TR199900047T2 - Gaba resept�rleri ligandlar� olarak ikame triazolo-piridazin t�revleri - Google Patents

Gaba resept�rleri ligandlar� olarak ikame triazolo-piridazin t�revleri

Info

Publication number: TR199900047T2
Authority: TR; Turkey
Prior art keywords: ligands; pyridazine derivatives; gaba receptors; triazolo; substituted triazolo
Prior art date: 1996-07-25

Application number

TR1999/00047T

Other languages

English (en)

Turkish (tr)

Inventor

Barff Broughton Howard

Robert Carling William

Luis Castro Pineiro Jose

Richard Guiblin Alexander

Madin Andrew

William Moore Kevin

Geoffrey Russell Michael

Joseph Street Lesl�E

Original Assignee

Merck Sharp & Dohme Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-17

Publication date

1999-03-22

1996-07-25 Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en

1996-12-06 Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en

1997-07-09 Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en

1997-07-17 Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited

1999-03-22 Publication of TR199900047T2 publication Critical patent/TR199900047T2/xx

Links

239000003446 ligand Substances 0.000 title abstract 2
CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
102000005915 GABA Receptors Human genes 0.000 title 1
108010005551 GABA Receptors Proteins 0.000 title 1
238000006467 substitution reaction Methods 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010010904 Convulsion Diseases 0.000 abstract 1
102000027484 GABAA receptors Human genes 0.000 abstract 1
108091008681 GABAA receptors Proteins 0.000 abstract 1
YRACHDVMKITFAZ-UHFFFAOYSA-N [1,2,4]triazolo[4,3-b]pyridazine Chemical class C1=CC=NN2C=NN=C21 YRACHDVMKITFAZ-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
230000036461 convulsion Effects 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TR1999/00047T 1996-07-25 1997-07-17 Gaba resept�rleri ligandlar� olarak ikame triazolo-piridazin t�revleri TR199900047T2 (xx)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9615645.0A GB9615645D0 (en)	1996-07-25	1996-07-25	Therapeutic agents
GBGB9625397.6A GB9625397D0 (en)	1996-12-06	1996-12-06	Therapeutic agents
GBGB9714420.8A GB9714420D0 (en)	1997-07-09	1997-07-09	Therapeutic agents

Publications (1)

Publication Number	Publication Date
TR199900047T2 true TR199900047T2 (xx)	1999-03-22

Family

ID=27268403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR1999/00047T TR199900047T2 (xx)	1996-07-25	1997-07-17	Gaba resept�rleri ligandlar� olarak ikame triazolo-piridazin t�revleri

Country Status (24)

Country	Link
US (1)	US6255305B1 (pt)
EP (1)	EP0915875B1 (pt)
JP (1)	JP4216905B2 (pt)
KR (1)	KR20000029548A (pt)
CN (1)	CN1251589A (pt)
AT (1)	ATE236904T1 (pt)
AU (1)	AU723098B2 (pt)
BG (1)	BG103112A (pt)
BR (1)	BR9710729A (pt)
CZ (1)	CZ18199A3 (pt)
DE (1)	DE69720732T2 (pt)
EA (1)	EA002436B1 (pt)
EE (1)	EE9900027A (pt)
ES (1)	ES2194205T3 (pt)
HU (1)	HUP0600527A2 (pt)
IL (1)	IL127911A0 (pt)
IS (1)	IS4949A (pt)
NO (1)	NO990304L (pt)
NZ (1)	NZ333768A (pt)
PL (1)	PL331072A1 (pt)
SK (1)	SK9399A3 (pt)
TR (1)	TR199900047T2 (pt)
WO (1)	WO1998004559A2 (pt)
YU (1)	YU2899A (pt)

