SU577982A3 - Способ получени 2-тетрагидрофурфурил6,7-бензоморфанов или их солей - Google Patents

Способ получени 2-тетрагидрофурфурил6,7-бензоморфанов или их солей

Info

Publication number: SU577982A3
Authority: SU; USSR - Soviet Union
Prior art keywords: mixture; mol; water; methanol; oxy
Prior art date: 1974-03-09

Application number

SU7502110984A

Other languages

English (en)

Russian (ru)

Inventor

Мерц Герберт

Лангбейн Адольф

Вальтер Герхард

Штокхаус Клаус

Original Assignee

К.Х.Берингер Зон (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-03-09

Filing date

1975-03-05

Publication date

1977-10-25

1975-03-05 Application filed by К.Х.Берингер Зон (Фирма) filed Critical К.Х.Берингер Зон (Фирма)

1977-10-25 Application granted granted Critical

1977-10-25 Publication of SU577982A3 publication Critical patent/SU577982A3/ru

Links

238000000034 method Methods 0.000 title description 4
150000003839 salts Chemical class 0.000 title description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 48
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 21
239000000203 mixture Substances 0.000 description 20
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 15
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 14
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
239000012452 mother liquor Substances 0.000 description 12
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 10
150000001875 compounds Chemical class 0.000 description 10
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 9
238000001953 recrystallisation Methods 0.000 description 9
239000000243 solution Substances 0.000 description 9
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
239000000126 substance Substances 0.000 description 7
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 5
229910000030 sodium bicarbonate Inorganic materials 0.000 description 5
235000017557 sodium bicarbonate Nutrition 0.000 description 5
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
239000013078 crystal Substances 0.000 description 4
238000001704 evaporation Methods 0.000 description 4
230000008020 evaporation Effects 0.000 description 4
239000002904 solvent Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 3
-1 hydrochloric acid Chemical class 0.000 description 3
239000000047 product Substances 0.000 description 3
FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000002168 alkylating agent Substances 0.000 description 2
229940100198 alkylating agent Drugs 0.000 description 2
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
229910021529 ammonia Inorganic materials 0.000 description 2
239000007795 chemical reaction product Substances 0.000 description 2
239000002026 chloroform extract Substances 0.000 description 2
230000008018 melting Effects 0.000 description 2
238000002844 melting Methods 0.000 description 2
239000010413 mother solution Substances 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
238000010992 reflux Methods 0.000 description 2
238000000926 separation method Methods 0.000 description 2
229910052938 sodium sulfate Inorganic materials 0.000 description 2
235000011152 sodium sulphate Nutrition 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000011550 stock solution Substances 0.000 description 2
VOHILFSOWRNVJJ-UHFFFAOYSA-N 2-(bromomethyl)oxolane Chemical compound BrCC1CCCO1 VOHILFSOWRNVJJ-UHFFFAOYSA-N 0.000 description 1
VBCKYDVWOPZOBA-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxymethyl)oxolane Chemical compound C1CCOC1COCC1CCCO1 VBCKYDVWOPZOBA-UHFFFAOYSA-N 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
101150066742 TRI1 gene Proteins 0.000 description 1
229910052770 Uranium Inorganic materials 0.000 description 1
230000032683 aging Effects 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
239000000292 calcium oxide Substances 0.000 description 1
ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
125000001309 chloro group Chemical group Cl* 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
239000012442 inert solvent Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
230000027939 micturition Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
239000012071 phase Substances 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
238000002791 soaking Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000009518 sodium iodide Nutrition 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
DNYWZCXLKNTFFI-UHFFFAOYSA-N uranium Chemical compound [U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U] DNYWZCXLKNTFFI-UHFFFAOYSA-N 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

SU7502110984A 1974-03-09 1975-03-05 Способ получени 2-тетрагидрофурфурил6,7-бензоморфанов или их солей SU577982A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2411382A DE2411382C3 (de)	1974-03-09	1974-03-09	2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung

Publications (1)

Publication Number	Publication Date
SU577982A3 true SU577982A3 (ru)	1977-10-25

Family

ID=5909593

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SU7502110984A SU577982A3 (ru)	1974-03-09	1975-03-05	Способ получени 2-тетрагидрофурфурил6,7-бензоморфанов или их солей
SU7502199294A SU577983A3 (ru)	1974-03-09	1975-12-19	Способ получени 2-тетрагидрофурфурил-6,7-бензоморфанов или их солей, рацематов или оптически активных антиподов
SU752199295A SU588916A3 (ru)	1974-03-09	1975-12-19	Способ получени 2-тетрагидрофурил-6,7-бензоморфанов или их солей

