SG165998A1 - 4-tetrazolyl-4phenylpiperidine derivatives for treating pain - Google Patents

4-tetrazolyl-4phenylpiperidine derivatives for treating pain

Info

Publication number: SG165998A1
Authority: SG; Singapore
Prior art keywords: tetrazolyl; derivatives; effective amount; treating pain; phenylpiperidine
Prior art date: 2002-11-18

Application number

SG200703631-2A

Other languages

English (en)

Inventor

Zhengming Chen

Original Assignee

Euro Celtique Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-18

Filing date

2003-11-17

Publication date

2010-11-29

2003-11-17 Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa

2010-11-29 Publication of SG165998A1 publication Critical patent/SG165998A1/en

Links

OGPKTRWLBLRODW-UHFFFAOYSA-N 4-phenyl-4-(2h-tetrazol-5-yl)piperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NNN=N1 OGPKTRWLBLRODW-UHFFFAOYSA-N 0.000 title abstract 2
-1 4-Tetrazolyl-4-phenylpiperidine Compound Chemical class 0.000 abstract 3
102000003840 Opioid Receptors Human genes 0.000 abstract 2
108090000137 Opioid Receptors Proteins 0.000 abstract 2
206010012735 Diarrhoea Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SG200703631-2A 2002-11-18 2003-11-17 4-tetrazolyl-4phenylpiperidine derivatives for treating pain SG165998A1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US42738102P	2002-11-18	2002-11-18
US46027803P	2003-04-03	2003-04-03
US48848803P	2003-07-17	2003-07-17
US10/714,066 US7202259B2 (en)	2002-11-18	2003-11-13	Therapeutic agents useful for treating pain

Publications (1)

Publication Number	Publication Date
SG165998A1 true SG165998A1 (en)	2010-11-29

Family

ID=32777221

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200703631-2A SG165998A1 (en)	2002-11-18	2003-11-17	4-tetrazolyl-4phenylpiperidine derivatives for treating pain

Country Status (36)

Country	Link
US (3)	US7202259B2 (fr)
EP (2)	EP1803718B1 (fr)
JP (2)	JP4601429B2 (fr)
KR (1)	KR20050115221A (fr)
CN (2)	CN101648941A (fr)
AP (1)	AP2210A (fr)
AR (1)	AR047008A1 (fr)
AT (2)	ATE358674T1 (fr)
AU (2)	AU2003294313B2 (fr)
BR (1)	BR0316305A (fr)
CA (1)	CA2506242C (fr)
CO (1)	CO5690588A2 (fr)
CR (2)	CR7877A (fr)
CY (2)	CY1107682T1 (fr)
DE (2)	DE60322451D1 (fr)
DK (2)	DK1562932T3 (fr)
EA (1)	EA008621B1 (fr)
EC (1)	ECSP055840A (fr)
ES (2)	ES2312150T3 (fr)
GE (1)	GEP20084539B (fr)
IL (1)	IL209352A0 (fr)
IS (2)	IS2720B (fr)
MA (1)	MA27565A1 (fr)
ME (1)	MEP48108A (fr)
MX (1)	MXPA05004669A (fr)
MY (1)	MY135647A (fr)
NI (1)	NI200500087A (fr)
NO (1)	NO20052894L (fr)
NZ (2)	NZ572685A (fr)
OA (1)	OA13010A (fr)
PT (2)	PT1803718E (fr)
RS (1)	RS51047B (fr)
SG (1)	SG165998A1 (fr)
SI (2)	SI1562932T1 (fr)
TW (2)	TWI343917B (fr)
WO (1)	WO2004046132A1 (fr)

