SMT201600281B - Trattamento di disturbi correlati a bdnf usando laquinimod - Google Patents

Trattamento di disturbi correlati a bdnf usando laquinimod

Info

Publication number: SMT201600281B
Authority: SM; San Marino
Prior art keywords: laquinimod; bdnf; treatment; related disorders; disorders
Prior art date: 2009-08-10

Application number

SM201600281T

Other languages

English (en)

Inventor

Liat Hayardeny

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-08-10

Filing date

2016-08-18

Publication date

2016-11-10

2016-08-18 Application filed by Teva Pharma filed Critical Teva Pharma

2016-11-10 Publication of SMT201600281B publication Critical patent/SMT201600281B/it

Links

102000004219 Brain-derived neurotrophic factor Human genes 0.000 title 1
108090000715 Brain-derived neurotrophic factor Proteins 0.000 title 1
GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 title 1
229960004577 laquinimod Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SM201600281T 2009-08-10 2016-08-18 Trattamento di disturbi correlati a bdnf usando laquinimod SMT201600281B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27392009P	2009-08-10	2009-08-10
PCT/US2010/002194 WO2011019375A1 (en)	2009-08-10	2010-08-09	Treatment of bdnf-related disorders using laquinimod

Publications (1)

Publication Number	Publication Date
SMT201600281B true SMT201600281B (it)	2016-11-10

Family

ID=43535297

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM201600281T SMT201600281B (it)	2009-08-10	2016-08-18	Trattamento di disturbi correlati a bdnf usando laquinimod

Country Status (19)

