SK284332B6 - Lokálne anestetikum na vonkajšie použitie - Google Patents

Lokálne anestetikum na vonkajšie použitie Download PDF

Info

Publication number: SK284332B6
Authority: SK; Slovakia
Prior art keywords: topical; lidocaine; anesthetic; external use; local anesthetic
Prior art date: 1996-10-14

Application number

SK482-99A

Other languages

English (en)

Slovak (sk)

Other versions

SK48299A3 (en

Inventor

Toshio Inagi

Akira Mada

Original Assignee

Kowa Company, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-14

Filing date

1997-10-06

Publication date

2005-01-03

1997-10-06 Application filed by Kowa Company, Ltd. filed Critical Kowa Company, Ltd.

2000-01-18 Publication of SK48299A3 publication Critical patent/SK48299A3/sk

2005-01-03 Publication of SK284332B6 publication Critical patent/SK284332B6/sk

Links

230000003444 anaesthetic effect Effects 0.000 title claims abstract description 33
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 57
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 48
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims abstract description 40
229960004194 lidocaine Drugs 0.000 claims abstract description 40
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
239000004480 active ingredient Substances 0.000 claims abstract description 18
150000003839 salts Chemical class 0.000 claims abstract description 18
239000003655 absorption accelerator Substances 0.000 claims abstract description 17
229960001807 prilocaine Drugs 0.000 claims abstract description 11
MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims abstract description 11
239000003589 local anesthetic agent Substances 0.000 claims description 50
230000000699 topical effect Effects 0.000 claims description 39
125000004432 carbon atom Chemical group C* 0.000 claims description 8
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 8
235000014113 dietary fatty acids Nutrition 0.000 claims description 7
239000000194 fatty acid Substances 0.000 claims description 7
229930195729 fatty acid Natural products 0.000 claims description 7
150000004665 fatty acids Chemical group 0.000 claims description 7
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 4
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 4
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 4
239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 4
239000005642 Oleic acid Substances 0.000 claims description 4
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 4
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 4
229960002446 octanoic acid Drugs 0.000 claims description 4
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
238000010521 absorption reaction Methods 0.000 abstract description 15
238000002156 mixing Methods 0.000 abstract description 9
239000000203 mixture Substances 0.000 description 30
239000000499 gel Substances 0.000 description 22
238000009472 formulation Methods 0.000 description 19
238000002360 preparation method Methods 0.000 description 17
239000000243 solution Substances 0.000 description 14
239000008194 pharmaceutical composition Substances 0.000 description 13
238000000034 method Methods 0.000 description 12
239000006071 cream Substances 0.000 description 11
238000012360 testing method Methods 0.000 description 10
239000000546 pharmaceutical excipient Substances 0.000 description 9
241000700198 Cavia Species 0.000 description 8
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
239000004615 ingredient Substances 0.000 description 6
239000000825 pharmaceutical preparation Substances 0.000 description 6
230000000052 comparative effect Effects 0.000 description 5
150000001875 compounds Chemical class 0.000 description 5
239000002552 dosage form Substances 0.000 description 5
238000003860 storage Methods 0.000 description 5
239000003814 drug Substances 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000003002 pH adjusting agent Substances 0.000 description 4
150000005846 sugar alcohols Polymers 0.000 description 4
239000003086 colorant Substances 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000000975 dye Substances 0.000 description 3
238000011156 evaluation Methods 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
-1 for example Substances 0.000 description 3
