SG75492G - Cephalosporin salts and injectable compositions - Google Patents

Cephalosporin salts and injectable compositions

Info

Publication number: SG75492G
Authority: SG; Singapore
Prior art keywords: salts; injectable compositions; alpha; methyl; cephalosporin salts
Prior art date: 1988-01-19

Application number

SG754/92A

Other languages

English (en)

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-19

Filing date

1992-07-24

Publication date

1992-10-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22510643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG75492(G) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-07-24 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1992-10-02 Publication of SG75492G publication Critical patent/SG75492G/en

Links

-1 Cephalosporin salts Chemical class 0.000 title abstract 2
229930186147 Cephalosporin Natural products 0.000 title 1
229940124587 cephalosporin Drugs 0.000 title 1
239000007972 injectable composition Substances 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 4
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 3
235000011007 phosphoric acid Nutrition 0.000 abstract 2
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N hydrochloric acid Substances Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
229960003646 lysine Drugs 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

SG754/92A 1988-01-19 1992-07-24 Cephalosporin salts and injectable compositions SG75492G (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/144,899 US4910301A (en)	1985-08-05	1988-01-19	Cefepime cephalosporin salts

Publications (1)

Publication Number	Publication Date
SG75492G true SG75492G (en)	1992-10-02

Family

ID=22510643

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG754/92A SG75492G (en)	1988-01-19	1992-07-24	Cephalosporin salts and injectable compositions

Country Status (32)

