SG73894G - Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydro-chloride and processes for preparing them - Google Patents

Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydro-chloride and processes for preparing them

Info

Publication number: SG73894G
Authority: SG; Singapore
Prior art keywords: melphalan; hydrochloride; preparing; hydro; chloride
Prior art date: 1987-11-19

Application number

SG73894A

Other languages

English (en)

Inventor

Stephen William Poole

Timothy Paul Stanley

Geoffrey Divall

Terence William Packham

Joseph Knight

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-19

Filing date

1994-06-03

Publication date

1994-11-25

1994-06-03 Application filed by Wellcome Found filed Critical Wellcome Found

1994-06-03 Priority to SG73894A priority Critical patent/SG73894G/en

1994-11-25 Publication of SG73894G publication Critical patent/SG73894G/en

Links

229960001924 melphalan Drugs 0.000 title abstract 4
SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 title abstract 4
OUUYBRCCFUEMLH-YDALLXLXSA-N [(1s)-2-[4-[bis(2-chloroethyl)amino]phenyl]-1-carboxyethyl]azanium;chloride Chemical compound Cl.OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 OUUYBRCCFUEMLH-YDALLXLXSA-N 0.000 title abstract 3
229960002514 melphalan hydrochloride Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
SGDBTWWWUNNDEQ-UHFFFAOYSA-N Merphalan Chemical compound OC(=O)C(N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-UHFFFAOYSA-N 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SG73894A 1987-11-19 1994-06-03 Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydro-chloride and processes for preparing them SG73894G (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
SG73894A SG73894G (en)	1987-11-19	1994-06-03	Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydro-chloride and processes for preparing them

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878727157A GB8727157D0 (en)	1987-11-19	1987-11-19	Pharmaceutical formulations
SG73894A SG73894G (en)	1987-11-19	1994-06-03	Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydro-chloride and processes for preparing them

Publications (1)

Publication Number	Publication Date
SG73894G true SG73894G (en)	1994-11-25

Family

ID=10627252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG73894A SG73894G (en)	1987-11-19	1994-06-03	Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydro-chloride and processes for preparing them

Country Status (22)