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US7202259B2 (en) *	2002-11-18	2007-04-10	Euro-Celtique S.A.	Therapeutic agents useful for treating pain
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AR047936A1 (es)	2003-04-30	2006-03-15	Purdue Pharma Ltd	Forma de dosificacion transdermica resistente a la manipulacion
WO2005075455A2 (fr)	2004-01-30	2005-08-18	Euro-Celtique S.A.	Procedes d'elaboration de composes de 4-tetrazolyl-4-phenylpiperidine
SE0401656D0 (sv) *	2004-06-24	2004-06-24	Astrazeneca Ab	Chemical compounds
EA013510B1 (ru) *	2005-11-21	2010-06-30	Пэдью Фарма Л.П.	Соединения 4-оксадиазолилпиперидина и их применение
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CA2810356C (fr)	2010-09-21	2016-06-14	Purdue Pharma L.P.	Analogues de buprenorphine
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US10138207B2 (en)	2012-11-09	2018-11-27	Purdue Pharma, L.P.	Benzomorphan analogs and the use thereof
EP2931729B1 (fr)	2012-12-07	2019-02-06	Purdue Pharma LP	Analogues de buprénorphine en tant que modulateurs d'un récepteur des opioïdes
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ES2631197T3 (es)	2012-12-14	2017-08-29	Purdue Pharma Lp	Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes
CA2900023A1 (fr)	2013-01-31	2014-08-07	Purdue Pharma L.P.	Analogues de benzomorphane et leur utilisation
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US9656962B2 (en)	2013-12-26	2017-05-23	Purdue Pharma L.P.	Ring-contracted morphinans and the use thereof
US9340542B2 (en)	2013-12-26	2016-05-17	Purdue Pharma L.P.	Propellane-based compounds and the use thereof
US9862726B2 (en)	2013-12-26	2018-01-09	Purdue Pharma L.P.	Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
EP3087078B1 (fr)	2013-12-26	2019-05-15	Purdue Pharma LP	Analogues 7-bêta-alkyle d'orvinols
EP3086790A4 (fr)	2013-12-27	2017-07-19	Purdue Pharma LP	Analogues de la morphinane 6-substitués et 7-substitués, et leurs utilisations
EP3148535A4 (fr)	2014-05-27	2017-11-29	Purdue Pharma LP	Morphinanes spirocycliques et utilisation associée
CA2951697A1 (fr)	2014-06-13	2015-12-17	Purdue Pharma L.P.	Derives d'azamophinan et leur utilisation
MA41125A (fr)	2014-12-05	2017-10-10	Purdue Pharma Lp	Dérivés de 6.7-cyclomorphinane et leur utilisation
CA3018750A1 (fr)	2016-03-22	2017-09-28	Regents Of The University Of Minnesota	Combinaison pour traiter la douleur
CN119606965A (zh)	2016-07-29	2025-03-14	詹森药业有限公司	治疗前列腺癌的方法
WO2018125716A1 (fr)	2017-01-02	2018-07-05	Purdue Pharma L.P.	Dérivés de morphinane et leur utilisation
CN117750958A (zh) *	2021-05-21	2024-03-22	普渡制药公司	治疗间质性膀胱炎/膀胱疼痛综合征的方法
JP2025521597A (ja) *	2022-06-24	2025-07-10	パーデュー、ファーマ、リミテッド、パートナーシップ	過活動膀胱症候群を治療または予防する方法