Country	Link
US (3)	US9585878B2 (it)
EP (2)	EP3064206B1 (it)
JP (1)	JP5859438B2 (it)
AU (2)	AU2010282948C1 (it)
CA (1)	CA2771203C (it)
CY (1)	CY1117916T1 (it)
DK (1)	DK2467372T3 (it)
ES (2)	ES2586843T3 (it)
HK (1)	HK1225970A1 (it)
HR (1)	HRP20160997T1 (it)
HU (1)	HUE029983T2 (it)
IL (1)	IL217901B (it)
ME (1)	ME02495B (it)
PL (2)	PL3064206T3 (it)
PT (1)	PT2467372T (it)
RS (1)	RS55071B1 (it)
SI (1)	SI2467372T1 (it)
SM (1)	SMT201600281B (it)
WO (1)	WO2011019375A1 (it)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ567088A (en) *	2005-10-19	2012-06-29	Teva Pharma	Crystals of laquinimod sodium, and process for the manufacture thereof
KR20150065951A (ko)	2006-06-12	2015-06-15	테바 파마슈티컬 인더스트리즈 리미티드	안정한 라퀴니모드 제제
EP2234485B1 (en)	2007-12-20	2013-11-13	Teva Pharmaceutical Industries, Ltd.	Stable laquinimod preparations
KR20110048571A (ko) *	2008-09-03	2011-05-11	테바 파마슈티컬 인더스트리즈 리미티드	면역 기능을 지닌 ２―옥소―１,２―다이하이드로―퀴놀린 조절제
PL2458992T3 (pl) *	2009-07-30	2016-07-29	Teva Pharma	Leczenie choroby Leśniowskiego-Crohna z użyciem lakwinimodu
WO2011019375A1 (en) *	2009-08-10	2011-02-17	Teva Pharmaceutical Industries Ltd.	Treatment of bdnf-related disorders using laquinimod
DK2542079T3 (da) *	2010-03-03	2014-08-25	Teva Pharma	Behandling af reumatoid artritis med en kombination af laquinimod og methotrexat
CA2791711A1 (en) *	2010-03-03	2011-09-09	Teva Pharmaceutical Industries Ltd.	Treatment of lupus arthritis using laquinimod
SG183512A1 (en) *	2010-03-03	2012-09-27	Teva Pharma	Treatment of lupus nephritis using laquinimod
WO2012006538A1 (en)	2010-07-09	2012-01-12	Teva Pharmaceutical Industries Ltd.	Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof
IN2014MN00333A (it) *	2011-07-28	2015-09-25	Teva Pharma
CA2851525A1 (en)	2011-10-12	2013-04-18	Teva Pharmaceutical Industries Ltd.	Treatment of multiple sclerosis with combination of laquinimod and fingolimod
CN104093310A (zh)	2012-02-03	2014-10-08	泰华制药工业有限公司	拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
JP6215238B2 (ja)	2012-02-16	2017-10-18	テバファーマシューティカルインダストリーズリミティド	Ｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４，５−ジ−ヒドロキシ−１−メチル−２−オキソ−３−キノリンカルボキサミド、その製剤、および使用
TW201350467A (zh)	2012-05-08	2013-12-16	Teva Pharma	Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh) *	2012-06-05	2014-01-01	Teva Pharma	使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) *	2012-08-13	2014-03-16	Teva Pharma	用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
TW201410243A (zh) *	2012-08-13	2014-03-16	Teva Pharma	用於治療大麻素受體型１（ｃｂ１）媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
MX2015003608A (es) *	2012-09-27	2015-06-05	Teva Pharma	Combinacion de laquinimod y pridopidina para tratar trastornos neurodegenerativos.
BR112015007782A2 (pt) *	2012-10-12	2017-07-04	Teva Pharma	laquinimod para reduzir danos talâmicos na esclerose múltipla
EP2916915A4 (en)	2012-11-07	2016-06-22	Teva Pharma	LAQUINIMOD AMINE SALTS
US20160046582A1 (en)	2013-03-14	2016-02-18	Teva Pharmaceutical Industries Ltd.	Crystals of laquinimod sodium and improved process for the manufacture thereof
US20160038435A1 (en)	2013-03-14	2016-02-11	Teva Pharmaceutical Industries Ltd.	Transdermal formulations of laquinimod
EP3068395A4 (en) *	2013-11-15	2017-07-12	Teva Pharmaceutical Industries Ltd.	Treatment of glaucoma using laquinimod
CA2933380A1 (en) *	2013-12-20	2015-06-25	Esther Lukasiewicz Hagai	Use of laquinimod to delay huntington's disease progression
WO2015168103A1 (en)	2014-04-29	2015-11-05	Teva Pharmaceutical Industries Ltd.	Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
EP3193870A4 (en) *	2014-09-16	2018-04-25	Teva Pharmaceutical Industries Ltd.	Treatment of neurodegenerative diseases with combination of laquinimod and fingolimod
US20210315865A1 (en) *	2018-08-16	2021-10-14	Biohaven Therapeutics Ltd.	Use of riluzole oral disintigrating tablets for treating diseases

