TR200103278T2 - Spiroimidazolidin türevleri, hazırlanışları, kullanışları ve bunları içeren farmasötik preparatlar. - Google Patents

Spiroimidazolidin türevleri, hazırlanışları, kullanışları ve bunları içeren farmasötik preparatlar.

Info

Publication number
TR200103278T2
TR200103278T2 TR2001/03278T TR200103278T TR200103278T2 TR 200103278 T2 TR200103278 T2 TR 200103278T2 TR 2001/03278 T TR2001/03278 T TR 2001/03278T TR 200103278 T TR200103278 T TR 200103278T TR 200103278 T2 TR200103278 T2 TR 200103278T2
Authority
TR
Turkey
Prior art keywords
cell
formula
compounds
adhesion
preparation
Prior art date
Application number
TR2001/03278T
Other languages
English (en)
Inventor
Wehner Volkmar
Ulrich Stilz Hans
Schmidt Wolfgang
Seiffge Dirk
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200103278T2 publication Critical patent/TR200103278T2/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Mevcut bulus, E, V, W, X, R1 ve R2 nin istemlerde belirtilen anlamlara sahip oldugu formül I'in spiroimidazolidin türevleri ile ilgilidir. Formül (I)'in bilesikleri, örnegin; romatoid artrit ya da alerjik bozukluklar gibi enflamatuvar hastaliklarin tedavisi ya da profilaksisi için uygun olan, farmasötik açidan aktif olan degerli bilesiklerdir. Formül (I)'in bilesikleri, lökositlerin yapisma ve hücre göçü inhibitörleri ve/veya integrinler grubuna ait olan VLA-4 yapisma reseptörü antagonistleridir. Bunlar genellikle, lökosit yapismasi ve/veya lökosit göçünün istenmeyen sonuçlarinin neden oldugu ya da bunlar ile iliskili hastaliklarin ya da VLA-4 reseptörlerinin etkilesimlerine dayanan hücre-hücre veya hücre-matrisk etkilesimlerinin rol oynadigi durumlarinin tedavisi ve profilaksisi için uygundurlar.
TR2001/03278T 1999-05-17 2000-05-06 Spiroimidazolidin türevleri, hazırlanışları, kullanışları ve bunları içeren farmasötik preparatlar. TR200103278T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19922462A DE19922462A1 (de) 1999-05-17 1999-05-17 Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate

Publications (1)

Publication Number Publication Date
TR200103278T2 true TR200103278T2 (tr) 2002-04-22

Family

ID=7908208

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03278T TR200103278T2 (tr) 1999-05-17 2000-05-06 Spiroimidazolidin türevleri, hazırlanışları, kullanışları ve bunları içeren farmasötik preparatlar.

Country Status (28)

Country Link
US (1) US6399643B1 (tr)
EP (1) EP1183241B1 (tr)
JP (1) JP4686029B2 (tr)
KR (1) KR100658962B1 (tr)
CN (1) CN1221535C (tr)
AR (1) AR023989A1 (tr)
AT (1) ATE250038T1 (tr)
AU (1) AU778814B2 (tr)
BR (1) BR0011296B1 (tr)
CA (1) CA2373433C (tr)
CZ (1) CZ301467B6 (tr)
DE (2) DE19922462A1 (tr)
DK (1) DK1183241T3 (tr)
ES (1) ES2204595T3 (tr)
HK (1) HK1047104B (tr)
HU (1) HU228917B1 (tr)
IL (2) IL146276A0 (tr)
MX (1) MXPA01011611A (tr)
NO (1) NO320687B1 (tr)
NZ (1) NZ515496A (tr)
PL (1) PL201421B1 (tr)
PT (1) PT1183241E (tr)
RU (1) RU2245879C2 (tr)
SI (1) SI1183241T1 (tr)
TR (1) TR200103278T2 (tr)
TW (1) TWI256386B (tr)
WO (1) WO2000069831A1 (tr)
ZA (1) ZA200109370B (tr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10111877A1 (de) * 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10134366A1 (de) * 2001-07-14 2003-01-23 Aventis Pharma Gmbh Verfahren zur Herstellung der enantiomeren Formen von 2-substituierten 2-(2,5-Dioxoimidazolidin-l-yl)-essigsäure- Derivaten
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
EP3326645B1 (en) 2010-10-25 2020-03-18 Biogen MA Inc. Methods for determining differences in alpha-4 integrin activity by correlating differences in svcam and/or smadcam levels

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DK0626861T4 (da) 1992-01-13 2004-08-16 Biogen Inc Behandling af astma.
JPH07506566A (ja) 1992-02-12 1995-07-20 バイオゲン　インコーポレイテッド 炎症性胃腸病の処置
DE4207254A1 (de) 1992-03-07 1993-09-09 Cassella Ag 4-oxo-2-thioxoimidazolidin-derivate
DE4213634A1 (de) 1992-04-24 1993-10-28 Cassella Ag 2,4-Dioxo-imidazolidin-Derivate
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Also Published As

Publication number Publication date
WO2000069831A1 (en) 2000-11-23
NO20015617D0 (no) 2001-11-16
DK1183241T3 (da) 2004-01-19
CN1356986A (zh) 2002-07-03
RU2245879C2 (ru) 2005-02-10
HUP0202364A2 (hu) 2002-11-28
HK1047104A1 (en) 2003-02-07
HU228917B1 (hu) 2013-06-28
ATE250038T1 (de) 2003-10-15
HK1047104B (zh) 2006-02-03
IL146276A0 (en) 2002-07-25
CN1221535C (zh) 2005-10-05
US6399643B1 (en) 2002-06-04
DE19922462A1 (de) 2000-11-23
IL146276A (en) 2007-06-03
TWI256386B (en) 2006-06-11
ES2204595T3 (es) 2004-05-01
CA2373433C (en) 2010-12-14
JP2002544261A (ja) 2002-12-24
NO20015617L (no) 2002-01-15
SI1183241T1 (en) 2004-02-29
NO320687B1 (no) 2006-01-16
KR100658962B1 (ko) 2006-12-21
DE60005337T2 (de) 2004-06-24
EP1183241B1 (en) 2003-09-17
PL201421B1 (pl) 2009-04-30
EP1183241A1 (en) 2002-03-06
JP4686029B2 (ja) 2011-05-18
BR0011296B1 (pt) 2011-08-23
AU778814B2 (en) 2004-12-23
PL351755A1 (en) 2003-06-16
BR0011296A (pt) 2002-02-26
HUP0202364A3 (en) 2003-10-28
CZ20014089A3 (cs) 2002-02-13
DE60005337D1 (de) 2003-10-23
NZ515496A (en) 2003-10-31
ZA200109370B (en) 2002-06-27
CZ301467B6 (cs) 2010-03-10
AU4756000A (en) 2000-12-05
KR20010113957A (ko) 2001-12-28
CA2373433A1 (en) 2000-11-23
MXPA01011611A (es) 2003-09-10
PT1183241E (pt) 2004-02-27
AR023989A1 (es) 2002-09-04

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