229960005015 local anesthetics Drugs 0.000 description 3
238000000926 separation method Methods 0.000 description 3
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
206010002091 Anaesthesia Diseases 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
241000700199 Cavia porcellus Species 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
239000004372 Polyvinyl alcohol Substances 0.000 description 2
239000002250 absorbent Substances 0.000 description 2
230000002745 absorbent Effects 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
230000037005 anaesthesia Effects 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
230000008602 contraction Effects 0.000 description 2
238000002845 discoloration Methods 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
239000008240 homogeneous mixture Substances 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
239000011259 mixed solution Substances 0.000 description 2
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
239000002674 ointment Substances 0.000 description 2
229920002451 polyvinyl alcohol Polymers 0.000 description 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
238000013112 stability test Methods 0.000 description 2
OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
WZSPWMATVLBWRS-UHFFFAOYSA-N 2-(diethylamino)-n-(2,6-dimethylphenyl)acetamide;n-(2-methylphenyl)-2-(propylamino)propanamide Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C WZSPWMATVLBWRS-UHFFFAOYSA-N 0.000 description 1
HUSXNIFVQFHSEA-UHFFFAOYSA-N 2-hydroxypropanoic acid;hydrochloride Chemical compound Cl.CC(O)C(O)=O HUSXNIFVQFHSEA-UHFFFAOYSA-N 0.000 description 1
235000009328 Amaranthus caudatus Nutrition 0.000 description 1
240000001592 Amaranthus caudatus Species 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920001328 Polyvinylidene chloride Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
235000020661 alpha-linolenic acid Nutrition 0.000 description 1
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
235000012735 amaranth Nutrition 0.000 description 1
239000004178 amaranth Substances 0.000 description 1
229940035674 anesthetics Drugs 0.000 description 1
238000010171 animal model Methods 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
229960000541 cetyl alcohol Drugs 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000002951 depilatory effect Effects 0.000 description 1
230000008021 deposition Effects 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
XLYOFNOQVPJJNP-DYCDLGHISA-N deuterium hydrogen oxide Chemical compound [2H]O XLYOFNOQVPJJNP-DYCDLGHISA-N 0.000 description 1
LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 1
229940043276 diisopropanolamine Drugs 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000004744 fabric Substances 0.000 description 1
239000003193 general anesthetic agent Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
238000011835 investigation Methods 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
229960004393 lidocaine hydrochloride Drugs 0.000 description 1
YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
229960004488 linolenic acid Drugs 0.000 description 1
KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
229940048276 new coccine Drugs 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000003883 ointment base Substances 0.000 description 1
235000021313 oleic acid Nutrition 0.000 description 1
239000002304 perfume Substances 0.000 description 1
GVKCHTBDSMQENH-UHFFFAOYSA-L phloxine B Chemical compound [Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 GVKCHTBDSMQENH-UHFFFAOYSA-L 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000005033 polyvinylidene chloride Substances 0.000 description 1
235000012731 ponceau 4R Nutrition 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
BJPJNTKRKALCPP-UHFFFAOYSA-N prilocaine hydrochloride Chemical compound [Cl-].CCC[NH2+]C(C)C(=O)NC1=CC=CC=C1C BJPJNTKRKALCPP-UHFFFAOYSA-N 0.000 description 1
229960005094 prilocaine hydrochloride Drugs 0.000 description 1
239000008213 purified water Substances 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000012552 review Methods 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
External Artificial Organs (AREA)
Cyclones (AREA)

