체 및 이의 용도
BR112022023413A2 (pt) 2020-06-05 2022-12-20 Merz Pharma Gmbh & Co Kgaa Tratamento de rugas faciais com toxina botulínica de alta dose e baixo volume
US20220010355A1 (en) * 2020-07-10 2022-01-13 Galderma Holding SA Cell based method for determination of botulinum toxin potency based on western blotting
CN113774023B (zh) * 2021-09-28 2022-11-25 中国食品药品检定研究院 人诱导多能干细胞诱导分化神经细胞评价模型的构建及其评价药物神经毒性的用途
WO2023135428A1 (en) 2022-01-14 2023-07-20 Galderma Holding SA Treatment of moderate to very severe glabellar lines and lateral canthal lines
EP4479012A1 (en) 2022-02-15 2024-12-25 Merz Pharma GmbH & Co. KGaA Liquid botulinum toxin formulation and use thereof
IL315004A (en) 2022-02-15 2024-10-01 Merz Pharma Gmbh & Co Kgaa : Liquid botulinum toxin formulation and its uses
TW202400122A (zh) 2022-02-28 2024-01-01 德商梅茲製藥有限兩合公司 肉毒桿菌毒素用於降低皮膚毛孔尺寸及/或皮脂產生之用途、以及降低皮膚毛孔尺寸及/或皮脂產生的方法
AR131172A1 (es) 2022-11-28 2025-02-19 Merz Pharma Gmbh & Co Kgaa Inyección de toxina botulínica en el platisma para el rejuvenecimiento del rostro inferior y del cuello
IL320937A (en) 2022-11-28 2025-07-01 Merz Pharma Gmbh & Co Kgaa High-concentration botulinum toxin treatment for neck rejuvenation
JP2025541064A (ja) 2022-12-15 2025-12-18 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン ボツリヌス毒素を含む注射可能なゲルおよびその使用
EP4680382A1 (en) 2023-03-15 2026-01-21 Merz Pharma GmbH & Co. KGaA A rocking shaker for treating at least one fluid sample
WO2024194181A1 (en) 2023-03-20 2024-09-26 Merz Therapeutics GmbH Nh3 scavenger for use in the treatment of mobility disability in a post-stroke patient
WO2024240868A1 (en) 2023-05-23 2024-11-28 Merz Therapeutics GmbH Botulinum toxin for treating peripheral neuropathic pain
CN121511091A (zh) 2023-07-12 2026-02-10 莫茨药物股份两合公司 通过肉毒杆菌毒素的色素沉着过度病况治疗
IL326140A (en) 2023-08-10 2026-03-01 Merz Pharma Gmbh & Co Kgaa Liquid formulation of botulinum toxin and its use
CN117887797B (zh) * 2023-12-27 2024-09-20 中国食品药品检定研究院 一种梭状芽胞杆菌神经毒素效价检测方法
WO2025228877A1 (en) 2024-04-29 2025-11-06 Merz Therapeutics GmbH Botulinum toxin for the preventive treatment of migraine
WO2026021713A1 (en) 2024-07-23 2026-01-29 Merz Therapeutics GmbH Uses of magnetic nerve stimulation associated with botulinum neurotoxin administration