Country	Link
US (1)	US4997651A (de)
EP (1)	EP0317281B1 (de)
JP (1)	JP2693191B2 (de)
KR (1)	KR970002607B1 (de)
AT (1)	ATE83922T1 (de)
AU (1)	AU619781B2 (de)
CA (1)	CA1341114C (de)
DE (1)	DE3877151T2 (de)
DK (1)	DK172794B1 (de)
ES (1)	ES2052745T3 (de)
FI (2)	FI90204C (de)
GB (1)	GB8727157D0 (de)
GR (1)	GR3007287T3 (de)
HK (1)	HK108994A (de)
HU (3)	HU207286B (de)
IE (1)	IE63996B1 (de)
IL (1)	IL88419A (de)
LV (1)	LV10179B (de)
NZ (2)	NZ239867A (de)
PT (1)	PT89028B (de)
SG (1)	SG73894G (de)
ZA (1)	ZA888674B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5695751A (en) *	1993-04-08	1997-12-09	Cornell Research Foundation, Inc.	Enhancing delivery of large neutral amino acid drugs
US5407672A (en) *	1993-04-08	1995-04-18	Cornell Research Foundation, Inc.	Enhancing the anti-tumor effect of melphalan with L-amino acid oxidase
US6020004A (en) *	1997-04-17	2000-02-01	Amgen Inc.	Biodegradable microparticles for the sustained delivery of therapeutic drugs
US5980904A (en) *	1998-11-18	1999-11-09	Amway Corporation	Skin whitening composition containing bearberry extract and a reducing agent
GB2386066A (en) *	2002-02-28	2003-09-10	Norbrook Lab Ltd	Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species
WO2004000229A2 (en) *	2002-06-24	2003-12-31	Research Development Foundation	Treatment of human multiple myeloma by curcumin
AU2004320907A1 (en)	2003-08-26	2006-04-13	Research Development Foundation	Osteoclastogenesis inhibitors and uses thereof
US8501818B2 (en)	2005-03-14	2013-08-06	Ceptaris Therapeutics, Inc.	Stabilized compositions of alkylating agents and methods of using same
US7872050B2 (en)	2005-03-14	2011-01-18	Yaupon Therapeutics Inc.	Stabilized compositions of volatile alkylating agents and methods of using thereof
TR201907794T4 (tr)	2008-03-27	2019-06-21	Helsinn Healthcare Sa	Alkilleyici maddelerin stabilize edilmiş bileşimleri ve bunları kullanım yöntemleri.
AR066943A1 (es) *	2008-06-10	2009-09-23	Eriochem Sa	Una composicion farmaceutica de melfalano
US11020363B2 (en)	2009-05-29	2021-06-01	Cydex Pharmaceuticals, Inc.	Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
PL2434886T3 (pl) *	2009-05-29	2020-05-18	Cydex Pharmaceuticals, Inc.	Kompozycje do wstrzykiwania melfalanu zawierające pochodną cyklodekstryny i sposoby ich wytwarzania i stosowania
AR077384A1 (es) *	2010-07-05	2011-08-24	Eriochem Sa	Una formulacion farmaceutica inyectable de melfalano.
US8921596B2 (en) *	2010-11-04	2014-12-30	Emcure Pharmaceuticals, Ltd.	Process for the preparation of melphalan hydrochloride
DK2701720T3 (en) *	2011-04-28	2017-10-09	Oncopeptides Ab	Lyophilized preparation with cytotoxic dipeptides
SMT202000058T1 (it) *	2012-10-26	2020-03-13	Oncopeptides Ab	Preparazioni liofilizzate di melfalan flufenammide
US9963422B2 (en)	2013-03-11	2018-05-08	Biophore India Pharmaceuticals Pvt. Ltd.	Process for the synthesis of melphalan and the hydrochloride salt
ITMI20130896A1 (it)	2013-05-31	2014-12-01	Farmabios Spa	Processo di purificazione di melphalan
PL3265075T3 (pl) *	2015-03-06	2020-10-05	Leadiant Biosciences S.P.A.	Terapia skojarzona szpiczaka mnogiego obejmująca roneparstat
US10537520B2 (en) *	2015-06-30	2020-01-21	Leiutis Pharmaceuticals Pvt. Ltd.	Stable liquid formulations of melphalan
EP3773498B1 (de) *	2018-03-29	2022-06-22	Project Pharmaceutics GmbH	Flüssige pharmazeutische formulierung
US10682326B1 (en)	2019-06-03	2020-06-16	Shilpa Medicare Limited	Stable melphalan liquid injectable formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB750155A (en) *	1953-03-17	1956-06-13	Nat Res Dev	Substituted alanines
US3032585A (en) *	1954-12-03	1962-05-01	Nat Res Dev	Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine
DE1292660B (de) *	1963-04-24	1969-04-17	Ural Polytechnitscheskij I Im	Verfahren zur Herstellung von p-(Bis-ª‰-chloraethyl-amino)-phenylalanin-hydrochlorid
US4029778A (en) *	1969-01-23	1977-06-14	Aktiebolaget Leo	Cortical steroid nitrogen mustard compositions and treatment therewith
RO57195A2 (de) *	1970-11-30	1974-09-01
FR2285855A1 (fr) *	1974-09-25	1976-04-23	Kohjin Co	Composition therapeutique lyophilisee a base de sel de cyclocytidine et son procede de preparation
JPS59186924A (ja) *	1983-04-08	1984-10-23	Kureha Chem Ind Co Ltd	ヒト免疫グロブリン結合抗腫瘍剤
US4696814A (en) *	1985-08-21	1987-09-29	Warner-Lambert Company	Parenteral phenytoin compositions
JPS62192357A (ja) *	1986-02-19	1987-08-22	Kureha Chem Ind Co Ltd	Ｎ−フタロイル−ｐ−ニトロ−Ｌ−フエニルアラニンの製造方法