SK482-99A 1996-10-14 1997-10-06 Lokálne anestetikum na vonkajšie použitie SK284332B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP27081396		1996-10-14
PCT/JP1997/003567 WO1998016212A1 (en)	1996-10-14	1997-10-06	Local anesthetic for external use

Publications (2)

Publication Number	Publication Date
SK48299A3 SK48299A3 (en)	2000-01-18
SK284332B6 true SK284332B6 (sk)	2005-01-03

Family

ID=17491384

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK482-99A SK284332B6 (sk)	1996-10-14	1997-10-06	Lokálne anestetikum na vonkajšie použitie

Country Status (31)

Country	Link
US (1)	US6429228B1 (de)
EP (1)	EP0957906B1 (de)
JP (1)	JP2001503035A (de)
KR (1)	KR20000049125A (de)
CN (1)	CN1135104C (de)
AT (1)	ATE214599T1 (de)
AU (1)	AU731946B2 (de)
BG (1)	BG103325A (de)
BR (1)	BR9711911A (de)
CA (1)	CA2268535A1 (de)
CZ (1)	CZ129899A3 (de)
DE (1)	DE69711237T2 (de)
DK (1)	DK0957906T3 (de)
EA (1)	EA001611B1 (de)
EE (1)	EE03743B1 (de)
ES (1)	ES2173485T3 (de)
HU (1)	HUP9904109A3 (de)
ID (1)	ID21773A (de)
IL (1)	IL129335A (de)
LT (1)	LT4585B (de)
MY (1)	MY118301A (de)
NO (1)	NO991731L (de)
NZ (1)	NZ335056A (de)
PL (1)	PL332724A1 (de)
PT (1)	PT957906E (de)
RO (1)	RO120604B1 (de)
SK (1)	SK284332B6 (de)
TR (1)	TR199900814T2 (de)
TW (1)	TW450815B (de)
WO (1)	WO1998016212A1 (de)
YU (1)	YU19399A (de)

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KR102080860B1 (ko) *	2018-04-11	2020-02-24	숭실대학교산학협력단	미세구조의 피부 흡수 증강제, 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제, 및 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제를 이용한 마취 방법
CN110090197A (zh) *	2019-04-19	2019-08-06	广州芮一生物科技有限公司	一种可成膜的麻醉面膜膏

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1997
- 1997-10-06 JP JP10518171A patent/JP2001503035A/ja not_active Ceased
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- 1997-10-06 PL PL97332724A patent/PL332724A1/xx unknown
- 1997-10-06 DK DK97942259T patent/DK0957906T3/da active
- 1997-10-06 BR BR9711911-3A patent/BR9711911A/pt not_active IP Right Cessation
- 1997-10-06 CZ CZ991298A patent/CZ129899A3/cs unknown
- 1997-10-06 DE DE69711237T patent/DE69711237T2/de not_active Expired - Lifetime
- 1997-10-06 KR KR1019990703209A patent/KR20000049125A/ko not_active Ceased
- 1997-10-06 PT PT97942259T patent/PT957906E/pt unknown
- 1997-10-06 TR TR1999/00814T patent/TR199900814T2/xx unknown
- 1997-10-06 CN CNB97180639XA patent/CN1135104C/zh not_active Expired - Fee Related
- 1997-10-06 AT AT97942259T patent/ATE214599T1/de not_active IP Right Cessation
- 1997-10-06 RO RO99-00416A patent/RO120604B1/ro unknown
- 1997-10-06 ES ES97942259T patent/ES2173485T3/es not_active Expired - Lifetime
- 1997-10-06 AU AU43996/97A patent/AU731946B2/en not_active Ceased
- 1997-10-06 NZ NZ335056A patent/NZ335056A/xx unknown
- 1997-10-06 HU HU9904109A patent/HUP9904109A3/hu unknown
- 1997-10-06 WO PCT/JP1997/003567 patent/WO1998016212A1/en not_active Ceased
- 1997-10-06 US US09/284,124 patent/US6429228B1/en not_active Expired - Fee Related
- 1997-10-06 EE EEP199900144A patent/EE03743B1/xx not_active IP Right Cessation
- 1997-10-06 EP EP97942259A patent/EP0957906B1/de not_active Expired - Lifetime
- 1997-10-06 EA EA199900376A patent/EA001611B1/ru not_active IP Right Cessation
- 1997-10-06 ID IDW990176A patent/ID21773A/id unknown
- 1997-10-06 YU YU19399A patent/YU19399A/sh unknown
- 1997-10-06 SK SK482-99A patent/SK284332B6/sk unknown
- 1997-10-06 CA CA002268535A patent/CA2268535A1/en not_active Abandoned
- 1997-10-10 MY MYPI97004764A patent/MY118301A/en unknown
- 1997-10-13 TW TW086114947A patent/TW450815B/zh not_active IP Right Cessation
1999
- 1999-04-13 NO NO991731A patent/NO991731L/no not_active Application Discontinuation
- 1999-04-13 BG BG103325A patent/BG103325A/xx unknown
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Also Published As