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411138D0 (en) * 1994-06-03 1994-07-27 Microbiological Res Authority Toxin assay
EP1595951A1 (en) * 1997-07-21 2005-11-16 Arpi Matossian-Rogers Diagnosis and treatment of diseases using peptides which are bound by specific anti-anti-t-cell receptor vbeta antibodies
US7115399B2 (en) 2001-07-31 2006-10-03 Allergan, Inc. Pinna reflex assay
US6984375B2 (en) 2001-08-03 2006-01-10 Allergan, Inc. Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles
US7332567B2 (en) 2001-08-28 2008-02-19 Allergan, Inc. Fret protease assays for clostridial toxins
GB2398636A (en) 2003-02-21 2004-08-25 Ipsen Ltd Method for determining the quantity of pre-synaptic neuromuscular blocking substance contained in a sample
WO2005076785A2 (en) 2003-12-19 2005-08-25 Wisconsin Alumni Research Foundation Method and compositions for detecting botulinum neurotoxin
ES2374822T3 (es) * 2004-02-24 2012-02-22 Allergan, Inc. Ensayo de selección de toxinas botul�?nicas.
GB2416849A (en) 2004-08-04 2006-02-08 Ipsen Ltd Method for determining the quantity of a pre-synaptic neuromuscular blocking substance in a sample
DE102005019302A1 (de) * 2005-04-26 2006-11-16 Toxogen Gmbh Carrier zum Targeting von Nervenzellen
ATE518882T1 (de) 2005-09-19 2011-08-15 Allergan Inc Mit clostridientoxin aktivierbare clostridientoxine
US8949033B2 (en) 2006-04-28 2015-02-03 The Chemo-Sero-Therapeutic Research Institute Method for quantification of neurotoxin
US8067192B2 (en) * 2007-06-05 2011-11-29 City Of Hope Methods for detection of botulinum neurotoxin
EP2235161A1 (en) * 2007-12-11 2010-10-06 Research Development Foundation Small molecules for neuronal differentiation of embryonic stem cells
EP2254608B1 (en) * 2008-02-07 2016-05-04 Shahar Cohen Compartmental extract compositions for tissue engineering
PT2271670E (pt) 2008-03-14 2014-11-28 Allergan Inc Ensaio imunobaseado da atividade do serotipo a da toxina botulínica
US8669048B2 (en) * 2008-06-24 2014-03-11 Parkinson's Institute Pluripotent cell lines and methods of use thereof
EP2191847A1 (en) * 2008-11-19 2010-06-02 Merz Pharma GmbH & Co.KGaA Method for preparing compositions comprising a protein, water and glycerol
WO2010096746A1 (en) * 2009-02-20 2010-08-26 Cellular Dynamics International, Inc. Methods and compositions for the differentiation of stem cells
KR101720961B1 (ko) * 2009-02-27 2017-03-29 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 다능성 세포의 분화
BRPI1008940A2 (pt) 2009-03-13 2020-10-27 Allergan, Inc. linhagem de célula clonal estabelecida suscetível à intoxicação por bont/a
WO2011031568A2 (en) * 2009-08-27 2011-03-17 Synaptic Research, Llc A NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS
US20120322670A1 (en) 2009-08-28 2012-12-20 Cellular Dynamics International, Inc. Identifying genetic variation in affected tissues
WO2011056971A2 (en) 2009-11-04 2011-05-12 Cellular Dynamics International, Inc. Episomal reprogramming with chemicals
WO2012123370A1 (en) 2011-03-11 2012-09-20 Merz Pharma Gmbh & Co. Kgaa Method for the determination of botulinum neurotoxin biological activity
DK2694644T3 (en) * 2011-03-30 2018-04-16 Cellular Dynamics Int Inc Priming of pluripotent stem cells for neural differentiation
EP2798077A2 (en) * 2011-12-31 2014-11-05 Allergan, Inc. Highly Sensitive Cell-Based Assay to Detect the Presence of Active Botulinum Neurotoxin Serotype-A
CA2866595A1 (en) * 2012-03-07 2013-09-12 Merz Pharma Gmbh & Co. Kgaa Means and methods for determining neurotoxin activity based on a modified luciferase
US8778623B2 (en) * 2012-09-14 2014-07-15 Wisconsin Alumni Research Foundation Compositions and methods of using differentiated cells sensitized to botulinum neurotoxin
US9102901B2 (en) * 2012-12-20 2015-08-11 Rohm And Haas Electronic Materials Llc Methods and compositions for removal of metal hardmasks

Also Published As

Publication number Publication date
US9217172B2 (en) 2015-12-22
RU2014117161A (ru) 2015-11-10
EP2761065A1 (en) 2014-08-06
PL2761065T3 (pl) 2018-02-28
BR112014007717A2 (pt) 2017-04-25
AU2012315783B2 (en) 2015-08-20
HK1199911A1 (en) 2015-07-24
EP2761065B1 (en) 2017-12-06
JP2014528724A (ja) 2014-10-30
KR101640694B1 (ko) 2016-07-18
CN103958747A (zh) 2014-07-30
CN103958747B (zh) 2017-03-01
AU2012315783A1 (en) 2014-04-17
CA2850531C (en) 2016-06-07
IL231768A0 (en) 2014-05-28
WO2013049508A1 (en) 2013-04-04
IL231768B (en) 2019-06-30
EP2761065A4 (en) 2015-05-06
MX348188B (es) 2017-06-01
JP5877617B2 (ja) 2016-03-08
LT2761065T (lt) 2018-01-10
KR20140086981A (ko) 2014-07-08
MX2014003874A (es) 2014-08-18
SI2761065T1 (en) 2018-02-28
ES2653249T3 (es) 2018-02-06
HUE037509T2 (hu) 2018-09-28
BR112014007717B1 (pt) 2021-07-20
RU2616281C2 (ru) 2017-04-13
CA2850531A1 (en) 2013-04-04
US20140234857A1 (en) 2014-08-21
HRP20171937T1 (hr) 2018-02-09

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