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3024257A (en)	1961-04-10	1962-03-06	Frosst & Co Charles E	Stable preparations of alkali metal salts of estrone sulfate
FR2340735A1 (fr)	1976-02-11	1977-09-09	Roussel Uclaf	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
IE52670B1 (en)	1981-03-03	1988-01-20	Leo Ab	Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
DE3437232A1 (de)	1984-10-10	1986-04-17	Mack Chem Pharm	Stabilisierte injektionsloesungen von piroxicam
US4737971A (en) *	1986-04-07	1988-04-12	American Telephone And Telegraph Company	Synchronization detection circuit
US5540934A (en)	1994-06-22	1996-07-30	Touitou; Elka	Compositions for applying active substances to or through the skin
US5912349A (en)	1997-01-31	1999-06-15	Pharmacia & Upjohn Company	Process for the preparation of roquinimex
US20030124187A1 (en)	1997-02-14	2003-07-03	Smithkline Beecham Laboratoires Pharmaceutiques,	Pharmaceutical formulations comprising amoxycillin and clavulanate
US6696407B1 (en) *	1997-03-21	2004-02-24	The Regents Of The University Of California	Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF
SE9801474D0 (sv)	1998-04-27	1998-04-27	Active Biotech Ab	Quinoline Derivatives
US6077851A (en) *	1998-04-27	2000-06-20	Active Biotech Ab	Quinoline derivatives
US6121287A (en)	1998-07-15	2000-09-19	Active Biotech Ab	Quinoline derivatives
SE9802549D0 (sv)	1998-07-15	1998-07-15	Active Biotech Ab	Quinoline derivatives
US6133285A (en)	1998-07-15	2000-10-17	Active Biotech Ab	Quinoline derivatives
SE9802550D0 (sv)	1998-07-15	1998-07-15	Active Biotech Ab	Quinoline derivatives
PL199781B1 (pl)	1999-10-25	2008-10-31	Active Biotech Ab	Nowe związki pochodne chinoliny, zastosowanie związków pochodnych chinoliny, zawierające je kompozycje farmaceutyczne i sposób ich wytwarzania
JP2002003401A (ja) *	2000-06-27	2002-01-09	Japan Science & Technology Corp	脳由来神経栄養因子誘導剤
EP1365794A2 (en)	2000-07-21	2003-12-03	Lue, Tom	Prevention and treatment of sexual arousal disorders
US6307050B1 (en)	2000-08-29	2001-10-23	R. T. Alamo Venture I Llc	Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6802422B2 (en)	2000-12-12	2004-10-12	Multi-Comp, Inc.	Sealed blister assembly
US6706733B2 (en)	2001-05-08	2004-03-16	Dainippon Ink And Chemicals, Inc.	Quinolinone derivative formulation and its production method
US20030119826A1 (en)	2001-09-24	2003-06-26	Pharmacia Corporation	Neuroprotective treatment methods using selective iNOS inhibitors
US6875869B2 (en)	2002-06-12	2005-04-05	Active Biotech Ab	Process for the manufacture of quinoline derivatives
SE0201778D0 (sv)	2002-06-12	2002-06-12	Active Biotech Ab	Process for the manufacture of quinoline derivatives
US7560557B2 (en)	2002-06-12	2009-07-14	Active Biotech Ag	Process for the manufacture of quinoline derivatives
US7820145B2 (en)	2003-08-04	2010-10-26	Foamix Ltd.	Oleaginous pharmaceutical and cosmetic foam
US20070292461A1 (en)	2003-08-04	2007-12-20	Foamix Ltd.	Oleaginous pharmaceutical and cosmetic foam
US7790197B2 (en)	2003-06-09	2010-09-07	Warner-Lambert Company Llc	Pharmaceutical compositions of atorvastatin
US20050271717A1 (en)	2003-06-12	2005-12-08	Alfred Berchielli	Pharmaceutical compositions of atorvastatin
US7605166B2 (en)	2003-06-25	2009-10-20	Elan Pharmaceuticals Inc.	Methods and compositions for treating rheumatoid arthritis
SE0400235D0 (sv)	2004-02-06	2004-02-06	Active Biotech Ab	New composition containing quinoline compounds
US8314124B2 (en)	2004-02-06	2012-11-20	Active Biotech Ab	Crystalline salts of quinoline compounds and methods for preparing them
WO2005097162A2 (en)	2004-04-01	2005-10-20	Elan Pharmaceuticals, Inc.	Steroid sparing agents and their use
EP1796710A4 (en)	2004-09-02	2010-05-26	Teva Pharma	THERAPY COMBINED WITH GLATIRAMER ACETATE AND N-ACETYLCYSTEINE TO TREAT MULTIPLE SCLEROSIS
HRP20160455T1 (hr) *	2004-09-09	2016-07-15	Yeda Research And Development Co., Ltd.	Smjese polipeptida, sastavi koji ih sadrže i postupci za njihovu pripremu, te njihove primjene