1987
- 1987-11-19 GB GB878727157A patent/GB8727157D0/en active Pending
1988
- 1988-11-16 AT AT88310805T patent/ATE83922T1/de not_active IP Right Cessation
- 1988-11-16 DE DE8888310805T patent/DE3877151T2/de not_active Expired - Lifetime
- 1988-11-16 EP EP88310805A patent/EP0317281B1/de not_active Expired - Lifetime
- 1988-11-16 ES ES88310805T patent/ES2052745T3/es not_active Expired - Lifetime
- 1988-11-18 ZA ZA888674A patent/ZA888674B/xx unknown
- 1988-11-18 JP JP63292228A patent/JP2693191B2/ja not_active Expired - Lifetime
- 1988-11-18 IL IL88419A patent/IL88419A/xx not_active IP Right Cessation
- 1988-11-18 HU HU91335A patent/HU207286B/hu unknown
- 1988-11-18 HU HU885953A patent/HU203197B/hu unknown
- 1988-11-18 DK DK198806466A patent/DK172794B1/da not_active IP Right Cessation
- 1988-11-18 AU AU25748/88A patent/AU619781B2/en not_active Expired
- 1988-11-18 PT PT89028A patent/PT89028B/pt not_active IP Right Cessation
- 1988-11-18 IE IE344788A patent/IE63996B1/en not_active IP Right Cessation
- 1988-11-18 HU HU91336A patent/HU206671B/hu unknown
- 1988-11-18 NZ NZ239867A patent/NZ239867A/en unknown
- 1988-11-18 CA CA000583540A patent/CA1341114C/en not_active Expired - Fee Related
- 1988-11-18 KR KR1019880015196A patent/KR970002607B1/ko not_active Expired - Lifetime
- 1988-11-18 US US07/273,227 patent/US4997651A/en not_active Expired - Lifetime
- 1988-11-18 NZ NZ227004A patent/NZ227004A/xx unknown
- 1988-11-18 FI FI885358A patent/FI90204C/fi not_active IP Right Cessation
1992
- 1992-10-15 FI FI924668A patent/FI102275B1/fi not_active IP Right Cessation
1993
- 1993-03-09 GR GR930400510T patent/GR3007287T3/el unknown
- 1993-12-28 LV LVP-93-1379A patent/LV10179B/en unknown
1994
- 1994-06-03 SG SG73894A patent/SG73894G/en unknown
- 1994-10-06 HK HK108994A patent/HK108994A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE3877151D1 (de)	1993-02-11
EP0317281A3 (en)	1989-08-09
LV10179B (en)	1995-06-20
LV10179A (lv)	1994-10-20
EP0317281A2 (de)	1989-05-24
NZ239867A (en)	1992-11-25
HK108994A (en)	1994-10-14
US4997651A (en)	1991-03-05
KR890007729A (ko)	1989-07-05
JP2693191B2 (ja)	1997-12-24
FI885358A0 (fi)	1988-11-18
DK646688A (da)	1989-05-20
FI102275B (fi)	1998-11-13
AU619781B2 (en)	1992-02-06
FI102275B1 (fi)	1998-11-13
NZ227004A (en)	1992-11-25
IE883447L (en)	1989-05-19
PT89028B (pt)	1993-02-26
FI885358L (fi)	1989-05-20
ATE83922T1 (de)	1993-01-15
DK172794B1 (da)	1999-07-19
ES2052745T3 (es)	1994-07-16
KR970002607B1 (ko)	1997-03-06
IL88419A (en)	1993-03-15
AU2574888A (en)	1989-05-25
IE63996B1 (en)	1995-06-28
CA1341114C (en)	2000-10-10
HU206671B (en)	1992-12-28
HU207286B (en)	1993-03-29
FI90204C (fi)	1994-01-10
HU203197B (en)	1991-06-28
FI924668L (fi)	1992-10-15
PT89028A (pt)	1988-12-01
GR3007287T3 (de)	1993-07-30
ZA888674B (en)	1990-07-25
HU9100335D0 (en)	1991-08-28
EP0317281B1 (de)	1992-12-30
IL88419A0 (en)	1989-06-30
HU910336D0 (en)	1991-08-28
DK646688D0 (da)	1988-11-18
FI924668A0 (fi)	1992-10-15
JPH01153628A (ja)	1989-06-15
FI90204B (fi)	1993-09-30
HUT48198A (en)	1989-05-29
DE3877151T2 (de)	1993-07-15
GB8727157D0 (en)	1987-12-23

