TR199800827T2 - 5-HT4, H3 resept�r ligandlar� olarak 5-fenil-3-(piperidin-4-il)-1,3,4-oksadiyazol-2(3H)-on t�revleri. - Google Patents

5-HT4, H3 resept�r ligandlar� olarak 5-fenil-3-(piperidin-4-il)-1,3,4-oksadiyazol-2(3H)-on t�revleri.

Info

Publication number: TR199800827T2
Authority: TR; Turkey
Prior art keywords: group; piperidin; alkyl; trevleri; reseptã
Prior art date: 1995-11-09

Application number

TR1998/00827T

Other languages

English (en)

Turkish (tr)

Inventor

Jegham Samir

Lochead Alistair

Galli Frederic

Nedelec Alain

Solignac Axelle

De Cruz Laurence

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-09

Filing date

1996-11-05

Publication date

1999-02-22

1995-11-09 Priority claimed from FR9513253A external-priority patent/FR2741070B1/fr

1995-11-09 Priority claimed from FR9513252A external-priority patent/FR2741069B1/fr

1996-03-04 Priority claimed from FR9602663A external-priority patent/FR2745574B1/fr

1996-11-05 Application filed by Synthelabo filed Critical Synthelabo

1999-02-22 Publication of TR199800827T2 publication Critical patent/TR199800827T2/xx

Links

-1 2, 3-dihydro-1H-inden-1-yl Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

TR1998/00827T 1995-11-09 1996-11-05 5-HT4, H3 resept�r ligandlar� olarak 5-fenil-3-(piperidin-4-il)-1,3,4-oksadiyazol-2(3H)-on t�revleri. TR199800827T2 (xx)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9513253A FR2741070B1 (fr)	1995-11-09	1995-11-09	Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
FR9513252A FR2741069B1 (fr)	1995-11-09	1995-11-09	Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
FR9602663A FR2745574B1 (fr)	1996-03-04	1996-03-04	Derives de 5-phenyl-3-(piperidin-4-yl)-1, 3, 4-oxadiazol-2 (3h)-one, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
TR199800827T2 true TR199800827T2 (xx)	1999-02-22

Family

ID=27253120

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR1998/00827T TR199800827T2 (xx)	1995-11-09	1996-11-05	5-HT4, H3 resept�r ligandlar� olarak 5-fenil-3-(piperidin-4-il)-1,3,4-oksadiyazol-2(3H)-on t�revleri.

Country Status (29)

