TR199901832T2 - Liyofillestirilmis morfogenetik insan kemik faktörü mp52 bilesimi. - Google Patents

Liyofillestirilmis morfogenetik insan kemik faktörü mp52 bilesimi.

Info

Publication number
TR199901832T2
TR199901832T2 TR1999/01832T TR9901832T TR199901832T2 TR 199901832 T2 TR199901832 T2 TR 199901832T2 TR 1999/01832 T TR1999/01832 T TR 1999/01832T TR 9901832 T TR9901832 T TR 9901832T TR 199901832 T2 TR199901832 T2 TR 199901832T2
Authority
TR
Turkey
Prior art keywords
morphogenetic
human bone
lyophilized
compound
bone factor
Prior art date
Application number
TR1999/01832T
Other languages
English (en)
Inventor
Inagaki Mitsuko
Original Assignee
Hoechst Marion Roussel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Ltd filed Critical Hoechst Marion Roussel Ltd
Publication of TR199901832T2 publication Critical patent/TR199901832T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Morfogenetik insan kemik faktörü MP52, 1:5-50'lik bir agirlik oraninda mannitol ile karistirilarak, ardindan liyofillestirme islemi uygulanarak, liyofillestirilmis, kararli bir morfogenetik insan kemik faktörü MP52 bilesimi elde edilmistir; sözkonusu bilesim, liyofillestirilmis morfogenetik insan kemik faktörü MP52 ürününün saklanma dönemi sirasinda renklenmesini ve atrofiye ugramasini engeller ve ayni zamanda, kullanim için yeniden olusturma sirasinda kohezyonu önler.
TR1999/01832T 1997-01-30 1998-01-29 Liyofillestirilmis morfogenetik insan kemik faktörü mp52 bilesimi. TR199901832T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1634997 1997-01-30

Publications (1)

Publication Number Publication Date
TR199901832T2 true TR199901832T2 (tr) 1999-12-21

Family

ID=11913900

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01832T TR199901832T2 (tr) 1997-01-30 1998-01-29 Liyofillestirilmis morfogenetik insan kemik faktörü mp52 bilesimi.

Country Status (22)

Country Link
EP (1) EP0972520B9 (tr)
JP (1) JP4209948B2 (tr)
KR (1) KR100548107B1 (tr)
CN (1) CN1152712C (tr)
AP (1) AP983A (tr)
AT (1) ATE302021T1 (tr)
AU (1) AU737595B2 (tr)
BR (1) BR9807537B1 (tr)
CA (1) CA2278546C (tr)
DE (1) DE69831223T9 (tr)
DK (1) DK0972520T3 (tr)
EA (1) EA001579B1 (tr)
ES (1) ES2244043T3 (tr)
HU (1) HU226554B1 (tr)
IL (2) IL130967A0 (tr)
NO (1) NO322334B1 (tr)
NZ (1) NZ336509A (tr)
PL (1) PL189381B1 (tr)
RS (1) RS49691B (tr)
SI (1) SI0972520T1 (tr)
TR (1) TR199901832T2 (tr)
WO (1) WO1998033514A1 (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957943B2 (en) † 1997-02-07 2008-11-26 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
WO2003030873A1 (en) * 2001-10-09 2003-04-17 Cellfactors Plc Therapeutic biological product and method for formation of new vascularised bone
ATE303169T1 (de) 2001-11-19 2005-09-15 Scil Technology Gmbh Homogen beschichtete vorrichtung mit osteoinduktiven und osteokonduktiven eigenschaften
AU2003253049A1 (en) 2002-09-10 2004-04-30 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
US20060204511A1 (en) * 2003-08-05 2006-09-14 Bouwstra Jan B Use of recombinant or synthetic gelatin as stabiliser in vaccines
CA2545458A1 (en) * 2003-11-10 2005-05-26 Arriva-Prometic Inc. Dry recombinant human alpha 1-antitrypsin formulation
US8372419B2 (en) 2004-03-10 2013-02-12 Scil Technology Gmbh Coated implants, their manufacturing and use thereof
US10360287B2 (en) 2015-05-22 2019-07-23 Microsoft Technology Licensing, Llc Unified messaging platform and interface for providing user callouts
US20160344677A1 (en) 2015-05-22 2016-11-24 Microsoft Technology Licensing, Llc Unified messaging platform for providing interactive semantic objects

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080879B1 (en) * 1981-11-28 1986-10-01 Sunstar Kabushiki Kaisha Pharmaceutical composition containing interferon in stable state
US5037644A (en) * 1986-10-27 1991-08-06 Cetus Corporation Pharmaceutical compositions of recombinant interleukin-2 and formulation processes
WO1993000050A1 (en) * 1991-06-21 1993-01-07 Genetics Institute, Inc. Pharmaceutical formulations of osteogenic proteins
JP2966592B2 (ja) * 1991-07-20 1999-10-25 萩原 義秀 安定化されたヒトモノクローナル抗体製剤
DK0625989T3 (da) * 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
CA2093836A1 (en) * 1992-04-24 1993-10-25 Wayne Gombotz Biodegradable tgf-.beta. delivery system for bone regeneration
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
WO1996029095A1 (en) * 1995-03-21 1996-09-26 Applied Research Systems Ars Holding N.V. Hcg liquid formulations
DE69636728T4 (de) * 1995-04-19 2007-06-28 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Neues protein und verfahren zu dessen herstellung

