SI9200193A - New isosteric peptides - Google Patents

New isosteric peptides Download PDF

Info

Publication number
SI9200193A
SI9200193A SI19929200193A SI9200193A SI9200193A SI 9200193 A SI9200193 A SI 9200193A SI 19929200193 A SI19929200193 A SI 19929200193A SI 9200193 A SI9200193 A SI 9200193A SI 9200193 A SI9200193 A SI 9200193A
Authority
SI
Slovenia
Prior art keywords
arg
dcha
pro
hooc
phenyl
Prior art date
Application number
SI19929200193A
Other languages
English (en)
Slovenian (sl)
Inventor
Butrus Atrash
David Michael Jones
Michael Szelke
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Publication of SI9200193A publication Critical patent/SI9200193A/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI19929200193A 1991-08-28 1992-08-27 New isosteric peptides SI9200193A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9102462A SE9102462D0 (sv) 1991-08-28 1991-08-28 New isosteric peptides

Publications (1)

Publication Number Publication Date
SI9200193A true SI9200193A (en) 1993-06-30

Family

ID=20383557

Family Applications (1)

Application Number Title Priority Date Filing Date
SI19929200193A SI9200193A (en) 1991-08-28 1992-08-27 New isosteric peptides

Country Status (27)

Country Link
US (1) US5424291A (cs)
EP (2) EP0605462B1 (cs)
JP (1) JP3353297B2 (cs)
CN (1) CN1069736A (cs)
AP (1) AP313A (cs)
AT (1) ATE212643T1 (cs)
AU (1) AU2499092A (cs)
BG (1) BG98583A (cs)
CA (1) CA2116527A1 (cs)
CZ (1) CZ38094A3 (cs)
DE (1) DE69232394T2 (cs)
DZ (1) DZ1613A1 (cs)
FI (1) FI940945A0 (cs)
HU (1) HUT66060A (cs)
IL (1) IL102840A0 (cs)
IS (1) IS3906A (cs)
MA (1) MA22632A1 (cs)
MX (1) MX9204767A (cs)
NO (1) NO940669L (cs)
NZ (1) NZ243675A (cs)
SE (1) SE9102462D0 (cs)
SI (1) SI9200193A (cs)
SK (1) SK23394A3 (cs)
TN (1) TNSN92076A1 (cs)
TW (1) TW221816B (cs)
WO (1) WO1993005069A1 (cs)
ZA (1) ZA925737B (cs)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA928581B (en) * 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
CA2122397A1 (en) * 1993-05-03 1994-11-04 Spencer D. Kimball Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
SK47796A3 (en) * 1993-10-15 1997-03-05 Rhone Poulenc Rorer Pharma Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
KR100388185B1 (ko) * 1995-02-17 2003-11-28 애보트 게엠베하 운트 콤파니 카게 트롬빈 억제제로서의 신규 디펩티드 아미딘
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TW541316B (en) 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
HUP0100082A3 (en) 1998-01-26 2001-12-28 Abbott Gmbh & Co Kg Thrombin inhibitor, peptide derivatives, pharmaceutical compositions comprising thereof and their use
US6417161B1 (en) 1998-04-24 2002-07-09 3-Dimensional Pharmaceuticals, Inc. Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
EE200100371A (et) 1999-01-13 2002-02-15 Astrazeneca Ab Amidinobensüülamiini derivaadid ja nende kasutamine trombiini inhibiitoritena
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
AU1226001A (en) * 1999-11-09 2001-06-06 Alcon Universal Limited Phospholipids of hydroxyeicosatetraenoic acid-like derivatives
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US7781424B2 (en) 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
ES2819218T3 (es) 2014-10-06 2021-04-15 Cortexyme Inc Inhibidores de lisina gingipaína
WO2017083433A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
EP3426674A4 (en) 2016-03-09 2019-08-14 Blade Therapeutics, Inc. CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
EP3481835A4 (en) 2016-07-05 2020-02-26 Blade Therapeutics, Inc. CALPAIN MODULATORS AND THERAPEUTIC USE THEREOF
KR102780603B1 (ko) 2016-09-16 2025-03-12 라이트하우스 파마슈티컬스, 인코포레이티드 리신 진지파인의 케톤 억제제
SG10201912574WA (en) 2016-09-28 2020-02-27 Blade Therapeutics Inc Calpain modulators and therapeutic uses thereof
SG11202008750XA (en) * 2018-03-28 2020-10-29 Blade Therapeutics Inc Calpain modulators and therapeutic uses thereof
US20220204457A1 (en) * 2019-03-21 2022-06-30 Cortexyme, Inc. Arginine gingipain inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
FI940945L (fi) 1994-02-28
ZA925737B (en) 1993-03-01
MX9204767A (es) 1993-05-01
TW221816B (cs) 1994-03-21
CN1069736A (zh) 1993-03-10
EP0530167A1 (en) 1993-03-03
MA22632A1 (fr) 1993-04-01
BG98583A (bg) 1994-09-30
DE69232394D1 (de) 2002-03-14
US5424291A (en) 1995-06-13
IS3906A (is) 1993-03-01
CA2116527A1 (en) 1993-03-18
FI940945A7 (fi) 1994-02-28
WO1993005069A1 (en) 1993-03-18
NO940669D0 (no) 1994-02-25
CZ38094A3 (en) 1994-08-17
TNSN92076A1 (fr) 1993-06-08
FI940945A0 (fi) 1994-02-28
EP0605462A1 (en) 1994-07-13
AP313A (en) 1994-02-10
NO940669L (no) 1994-04-19
AP9200418A0 (en) 1992-10-31
EP0605462B1 (en) 2002-01-30
HU9400589D0 (en) 1994-05-30
DE69232394T2 (de) 2002-08-22
ATE212643T1 (de) 2002-02-15
NZ243675A (en) 1994-06-27
IL102840A0 (en) 1993-01-31
JPH06510059A (ja) 1994-11-10
JP3353297B2 (ja) 2002-12-03
HUT66060A (en) 1994-09-28
DZ1613A1 (fr) 2002-02-17
SE9102462D0 (sv) 1991-08-28
SK23394A3 (en) 1994-08-10
AU2499092A (en) 1993-04-05

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