TR199801870A2 - Yeni 5-halka-heterosiklenler, bunlarin üretimi, bunlarin kullanimi. - Google Patents

Yeni 5-halka-heterosiklenler, bunlarin üretimi, bunlarin kullanimi.

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Publication number
TR199801870A2
TR199801870A2 TR1998/01870A TR9801870A TR199801870A2 TR 199801870 A2 TR199801870 A2 TR 199801870A2 TR 1998/01870 A TR1998/01870 A TR 1998/01870A TR 9801870 A TR9801870 A TR 9801870A TR 199801870 A2 TR199801870 A2 TR 199801870A2
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Turkey
Prior art keywords
compounds
formula
vla
receptors
prevention
Prior art date
Application number
TR1998/01870A
Other languages
English (en)
Inventor
Wehner Volkmar
Ulrich Stilz Hans
Schmidt Wolfgang
Seiffge Dirk
Original Assignee
Hoechst Marion Roussel Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Deutschland Gmbh filed Critical Hoechst Marion Roussel Deutschland Gmbh
Publication of TR199801870A2 publication Critical patent/TR199801870A2/tr

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    • C07K—PEPTIDES
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    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Genetics & Genomics (AREA)
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  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
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  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)

Abstract

Mevcut bulusun konusu formül I'e göre olan bilesiklerdir, ki bilesiklerde B, E, W, Y, Z, R, R2, R2a, R2b, R3, g ve h istemlerde belirtilen anlamlara sahiptirler. Formül I'e göre bilesikler degerli ilaç aktif maddeleri olup, bunlar örnek olarak römatoid artritis gibi iltihap hastaliklarinin veya alerjik hastaliklarin tedavisi ve önlenmesi için uygundurlar. Formül I'e göre olan bilesikler integrin grubuna ait adhasyon reseptörleri VLA-4'lerin lökositlerinin ve/veya antagonistlerinin adhasyonunun ve migrasyonunun inhibitörleri olmaktadir. Sözkonusu bilesikler genel olarak arzu edilmeyen miktarda lökosit adhasyonunun ve/veya lökosit migrasyonunun neden oldugu veya buna bagli olan veya hücre-hücre veya hücre-matriks interaksiyonunun rol oynadigi ve VLA-4-reseptörlerinin ligandlari ile birlikte degisik etkisine dayanan hastaliklarinin tedavisi ya da önlenmesi için uygun olmaktadirlar.
TR1998/01870A 1997-09-23 1998-09-21 Yeni 5-halka-heterosiklenler, bunlarin üretimi, bunlarin kullanimi. TR199801870A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19741873A DE19741873A1 (de) 1997-09-23 1997-09-23 Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate

Publications (1)

Publication Number Publication Date
TR199801870A2 true TR199801870A2 (tr) 1999-04-21

Family

ID=7843291

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/01870A TR199801870A2 (tr) 1997-09-23 1998-09-21 Yeni 5-halka-heterosiklenler, bunlarin üretimi, bunlarin kullanimi.

Country Status (24)

Country Link
US (1) US6034238A (tr)
EP (1) EP0905139B1 (tr)
JP (1) JP4603104B2 (tr)
KR (1) KR19990030046A (tr)
CN (1) CN1216767A (tr)
AT (1) ATE421524T1 (tr)
AU (1) AU748579B2 (tr)
BR (1) BR9803969A (tr)
CA (1) CA2247735A1 (tr)
CZ (1) CZ303198A3 (tr)
DE (2) DE19741873A1 (tr)
HR (1) HRP980519A2 (tr)
HU (1) HUP9802143A3 (tr)
ID (1) ID20915A (tr)
IL (1) IL126278A0 (tr)
MY (1) MY134191A (tr)
NO (1) NO984414L (tr)
NZ (1) NZ331983A (tr)
PL (1) PL191149B1 (tr)
RU (1) RU2240326C2 (tr)
SK (1) SK129598A3 (tr)
TR (1) TR199801870A2 (tr)
TW (1) TW588051B (tr)
ZA (1) ZA988668B (tr)

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KR19990030046A (ko) 1999-04-26
IL126278A0 (en) 1999-05-09
DE19741873A1 (de) 1999-03-25
HRP980519A2 (en) 1999-06-30
CN1216767A (zh) 1999-05-19
DE59814334D1 (de) 2009-03-12
NZ331983A (en) 2000-02-28
US6034238A (en) 2000-03-07
NO984414L (no) 1999-03-24
AU748579B2 (en) 2002-06-06
ZA988668B (en) 1999-03-23
EP0905139B1 (de) 2009-01-21
TW588051B (en) 2004-05-21
CA2247735A1 (en) 1999-03-23
BR9803969A (pt) 2000-05-02
SK129598A3 (en) 1999-04-13
JP4603104B2 (ja) 2010-12-22
AU8614898A (en) 1999-04-15
EP0905139A3 (de) 2002-12-18
HU9802143D0 (en) 1998-11-30
NO984414D0 (no) 1998-09-22
MY134191A (en) 2007-11-30
HUP9802143A2 (hu) 1999-06-28
CZ303198A3 (cs) 1999-04-14
HUP9802143A3 (en) 1999-11-29
ATE421524T1 (de) 2009-02-15
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JPH11180960A (ja) 1999-07-06

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