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2003
- 2003-11-13 US US10/714,066 patent/US7202259B2/en not_active Expired - Lifetime
- 2003-11-17 AU AU2003294313A patent/AU2003294313B2/en not_active Ceased
- 2003-11-17 RS YUP-2005/0375A patent/RS51047B/sr unknown
- 2003-11-17 AT AT03789796T patent/ATE358674T1/de active
- 2003-11-17 CA CA2506242A patent/CA2506242C/fr not_active Expired - Fee Related
- 2003-11-17 SG SG200703631-2A patent/SG165998A1/en unknown
- 2003-11-17 SI SI200330814T patent/SI1562932T1/sl unknown
- 2003-11-17 WO PCT/US2003/036742 patent/WO2004046132A1/fr not_active Ceased
- 2003-11-17 SI SI200331358T patent/SI1803718T1/sl unknown
- 2003-11-17 CN CN200910173679A patent/CN101648941A/zh active Pending
- 2003-11-17 NZ NZ572685A patent/NZ572685A/en not_active IP Right Cessation
- 2003-11-17 GE GEAP20038846A patent/GEP20084539B/en unknown
- 2003-11-17 AT AT07006697T patent/ATE402167T1/de active
- 2003-11-17 KR KR1020057008903A patent/KR20050115221A/ko not_active Abandoned
- 2003-11-17 DE DE60322451T patent/DE60322451D1/de not_active Expired - Lifetime
- 2003-11-17 BR BR0316305-9A patent/BR0316305A/pt not_active IP Right Cessation
- 2003-11-17 ES ES07006697T patent/ES2312150T3/es not_active Expired - Lifetime
- 2003-11-17 MX MXPA05004669A patent/MXPA05004669A/es active IP Right Grant
- 2003-11-17 JP JP2004570427A patent/JP4601429B2/ja not_active Expired - Fee Related
- 2003-11-17 NZ NZ540068A patent/NZ540068A/en not_active IP Right Cessation
- 2003-11-17 DE DE60313021T patent/DE60313021T2/de not_active Expired - Lifetime
- 2003-11-17 AP AP2005003297A patent/AP2210A/xx active
- 2003-11-17 PT PT07006697T patent/PT1803718E/pt unknown
- 2003-11-17 DK DK03789796T patent/DK1562932T3/da active
- 2003-11-17 DK DK07006697T patent/DK1803718T3/da active
- 2003-11-17 ME MEP-481/08A patent/MEP48108A/xx unknown
- 2003-11-17 PT PT03789796T patent/PT1562932E/pt unknown
- 2003-11-17 EA EA200500726A patent/EA008621B1/ru not_active IP Right Cessation
- 2003-11-17 EP EP07006697A patent/EP1803718B1/fr not_active Expired - Lifetime
- 2003-11-17 CN CNB2003801035027A patent/CN100567288C/zh not_active Expired - Fee Related
- 2003-11-17 EP EP03789796A patent/EP1562932B9/fr not_active Expired - Lifetime
- 2003-11-17 OA OA1200500145A patent/OA13010A/en unknown
- 2003-11-17 ES ES03789796T patent/ES2285235T3/es not_active Expired - Lifetime
- 2003-11-18 MY MYPI20034402A patent/MY135647A/en unknown
- 2003-11-18 TW TW092132303A patent/TWI343917B/zh not_active IP Right Cessation
- 2003-11-18 TW TW096151468A patent/TW200819436A/zh unknown
- 2003-11-19 AR ARP030104269A patent/AR047008A1/es unknown
2005
- 2005-04-19 IS IS7812A patent/IS2720B/is unknown
- 2005-04-22 NI NI200500087A patent/NI200500087A/es unknown
- 2005-05-20 CO CO05048789A patent/CO5690588A2/es not_active Application Discontinuation
- 2005-06-07 EC EC2005005840A patent/ECSP055840A/es unknown
- 2005-06-13 MA MA28335A patent/MA27565A1/fr unknown
- 2005-06-14 NO NO20052894A patent/NO20052894L/no not_active Application Discontinuation
- 2005-06-16 CR CR7877A patent/CR7877A/es unknown
2007
- 2007-03-28 US US11/729,660 patent/US7687518B2/en not_active Expired - Lifetime
- 2007-06-21 CY CY20071100825T patent/CY1107682T1/el unknown
2008
- 2008-10-16 CY CY20081101151T patent/CY1108422T1/el unknown
2009
- 2009-09-21 CR CR11037A patent/CR11037A/es not_active Application Discontinuation
- 2009-11-10 US US12/615,510 patent/US8026254B2/en not_active Expired - Lifetime
2010
- 2010-03-12 JP JP2010056560A patent/JP2010163452A/ja active Pending
- 2010-07-21 IS IS8913A patent/IS8913A/is unknown
- 2010-11-16 IL IL209352A patent/IL209352A0/en unknown
- 2010-11-25 AU AU2010246411A patent/AU2010246411A1/en not_active Abandoned