Publication number	Publication date
EP0957906B1 (de)	2002-03-20
DK0957906T3 (da)	2002-05-27
DE69711237D1 (de)	2002-04-25
MY118301A (en)	2004-09-30
IL129335A (en)	2004-08-31
RO120604B1 (ro)	2006-05-30
ATE214599T1 (de)	2002-04-15
AU4399697A (en)	1998-05-11
EE03743B1 (et)	2002-06-17
EE9900144A (et)	1999-12-15
YU19399A (sh)	2001-09-28
DE69711237T2 (de)	2002-10-17
LT99036A (en)	1999-07-26
JP2001503035A (ja)	2001-03-06
IL129335A0 (en)	2000-02-17
ID21773A (id)	1999-07-22
WO1998016212A1 (en)	1998-04-23
NZ335056A (en)	2000-08-25
CZ129899A3 (cs)	1999-09-15
TR199900814T2 (xx)	1999-07-21
TW450815B (en)	2001-08-21
HUP9904109A2 (hu)	2000-04-28
US6429228B1 (en)	2002-08-06
ES2173485T3 (es)	2002-10-16
LT4585B (lt)	1999-12-27
EP0957906A1 (de)	1999-11-24
BG103325A (en)	2000-01-31
PT957906E (pt)	2002-07-31
CA2268535A1 (en)	1998-04-23
NO991731D0 (no)	1999-04-13
BR9711911A (pt)	2000-01-18
AU731946B2 (en)	2001-04-05
SK48299A3 (en)	2000-01-18
EA001611B1 (ru)	2001-06-25
NO991731L (no)	1999-06-14
EA199900376A1 (ru)	1999-10-28
CN1135104C (zh)	2004-01-21
PL332724A1 (en)	1999-10-11
CN1240353A (zh)	2000-01-05
HUP9904109A3 (en)	2000-11-28
KR20000049125A (ko)	2000-07-25

Publication	Publication Date	Title
SK48299A3 (en)	2000-01-18	Local anesthetic for external use
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DE69715049T2 (de)	2003-04-03	Tranilast enthaltendes externum und verfahren zu dessen herstellung
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JP7190538B2 (ja)	2022-12-15	医薬組成物
JP2001199883A (ja)	2001-07-24	消炎鎮痛外用剤
JPS58185514A (ja)	1983-10-29	新規な局所用消炎鎮痛ゲル状クリ−ム剤
JP2013087084A (ja)	2013-05-13	含嗽剤用液体組成物
JPH0640947A (ja)	1994-02-15	経皮吸収製剤用組成物および経皮吸収製剤
JP2019006737A (ja)	2019-01-17	医薬組成物
JP2003335663A (ja)	2003-11-25	消炎鎮痛外用剤
JPS5883622A (ja)	1983-05-19	消炎鎮痛ゲル状クリーム剤
KR20090074158A (ko)	2009-07-06	디하이드로피리딘 칼슘 길항제를 포함하는 국소성 조성물
JPH0276816A (ja)	1990-03-16	外用剤
JPH0696527B2 (ja)	1994-11-30	消炎鎮痛ゲル剤
EP0367586B1 (de)	1992-06-17	Primycin-Lösungen
KR20260006651A (ko)	2026-01-13	안정성이 개선된 페놀 유도체의 약학적 조성물 및 그의 용도
JPH0121131B2 (de)	1989-04-19
JP2516481B2 (ja)	1996-07-24	消炎鎮痛ゲル製剤
TW200418516A (en)	2004-10-01	Droplet dispersed ointment
JPH11199485A (ja)	1999-07-27	抗真菌持続性外用剤
JPH03287529A (ja)	1991-12-18	レフェタミンの経皮吸収製剤
JPS60166617A (ja)	1985-08-29	塩酸ニカルジピン外用剤
JP2004307515A (ja)	2004-11-04	消炎鎮痛外用剤
JPS6341367B2 (de)	1988-08-17