SK12752003A3 - Prípravky užitočné na liečbu patológií odpovedajúce na aktiváciu PPAR-gamma receptora - Google Patents

Prípravky užitočné na liečbu patológií odpovedajúce na aktiváciu PPAR-gamma receptora Download PDF

Info

Publication number: SK12752003A3
Authority: SK; Slovakia
Prior art keywords: formula; treatment; ppar; spirolaxin; activation
Prior art date: 2001-03-16

Application number

SK1275-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Claudio Pisano

Teresa Riccioni

Original Assignee

Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-16

Filing date

2002-03-01

Publication date

2004-01-08

2002-03-01 Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.

2004-01-08 Publication of SK12752003A3 publication Critical patent/SK12752003A3/sk

Links

230000004913 activation Effects 0.000 title claims abstract description 21
230000007170 pathology Effects 0.000 title claims abstract description 19
108010016731 PPAR gamma Proteins 0.000 title claims description 28
102000000536 PPAR gamma Human genes 0.000 title claims 6
239000000203 mixture Substances 0.000 title 1
CZIMFHQXGMXDMO-DGROVODQSA-N (3r)-5-hydroxy-7-methoxy-3-[5-[(2r,5r,7r)-2-methyl-1,6-dioxaspiro[4.5]decan-7-yl]pentyl]-3h-2-benzofuran-1-one Chemical compound C([C@H](O1)CCCCC[C@@H]2C=3C=C(O)C=C(C=3C(=O)O2)OC)CC[C@@]21CC[C@@H](C)O2 CZIMFHQXGMXDMO-DGROVODQSA-N 0.000 claims abstract description 29
230000003211 malignant effect Effects 0.000 claims abstract description 11
230000001154 acute effect Effects 0.000 claims abstract description 10
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 20
230000000694 effects Effects 0.000 claims description 17
229960001727 tretinoin Drugs 0.000 claims description 15
230000004069 differentiation Effects 0.000 claims description 11
239000003814 drug Substances 0.000 claims description 11
102000004877 Insulin Human genes 0.000 claims description 10
108090001061 Insulin Proteins 0.000 claims description 10
229940125396 insulin Drugs 0.000 claims description 10
239000002246 antineoplastic agent Substances 0.000 claims description 8
108060001084 Luciferase Proteins 0.000 claims description 7
238000002360 preparation method Methods 0.000 claims description 7
239000005089 Luciferase Substances 0.000 claims description 6
229940041181 antineoplastic drug Drugs 0.000 claims description 6
208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 6
229940079593 drug Drugs 0.000 claims description 5
208000032839 leukemia Diseases 0.000 claims description 5
239000004480 active ingredient Substances 0.000 claims description 4
206010028980 Neoplasm Diseases 0.000 claims description 3
239000013612 plasmid Substances 0.000 claims description 3
238000001890 transfection Methods 0.000 claims description 3
108090000790 Enzymes Proteins 0.000 claims description 2
102000004190 Enzymes Human genes 0.000 claims description 2
241000590002 Helicobacter pylori Species 0.000 claims description 2
206010024305 Leukaemia monocytic Diseases 0.000 claims description 2
208000028018 Lymphocytic leukaemia Diseases 0.000 claims description 2
229940123237 Taxane Drugs 0.000 claims description 2
229940122803 Vinca alkaloid Drugs 0.000 claims description 2
229940100198 alkylating agent Drugs 0.000 claims description 2
239000002168 alkylating agent Substances 0.000 claims description 2
239000003242 anti bacterial agent Substances 0.000 claims description 2
229940088710 antibiotic agent Drugs 0.000 claims description 2
239000003534 dna topoisomerase inhibitor Substances 0.000 claims description 2
229940088598 enzyme Drugs 0.000 claims description 2
229940037467 helicobacter pylori Drugs 0.000 claims description 2
208000003747 lymphoid leukemia Diseases 0.000 claims description 2
238000000034 method Methods 0.000 claims description 2
201000006894 monocytic leukemia Diseases 0.000 claims description 2
208000025113 myeloid leukemia Diseases 0.000 claims description 2
229930014626 natural product Natural products 0.000 claims description 2
239000000546 pharmaceutical excipient Substances 0.000 claims description 2
210000002966 serum Anatomy 0.000 claims description 2
229940044693 topoisomerase inhibitor Drugs 0.000 claims description 2
208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 1
208000031226 Hyperlipidaemia Diseases 0.000 claims 1
208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 1
230000001939 inductive effect Effects 0.000 claims 1
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 abstract description 11
102000005962 receptors Human genes 0.000 abstract description 7
108020003175 receptors Proteins 0.000 abstract description 7
229930002330 retinoic acid Natural products 0.000 abstract description 5
102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract description 4
108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract description 4
206010022491 Insulin resistant diabetes Diseases 0.000 abstract description 3
CZIMFHQXGMXDMO-UHFFFAOYSA-N Spirolaxine Natural products O1C(=O)C=2C(OC)=CC(O)=CC=2C1CCCCCC(O1)CCCC21CCC(C)O2 CZIMFHQXGMXDMO-UHFFFAOYSA-N 0.000 abstract 2
102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 description 22
210000004027 cell Anatomy 0.000 description 18
150000001875 compounds Chemical class 0.000 description 16
206010012601 diabetes mellitus Diseases 0.000 description 8
210000004881 tumor cell Anatomy 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 4
