TR200103805T2 - Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler - Google Patents

Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler

Info

Publication number
TR200103805T2
TR200103805T2 TR2001/03805T TR200103805T TR200103805T2 TR 200103805 T2 TR200103805 T2 TR 200103805T2 TR 2001/03805 T TR2001/03805 T TR 2001/03805T TR 200103805 T TR200103805 T TR 200103805T TR 200103805 T2 TR200103805 T2 TR 200103805T2
Authority
TR
Turkey
Prior art keywords
replication
respiratory syncytial
syncytial virus
inhibit
substances
Prior art date
Application number
TR2001/03805T
Other languages
English (en)
Inventor
Eduard Janssens Frans
Fernand Armand Lacrampe Jean
Emile Georges Guillemont Jerome
Gaston Venet Marc
Jozef Lodenwijk Marcel Andries Koenraad
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR200103805T2 publication Critical patent/TR200103805T2/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Bu bulus, solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler olarak formül (I) e sahip bilesikler, bunlarin ön ilaçlari, N-oksitler, katilma tuzlari, kuaterner aminleri, metal kompleksleri ve streokimyasal izomerik sekiller; bunlarin hazirlanmasi, bunlari ihtiva eden terkipler ve bunlarin ilaç olarak kullanimi ile ilgili olup; burada -a1=a2-a3=a4, formül -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- veya -CH=CH-CH=N- ye sahip bir radikaldir; Q, (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) ve (b-8) formülüne sahip bir radikaldir; G, bir dogrudan bag veya istege bagli olarak sübstitüe edilmis bir C1-10alkandiildir; R1, istege bagli olarak sübstitüe edilmis bir bisiklik heterolhalkadir; ve diger degiskenler tarifnamede tarif edildigi gibidir.
TR2001/03805T 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler TR200103805T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202089 1999-06-28

Publications (1)

Publication Number Publication Date
TR200103805T2 true TR200103805T2 (tr) 2002-06-21

Family

ID=8240374

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2001/03805T TR200103805T2 (tr) 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler
TR2005/00707T TR200500707T2 (tr) 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2005/00707T TR200500707T2 (tr) 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.

Country Status (34)

Country Link
US (2) US7071192B1 (tr)
EP (2) EP1400519B1 (tr)
JP (1) JP2003503403A (tr)
KR (1) KR100731273B1 (tr)
CN (1) CN1171887C (tr)
AR (1) AR024495A1 (tr)
AT (2) ATE259796T1 (tr)
AU (1) AU774829B2 (tr)
BG (1) BG65373B1 (tr)
BR (1) BR0011997A (tr)
CA (1) CA2376785A1 (tr)
CZ (1) CZ20014573A3 (tr)
DE (2) DE60008382T2 (tr)
DK (1) DK1196410T3 (tr)
EA (1) EA004746B1 (tr)
EE (1) EE04592B1 (tr)
ES (2) ES2215670T3 (tr)
HK (1) HK1045998B (tr)
HR (2) HRP20080390A2 (tr)
HU (1) HUP0201789A3 (tr)
IL (2) IL147328A0 (tr)
MX (1) MXPA02000117A (tr)
MY (1) MY129810A (tr)
NO (1) NO321599B1 (tr)
NZ (1) NZ515392A (tr)
PL (1) PL200694B1 (tr)
PT (1) PT1196410E (tr)
SI (1) SI1196410T1 (tr)
SK (1) SK18952001A3 (tr)
TR (2) TR200103805T2 (tr)
TW (1) TWI267513B (tr)
UA (1) UA75866C2 (tr)
WO (1) WO2001000615A1 (tr)
ZA (1) ZA200110473B (tr)

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Also Published As

Publication number Publication date
HRP20080390A2 (en) 2008-12-31
KR20020000815A (ko) 2002-01-05
EE200100694A (et) 2003-02-17
EP1400519B1 (en) 2007-03-07
PL200694B1 (pl) 2009-01-30
NO20016370D0 (no) 2001-12-27
TR200500707T2 (tr) 2005-04-21
BG65373B1 (bg) 2008-04-30
HUP0201789A3 (en) 2003-12-29
DE60033859D1 (de) 2007-04-19
WO2001000615A1 (en) 2001-01-04
EP1400519A1 (en) 2004-03-24
SK18952001A3 (sk) 2002-11-06
JP2003503403A (ja) 2003-01-28
ES2283716T3 (es) 2007-11-01
CN1171887C (zh) 2004-10-20
WO2001000615A8 (en) 2002-01-10
AU774829B2 (en) 2004-07-08
MY129810A (en) 2007-05-31
AR024495A1 (es) 2002-10-02
IL147328A (en) 2007-06-03
ATE356121T1 (de) 2007-03-15
DE60008382T2 (de) 2004-12-02
IL147328A0 (en) 2002-08-14
CA2376785A1 (en) 2001-01-04
NO20016370L (no) 2001-12-27
SI1196410T1 (en) 2004-08-31
NZ515392A (en) 2004-03-26
AU5222200A (en) 2001-01-31
HK1045998B (zh) 2005-06-03
UA75866C2 (en) 2006-06-15
DE60008382D1 (en) 2004-03-25
DE60033859T2 (de) 2007-11-08
EP1196410A1 (en) 2002-04-17
HRP20010934A2 (en) 2003-06-30
US20060058309A1 (en) 2006-03-16
EE04592B1 (et) 2006-02-15
ES2215670T3 (es) 2004-10-16
TWI267513B (en) 2006-12-01
US7407969B2 (en) 2008-08-05
DK1196410T3 (da) 2004-06-28
ATE259796T1 (de) 2004-03-15
MXPA02000117A (es) 2002-07-02
PL352385A1 (en) 2003-08-25
EA004746B1 (ru) 2004-08-26
HK1045998A1 (en) 2002-12-20
ZA200110473B (en) 2003-03-20
BG106288A (en) 2002-10-31
CZ20014573A3 (cs) 2002-05-15
KR100731273B1 (ko) 2007-06-21
EP1196410B1 (en) 2004-02-18
EA200200086A1 (ru) 2002-06-27
US7071192B1 (en) 2006-07-04
BR0011997A (pt) 2002-03-05
NO321599B1 (no) 2006-06-06
CN1358182A (zh) 2002-07-10
PT1196410E (pt) 2004-07-30
HUP0201789A2 (hu) 2002-11-28

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