Also Published As

Publication number Publication date
JP4209948B2 (ja) 2009-01-14
HUP0002386A3 (en) 2002-09-30
NZ336509A (en) 2001-03-30
CA2278546C (en) 2008-04-01
YU34999A (sh) 2002-08-12
KR20000070586A (ko) 2000-11-25
AU5679198A (en) 1998-08-25
RS49691B (sr) 2007-12-31
SI0972520T1 (sl) 2006-02-28
NO993702D0 (no) 1999-07-29
DE69831223D1 (de) 2005-09-22
WO1998033514A1 (en) 1998-08-06
ES2244043T3 (es) 2005-12-01
EP0972520B1 (en) 2005-08-17
AU737595B2 (en) 2001-08-23
NO322334B1 (no) 2006-09-18
NO993702L (no) 1999-09-29
BR9807537A (pt) 2000-03-21
EA199900694A1 (ru) 2000-04-24
PL189381B1 (pl) 2005-07-29
DK0972520T3 (da) 2005-12-19
IL130967A0 (en) 2001-01-28
HUP0002386A2 (hu) 2000-11-28
ATE302021T1 (de) 2005-09-15
IL130967A (en) 2006-12-10
EP0972520A4 (en) 2002-11-05
CA2278546A1 (en) 1998-08-06
CN1152712C (zh) 2004-06-09
EP0972520A1 (en) 2000-01-19
EP0972520B9 (en) 2006-03-22
KR100548107B1 (ko) 2006-02-02
PL334852A1 (en) 2000-03-27
AP983A (en) 2001-07-16
CN1244127A (zh) 2000-02-09
AP9901602A0 (en) 1999-09-30
BR9807537B1 (pt) 2009-01-13
DE69831223T9 (de) 2006-12-07
DE69831223T2 (de) 2006-02-16
EA001579B1 (ru) 2001-06-25
HU226554B1 (en) 2009-03-30

Similar Documents

Publication Publication Date Title
TR199901832T2 (tr) Liyofillestirilmis morfogenetik insan kemik faktörü mp52 bilesimi.
CA2281562A1 (en) Forskolin for promoting lean body mass
EP1093819A3 (en) Compounds and compositions for delivering active agents
HUP0002322A3 (en) Multivalent vaccine composition with mixed carrier
TR199801179T2 (tr) Yeni taksoitler, bunlarin hazirlanmalari ve ilaç bilesimleri.
FI961196L (fi) Aktiviinin reseptoreita muistuttava kinaasi(alk), joka kuuluu TGF-reseptoriperheeseen ja/tai BMP-reseptoriperheeseen
MX9705710A (es) Compuestos con propiedades de liberacion de la hormona del crecimiento.
PL325267A1 (en) High-modulus composition for making belts and belts made therefrom
TR199802762T2 (tr) Yüksek miktarda ilaç içeren, hizli parçalanan ve hizli eriyen bilesimlerin hazirlanmasi için granülat.
AR059902A2 (es) Complejo de factor viii/vwf o factor viii:c
FI990134L (fi) Pyridatsino-(4,5-beta)-kinoliini-5-oksidijohdannaisia, niiden valmistus ja niiden käyttö glysiiniantagonisteina
BR9815457A (pt) Kit de partida contendo composições de ácido nicotìnico e uso de ácido nicotìnico em uma formulação de liberação continuada
TW364850B (en) Nematocidal compositions
MX9206678A (es) Composiciones reactivas de poliuretano,de dos componentes
ES2140489T3 (es) Receptor de interferona soluble, su preparacion y su uso.
FI950290A7 (fi) Uusia bioaktiivisia koostumuksia, niiden valmistus ja käyttö
EE04317B1 (et) 4-okso-3,5-dihüdro-4H-püridasino[4.5-b]indool-1-etaanamiidi derivaadid, nende valmistamine ja kasutamine raviks
BR9305261A (pt) Composição implantável com liberação controlada
TR199900872T1 (tr) Bir heteroetinilen radikali ile bagli bi-aromatik bilesikler ve bunlari ihtiva eden farmasötik ve kozmetik kompozisyonlar.
EE200000207A (et) 8-asabitsüklo[3.2.1]oktaan-3-metaanamiini derivaadid, nende valmistamine ja terapeutiline kasutamine
JO1999B1 (en) Isotopes of the hormone 'LH-RH' have their uses and the chemical compounds they contain
AU4870390A (en) Low dose benazepril and thiazide diuretic composition
ATE311886T1 (de) Verwendung einer zusammensetzung enthaltend 5- androsten-3beta,17alpha-diol
TR199900748A2 (tr) Osteinduktif protein ve dorsalize faktörünün kombinasyonunun kullanilmasi.
Gray et al. Interaction of antihistamines with the sigma and phencylidine (PCP) receptors