239000003446 ligand Substances 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
230000003914 insulin secretion Effects 0.000 description 3
JPXMTWWFLBLUCD-UHFFFAOYSA-N nitro blue tetrazolium(2+) Chemical compound COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 JPXMTWWFLBLUCD-UHFFFAOYSA-N 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
238000002560 therapeutic procedure Methods 0.000 description 3
GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 3
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
239000012980 RPMI-1640 medium Substances 0.000 description 2
102000034527 Retinoid X Receptors Human genes 0.000 description 2
108010038912 Retinoid X Receptors Proteins 0.000 description 2
238000009825 accumulation Methods 0.000 description 2
230000003178 anti-diabetic effect Effects 0.000 description 2
229940127089 cytotoxic agent Drugs 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
239000012894 fetal calf serum Substances 0.000 description 2
230000004153 glucose metabolism Effects 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
230000037356 lipid metabolism Effects 0.000 description 2
150000002632 lipids Chemical group 0.000 description 2
230000035772 mutation Effects 0.000 description 2
208000011580 syndromic disease Diseases 0.000 description 2
230000002103 transcriptional effect Effects 0.000 description 2
230000005945 translocation Effects 0.000 description 2
GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 2
229960001641 troglitazone Drugs 0.000 description 2
ILLYYNHLCANIBL-YCNIQYBTSA-N (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-2-en-1-yl)nona-2,4,6,8-tetraenoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1C(C)=CCCC1(C)C ILLYYNHLCANIBL-YCNIQYBTSA-N 0.000 description 1
206010003210 Arteriosclerosis Diseases 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
101000573199 Homo sapiens Protein PML Proteins 0.000 description 1
206010022489 Insulin Resistance Diseases 0.000 description 1
206010023379 Ketoacidosis Diseases 0.000 description 1
208000007976 Ketosis Diseases 0.000 description 1
241001529936 Murinae Species 0.000 description 1
108020005497 Nuclear hormone receptor Proteins 0.000 description 1
201000007737 Retinal degeneration Diseases 0.000 description 1
208000032464 Retinoic acid syndrome Diseases 0.000 description 1
241001085824 Sporotrichum laxum Species 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
230000002547 anomalous effect Effects 0.000 description 1
230000003627 anti-cholesterol Effects 0.000 description 1
230000001028 anti-proliverative effect Effects 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
239000003472 antidiabetic agent Substances 0.000 description 1
208000011775 arteriosclerosis disease Diseases 0.000 description 1
239000011324 bead Substances 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
230000011712 cell development Effects 0.000 description 1
230000024245 cell differentiation Effects 0.000 description 1
230000004663 cell proliferation Effects 0.000 description 1
210000000349 chromosome Anatomy 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000034994 death Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
239000008103 glucose Substances 0.000 description 1
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
210000003714 granulocyte Anatomy 0.000 description 1
238000005734 heterodimerization reaction Methods 0.000 description 1
102000054896 human PML Human genes 0.000 description 1
238000000099 in vitro assay Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000003993 interaction Effects 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
206010024378 leukocytosis Diseases 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
230000006371 metabolic abnormality Effects 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
210000000066 myeloid cell Anatomy 0.000 description 1
201000001119 neuropathy Diseases 0.000 description 1
230000007823 neuropathy Effects 0.000 description 1
102000006255 nuclear receptors Human genes 0.000 description 1
108020004017 nuclear receptors Proteins 0.000 description 1
208000033808 peripheral neuropathy Diseases 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
210000004765 promyelocyte Anatomy 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000004258 retinal degeneration Effects 0.000 description 1
108090000064 retinoic acid receptors Proteins 0.000 description 1
102000027483 retinoid hormone receptors Human genes 0.000 description 1
108091008679 retinoid hormone receptors Proteins 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
231100000378 teratogenic Toxicity 0.000 description 1
230000003390 teratogenic effect Effects 0.000 description 1
150000001467 thiazolidinediones Chemical class 0.000 description 1
206010043554 thrombocytopenia Diseases 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
230000006496 vascular abnormality Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SK1275-2003A 2001-03-16 2002-03-01 Prípravky užitočné na liečbu patológií odpovedajúce na aktiváciu PPAR-gamma receptora SK12752003A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001RM000136A ITRM20010136A1 (it)	2001-03-16	2001-03-16	Composti utili per il trattamento di patologie che rispondono all'attivazione del recettore ppar-gamma.
PCT/IT2002/000127 WO2002074291A2 (en)	2001-03-16	2002-03-01	Compositions useful for the treatment of pathologies responding to the activation of ppar-gamma receptor