Publication	Publication Date	Title
SG73894G (en)	1994-11-25	Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydro-chloride and processes for preparing them
UA32512C2 (uk)	2001-02-15	Похідні ксантину, спосіб їх одержання, та фармацевтична композиція
HUT59306A (en)	1992-05-28	Process for producing pharmaceutical compositions comprising l-carnitine
IL86782A (en)	1993-04-04	Amino acid derivatives, processes for the preparation thereof and pharmaceutical compositions comprising the same
PT82841A (en)	1986-07-01	Process for the preparation of novel amino acid derivatives and of pharmaceutical compositions containing the same
IL84446A0 (en)	1988-04-29	3-pyrrolidinylthio-1-azabicyclo-(3.2.0)hept-2-ene-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
HUT51269A (en)	1990-04-28	Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same
GR3002605T3 (en)	1993-01-25	Pharmaceutical compositions containing a derivative of 3-hydroxy-butanoic acid chosen among oligomers of this acid and among esters of this acid or of these oligomers with 1,3-butane-diol
PT80752A (en)	1985-08-01	Process for preparing solid medicament formulations containing dihydropyridines
HUT50334A (en)	1990-01-29	Process for producing arylpiperazinyl-alkilenephenyl-p-heterocycluc compounds, pharmaceutically acceptable acid addition salts thereof and pharmaceutical compositions comprising the compounds as active ingredient
DE2961609D1 (en)	1982-02-11	Sila-substituted 1,4-dihydropyridine derivatives, processes for their preparation, pharmaceutical compositions and process for their preparation
HUT50787A (en)	1990-03-28	Process for producing pharmaceutical compositions comprising 4-aryl-4-piperidine-, pyrrolidine- or hexahydroazepincarbinol derivatives or heterocyclic analogs thereof as active ingredient and process for producing the new compounds
IL61989A (en)	1983-12-30	1-(1,3,4-oxadiazolyl-phenoxy)-3-(phenylpiperazino)propan-2-ols and their derivatives,their preparation and pharmaceutical compositions containing them
IL85189A (en)	1992-06-21	Beta-alkyl substituted melatonins,their preparation and pharmaceutical compositions containing them
HUT54166A (en)	1991-01-28	Process for producing 1,1-dioxocefem-4-carbothiol acid derivatives and pharmaceutical compositions comprising same as active ingredient
HUT46364A (en)	1988-10-28	Process for producing 1,12-dihydroxy-1,6,12,13-tetraaza-dicyclodocosane-2,5,13,16-tetron and pharmaceutical compositions comprising this compound as active ingredient
IT1228437B (it)	1991-06-17	"derivati di 2,3,4,5,6,7 esaidro 2,7-metano-1,5 benzossazonina (rispettivamente 1,4 benzossazonina), procedimento per la loro preparazione e prodotti medicinali che contengono questi composti.
MY105860A (en)	1995-02-28	Pharmaceutical formulations.
DE3264718D1 (en)	1985-08-22	Piperazinoquinazoline antihypertensives, processes for preparing them, pharmaceutical compositions containing them, and immunogenic protein conjugates formed from them
HUT51641A (en)	1990-05-28	Process for producing pseudoprimycin and its components, as well as pharmaceutical compositions comprising such active ingredient
HUT46693A (en)	1988-11-28	Process for producing dioxabicyclo/3,3,0/oktanon-oxim-ethers and pharmaceutical compositions containing them as active components
HUT50442A (en)	1990-02-28	Process for producing pharmaceutical composition comprising sour dock extract as active ingredient