Country	Link
US (1)	US4910301A (fr)
JP (1)	JPH0725768B2 (fr)
KR (1)	KR950003612B1 (fr)
AT (1)	AT399878B (fr)
AU (1)	AU615509B2 (fr)
BE (1)	BE1002749A5 (fr)
CA (1)	CA1298288C (fr)
CY (1)	CY1663A (fr)
CZ (1)	CZ281602B6 (fr)
DD (2)	DD284807A5 (fr)
DE (1)	DE3901359A1 (fr)
DK (1)	DK162054C (fr)
EG (1)	EG18749A (fr)
ES (1)	ES2012948A6 (fr)
FI (1)	FI86854C (fr)
FR (1)	FR2626003B1 (fr)
GB (1)	GB2213819B (fr)
GR (1)	GR1001218B (fr)
HK (1)	HK72292A (fr)
HU (1)	HU205940B (fr)
IE (1)	IE67447B1 (fr)
IT (1)	IT1229528B (fr)
LU (1)	LU87432A1 (fr)
NL (1)	NL192266C (fr)
NZ (1)	NZ227605A (fr)
OA (1)	OA09227A (fr)
PT (1)	PT89474B (fr)
SE (1)	SE505258C2 (fr)
SG (1)	SG75492G (fr)
SK (1)	SK281768B6 (fr)
YU (1)	YU221188A (fr)
ZA (1)	ZA89407B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5244891A (en) *	1985-08-05	1993-09-14	Bristol-Myers Squibb Company	Injectable compositions of cefepime dihydrochloride hydrate
ES2061918T3 (es) *	1988-12-27	1994-12-16	Chugai Pharmaceutical Co Ltd	Procedimiento para la purificacion de 1,2-bis (nicotinamido) propano.
CA2011116C (fr) *	1989-03-06	1999-11-16	Murray A. Kaplan	Dihydrochlorure de bmy-28142 lyophilise pour usage parenteral
DE3919259A1 (de) *	1989-06-13	1990-12-20	Hoechst Ag	Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
YU81692A (sh) *	1991-09-10	1995-03-27	Bristol-Myers Co.	Postupak za proizvodnju cefalosporinskog antibiotika
US5594129A (en) *	1991-09-10	1997-01-14	Bristol-Myers Squibb Company	Process for the preparation of a cephalosporin antibiotic
US5698703A (en) *	1991-09-10	1997-12-16	Bristol-Myers Squibb Company	Syn-isomer of thiazolyl intermediate and process for the preparation thereof
IL103110A (en) *	1991-09-10	1997-04-15	Bristol Myers Squibb Co	Anhydrous process for preparing cefepime dihydrochloride hydrate
TW232695B (fr) *	1992-07-24	1994-10-21	Bristol Myers Squibb Co
US5401842A (en) *	1992-09-08	1995-03-28	Bristol-Myers Squibb Company	Injectable compositions of a cephalosporin dihydrate salt
US5391729A (en) *	1992-09-08	1995-02-21	Bristol-Myers Squibb Company	Crystalline dihydrate of a cephalosporin salt
CA2101571A1 (fr) *	1992-09-08	1994-03-09	Elizabeth A. Garofalo	Dihydrate cristallise d'un sel de cephalosporine dihydrate; compositions injectables a base de ce compose
JPH0840907A (ja)	1994-08-03	1996-02-13	Meiji Seika Kaisha Ltd	セファロスポリン注射剤
WO2005094800A2 (fr) *	2004-03-31	2005-10-13	Lupin Ltd.	Composition de cefepime co-precipite et procede de preparation correspondant
US20070111980A1 (en) *	2004-07-16	2007-05-17	Bandi Parthasaradhi Reddy	Process for preparing pure cephalosporine intermediates
ITMI20051684A1 (it) *	2005-09-13	2007-03-14	Harvest Lodge Ltd	Procedimento per la produzione del dicloridrato di amminoacidi
ITMI20060422A1 (it) *	2006-03-09	2007-09-10	Harvest Lodge Ltd	Procedimento diretto per la produzione del dicloridrato di un amminoacido
US8151846B2 (en) *	2006-12-15	2012-04-10	Center Line Wheel Corporation	Wheel having inner bead-lock
AR077320A1 (es) *	2009-07-20	2011-08-17	Intervet Int Bv	Metodo para la preparacion de particulas de cefquinoma y formulaciones farmaceuticas que las comprenden.
CN103304580B (zh) *	2013-06-09	2014-07-09	四川省惠达药业有限公司	一种盐酸头孢吡肟化合物、其制备方法及其药物组合物
CN108463461B (zh) *	2015-12-10	2021-11-19	奈加-Rgm制药有限公司	头孢烯化合物、其制备和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4029655A (en) *	1975-04-11	1977-06-14	Eli Lilly And Company	Method of preparing stable sterile crystalline cephalosporins for parenteral administration
JPS55151588A (en) *	1979-05-14	1980-11-26	Takeda Chem Ind Ltd	Preparation of cephalosporin salt crystal
CH654010A5 (de) *	1979-05-25	1986-01-31	Glaxo Group Ltd	Zwischenprodukte zur verwendung bei der herstellung von cephalosporin-antibiotika.
US4329453A (en) *	1979-10-02	1982-05-11	Glaxo Group Limited	Cephalosporin antibiotic
CA1213882A (fr) *	1982-03-04	1986-11-12	Jun Okumura	Cephalosporines
US4406899A (en) *	1982-03-04	1983-09-27	Bristol-Myers Company	Cephalosporins
US4525473A (en) *	1983-03-30	1985-06-25	Bristol-Myers Company	Cephalosporins
US4537959A (en) *	1984-03-26	1985-08-27	Eli Lilly And Company	Crystalline cephalosporin antibiotic salt
US4751295A (en) *	1984-04-09	1988-06-14	Bristol-Myers Company	Cephalosporin derivatives
US4749694A (en) *	1984-04-26	1988-06-07	Merck & Co., Inc.	Novel lysine esters used as absorption
FR2585705B1 (fr) *	1985-08-05	1989-01-13	Bristol Myers Co	Sels de cephalosporine et compositions injectables
US4808617A (en) *	1985-12-18	1989-02-28	Bristol-Myers Company	Lyophilized or precipitated cephalosporin zwitterion and salt combination
US4791196A (en) *	1986-09-26	1988-12-13	Sankyo Company Limited	Crystalline cephem carboxylic acid addition salt