Publications (1)

Publication Number	Publication Date
SK12752003A3 true SK12752003A3 (sk)	2004-01-08

Family

ID=11455333

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1275-2003A SK12752003A3 (sk)	2001-03-16	2002-03-01	Prípravky užitočné na liečbu patológií odpovedajúce na aktiváciu PPAR-gamma receptora

Country Status (19)

Country	Link
US (4)	US6897235B2 (cs)
EP (1)	EP1368025B1 (cs)
JP (1)	JP4276842B2 (cs)
KR (1)	KR100851678B1 (cs)
CN (2)	CN1286456C (cs)
AT (1)	ATE308984T1 (cs)
AU (1)	AU2002247951B2 (cs)
BR (1)	BR0208157A (cs)
CA (1)	CA2440979C (cs)
CZ (1)	CZ20032523A3 (cs)
DE (1)	DE60207215T2 (cs)
DK (1)	DK1368025T3 (cs)
ES (1)	ES2249568T3 (cs)
HU (1)	HUP0303518A3 (cs)
IT (1)	ITRM20010136A1 (cs)
MX (1)	MXPA03008317A (cs)
PL (1)	PL369295A1 (cs)
SK (1)	SK12752003A3 (cs)
WO (1)	WO2002074291A2 (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7041691B1 (en)	1999-06-30	2006-05-09	Amgen Inc.	Compounds for the modulation of PPARγ activity
US20030171399A1 (en)	2000-06-28	2003-09-11	Tularik Inc.	Quinolinyl and benzothiazolyl modulators
ES2327639T3 (es) *	2003-05-14	2009-11-02	Dsm Ip Assets B.V.	Uso de derivados de ftalida para el tratamiento y prevecion de diabetes mellitus.
US7223761B2 (en)	2003-10-03	2007-05-29	Amgen Inc.	Salts and polymorphs of a potent antidiabetic compound
KR20090066289A (ko)	2006-09-08	2009-06-23	로드아일랜드하스피틀	알코올 유발성 뇌 질환의 치료, 예방 및 역행