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
SU7502199294A SU577983A3 (ru)	1974-03-09	1975-12-19	Способ получени 2-тетрагидрофурфурил-6,7-бензоморфанов или их солей, рацематов или оптически активных антиподов
SU752199295A SU588916A3 (ru)	1974-03-09	1975-12-19	Способ получени 2-тетрагидрофурил-6,7-бензоморфанов или их солей

Country Status (25)

Country	Link
JP (1)	JPS5827275B2 (he)
AT (1)	AT344332B (he)
BE (1)	BE826440A (he)
BG (3)	BG25087A3 (he)
CA (1)	CA1049511A (he)
CH (8)	CH612425A5 (he)
CS (1)	CS188221B2 (he)
DD (1)	DD119236A5 (he)
DE (1)	DE2411382C3 (he)
DK (1)	DK137188C (he)
ES (6)	ES440345A1 (he)
FI (1)	FI63571C (he)
FR (1)	FR2262984B1 (he)
GB (1)	GB1496418A (he)
HU (1)	HU177408B (he)
IE (1)	IE40945B1 (he)
IL (1)	IL46760A (he)
NL (1)	NL7502724A (he)
NO (1)	NO141800C (he)
PH (1)	PH14127A (he)
PL (3)	PL93699B1 (he)
RO (2)	RO69617A (he)
SE (1)	SE421919B (he)
SU (3)	SU577982A3 (he)
ZA (1)	ZA751394B (he)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2716687A1 (de) *	1977-04-15	1978-10-19	Boehringer Sohn Ingelheim	2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
DE2828039A1 (de) *	1978-06-26	1980-01-10	Boehringer Sohn Ingelheim	2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
US6992107B1 (en)	1995-03-10	2006-01-31	Photocure Asa	Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US7530461B2 (en)	1995-03-10	2009-05-12	Photocure Asa	Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6492420B2 (en)	1995-03-10	2002-12-10	Photocure As	Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
DE122006000051I1 (de) *	1995-03-10	2007-01-04	Photocure Asa	Ester der 5-Aminolevulins{ure als Mittel zur Photosensibillisierung in der Chemotherapie
GB0018528D0 (en)	2000-07-27	2000-09-13	Photocure Asa	Compounds
US6723750B2 (en)	2002-03-15	2004-04-20	Allergan, Inc.	Photodynamic therapy for pre-melanomas
JP5451611B2 (ja)	2007-07-26	2014-03-26	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
US8859580B2 (en)	2007-11-16	2014-10-14	Boehringer Ingelheim International Gmbh	Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
CA2708303A1 (en)	2007-12-11	2009-06-18	Vitae Pharmaceuticals, Inc.	Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en)	2008-01-07	2009-08-16	Vitae Pharmaceuticals Inc	Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en)	2008-01-24	2009-07-30	Vitae Pharmaceuticals, Inc.	Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8598160B2 (en)	2008-02-15	2013-12-03	Vitae Pharmaceuticals, Inc.	Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
KR20110002492A (ko)	2008-05-01	2011-01-07	비타이 파마슈티컬즈, 인코포레이티드	11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
TW201004945A (en)	2008-05-01	2010-02-01	Vitae Pharmaceuticals Inc	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291370B1 (en)	2008-05-01	2013-11-27	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8765780B2 (en)	2008-05-13	2014-07-01	Boehringer Ingelheim International Gmbh	Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
WO2010011314A1 (en)	2008-07-25	2010-01-28	Boehringer Ingelheim International Gmbh	Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
US8846668B2 (en)	2008-07-25	2014-09-30	Vitae Pharmaceuticals, Inc.	Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
UA109255C2 (ru)	2009-04-30	2015-08-10	Берінгер Інгельхайм Інтернешнл Гмбх	Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
WO2011011123A1 (en)	2009-06-11	2011-01-27	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
AR078887A1 (es)	2009-11-06	2011-12-07	Boehringer Ingelheim Int	Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
EP2582698B1 (en)	2010-06-16	2016-09-14	Vitae Pharmaceuticals, Inc.	Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en)	2011-08-17	2014-05-27	Boehringer Ingelheim International Gmbh	Indenopyridine derivatives