Country	Link
US (1)	US5929089A (2)
EP (1)	EP0863897B1 (2)
JP (1)	JP4263240B2 (2)
CN (1)	CN1077891C (2)
AR (1)	AR004708A1 (2)
AT (1)	ATE181328T1 (2)
AU (1)	AU707325B2 (2)
BG (1)	BG63463B1 (2)
BR (1)	BR9611311A (2)
CA (1)	CA2236357C (2)
CO (1)	CO4770968A1 (2)
CZ (1)	CZ287268B6 (2)
DE (1)	DE69602970T2 (2)
EE (1)	EE03487B1 (2)
ES (1)	ES2135934T3 (2)
GR (1)	GR3030823T3 (2)
HU (1)	HUP0001168A3 (2)
IL (1)	IL124364A (2)
MX (1)	MX9803696A (2)
NO (1)	NO309606B1 (2)
NZ (1)	NZ321626A (2)
PL (1)	PL186204B1 (2)
RU (1)	RU2167160C2 (2)
SI (1)	SI0863897T1 (2)
SK (1)	SK282335B6 (2)
TR (1)	TR199800827T2 (2)
TW (1)	TW371303B (2)
UA (1)	UA50748C2 (2)
WO (1)	WO1997017345A1 (2)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW467902B (en) *	1996-07-31	2001-12-11	Bristol Myers Squibb Co	Diphenyl heterocycles as potassium channel modulators
FR2762316B1 (fr) *	1997-04-18	1999-12-17	Sanofi Synthelabo	Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
WO1998050383A1 (fr) *	1997-05-06	1998-11-12	Sanofi-Synthelabo	Derives de 5-phenyl-1,3,4-oxadiazol-2(3h)-one et leur utilisation comme ligands 5-ht4
FR2763068B1 (fr) *	1997-05-06	1999-06-04	Synthelabo	Derives de 3-(pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
GB9715816D0 (en) *	1997-07-25	1997-10-01	Black James Foundation	Histamine H receptor ligands
US6960579B1 (en)	1998-05-19	2005-11-01	Alcon Manufacturing, Ltd.	Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
CN1269484C (zh)	1998-09-18	2006-08-16	艾尔科实验室公司	用于治疗青光眼的5－羟色胺激活性激动剂
EP1173168A2 (en) *	1999-04-28	2002-01-23	Respiratorius AB	Compound for use as a medicament for treatment of disorders involving bronchocontraction
CN1355698A (zh) *	1999-06-15	2002-06-26	呼吸器有限公司	可用作治疗有关支气管收缩的机能障碍的药物的化合物
CZ2003686A3 (cs)	2000-08-08	2003-08-13	Ortho Mcneil Pharmaceutical, Inc.	Neimidazolové aryloxypiperidiny
US6638967B2 (en)	2000-08-08	2003-10-28	Ortho-Mcneil Phamraceutical, Inc.	Thiophene of furan pyrrolidine compounds
ATE319696T1 (de)	2000-08-08	2006-03-15	Ortho Mcneil Pharm Inc	Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden
EP1421071B1 (en)	2001-07-02	2009-11-18	High Point Pharmaceuticals, LLC	Substituted piperazine and diazepane derivaives as histamine h3 receptor modulators
US7208497B2 (en)	2001-07-02	2007-04-24	Novo Nordisk A/S	Substituted piperazines and diazepanes
US20030186963A1 (en)	2001-09-14	2003-10-02	Dorwald Florencio Zaragoza	Substituted piperidines
EP1430027B1 (en)	2001-09-14	2010-09-01	High Point Pharmaceuticals, LLC	Novel aminoazetidine, -pyrrolidine and -piperidine derivatives
US6673829B2 (en)	2001-09-14	2004-01-06	Novo Nordisk A/S	Aminoazetidine,-pyrrolidine and -piperidine derivatives
DE60234616D1 (de) *	2001-09-14	2010-01-14	High Point Pharmaceuticals Llc	Substituierte piperidinen mit selektiver bindungsfähigkeit zu histamin h3-rezeptoren
US7064135B2 (en)	2001-10-12	2006-06-20	Novo Nordisk Inc.	Substituted piperidines
EP2243776A1 (en)	2001-10-12	2010-10-27	High Point Pharmaceuticals, LLC	Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor
WO2003051352A1 (en)	2001-12-14	2003-06-26	Alcon, Inc.	Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
US20030236259A1 (en) *	2002-02-05	2003-12-25	Rolf Hohlweg	Novel aryl- and heteroarylpiperazines
GB0211230D0 (en) *	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
US7332508B2 (en)	2002-12-18	2008-02-19	Novo Nordisk A/S	Substituted homopiperidine, piperidine or pyrrolidine derivatives
GB0325956D0 (en) *	2003-11-06	2003-12-10	Addex Pharmaceuticals Sa	Novel compounds
WO2005123718A2 (en)	2004-06-15	2005-12-29	Pfizer Japan Inc.	Benzimidazolone carboxylic acid derivatives
US7737163B2 (en)	2004-06-15	2010-06-15	Pfizer Inc.	Benzimidazolone carboxylic acid derivatives
RU2499795C2 (ru)	2005-07-04	2013-11-27	Хай Пойнт Фармасьютикалс, ЛЛС	Антагонисты гистаминовых н3-рецепторов
WO2007063012A1 (en) *	2005-12-01	2007-06-07	F. Hoffmann-La Roche Ag	Heteroaryl substituted piperidine derivatives as l-cpt1 inhibitors
SG163547A1 (en)	2006-05-29	2010-08-30	High Point Pharmaceuticals Llc	3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
EP2014656A3 (en) *	2007-06-11	2011-08-24	High Point Pharmaceuticals, LLC	New heteocyclic h3 antagonists
AP3307A (en) *	2011-09-19	2015-06-30	Suven Life Sciences Ltd	Heteroaryl compounds as 5-HT4 receptor ligands

