SK140699A3 - Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment - Google Patents

Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment Download PDF

Info

Publication number: SK140699A3
Authority: SK; Slovakia
Prior art keywords: formula; compound; pharmaceutically acceptable; condition; disease
Prior art date: 1997-05-05

Application number

SK1406-99A

Other languages

English (en)

Slovak (sk)

Inventor

James Macdonald

James Matz

William Shakespeare

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-05

Filing date

1998-04-28

Publication date

2000-06-12

1998-04-28 Application filed by Astra Ab filed Critical Astra Ab

2000-06-12 Publication of SK140699A3 publication Critical patent/SK140699A3/sk

Links

238000002360 preparation method Methods 0.000 title claims abstract description 10
238000011282 treatment Methods 0.000 title claims description 23
239000000203 mixture Substances 0.000 title abstract description 25
150000001409 amidines Chemical class 0.000 title description 5
150000001875 compounds Chemical class 0.000 claims abstract description 112
150000003839 salts Chemical class 0.000 claims abstract description 42
238000000034 method Methods 0.000 claims abstract description 38
230000003287 optical effect Effects 0.000 claims abstract description 26
230000008569 process Effects 0.000 claims abstract description 11
230000001537 neural effect Effects 0.000 claims abstract description 9
102000001708 Protein Isoforms Human genes 0.000 claims abstract description 7
108010029485 Protein Isoforms Proteins 0.000 claims abstract description 7
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims abstract description 6
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims abstract description 3
102000008299 Nitric Oxide Synthase Human genes 0.000 claims description 18
108010021487 Nitric Oxide Synthase Proteins 0.000 claims description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
201000010099 disease Diseases 0.000 claims description 16
239000002253 acid Substances 0.000 claims description 15
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238000011321 prophylaxis Methods 0.000 claims description 11
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BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 10
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208000023105 Huntington disease Diseases 0.000 claims description 6
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BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 6
WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims description 5
WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 3
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CSACSOOYFUXTIP-UHFFFAOYSA-N n'-(2-methyl-3,4-dihydro-1h-isoquinolin-7-yl)thiophene-2-carboximidamide Chemical compound C1=C2CN(C)CCC2=CC=C1NC(=N)C1=CC=CS1 CSACSOOYFUXTIP-UHFFFAOYSA-N 0.000 claims description 3
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VZKZUPIDSUVHLB-UHFFFAOYSA-N n'-(2-butyl-3,4-dihydro-1h-isoquinolin-7-yl)thiophene-2-carboximidamide Chemical compound C1=C2CN(CCCC)CCC2=CC=C1NC(=N)C1=CC=CS1 VZKZUPIDSUVHLB-UHFFFAOYSA-N 0.000 claims description 2
HWZSHHNOIXRTJD-UHFFFAOYSA-N n'-(2-ethyl-3,4-dihydro-1h-isoquinolin-7-yl)thiophene-2-carboximidamide Chemical compound C1=C2CN(CC)CCC2=CC=C1NC(=N)C1=CC=CS1 HWZSHHNOIXRTJD-UHFFFAOYSA-N 0.000 claims description 2
LGOGDAYURLJNDA-UHFFFAOYSA-N n'-(2-propan-2-yl-3,4-dihydro-1h-isoquinolin-7-yl)thiophene-2-carboximidamide Chemical compound C1=C2CN(C(C)C)CCC2=CC=C1N=C(N)C1=CC=CS1 LGOGDAYURLJNDA-UHFFFAOYSA-N 0.000 claims description 2
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238000003786 synthesis reaction Methods 0.000 description 7
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 6
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SK1406-99A 1997-05-05 1998-04-28 Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment SK140699A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9701682A SE9701682D0 (sv)	1997-05-05	1997-05-05	Compounds
PCT/SE1998/000792 WO1998050380A1 (en)	1997-05-05	1998-04-28	Compounds

Publications (1)

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SK140699A3 true SK140699A3 (en)	2000-06-12

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SK1406-99A SK140699A3 (en)	1997-05-05	1998-04-28	Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment

Country Status (28)

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US (1)	US6166030A (da)
EP (1)	EP0983266B1 (da)
JP (1)	JP2001523263A (da)
KR (1)	KR20010012227A (da)
CN (1)	CN1255130A (da)
AR (1)	AR012602A1 (da)
AT (1)	ATE210661T1 (da)
AU (1)	AU734394B2 (da)
BR (1)	BR9808725A (da)
CA (1)	CA2287999A1 (da)
DE (1)	DE69802923T2 (da)
DK (1)	DK0983266T3 (da)
EE (1)	EE9900475A (da)
ES (1)	ES2168757T3 (da)
HU (1)	HUP0003766A3 (da)
ID (1)	ID23156A (da)
IL (1)	IL132677A0 (da)
IS (1)	IS5237A (da)
MX (1)	MXPA99009874A (da)
NO (1)	NO995404L (da)
NZ (1)	NZ500676A (da)
PL (1)	PL336854A1 (da)
PT (1)	PT983266E (da)
SE (1)	SE9701682D0 (da)
SK (1)	SK140699A3 (da)
TR (1)	TR199902719T2 (da)
WO (1)	WO1998050380A1 (da)
ZA (1)	ZA983740B (da)

