TW200738656A - N-oxides as prodrugs of piperazine and piperidine derivatives - Google Patents

N-oxides as prodrugs of piperazine and piperidine derivatives

Info

Publication number: TW200738656A
Authority: TW; Taiwan
Prior art keywords: art; relates; disease; manufacture; disclosed
Prior art date: 2005-08-22

Application number

TW095130407A

Other languages

English (en)

Chinese (zh)

Inventor

Theodorus S M Koopman

Hendrik J Koster

Marinus Verhage

Van Amsterdam

Roelof W Feenstra

Andrew C Mccreary

Mayke B Hesselink

Van Scharrenburg

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-22

Filing date

2006-08-18

Publication date

2007-10-16

2006-08-18 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2007-10-16 Publication of TW200738656A publication Critical patent/TW200738656A/zh

Links

GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
150000001204 N-oxides Chemical class 0.000 title abstract 2
150000003053 piperidines Chemical class 0.000 title abstract 2
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
239000003814 drug Substances 0.000 abstract 3
238000004519 manufacturing process Methods 0.000 abstract 3
230000009286 beneficial effect Effects 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010003805 Autism Diseases 0.000 abstract 1
208000020706 Autistic disease Diseases 0.000 abstract 1
206010012335 Dependence Diseases 0.000 abstract 1
208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000020114 Schizophrenia and other psychotic disease Diseases 0.000 abstract 1
208000012886 Vertigo Diseases 0.000 abstract 1
230000016571 aggressive behavior Effects 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
230000019771 cognition Effects 0.000 abstract 1
235000019788 craving Nutrition 0.000 abstract 1
208000029364 generalized anxiety disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
208000019906 panic disease Diseases 0.000 abstract 1
231100000889 vertigo Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

TW095130407A 2005-08-22 2006-08-18 N-oxides as prodrugs of piperazine and piperidine derivatives TW200738656A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05107671		2005-08-22

Publications (1)

Publication Number	Publication Date
TW200738656A true TW200738656A (en)	2007-10-16

Family

ID=35502590

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095130407A TW200738656A (en)	2005-08-22	2006-08-18	N-oxides as prodrugs of piperazine and piperidine derivatives

Country Status (6)

Country	Link
CN (1)	CN101248053B (pt)
AR (1)	AR058022A1 (pt)
BR (1)	BRPI0614843A2 (pt)
TW (1)	TW200738656A (pt)
UA (1)	UA94718C2 (pt)
ZA (1)	ZA200800741B (pt)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE503170A (pt) *	1975-09-02
JP3989554B2 (ja) *	1996-03-29	2007-10-10	デユフアー・インターナシヨナル・リサーチ・ベー・ブイ	ピペラジンおよびピペリジン化合物
UA71590C2 (en) *	1998-11-13	2004-12-15	Duphar Int Res	Piperazine and piperidine derivatives
EP1283838B1 (en) *	2000-05-12	2003-12-03	Solvay Pharmaceuticals B.V.	Piperazine and piperidine compounds
US20050085510A1 (en) *	2002-01-16	2005-04-21	Telefonaktiebolaget Lm Ericsson (Publ)	Prucalopride-n-oxide

2006
- 2006-08-17 AR ARP060103590 patent/AR058022A1/es not_active Application Discontinuation
- 2006-08-18 TW TW095130407A patent/TW200738656A/zh unknown
- 2006-08-21 UA UAA200803586A patent/UA94718C2/ru unknown
- 2006-08-21 CN CN2006800306608A patent/CN101248053B/zh not_active Expired - Fee Related
- 2006-08-21 BR BRPI0614843-3A patent/BRPI0614843A2/pt not_active IP Right Cessation
2008
- 2008-01-24 ZA ZA200800741A patent/ZA200800741B/xx unknown

Also Published As

Publication number	Publication date
ZA200800741B (en)	2009-01-28
AR058022A1 (es)	2008-01-23
CN101248053B (zh)	2011-06-01
UA94718C2 (ru)	2011-06-10
HK1120261A1 (en)	2009-03-27
CN101248053A (zh)	2008-08-20
BRPI0614843A2 (pt)	2012-12-04

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