1988
- 1988-01-19 US US07/144,899 patent/US4910301A/en not_active Expired - Lifetime
- 1988-12-06 YU YU02211/88A patent/YU221188A/xx unknown
1989
- 1989-01-12 NZ NZ227605A patent/NZ227605A/en unknown
- 1989-01-13 SK SK243-89A patent/SK281768B6/sk unknown
- 1989-01-13 CZ CS89243A patent/CZ281602B6/cs not_active IP Right Cessation
- 1989-01-16 FI FI890213A patent/FI86854C/fi not_active IP Right Cessation
- 1989-01-16 ES ES8900146A patent/ES2012948A6/es not_active Expired - Fee Related
- 1989-01-17 IT IT8947539A patent/IT1229528B/it active
- 1989-01-17 GR GR890100025A patent/GR1001218B/el not_active IP Right Cessation
- 1989-01-18 OA OA59509A patent/OA09227A/fr unknown
- 1989-01-18 FR FR8900553A patent/FR2626003B1/fr not_active Expired - Lifetime
- 1989-01-18 HU HU89185A patent/HU205940B/hu unknown
- 1989-01-18 DD DD89333774A patent/DD284807A5/de unknown
- 1989-01-18 DE DE3901359A patent/DE3901359A1/de active Granted
- 1989-01-18 KR KR1019890000493A patent/KR950003612B1/ko not_active Expired - Lifetime
- 1989-01-18 LU LU87432A patent/LU87432A1/fr unknown
- 1989-01-18 ZA ZA89407A patent/ZA89407B/xx unknown
- 1989-01-18 CA CA000588576A patent/CA1298288C/fr not_active Expired - Lifetime
- 1989-01-18 GB GB8901073A patent/GB2213819B/en not_active Expired - Lifetime
- 1989-01-18 DD DD89325118A patent/DD283397A5/de unknown
- 1989-01-18 IE IE14489A patent/IE67447B1/en not_active IP Right Cessation
- 1989-01-18 DK DK020789A patent/DK162054C/da not_active IP Right Cessation
- 1989-01-18 SE SE8900173A patent/SE505258C2/sv not_active IP Right Cessation
- 1989-01-18 EG EG2189A patent/EG18749A/xx active
- 1989-01-18 AT AT0008589A patent/AT399878B/de not_active IP Right Cessation
- 1989-01-18 PT PT89474A patent/PT89474B/pt not_active IP Right Cessation
- 1989-01-18 BE BE8900051A patent/BE1002749A5/fr active
- 1989-01-18 NL NL8900111A patent/NL192266C/nl not_active IP Right Cessation
- 1989-01-19 JP JP1008776A patent/JPH0725768B2/ja not_active Expired - Lifetime
- 1989-01-19 AU AU28623/89A patent/AU615509B2/en not_active Expired
1992
- 1992-07-24 SG SG754/92A patent/SG75492G/en unknown
- 1992-09-24 HK HK722/92A patent/HK72292A/xx not_active IP Right Cessation
1993
- 1993-05-14 CY CY1663A patent/CY1663A/en unknown