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07285862A (ja) *	1994-04-21	1995-10-31	Kokka Iyaku Kanrikyoku Shisen Kokinso Kogyo Kenkyusho	脂質低下剤
JPH107557A (ja) *	1996-06-17	1998-01-13	Banyu Pharmaceut Co Ltd	抗腫瘍性物質スピロラキシン
US6440961B1 (en)	1997-10-27	2002-08-27	Dr. Reddy's Research Foundation	Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
IT1317001B1 (it) *	2000-03-13	2003-05-26	Sigma Tau Ind Farmaceuti	Uso della spirolaxina per il trattamento di patologie associate ad unaalterata angiogenesi.

2001
- 2001-03-16 IT IT2001RM000136A patent/ITRM20010136A1/it unknown
2002
- 2002-03-01 HU HU0303518A patent/HUP0303518A3/hu unknown
- 2002-03-01 MX MXPA03008317A patent/MXPA03008317A/es active IP Right Grant
- 2002-03-01 ES ES02717031T patent/ES2249568T3/es not_active Expired - Lifetime
- 2002-03-01 KR KR1020037012030A patent/KR100851678B1/ko not_active Expired - Fee Related
- 2002-03-01 SK SK1275-2003A patent/SK12752003A3/sk unknown
- 2002-03-01 CA CA2440979A patent/CA2440979C/en not_active Expired - Fee Related
- 2002-03-01 DE DE60207215T patent/DE60207215T2/de not_active Expired - Lifetime
- 2002-03-01 JP JP2002572999A patent/JP4276842B2/ja not_active Expired - Fee Related
- 2002-03-01 CN CNB028081382A patent/CN1286456C/zh not_active Expired - Fee Related
- 2002-03-01 CZ CZ20032523A patent/CZ20032523A3/cs unknown
- 2002-03-01 AT AT02717031T patent/ATE308984T1/de not_active IP Right Cessation
- 2002-03-01 PL PL02369295A patent/PL369295A1/xx not_active Application Discontinuation
- 2002-03-01 EP EP02717031A patent/EP1368025B1/en not_active Expired - Lifetime
- 2002-03-01 US US10/471,786 patent/US6897235B2/en not_active Expired - Fee Related
- 2002-03-01 DK DK02717031T patent/DK1368025T3/da active
- 2002-03-01 AU AU2002247951A patent/AU2002247951B2/en not_active Ceased
- 2002-03-01 WO PCT/IT2002/000127 patent/WO2002074291A2/en not_active Ceased
- 2002-03-01 BR BR0208157-1A patent/BR0208157A/pt not_active IP Right Cessation
- 2002-03-01 CN CNB2006100057819A patent/CN100462073C/zh not_active Expired - Fee Related
2004
- 2004-07-13 US US10/889,030 patent/US20040242675A1/en not_active Abandoned
- 2004-07-13 US US10/889,029 patent/US7276533B2/en not_active Expired - Fee Related
- 2004-10-18 US US10/965,740 patent/US20050131060A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ATE308984T1 (de)	2005-11-15
US20050131060A1 (en)	2005-06-16
US20040241228A1 (en)	2004-12-02
US6897235B2 (en)	2005-05-24
HK1096850A1 (zh)	2007-06-15
HUP0303518A3 (en)	2005-12-28
JP4276842B2 (ja)	2009-06-10
US20040092540A1 (en)	2004-05-13
CA2440979C (en)	2010-07-13
US20040242675A1 (en)	2004-12-02
CN1286456C (zh)	2006-11-29
CZ20032523A3 (cs)	2004-05-12
ITRM20010136A1 (it)	2002-09-16
CN1839823A (zh)	2006-10-04
HK1075006A1 (en)	2005-12-02
JP2004523578A (ja)	2004-08-05
MXPA03008317A (es)	2003-12-11
WO2002074291A2 (en)	2002-09-26
HUP0303518A2 (hu)	2004-03-01
DK1368025T3 (da)	2005-12-19
DE60207215D1 (de)	2005-12-15
EP1368025A2 (en)	2003-12-10
CN1610545A (zh)	2005-04-27
ITRM20010136A0 (it)	2001-03-16
AU2002247951B2 (en)	2007-03-01
CA2440979A1 (en)	2002-09-26
KR20040025905A (ko)	2004-03-26
ES2249568T3 (es)	2006-04-01
EP1368025B1 (en)	2005-11-09
BR0208157A (pt)	2004-03-02
PL369295A1 (en)	2005-04-18
WO2002074291A3 (en)	2003-03-13
DE60207215T2 (de)	2006-07-20
KR100851678B1 (ko)	2008-08-13
CN100462073C (zh)	2009-02-18
US7276533B2 (en)	2007-10-02