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Publication number	Publication date
CY1108422T1 (el)	2014-04-09
AP2210A (en)	2011-02-25
AU2003294313A1 (en)	2004-06-15
JP2006525944A (ja)	2006-11-16
NO20052894D0 (no)	2005-06-14
KR20050115221A (ko)	2005-12-07
AU2003294313B2 (en)	2010-08-26
DE60322451D1 (de)	2008-09-04
ES2285235T3 (es)	2007-11-16
HK1086829A1 (zh)	2006-09-29
CA2506242A1 (fr)	2004-06-03
JP2010163452A (ja)	2010-07-29
DE60313021D1 (de)	2007-05-16
DK1562932T3 (da)	2007-08-13
TW200418828A (en)	2004-10-01
EP1803718B1 (fr)	2008-07-23
EP1562932B1 (fr)	2007-04-04
OA13010A (en)	2006-11-10
US8026254B2 (en)	2011-09-27
IS2720B (is)	2011-02-15
SI1562932T1 (sl)	2007-08-31
IS8913A (is)	2010-07-21
CN101648941A (zh)	2010-02-17
IS7812A (is)	2005-04-19
CN100567288C (zh)	2009-12-09
US7202259B2 (en)	2007-04-10
MA27565A1 (fr)	2005-10-03
AU2010246411A1 (en)	2010-12-16
CR11037A (es)	2009-10-29
US20040152689A1 (en)	2004-08-05
DE60313021T2 (de)	2007-12-13
NO20052894L (no)	2005-06-14
PT1803718E (pt)	2008-09-26
TW200819436A (en)	2008-05-01
MY135647A (en)	2008-06-30
US20100069437A1 (en)	2010-03-18
ES2312150T3 (es)	2009-02-16
EA008621B1 (ru)	2007-06-29
BR0316305A (pt)	2005-09-27
ECSP055840A (es)	2005-08-11
EA200500726A1 (ru)	2005-10-27
JP4601429B2 (ja)	2010-12-22
ATE402167T1 (de)	2008-08-15
CY1107682T1 (el)	2013-04-18
SI1803718T1 (sl)	2008-12-31
NI200500087A (es)	2007-07-24
DK1803718T3 (da)	2008-10-27
AR047008A1 (es)	2006-01-04
US20070179141A1 (en)	2007-08-02
NZ572685A (en)	2010-06-25
NZ540068A (en)	2007-07-27
RS20050375A (sr)	2007-11-15
PT1562932E (pt)	2007-07-02
WO2004046132A1 (fr)	2004-06-03
IL209352A0 (en)	2011-01-31
EP1803718A1 (fr)	2007-07-04
ATE358674T1 (de)	2007-04-15
CO5690588A2 (es)	2006-10-31
TWI343917B (en)	2011-06-21
US7687518B2 (en)	2010-03-30
CR7877A (es)	2005-11-30
EP1562932A1 (fr)	2005-08-17
GEP20084539B (en)	2008-11-25
AP2005003297A0 (en)	2005-06-30
RS51047B (sr)	2010-10-31
EP1562932B9 (fr)	2007-09-12
CA2506242C (fr)	2011-07-05
CN1711256A (zh)	2005-12-21
MXPA05004669A (es)	2005-06-08
MEP48108A (en)	2011-02-10

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MY135647A (en)	2008-06-30	4-tetrazolyl-4-phenylpiperidine compounds
CY1109031T1 (el)	2014-07-02	Τριαζασπιρο ενωσεις χρησιμες για την αντιμετωπιση ή προληψη πονου
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MXPA05003501A (es)	2005-10-19	Metodos para tratamiento del dolor administrando un antagonista del factor de crecimiento del nervio y un analgesico opioide y composiciones que los contienen.
AU2003268144A1 (en)	2004-03-11	Transdermal dosage form comprising an active agent and a salt and free-baseform of an antagonist
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EP1555955A4 (fr)	2009-11-11	Application d'une thermotherapie destinee a empecher la croissance de tumeurs
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EA200401345A1 (ru)	2005-08-25	Лечение гастропареза
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BRPI0417902A (pt)	2007-04-10	piperazinas úteis no tratamento da dor
PL372096A1 (en)	2005-07-11	Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
AU2001259801A1 (en)	2001-11-20	3-methoxybenzyl thiourea derivatives and improved lipid compositions containing same
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IL126175A (en)	2003-05-29	Pharmaceutical compositions containing endothelin antagonists and novel endothelin antagonists
TNSN05114A1 (en)	2007-05-14	4-tetrazolyl -4 phenylpiperidine derivatives for treating pain
GB0218811D0 (en)	2002-09-18	Salts of morphine-6-glucuronide
DE60102481D1 (en)	2004-04-29	Purinriboside als antiarrhythmika
DE69831959D1 (de)	2006-03-02	Verwendung von (E)-metanicotinederivate als Analgetika
TW200510348A (en)	2005-03-16	5-aryltetrazole compounds, compositions thereof, and uses therefor