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5055476A (en) *	1990-08-13	1991-10-08	Hoechst-Roussel Pharmaceuticals Incorporated	3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives
CA2116024A1 (en) *	1991-08-20	1993-03-04	Francis David King	5-ht4 receptor antagonists
CA2118812C (en) *	1991-09-12	2006-01-17	Francis David King	5-ht4 receptor antagonists
EP0625149A1 (en) *	1992-02-06	1994-11-23	Smithkline Beecham Plc	Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
GB9219163D0 (en) *	1992-09-10	1992-10-28	Smithkline Beecham Plc	Pharmaceuticals
JPH06157518A (ja) *	1992-11-27	1994-06-03	Yamanouchi Pharmaceut Co Ltd	新規なオキサジアゾール誘導体又はその塩

1996
- 1996-11-05 AU AU75001/96A patent/AU707325B2/en not_active Ceased
- 1996-11-05 DE DE69602970T patent/DE69602970T2/de not_active Expired - Lifetime
- 1996-11-05 RU RU98110976/04A patent/RU2167160C2/ru not_active IP Right Cessation
- 1996-11-05 SK SK599-98A patent/SK282335B6/sk not_active IP Right Cessation
- 1996-11-05 NZ NZ321626A patent/NZ321626A/xx not_active IP Right Cessation
- 1996-11-05 EE EE9800155A patent/EE03487B1/xx not_active IP Right Cessation
- 1996-11-05 CN CN96198208A patent/CN1077891C/zh not_active Expired - Fee Related
- 1996-11-05 SI SI9630092T patent/SI0863897T1/xx not_active IP Right Cessation
- 1996-11-05 TR TR1998/00827T patent/TR199800827T2/xx unknown
- 1996-11-05 CA CA002236357A patent/CA2236357C/en not_active Expired - Fee Related
- 1996-11-05 PL PL96326671A patent/PL186204B1/pl not_active IP Right Cessation
- 1996-11-05 AT AT96937390T patent/ATE181328T1/de active
- 1996-11-05 US US09/068,390 patent/US5929089A/en not_active Expired - Lifetime
- 1996-11-05 EP EP96937390A patent/EP0863897B1/fr not_active Expired - Lifetime
- 1996-11-05 ES ES96937390T patent/ES2135934T3/es not_active Expired - Lifetime
- 1996-11-05 JP JP51791797A patent/JP4263240B2/ja not_active Expired - Fee Related
- 1996-11-05 WO PCT/FR1996/001730 patent/WO1997017345A1/fr not_active Ceased
- 1996-11-05 BR BR9611311A patent/BR9611311A/pt not_active IP Right Cessation
- 1996-11-05 UA UA98031589A patent/UA50748C2/uk unknown
- 1996-11-05 HU HU0001168A patent/HUP0001168A3/hu unknown
- 1996-11-05 IL IL12436496A patent/IL124364A/xx not_active IP Right Cessation
- 1996-11-05 CZ CZ19981421A patent/CZ287268B6/cs not_active IP Right Cessation
- 1996-11-07 TW TW085113594A patent/TW371303B/zh not_active IP Right Cessation
- 1996-11-08 AR ARP960105098A patent/AR004708A1/es active IP Right Grant
- 1996-11-08 CO CO96059097A patent/CO4770968A1/es unknown
1998
- 1998-04-28 BG BG102412A patent/BG63463B1/bg unknown
- 1998-05-07 NO NO982092A patent/NO309606B1/no not_active IP Right Cessation
- 1998-05-08 MX MX9803696A patent/MX9803696A/es unknown
1999
- 1999-07-20 GR GR990401913T patent/GR3030823T3/el unknown