1974
- 1974-03-09 DE DE2411382A patent/DE2411382C3/de not_active Expired
1975
- 1975-02-28 AT AT153875A patent/AT344332B/de not_active IP Right Cessation
- 1975-03-05 SU SU7502110984A patent/SU577982A3/ru active
- 1975-03-05 CH CH280275A patent/CH612425A5/xx not_active IP Right Cessation
- 1975-03-06 FI FI750652A patent/FI63571C/fi not_active IP Right Cessation
- 1975-03-07 NL NL7502724A patent/NL7502724A/xx not_active Application Discontinuation
- 1975-03-07 ZA ZA751394A patent/ZA751394B/xx unknown
- 1975-03-07 BG BG029183A patent/BG25087A3/xx unknown
- 1975-03-07 IE IE505/75A patent/IE40945B1/xx unknown
- 1975-03-07 RO RO7589653A patent/RO69617A/ro unknown
- 1975-03-07 JP JP50027915A patent/JPS5827275B2/ja not_active Expired
- 1975-03-07 HU HU75BO1536A patent/HU177408B/hu unknown
- 1975-03-07 CA CA221,554A patent/CA1049511A/en not_active Expired
- 1975-03-07 DD DD184642A patent/DD119236A5/xx unknown
- 1975-03-07 BG BG030537A patent/BG24813A4/xx unknown
- 1975-03-07 NO NO750773A patent/NO141800C/no unknown
- 1975-03-07 BE BE154138A patent/BE826440A/xx not_active IP Right Cessation
- 1975-03-07 FR FR7507239A patent/FR2262984B1/fr not_active Expired
- 1975-03-07 RO RO7589654A patent/RO70051A/ro unknown
- 1975-03-07 IL IL46760A patent/IL46760A/xx unknown
- 1975-03-07 SE SE7502592A patent/SE421919B/xx not_active IP Right Cessation
- 1975-03-07 DK DK92975A patent/DK137188C/da active
- 1975-03-07 BG BG030538A patent/BG24814A4/xx unknown
- 1975-03-07 GB GB9633/75A patent/GB1496418A/en not_active Expired
- 1975-03-08 PL PL1975191318A patent/PL93699B1/pl unknown
- 1975-03-08 PL PL1975178582A patent/PL93499B1/pl unknown
- 1975-03-08 PL PL1975191319A patent/PL93700B1/pl unknown
- 1975-03-10 CS CS751583A patent/CS188221B2/cs unknown
- 1975-03-10 PH PH16895A patent/PH14127A/en unknown
- 1975-08-20 ES ES440345A patent/ES440345A1/es not_active Expired
- 1975-08-20 ES ES440350A patent/ES440350A1/es not_active Expired
- 1975-08-20 ES ES440347A patent/ES440347A1/es not_active Expired
- 1975-08-20 ES ES440348A patent/ES440348A1/es not_active Expired
- 1975-08-20 ES ES440346A patent/ES440346A1/es not_active Expired
- 1975-08-20 ES ES440349A patent/ES440349A1/es not_active Expired
- 1975-12-19 SU SU7502199294A patent/SU577983A3/ru active
- 1975-12-19 SU SU752199295A patent/SU588916A3/ru active
1979
- 1979-04-24 CH CH384379A patent/CH620439A5/de not_active IP Right Cessation
- 1979-04-24 CH CH384979A patent/CH622017A5/de not_active IP Right Cessation
- 1979-04-24 CH CH384679A patent/CH620440A5/de not_active IP Right Cessation
- 1979-04-24 CH CH384779A patent/CH622016A5/de not_active IP Right Cessation
- 1979-04-24 CH CH384479A patent/CH622014A5/de not_active IP Right Cessation
- 1979-04-24 CH CH384579A patent/CH622015A5/de not_active IP Right Cessation
- 1979-04-24 CH CH384879A patent/CH620681A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
NL7502724A (nl)	1975-09-11
RO69617A (ro)	1980-08-15
FI63571C (fi)	1983-07-11
PL93700B1 (he)	1977-06-30
FR2262984A1 (he)	1975-10-03
PL93699B1 (he)	1977-06-30
DK92975A (he)	1975-09-10
CH622014A5 (en)	1981-03-13
NO141800B (no)	1980-02-04
CH622016A5 (en)	1981-03-13
FR2262984B1 (he)	1978-07-28
BG25087A3 (bg)	1978-07-12
DE2411382B2 (de)	1979-01-18
PH14127A (en)	1981-02-26
ES440349A1 (es)	1977-03-01
FI750652A7 (he)	1975-09-10
NO141800C (no)	1980-06-04
CH620439A5 (en)	1980-11-28
BE826440A (fr)	1975-09-08
HU177408B (en)	1981-10-28
BG24813A4 (bg)	1978-05-12
ES440345A1 (es)	1977-03-01
CH622017A5 (en)	1981-03-13
ES440348A1 (es)	1977-06-01
PL93499B1 (he)	1977-05-30
IL46760A0 (en)	1975-05-22
IE40945L (en)	1975-09-09
ES440346A1 (es)	1977-03-01
AU7894275A (en)	1976-09-16
DE2411382A1 (de)	1975-09-18
RO70051A (ro)	1980-12-30
JPS5827275B2 (ja)	1983-06-08
DE2411382C3 (de)	1979-09-06
CH622015A5 (en)	1981-03-13
JPS50123675A (he)	1975-09-29
CA1049511A (en)	1979-02-27
SE7502592L (he)	1975-09-10
ATA153875A (de)	1977-11-15
ZA751394B (en)	1976-11-24
CS188221B2 (en)	1979-02-28
IE40945B1 (en)	1979-09-12
NO750773L (he)	1975-09-10
ES440350A1 (es)	1977-03-16
DK137188B (da)	1978-01-30
DK137188C (da)	1978-07-03
SU588916A3 (ru)	1978-01-15
SE421919B (sv)	1982-02-08
GB1496418A (en)	1977-12-30
ES440347A1 (es)	1977-06-01
FI63571B (fi)	1983-03-31
CH620681A5 (en)	1980-12-15
IL46760A (en)	1978-12-17
BG24814A4 (bg)	1978-05-12
SU577983A3 (ru)	1977-10-25
CH612425A5 (en)	1979-07-31
AT344332B (de)	1978-07-10
DD119236A5 (he)	1976-04-12
CH620440A5 (en)	1980-11-28