US20060205822A1 (en)	2004-12-22	2006-09-14	Forest Laboratories, Inc.	1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
WO2007142667A2 (en)	2005-10-13	2007-12-13	Human Genome Sciences, Inc.	Treatment of patients with autoantibody positive disease
US9168286B2 (en)	2005-10-13	2015-10-27	Human Genome Sciences, Inc.	Methods and compositions for use in treatment of patients with autoantibody positive disease
NZ567088A (en)	2005-10-19	2012-06-29	Teva Pharma	Crystals of laquinimod sodium, and process for the manufacture thereof
WO2007048788A1 (en)	2005-10-26	2007-05-03	Laboratoires Serono S.A.	Sulfonamide derivatives and use thereof for the modulation of metalloproteinases
US8367629B2 (en)	2006-02-14	2013-02-05	Noxxon Pharma Ag	MCP-1 binding nucleic acids and use thereof
US20070207141A1 (en)	2006-02-28	2007-09-06	Ivan Lieberburg	Methods of treating inflammatory and autoimmune diseases with natalizumab
US8410115B2 (en)	2006-02-28	2013-04-02	Elan Pharmaceuticals, Inc.	Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
MX2008011176A (es)	2006-03-03	2008-09-10	Elan Pharm Inc	Metodos para tratar padecimientos inflamatorios y autoinmunes con natalizumab.
US9399061B2 (en)	2006-04-10	2016-07-26	Abbvie Biotechnology Ltd	Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis
WO2007139887A2 (en)	2006-05-22	2007-12-06	Cargill, Incorporated	Methods for treating bone or joint inflammation
US20080118553A1 (en) *	2006-06-12	2008-05-22	Anton Frenkel	Tannate salt form of polypeptide mixtures, their preparation and use
KR20150065951A (ko)	2006-06-12	2015-06-15	테바 파마슈티컬 인더스트리즈 리미티드	안정한 라퀴니모드 제제
EP2056818B1 (en) *	2006-08-11	2011-05-25	The Johns Hopkins University	Compositions and methods for neuroprotection
HRP20121034T1 (hr)	2006-08-17	2013-01-31	University Of Chicago	Lijeäśenje upalnih bolesti
JP2010513518A (ja)	2006-12-19	2010-04-30	メリマックファーマシューティカルズインコーポレーティッド	多発性硬化症治療ためのα‐フェトプロテインおよび免疫調節作用物質の同時投与方法
US8138201B2 (en) *	2007-07-11	2012-03-20	Medicinova, Inc.	Treatment of progressive neurodegenerative disease with ibudilast
JP2009084271A (ja) *	2007-09-07	2009-04-23	Toyama Univ	脳由来神経栄養因子の発現誘導剤および発現誘導方法
EP2214657A1 (en)	2007-10-23	2010-08-11	UCB Pharma GmbH	Compounds for treating demyelination conditions
EP2234485B1 (en)	2007-12-20	2013-11-13	Teva Pharmaceutical Industries, Ltd.	Stable laquinimod preparations
KR20110048571A (ko)	2008-09-03	2011-05-11	테바 파마슈티컬 인더스트리즈 리미티드	면역 기능을 지닌 ２―옥소―１,２―다이하이드로―퀴놀린 조절제
AR073295A1 (es)	2008-09-16	2010-10-28	Genentech Inc	Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion.
NZ593090A (en) *	2008-11-13	2013-06-28	Link Medicine Corp	Azaquinolinone derivatives and uses thereof
JP2012530701A (ja)	2009-06-19	2012-12-06	テバファーマシューティカルインダストリーズリミティド	多発性硬化症のラキニモドでの治療
WO2011019375A1 (en) *	2009-08-10	2011-02-17	Teva Pharmaceutical Industries Ltd.	Treatment of bdnf-related disorders using laquinimod
DK2542079T3 (da)	2010-03-03	2014-08-25	Teva Pharma	Behandling af reumatoid artritis med en kombination af laquinimod og methotrexat
CA2791711A1 (en)	2010-03-03	2011-09-09	Teva Pharmaceutical Industries Ltd.	Treatment of lupus arthritis using laquinimod
SG183512A1 (en)	2010-03-03	2012-09-27	Teva Pharma	Treatment of lupus nephritis using laquinimod
EP2590653A4 (en)	2010-07-09	2014-01-01	Teva Pharma	5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROCHINOLINE-3-CARBOXAMIDE, SALT THEREOF AND APPLICATIONS THEREOF
WO2012006538A1 (en)	2010-07-09	2012-01-12	Teva Pharmaceutical Industries Ltd.	Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof
AU2011338647A1 (en)	2010-12-07	2013-07-04	Teva Pharmaceutical Industries Ltd.	Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients
CA2851525A1 (en)	2011-10-12	2013-04-18	Teva Pharmaceutical Industries Ltd.	Treatment of multiple sclerosis with combination of laquinimod and fingolimod