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1997
- 1997-05-05 SE SE9701682A patent/SE9701682D0/xx unknown
- 1997-05-05 US US09/068,944 patent/US6166030A/en not_active Expired - Fee Related
1998
- 1998-04-24 AR ARP980101929A patent/AR012602A1/es not_active Application Discontinuation
- 1998-04-28 CN CN98804839A patent/CN1255130A/zh active Pending
- 1998-04-28 AU AU74600/98A patent/AU734394B2/en not_active Ceased
- 1998-04-28 PL PL98336854A patent/PL336854A1/xx unknown
- 1998-04-28 DK DK98921953T patent/DK0983266T3/da active
- 1998-04-28 KR KR1019997010176A patent/KR20010012227A/ko not_active Withdrawn
- 1998-04-28 WO PCT/SE1998/000792 patent/WO1998050380A1/en not_active Ceased
- 1998-04-28 AT AT98921953T patent/ATE210661T1/de not_active IP Right Cessation
- 1998-04-28 ID IDW991285A patent/ID23156A/id unknown
- 1998-04-28 SK SK1406-99A patent/SK140699A3/sk unknown
- 1998-04-28 CA CA002287999A patent/CA2287999A1/en not_active Abandoned
- 1998-04-28 DE DE69802923T patent/DE69802923T2/de not_active Expired - Fee Related
- 1998-04-28 EP EP98921953A patent/EP0983266B1/en not_active Expired - Lifetime
- 1998-04-28 BR BR9808725-8A patent/BR9808725A/pt not_active IP Right Cessation
- 1998-04-28 HU HU0003766A patent/HUP0003766A3/hu unknown
- 1998-04-28 IL IL13267798A patent/IL132677A0/xx unknown
- 1998-04-28 JP JP54796898A patent/JP2001523263A/ja active Pending
- 1998-04-28 ES ES98921953T patent/ES2168757T3/es not_active Expired - Lifetime
- 1998-04-28 TR TR1999/02719T patent/TR199902719T2/xx unknown
- 1998-04-28 NZ NZ500676A patent/NZ500676A/en unknown
- 1998-04-28 MX MXPA99009874A patent/MXPA99009874A/es unknown
- 1998-04-28 PT PT98921953T patent/PT983266E/pt unknown
- 1998-04-28 EE EEP199900475A patent/EE9900475A/xx unknown
- 1998-05-04 ZA ZA983740A patent/ZA983740B/xx unknown
1999
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Also Published As

Publication number	Publication date
NO995404D0 (no)	1999-11-04
MXPA99009874A (es)	2004-09-30
IS5237A (is)	1999-11-01
ES2168757T3 (es)	2002-06-16
ID23156A (id)	2000-03-23
CN1255130A (zh)	2000-05-31
ATE210661T1 (de)	2001-12-15
HUP0003766A3 (en)	2001-09-28
NZ500676A (en)	2001-05-25
NO995404L (no)	2000-01-05
EE9900475A (et)	2000-06-15
AU7460098A (en)	1998-11-27
CA2287999A1 (en)	1998-11-12
TR199902719T2 (xx)	2000-02-21
DE69802923T2 (de)	2002-07-04
WO1998050380A1 (en)	1998-11-12
HUP0003766A2 (en)	2001-03-28
DE69802923D1 (de)	2002-01-24
JP2001523263A (ja)	2001-11-20
DK0983266T3 (da)	2002-03-11
US6166030A (en)	2000-12-26
ZA983740B (en)	1999-02-19
EP0983266A1 (en)	2000-03-08
AR012602A1 (es)	2000-11-08
AU734394B2 (en)	2001-06-14
SE9701682D0 (sv)	1997-05-05
PT983266E (pt)	2002-05-31
KR20010012227A (ko)	2001-02-15
EP0983266B1 (en)	2001-12-12
BR9808725A (pt)	2000-07-11
PL336854A1 (en)	2000-07-17
IL132677A0 (en)	2001-03-19

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JPH09501918A (ja)	1997-02-25	酸化窒素合成酵素活性を有するアミジン誘導体
US5972927A (en)	1999-10-26	Diazepinoindoles as phosphodiesterase 4 inhibitors
AU2018207402B2 (en)	2023-09-28	Bicyclic inhibitors of histone deacetylase
EP0782567B1 (en)	1999-06-30	Isothiourea derivatives as no synthase inhibitors
RU2157802C2 (ru)	2000-10-20	Бициклические производные изотиомочевины, способ их получения и фармацевтическая композиция на их основе
SK140699A3 (en)	2000-06-12	Amidine derivatives, preparation method thereof, compositions containing them and their use for the treatment
EP0861250B1 (en)	2002-02-13	Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
US6489322B1 (en)	2002-12-03	Amidine derivatives as inhibitors of nitric oxide synthase
JP6880325B2 (ja)	2021-06-02	新規なｎ−［（ピリミジニルアミノ）プロパニル］−、ｎ−［（ピリジルアミノ）プロパニル］−およびｎ−［（ピラジニルアミノ）プロパニル］アリールカルボキサミド
SK281442B6 (sk)	2001-03-12	Bicyklické amidínové deriváty, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie
US5929085A (en)	1999-07-27	Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase
CZ388999A3 (cs)	2000-04-12	Sloučeniny
MXPA00001586A (es)	2004-09-27	Proceso para la creacion de un plano optico que genera una vision en tercera dimension.
CZ388899A3 (cs)	2000-04-12	Amidinové deriváty jako inhibitory syntasy oxidu dusnatého
US6140322A (en)	2000-10-31	Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
RU2155761C2 (ru)	2000-09-10	Бициклические производные амидина, способ их получения, фармацевтическая композиция и способ ингибирования синтетазы окиси азота
HUT77376A (hu)	1998-04-28	Biciklusos amidinszármazékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk