SK595390A3 - Pharmaceutical composition with antimycotic activity - Google Patents

Pharmaceutical composition with antimycotic activity Download PDF

Info

Publication number: SK595390A3
Authority: SK; Slovakia
Prior art keywords: weight; polyethylene glycol; tetrahydrofurfuryl; pharmaceutical preparation; preparation according
Prior art date: 1989-11-29

Application number

SK5953-90A

Other languages

English (en)

Slovak (sk)

Other versions

SK280599B6 (sk

Inventor

Walter Fries

Original Assignee

Mack Chem Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-29

Filing date

1990-11-29

Publication date

2000-04-10

1990-11-29 Application filed by Mack Chem Pharm filed Critical Mack Chem Pharm

2000-04-10 Publication of SK280599B6 publication Critical patent/SK280599B6/sk

2000-04-10 Publication of SK595390A3 publication Critical patent/SK595390A3/sk

Links

239000008194 pharmaceutical composition Substances 0.000 title claims description 8
230000001857 anti-mycotic effect Effects 0.000 title description 3
229920001223 polyethylene glycol Polymers 0.000 claims abstract description 22
239000002202 Polyethylene glycol Substances 0.000 claims abstract description 21
239000002904 solvent Substances 0.000 claims abstract description 17
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
229910052801 chlorine Inorganic materials 0.000 claims abstract description 9
229910052731 fluorine Inorganic materials 0.000 claims abstract description 9
229910052794 bromium Inorganic materials 0.000 claims abstract description 7
125000001424 substituent group Chemical group 0.000 claims abstract description 5
229910052740 iodine Inorganic materials 0.000 claims abstract description 4
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims abstract description 3
239000000825 pharmaceutical preparation Substances 0.000 claims abstract 6
125000006353 oxyethylene group Chemical group 0.000 claims description 9
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 7
239000000460 chlorine Substances 0.000 claims description 7
239000004480 active ingredient Substances 0.000 claims description 6
239000011737 fluorine Substances 0.000 claims description 6
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 5
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 5
229940042055 systemic antimycotics triazole derivative Drugs 0.000 claims description 4
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
230000000843 anti-fungal effect Effects 0.000 claims description 3
239000011630 iodine Substances 0.000 claims description 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
150000001875 compounds Chemical class 0.000 abstract description 8
238000007911 parenteral administration Methods 0.000 abstract description 7
-1 and C1 to C4 Chemical group 0.000 abstract description 6
239000003814 drug Substances 0.000 abstract description 4
229940079593 drug Drugs 0.000 abstract description 3
125000000217 alkyl group Chemical group 0.000 abstract description 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000000243 solution Substances 0.000 description 15
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 9
239000013543 active substance Substances 0.000 description 6
239000000203 mixture Substances 0.000 description 6
229910052757 nitrogen Inorganic materials 0.000 description 6
239000007927 intramuscular injection Substances 0.000 description 5
238000010255 intramuscular injection Methods 0.000 description 5
241001465754 Metazoa Species 0.000 description 4
ZSGIJNNWWQMATG-UHFFFAOYSA-N 6-[(2,4-dichlorophenoxy)methyl]-3-[4-[6-[(2,4-dichlorophenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]butyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Chemical compound ClC1=CC(Cl)=CC=C1OCC(S1)=NN2C1=NN=C2CCCCC1=NN=C2N1N=C(COC=1C(=CC(Cl)=CC=1)Cl)S2 ZSGIJNNWWQMATG-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
235000019445 benzyl alcohol Nutrition 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
230000001954 sterilising effect Effects 0.000 description 3
238000004659 sterilization and disinfection Methods 0.000 description 3
238000003756 stirring Methods 0.000 description 3
239000000126 substance Substances 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 description 2
229920002556 Polyethylene Glycol 300 Polymers 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
230000000740 bleeding effect Effects 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
230000000302 ischemic effect Effects 0.000 description 2
230000017074 necrotic cell death Effects 0.000 description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
YNRGDPQTVDWXPB-UHFFFAOYSA-N 3-(1,2,4-triazol-3-ylidene)-1,2,4-triazole Chemical class N1=NC=NC1=C1N=NC=N1 YNRGDPQTVDWXPB-UHFFFAOYSA-N 0.000 description 1
125000006306 4-iodophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1I 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
206010018910 Haemolysis Diseases 0.000 description 1
OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
241000700159 Rattus Species 0.000 description 1
239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 description 1
239000002543 antimycotic Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000005587 bubbling Effects 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
230000008588 hemolysis Effects 0.000 description 1
230000002949 hemolytic effect Effects 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
AQYSYJUIMQTRMV-UHFFFAOYSA-N hypofluorous acid Chemical group FO AQYSYJUIMQTRMV-UHFFFAOYSA-N 0.000 description 1
230000007794 irritation Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
210000001087 myotubule Anatomy 0.000 description 1
239000003182 parenteral nutrition solution Substances 0.000 description 1
239000002831 pharmacologic agent Substances 0.000 description 1
229940068886 polyethylene glycol 300 Drugs 0.000 description 1
102220063383 rs786204916 Human genes 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
230000019432 tissue death Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

SK5953-90A 1989-11-29 1990-11-29 Pharmaceutical composition with antimycotic activity SK595390A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3939492A DE3939492A1 (de)	1989-11-29	1989-11-29	Pharmazeutische zubereitungen

Publications (2)

Publication Number	Publication Date
SK280599B6 SK280599B6 (sk)	2000-04-10
SK595390A3 true SK595390A3 (en)	2000-04-10

Family

ID=6394433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK5953-90A SK595390A3 (en)	1989-11-29	1990-11-29	Pharmaceutical composition with antimycotic activity

Country Status (29)

Country	Link
US (1)	US5118698A (fr)
EP (1)	EP0430149B1 (fr)
JP (1)	JPH0660097B2 (fr)
KR (1)	KR940000066B1 (fr)
CN (1)	CN1035357C (fr)
AT (1)	ATE102051T1 (fr)
AU (1)	AU626480B2 (fr)
BR (1)	BR9006025A (fr)
CA (1)	CA2030911C (fr)
CY (1)	CY1970A (fr)
CZ (1)	CZ282898B6 (fr)
DE (2)	DE3939492A1 (fr)
DK (1)	DK0430149T3 (fr)
EG (1)	EG19557A (fr)
ES (1)	ES2062271T3 (fr)
FI (1)	FI103713B1 (fr)
HK (1)	HK216896A (fr)
HU (1)	HU220867B1 (fr)
IE (1)	IE64672B1 (fr)
IL (1)	IL96450A (fr)
MX (1)	MX23518A (fr)
MY (1)	MY104540A (fr)
NO (1)	NO180475C (fr)
NZ (1)	NZ236255A (fr)
PT (1)	PT96003B (fr)
RU (1)	RU2038080C1 (fr)
SK (1)	SK595390A3 (fr)
YU (1)	YU227290A (fr)
ZA (1)	ZA909549B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE164080T1 (de) *	1990-05-10	1998-04-15	Bechgaard Int Res	Pharmazeutische zubereitung enthaltend n- glykofurole und n-äthylenglykole
US5397771A (en) *	1990-05-10	1995-03-14	Bechgaard International Research And Development A/S	Pharmaceutical preparation
JP3485540B2 (ja) *	2000-12-28	2004-01-13	新日本製鐵株式会社	低騒音トランス
WO2002067899A1 (fr) *	2001-02-28	2002-09-06	Akzo Nobel N.V.	Emulsions de type huileux injectables
EP1471887B1 (fr)	2002-02-04	2010-04-21	Elan Pharma International Ltd.	Compositions nanoparticulaires a stabilisateur superficiel de lysozyme
EP2283864A1 (fr) *	2002-07-16	2011-02-16	Elan Pharma International Ltd.	Composition liquide contenant des nanoparticules stabilisées d'une substance active

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1196284A (fr) *	1982-05-28	1985-11-05	Joshua Oduro-Yeboah	Produits pharmaceutiques
GR79307B (fr) *	1982-06-09	1984-10-22	Pfizer
DK476385A (da) *	1984-10-19	1986-04-20	Schering Corp	1,3-bis(1h-1,2,4-triazol-1-yl)-2-flour-2-(2,4-difluorphenyl)propan, antifungale midler indeholdende denne forbindelse, og fremgangsmaade til fremstilling af denne forbindelse

1989
- 1989-11-29 DE DE3939492A patent/DE3939492A1/de not_active Withdrawn
1990
- 1990-11-22 IL IL9645090A patent/IL96450A/en not_active IP Right Cessation
- 1990-11-24 MY MYPI90002080A patent/MY104540A/en unknown
- 1990-11-26 AT AT90122574T patent/ATE102051T1/de not_active IP Right Cessation
- 1990-11-26 EP EP90122574A patent/EP0430149B1/fr not_active Expired - Lifetime
- 1990-11-26 NO NO905106A patent/NO180475C/no unknown
- 1990-11-26 DK DK90122574.8T patent/DK0430149T3/da active
- 1990-11-26 FI FI905814A patent/FI103713B1/fi active IP Right Grant
- 1990-11-26 ES ES90122574T patent/ES2062271T3/es not_active Expired - Lifetime
- 1990-11-26 JP JP2322243A patent/JPH0660097B2/ja not_active Expired - Lifetime
- 1990-11-26 DE DE69007029T patent/DE69007029T2/de not_active Expired - Fee Related
- 1990-11-27 KR KR1019900019249A patent/KR940000066B1/ko not_active Expired - Fee Related
- 1990-11-27 PT PT96003A patent/PT96003B/pt not_active IP Right Cessation
- 1990-11-27 CA CA002030911A patent/CA2030911C/fr not_active Expired - Fee Related
- 1990-11-27 US US07/618,438 patent/US5118698A/en not_active Expired - Lifetime
- 1990-11-28 ZA ZA909549A patent/ZA909549B/xx unknown
- 1990-11-28 IE IE428290A patent/IE64672B1/en not_active IP Right Cessation
- 1990-11-28 MX MX2351890A patent/MX23518A/es unknown
- 1990-11-28 EG EG71290A patent/EG19557A/xx active
- 1990-11-28 HU HU682/90A patent/HU220867B1/hu not_active IP Right Cessation
- 1990-11-28 NZ NZ236255A patent/NZ236255A/en unknown
- 1990-11-28 BR BR909006025A patent/BR9006025A/pt not_active Application Discontinuation
- 1990-11-28 RU SU904831852A patent/RU2038080C1/ru not_active IP Right Cessation
- 1990-11-28 AU AU67065/90A patent/AU626480B2/en not_active Ceased
- 1990-11-28 CN CN90109689A patent/CN1035357C/zh not_active Expired - Fee Related
- 1990-11-28 YU YU227290A patent/YU227290A/sh unknown
- 1990-11-29 CZ CS905953A patent/CZ282898B6/cs not_active IP Right Cessation
- 1990-11-29 SK SK5953-90A patent/SK595390A3/sk unknown
1996
- 1996-12-19 HK HK216896A patent/HK216896A/en not_active IP Right Cessation
1997
- 1997-09-05 CY CY197097A patent/CY1970A/xx unknown

Also Published As

Publication number	Publication date
EP0430149A3 (en)	1991-09-25
DK0430149T3 (da)	1994-03-28
PT96003A (pt)	1991-09-13
DE3939492A1 (de)	1991-06-06
NO905106L (no)	1991-05-30
DE69007029T2 (de)	1994-06-09
NO905106D0 (no)	1990-11-26
CN1035357C (zh)	1997-07-09
KR910009286A (ko)	1991-06-28
AU6706590A (en)	1991-08-08
HUT57039A (en)	1991-11-28
NO180475C (no)	1997-04-30
PT96003B (pt)	1998-01-30
IL96450A (en)	1994-10-21
EG19557A (en)	1997-08-31
EP0430149A2 (fr)	1991-06-05
CY1970A (en)	1997-09-05
HK216896A (en)	1996-12-27
EP0430149B1 (fr)	1994-03-02
JPH03176421A (ja)	1991-07-31
KR940000066B1 (ko)	1994-01-05
RU2038080C1 (ru)	1995-06-27
ATE102051T1 (de)	1994-03-15
YU227290A (sh)	1993-10-20
CA2030911C (fr)	1995-02-07
FI905814L (fi)	1991-05-30
SK280599B6 (sk)	2000-04-10
ZA909549B (en)	1992-06-24
AU626480B2 (en)	1992-07-30
IE904282A1 (en)	1991-06-05
CA2030911A1 (fr)	1991-05-30
JPH0660097B2 (ja)	1994-08-10
HU220867B1 (en)	2002-06-29
CZ595390A3 (en)	1997-06-11
BR9006025A (pt)	1991-09-24
US5118698A (en)	1992-06-02
IE64672B1 (en)	1995-08-23
CZ282898B6 (cs)	1997-11-12
MY104540A (en)	1994-04-30
ES2062271T3 (es)	1994-12-16
FI103713B (fi)	1999-08-31
NO180475B (no)	1997-01-20
DE69007029D1 (de)	1994-04-07
FI103713B1 (fi)	1999-08-31
NZ236255A (en)	1992-02-25
MX23518A (es)	1993-04-01
CN1052046A (zh)	1991-06-12
FI905814A0 (fi)	1990-11-26

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