Publication	Publication Date	Title
SU691089A3 (ru)	1979-10-05	Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU606549A3 (ru)	1978-05-05	Способ получени фенилалкиламинов или их солей
CS228912B2 (en)	1984-05-14	Method of preparing isosorbid-5-nitrate
SU546280A3 (ru)	1977-02-05	Способ получени 2-(3-) 4-дифенилметил-1-пиперазинил (-пропил)- -триазоло (1,5- ) пиридина или его дигидрохлорида
SU665800A3 (ru)	1979-05-30	Способ получени 2-бром6 фтор- - 2-имидазолинилиденбензамина или его соли
SU795478A3 (ru)	1981-01-07	Способ получени 7-азабензимидазо-лОВ или иХ СОлЕй
SU453830A3 (ru)	1974-12-15	Способ получения соответственно замещенного фенацетилгуанидина
SU458131A3 (ru)	1975-01-25	Способ получени шифровых оснований 7-амино-3-дезацфетоксицефалоспорановой кислоты
US2906757A (en)	1959-09-29	Their preparation
SU609465A3 (ru)	1978-05-30	Способ получени проивзодных бензилпиримидина или их солей
SU694071A3 (ru)	1979-10-25	Способ получени производных пиперазина или их кислых аддитивных солей или четвертичных солей
SU554816A3 (ru)	1977-04-15	Способ получени азотсодержащих полициклических соединений или их солей, или рацематов, или оптических антиподов
SU922108A1 (ru)	1982-04-23	Способ получени производных 6-метил-8 @ -гидразинометилэрголина или их солей
JP2578797B2 (ja)	1997-02-05	Ｎ−（スルホニルメチル）ホルムアミド類の製造法
US4468518A (en)	1984-08-28	Imidazole guanidine compounds and method of making same
US4443621A (en)	1984-04-17	p-Nitrophenyl 3-bromo-2,2-diethoxy-propionate and synthetic utility therefor
US4560764A (en)	1985-12-24	Synthesis of an imidazolyl isothiourea
JPS6148839B2 (he)	1986-10-25
US3291800A (en)	1966-12-13	3-substituted derivatives of yohimbane alkaloids and process for their production
SU648080A3 (ru)	1979-02-15	Способ получени 1-трет.-бутиламино3-(2,5-дихлорфенокси)-2пропанола, его соли, рацемата или оптического антипода
US4520201A (en)	1985-05-28	Synthesis of cimetidine and analogs thereof
US3931214A (en)	1976-01-06	2-Amino-2-oxazolines and process for preparing them
IL37410A (en)	1972-05-30	Gamma-lactones of 2h-1,3-thiazine-4-carboxylic acid
US3221011A (en)	1965-11-30	Dibenzazepine derivatives
US3271415A (en)	1966-09-06	Preparation of 1-hydroxy-3-amino-pyrrolidone-2 and derivatives thereof