Legal Events

Date	Code	Title	Description
2011-11-04	FB9A	Suspension of patent application procedure

Publication	Publication Date	Title
TWI330084B (en)	2010-09-11	Combination therapy comprising glucose reabsorption inhibitors and ppar modulators
Roepke et al.	2009	Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis
Ren et al.	2003	Impact of estrogen replacement on ventricular myocyte contractile function and protein kinase B/Akt activation
EA022166B1 (ru)	2015-11-30	Синтетические тритерпеноиды и их применение в лечении заболеваний
US20150241448A1 (en)	2015-08-27	Lanthionine synthetase component c-like proteins as molecular targets for preventing and treating diseases and disorders
Hung et al.	2019	The protective role of peroxisome proliferator-activated receptor-gamma in seizure and neuronal excitotoxicity
Yasuda et al.	2009	Antidiabetic drug pioglitazone protects the heart via activation of PPAR-γ receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction
EP2683382A2 (en)	2014-01-15	Dosing regimens for the treatment of fabry disease
KR20160070154A (ko)	2016-06-17	미토콘드리아병을 치료하기 위한 시스테아민 및 이의 유도체의 용도
CN113613654B (zh)	2024-01-26	普那布林在制备增加非转移性乳腺癌患者触珠蛋白的药物中的用途
JPWO2004093910A1 (ja)	2006-07-13	ＰＰＡＲδアゴニストによる脳神経変性疾患治療剤
EP1368025B1 (en)	2005-11-09	Compositions useful for the treatment of pathologies responding to the activation of ppar-gamma receptor
CN119818652B (zh)	2025-07-11	一种治疗阿尔茨海默症的药物组合物
AU2002247951A1 (en)	2003-03-27	Compositions useful for the treatment of pathologies responding to the activation of ppar-gamma receptor
US20240216320A1 (en)	2024-07-04	Compositions and methods for treating sickle cell disease
US20020031539A1 (en)	2002-03-14	Oxidized forms of retinoic acid as ligands for peroxisome proliferator activated receptor gamma
HK1096850B (en)	2009-11-06	Compositions useful for the treatment of pathologies responding to the activation of ppar-gamma receptor
HK1075006B (en)	2007-06-01	Use of spirolaxine for the preparation of a medicament treating type 2 insulin-resistant diabetes mellitus
WO2022061962A1 (zh)	2022-03-31	一种l型氨基酸转运蛋白抑制剂或拮抗剂有效干预糖尿病的方法
WO2005084709A1 (ja)	2005-09-15	排尿障害治療薬
HK40036814A (en)	2021-06-04	Dosing regimens for the treatment of fabry disease