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US6297235B1 (en)	1997-08-28	2001-10-02	Merck Sharp & Dohme Ltd.	Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9718254D0 (en)	1997-08-28	1997-11-05	Merck Sharp & Dohme	Therapeutic agents
AU1041599A (en) *	1997-11-13	1999-06-07	Jose Luis Castro Pineiro	Therapeutic uses of triazolo-pyridazine derivatives
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US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
EP1047697A1 (en) *	1998-01-14	2000-11-02	MERCK SHARP & DOHME LTD.	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801202D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
YU43800A (sh) *	1998-01-21	2002-12-10	Merck Sharp & Dohme Limited	Triazolo-piridazin derivati kao ligandi za gaba receptore
GB9801234D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
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GB9801210D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en) *	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
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GB9813006D0 (en) *	1998-06-16	1998-08-12	Merck Sharp & Dohme	Therapeutic agents
GB9813576D0 (en) *	1998-06-24	1998-08-19	Merck Sharp & Dohme	Therapeutic agents
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
CA2346659A1 (en) *	1998-10-06	2000-04-13	Michiyo Gyoten	Condensed pyridazine compounds, their production and use
CA2346289A1 (en) *	1998-10-16	2000-04-27	Merck Sharp & Dohme Limited	Pyrazolo-triazine derivatives as ligands for gaba receptors
IT1303272B1 (it)	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en) *	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
JP2002535407A (ja) *	1999-01-27	2002-10-22	メルクシャープエンドドームリミテッド	Ｇａｂａ受容体のリガンドとしてのトリアゾロピリダジン誘導体
GB9903119D0 (en) *	1999-02-11	1999-04-07	Merck Sharp & Dohme	Therapeutic agents
US6737242B1 (en)	1999-05-07	2004-05-18	Neurogen Corporation	Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en) *	1999-08-23	1999-10-27	Merck Sharp & Dohme	Therapeutic agents
GB9921351D0 (en)	1999-09-09	1999-11-10	Merck Sharp & Dohme	Therapeutic agents
US6355638B1 (en) *	1999-11-25	2002-03-12	Merck Sharp & Dohme Ltd.	Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en)	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929685D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929687D0 (en)	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0000564D0 (en)	2000-01-11	2000-03-01	Merck Sharp & Dohme	Therapeutic agents
GB0008696D0 (en)	2000-04-07	2000-05-31	Merck Sharp & Dohme	Therapeutic agents
GB0017518D0 (en) *	2000-07-17	2000-08-30	Merck Sharp & Dohme	Therapeutic agents
GB0018473D0 (en) *	2000-07-27	2000-09-13	Merck Sharp & Dohme	Therapeutic agents
GB0028583D0 (en)	2000-11-23	2001-01-10	Merck Sharp & Dohme	Therapeutic compounds
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US7638541B2 (en)	2006-12-28	2009-12-29	Metabolex Inc.	5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
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CN107344936B (zh) *	2016-05-06	2022-06-03	上海赛默罗生物科技有限公司	三唑哒嗪类衍生物、其制备方法、药物组合物和用途
AU2017305392A1 (en)	2016-08-03	2019-02-21	Cymabay Therapeutics, Inc.	Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
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KR20220087507A (ko) *	2019-10-23	2022-06-24	뉴로사이클 테라퓨틱스, 인크.	Gabaa 수용체 조절제를 사용한 간질 병태의 치료
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1997
- 1997-07-17 ES ES97931960T patent/ES2194205T3/es not_active Expired - Lifetime
- 1997-07-17 SK SK93-99A patent/SK9399A3/sk unknown
- 1997-07-17 TR TR1999/00047T patent/TR199900047T2/xx unknown
- 1997-07-17 AT AT97931960T patent/ATE236904T1/de not_active IP Right Cessation
- 1997-07-17 IL IL12791197A patent/IL127911A0/xx unknown
- 1997-07-17 US US09/155,587 patent/US6255305B1/en not_active Expired - Lifetime
- 1997-07-17 EA EA199900164A patent/EA002436B1/ru not_active IP Right Cessation
- 1997-07-17 HU HU0600527A patent/HUP0600527A2/hu unknown
- 1997-07-17 CN CN97196641A patent/CN1251589A/zh active Pending
- 1997-07-17 NZ NZ333768A patent/NZ333768A/xx unknown
- 1997-07-17 AU AU35539/97A patent/AU723098B2/en not_active Ceased
- 1997-07-17 DE DE69720732T patent/DE69720732T2/de not_active Expired - Lifetime
- 1997-07-17 BR BR9710729A patent/BR9710729A/pt unknown
- 1997-07-17 EE EEP199900027A patent/EE9900027A/xx unknown
- 1997-07-17 EP EP97931960A patent/EP0915875B1/en not_active Expired - Lifetime
- 1997-07-17 WO PCT/GB1997/001946 patent/WO1998004559A2/en not_active Ceased
- 1997-07-17 PL PL97331072A patent/PL331072A1/xx unknown
- 1997-07-17 YU YU2899A patent/YU2899A/sh unknown
- 1997-07-17 KR KR1019997000606A patent/KR20000029548A/ko not_active Withdrawn
- 1997-07-17 CZ CZ99181A patent/CZ18199A3/cs unknown
- 1997-07-17 JP JP50858598A patent/JP4216905B2/ja not_active Expired - Fee Related
1999
- 1999-01-19 IS IS4949A patent/IS4949A/is unknown
- 1999-01-22 NO NO990304A patent/NO990304L/no not_active Application Discontinuation
- 1999-01-25 BG BG103112A patent/BG103112A/xx unknown

Also Published As

Publication number	Publication date
NO990304L (no)	1999-03-25
AU723098B2 (en)	2000-08-17
JP4216905B2 (ja)	2009-01-28
EA002436B1 (ru)	2002-04-25
NO990304D0 (no)	1999-01-22
IL127911A0 (en)	1999-11-30
WO1998004559A2 (en)	1998-02-05
YU2899A (sh)	2000-03-21
JP2002514169A (ja)	2002-05-14
BG103112A (en)	1999-09-30
KR20000029548A (ko)	2000-05-25
US6255305B1 (en)	2001-07-03
EA199900164A1 (ru)	2000-04-24
CN1251589A (zh)	2000-04-26
ES2194205T3 (es)	2003-11-16
DE69720732T2 (de)	2004-01-29
AU3553997A (en)	1998-02-20
DE69720732D1 (de)	2003-05-15
PL331072A1 (en)	1999-06-21
IS4949A (is)	1999-01-19
HUP0600527A2 (en)	2006-11-28
ATE236904T1 (de)	2003-04-15
EP0915875A2 (en)	1999-05-19
BR9710729A (pt)	1999-08-17
CZ18199A3 (cs)	1999-06-16
NZ333768A (en)	2000-09-29
SK9399A3 (en)	2000-04-10
EP0915875B1 (en)	2003-04-09
EE9900027A (et)	1999-08-16

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WO2001038326A3 (en)	2002-05-10	Imidazo-pyridine derivatives as ligands for gaba receptors
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ATE284403T1 (de)	2004-12-15	Triazolopyridazinderivate als liganden für gaba- rezeptoren
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TR200003789T2 (tr)	2001-04-20	İkameli triazolo-piridazin türevi ve bundan yapılan farmasötik bileşimler.
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TW350843B (en)	1999-01-21	2-(4-pyrazolyloxy-pyrimidin-5-yl) acetic acid derivatives
TR200002100T2 (tr)	2000-12-21	GABA reseptörleri için ligandlar olarak triazolo-piridazin türevleri