2010
- 2010-08-09 WO PCT/US2010/002194 patent/WO2011019375A1/en not_active Ceased
- 2010-08-09 SI SI201031245A patent/SI2467372T1/sl unknown
- 2010-08-09 HU HUE10808442A patent/HUE029983T2/en unknown
- 2010-08-09 PL PL16160522T patent/PL3064206T3/pl unknown
- 2010-08-09 ES ES10808442.7T patent/ES2586843T3/es active Active
- 2010-08-09 US US12/806,275 patent/US9585878B2/en active Active
- 2010-08-09 ME MEP-2016-162A patent/ME02495B/me unknown
- 2010-08-09 ES ES16160522T patent/ES2731052T3/es active Active
- 2010-08-09 PL PL10808442T patent/PL2467372T3/pl unknown
- 2010-08-09 RS RS20160664A patent/RS55071B1/sr unknown
- 2010-08-09 PT PT108084427T patent/PT2467372T/pt unknown
- 2010-08-09 EP EP16160522.5A patent/EP3064206B1/en active Active
- 2010-08-09 CA CA2771203A patent/CA2771203C/en active Active
- 2010-08-09 JP JP2012524692A patent/JP5859438B2/ja not_active Expired - Fee Related
- 2010-08-09 AU AU2010282948A patent/AU2010282948C1/en not_active Ceased
- 2010-08-09 EP EP10808442.7A patent/EP2467372B1/en active Active
- 2010-08-09 DK DK10808442.7T patent/DK2467372T3/en active
- 2010-08-09 HR HRP20160997TT patent/HRP20160997T1/hr unknown
2012
- 2012-02-02 IL IL217901A patent/IL217901B/en active IP Right Grant
2016
- 2016-02-22 US US15/049,942 patent/US20160243103A1/en not_active Abandoned
- 2016-08-16 CY CY20161100805T patent/CY1117916T1/el unknown
- 2016-08-18 SM SM201600281T patent/SMT201600281B/it unknown
- 2016-12-16 HK HK16114333.9A patent/HK1225970A1/en unknown
- 2016-12-21 AU AU2016277618A patent/AU2016277618A1/en not_active Abandoned
2017
- 2017-02-07 US US15/426,626 patent/US20170239234A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP5859438B2 (ja)	2016-02-10
SI2467372T1 (sl)	2016-09-30
HK1225970A1 (en)	2017-09-22
IL217901A0 (en)	2012-03-29
EP2467372A4 (en)	2013-01-09
AU2016277618A1 (en)	2017-01-19
EP3064206A1 (en)	2016-09-07
JP2013501784A (ja)	2013-01-17
PL3064206T3 (pl)	2020-02-28
US20110034508A1 (en)	2011-02-10
HRP20160997T1 (hr)	2016-10-07
PL2467372T3 (pl)	2017-04-28
CA2771203C (en)	2019-04-09
PT2467372T (pt)	2016-08-23
HUE029983T2 (en)	2017-04-28
RS55071B1 (sr)	2016-12-30
ES2586843T3 (es)	2016-10-19
ES2731052T3 (es)	2019-11-13
EP3064206B1 (en)	2019-03-20
AU2010282948C1 (en)	2017-03-02
CA2771203A1 (en)	2011-02-17
AU2010282948B2 (en)	2016-09-29
ME02495B (me)	2017-02-20
US20170239234A1 (en)	2017-08-24
IL217901B (en)	2018-12-31
CY1117916T1 (el)	2017-05-17
WO2011019375A1 (en)	2011-02-17
EP2467372A1 (en)	2012-06-27
AU2010282948A1 (en)	2012-04-05
DK2467372T3 (en)	2016-08-22
US9585878B2 (en)	2017-03-07
US20160243103A1 (en)	2016-08-25
EP2467372B1 (en)	2016-05-18

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