Also Published As

Publication number	Publication date
AU7500196A (en)	1997-05-29
CO4770968A1 (es)	1999-04-30
PL186204B1 (pl)	2003-11-28
NZ321626A (en)	1998-10-28
DE69602970T2 (de)	2000-01-20
IL124364A0 (en)	1998-12-06
SK59998A3 (en)	1998-11-04
ES2135934T3 (es)	1999-11-01
NO309606B1 (no)	2001-02-26
CZ287268B6 (en)	2000-10-11
UA50748C2 (uk)	2002-11-15
JP4263240B2 (ja)	2009-05-13
NO982092D0 (no)	1998-05-07
SK282335B6 (sk)	2002-01-07
CA2236357A1 (en)	1997-05-15
ATE181328T1 (de)	1999-07-15
JP2000500125A (ja)	2000-01-11
AR004708A1 (es)	1999-03-10
EE9800155A (et)	1998-12-15
CA2236357C (en)	2006-10-17
CN1202169A (zh)	1998-12-16
DE69602970D1 (de)	1999-07-22
HK1016165A1 (en)	1999-10-29
BR9611311A (pt)	1999-06-29
TW371303B (en)	1999-10-01
CZ142198A3 (cs)	1998-08-12
RU2167160C2 (ru)	2001-05-20
EE03487B1 (et)	2001-08-15
AU707325B2 (en)	1999-07-08
IL124364A (en)	2001-08-08
NO982092L (no)	1998-06-29
MX9803696A (es)	1998-09-30
WO1997017345A1 (fr)	1997-05-15
SI0863897T1 (en)	1999-10-31
CN1077891C (zh)	2002-01-16
EP0863897A1 (fr)	1998-09-16
HUP0001168A3 (en)	2001-07-30
BG102412A (en)	1999-08-31
HUP0001168A2 (hu)	2001-04-28
GR3030823T3 (en)	1999-11-30
PL326671A1 (en)	1998-10-12
US5929089A (en)	1999-07-27
BG63463B1 (bg)	2002-02-28
EP0863897B1 (fr)	1999-06-16

Publication	Publication Date	Title
TR199800827T2 (xx)	1999-02-22	5-HT4, H3 resept�r ligandlar� olarak 5-fenil-3-(piperidin-4-il)-1,3,4-oksadiyazol-2(3H)-on t�revleri.
GB2365430B (en)	2002-08-28	Acylphosphine photoinitiators and intermediates
DE69705874D1 (de)	2001-09-06	Verwendung von Östrogenantagonisten und - agonisten zur Hemmung pathologischer Zustände
TW347387B (en)	1998-12-11	Piperidine derivatives
PE17995A1 (es)	1995-07-18	Antagonista triciclico de vasopresina de benzacepina
BR9903586A (pt)	2000-09-26	Composições de toner
CO4290421A1 (es)	1996-04-17	Antagonistas del receptor de aminoacidos excitativos
TR200001463T2 (tr)	2000-12-21	P maddesi antagonistleri olarak, piperidinilaminometil-triflorometil-siklik eter bileşikleri
TW427979B (en)	2001-04-01	A condensed piperidine compound
AR004965A1 (es)	1999-04-07	Procedimiento de preparacion de derivados de fenilimidazolidina
EA200100059A2 (ru)	2001-08-27	Новые бензолсульфонамидные производные, способ их получения и содержащие их фармацевтические композиции
BG103810A (en)	2000-06-30	Derivatives of 5-aryl-3-(8-azabicyclo(3.2.1)oct-3-yl)-1,3,4-oxadiazol-2(3h)-on as ligands of 5-ht4 receptors
TR199700802T2 (xx)	2002-04-22	Triazin t�revleri.
FI932874A0 (fi)	1993-06-21	6,7-modifierade 11b-aryl-4-estrener
DE60010276D1 (de)	2004-06-03	Neuartige vitamin-d analoge
KR930702269A (ko)	1993-09-08	포스포리파제 a2저해 물질
TR200000734T2 (tr)	2000-11-21	Seçici bir 5-HT1A/5-HT1B antagonistinin veya kısmi antagonistinin bir bileşimi.
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ATE478843T1 (de)	2010-09-15	Gamma-glutamyl- und beta-aspartyl-reste enthaltende immunomodulatoren und entsprechende methoden
DE59606435D1 (de)	2001-03-22	17-difluormethylen-estratriene
DK1023287T3 (da)	2002-10-14	Derivater af 3-oxo-(2H)-1,2,4-triazin som ligander for 5HT1a-receptorer
AR024797A1 (es)	2002-10-23	Forma cristalina iii de la n-(4-(5-dimetilaminonaftalen-1-sulfonilamino)fenil)-3-hidroxi-2,2-dimetilpropionamida
PT86852A (pt)	1988-03-01	Procede de preparation des nouveaux acetamides derives de la dihydro-2,3 phenyl-3 benzofurannone-2
ECSP982664A (es)	1999-04-13	Nuevos derivados de 2- (3h) oxazolona
CO4290418A1 (es)	1996-04-17	Nuevos compuestos de n-hidroxiurea que inhiben la accion de la enzima lipooxigenasa . .