Also Published As

Publication number	Publication date
IT1229528B (it)	1991-09-04
SE8900173L (en)	1989-01-18
DE3901359A1 (de)	1989-10-05
PT89474A (pt)	1990-02-08
GB2213819A (en)	1989-08-23
IE67447B1 (en)	1996-04-03
LU87432A1 (fr)	1989-08-30
JPH029885A (ja)	1990-01-12
PT89474B (pt)	1993-12-31
AU2862389A (en)	1989-07-20
NZ227605A (en)	1991-06-25
GR1001218B (el)	1993-06-21
BE1002749A5 (fr)	1991-05-28
DE3901359C2 (fr)	1992-04-30
HK72292A (en)	1992-10-02
IT8947539A0 (it)	1988-01-17
HUT50347A (en)	1990-01-29
KR890011895A (ko)	1989-08-23
CZ281602B6 (cs)	1996-11-13
US4910301A (en)	1990-03-20
SE505258C2 (sv)	1997-07-21
ATA8589A (de)	1994-12-15
FI890213L (fi)	1989-07-20
AU615509B2 (en)	1991-10-03
SE8900173D0 (sv)	1989-01-18
NL192266B (nl)	1996-12-02
OA09227A (fr)	1992-06-30
KR950003612B1 (ko)	1995-04-17
EG18749A (en)	1993-12-30
DD283397A5 (de)	1990-10-10
SK24389A3 (en)	2000-12-11
FI86854C (fi)	1992-10-26
HU205940B (en)	1992-07-28
FI890213A0 (fi)	1989-01-16
GB2213819B (en)	1991-11-27
NL8900111A (nl)	1989-08-16
ZA89407B (en)	1989-09-27
AT399878B (de)	1995-08-25
FR2626003B1 (fr)	1992-10-16
GB8901073D0 (en)	1989-03-15
FI86854B (fi)	1992-07-15
FR2626003A1 (fr)	1989-07-21
YU221188A (en)	1990-04-30
DK20789D0 (da)	1989-01-18
JPH0725768B2 (ja)	1995-03-22
CA1298288C (fr)	1992-03-31
DD284807A5 (de)	1990-11-28
SK281768B6 (sk)	2001-07-10
DK162054C (da)	1992-02-10
ES2012948A6 (es)	1990-04-16
CY1663A (en)	1993-05-14
IE890144L (en)	1989-07-19
NL192266C (nl)	1997-04-03
DK20789A (da)	1989-07-20
DK162054B (da)	1991-09-09
CZ24389A3 (en)	1996-08-14

Publication	Publication Date	Title
GB2213819B (en)	1991-11-27	Cephalosporin salts and injectable compositions
AU533708B2 (en)	1983-12-08	7-(2-alkoxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl) acetamido) cephalosporanic acid derivatives
HUT44258A (en)	1988-02-29	Process for preparing acyl derivatives
NO171313C (no)	1993-02-24	Fremgangsmaate for fremstilling av krystaller av 7beta-((z)-2-(5-amino-1,2,4-tiadiazol-3-yl)-2-metoksyiminoacetamido)-3-(1-imidazo(1,2-b)-pyridazinium)metyl-3-cefem-4-karboksylathydroklorid
AR243894A1 (es)	1993-09-30	Metodo para preparar sales cristalinas estables de cefalosporinas utiles para formular composiciones inyectables.
EP0401857A3 (fr)	1991-07-31	Fénamates 1,3,4-thiadiazoles et 1,3,4-oxadiazoles comme agents anti-inflammatoires
PH23648A (en)	1989-09-27	Improved method for preparing crystalline cefadroxil monohydrate
ATE63814T1 (de)	1991-06-15	Injektionsloesung von cephalosporinen.
EP0238061A3 (en)	1989-05-17	Cephalosporin derivatives, processes for their preparation and antibacterial agents
EP0377987A3 (fr)	1991-08-28	Procédé d'acylation pour l'obtention de dérivés de céphalosporine
PH20664A (en)	1987-03-23	Esters of 3-(1,2,3-thiadiazol-5-yl)thiomethyl)cephalosporin derivatives
NO884486L (no)	1989-04-10	Fremgangsmaate for fremstilling av cefalosporinderivater med forbedrede farmakokinetika.
EP0272061A3 (fr)	1990-03-28	Sels et solvats cristallins de céphalosporine antibiotique
EP0222577A3 (fr)	1988-10-05	Céphalosporine cristalline monohydratée
JPS52122386A (en)	1977-10-14	Cephalosporin analogous compounds as antibacterials
CA1270833C (fr)	1990-06-26	Derives de la 2,5-pyrrolidinedione utiles comme agents anti-arhytmisants
JPS6475492A (en)	1989-03-22	Novel cephem compound and salts thereof
IT7920115A0 (it)	1979-02-12	Procedimento per la produzione di antibiotici derivati dall'acido 7-ammino cefalosporanico.
GB8718905D0 (en)	1987-09-16	Salts of new cephem compounds