TW200800981A - 8-azabicyclo[3.2.1]octane compounds as MU opioid receptor antagonists - Google Patents

8-azabicyclo[3.2.1]octane compounds as MU opioid receptor antagonists

Info

Publication number: TW200800981A
Authority: TW; Taiwan
Prior art keywords: opioid receptor; compounds; azabicyclo; receptor antagonists; octane compounds
Prior art date: 2006-03-01

Application number

TW096106339A

Other languages

English (en)

Other versions

TWI379832B (en

Inventor

Daniel D Long

Lan Jiang

Timothy J Church

John R Jacobsen

Daisuke Roland Saito

Ioanna Stergiades

Dyke Priscilla M Van

Original Assignee

Theravance Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-01

Filing date

2007-02-26

Publication date

2008-01-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200800981(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-02-26 Application filed by Theravance Inc filed Critical Theravance Inc

2008-01-01 Publication of TW200800981A publication Critical patent/TW200800981A/zh

2012-12-21 Application granted granted Critical

2012-12-21 Publication of TWI379832B publication Critical patent/TWI379832B/zh

Links

102000051367 mu Opioid Receptors Human genes 0.000 title abstract 3
108020001612 μ-opioid receptors Proteins 0.000 title abstract 3
DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical class C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 title abstract 2
229940123257 Opioid receptor antagonist Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
239000005557 antagonist Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

TW096106339A 2006-03-01 2007-02-26 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists TWI379832B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US77796206P	2006-03-01	2006-03-01
US84102806P	2006-08-30	2006-08-30

Publications (2)

Publication Number	Publication Date
TW200800981A true TW200800981A (en)	2008-01-01
TWI379832B TWI379832B (en)	2012-12-21

Family

ID=38436795

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW096106339A TWI379832B (en)	2006-03-01	2007-02-26	8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Country Status (24)

Country	Link
US (11)	US7622508B2 (zh)
EP (1)	EP2001876B1 (zh)
JP (2)	JP5086280B2 (zh)
KR (1)	KR101376479B1 (zh)
AR (1)	AR059690A1 (zh)
AT (1)	ATE509928T1 (zh)
AU (1)	AU2007224213B2 (zh)
BR (1)	BRPI0708490B8 (zh)
CA (1)	CA2646409C (zh)
CY (1)	CY1111747T1 (zh)
DK (1)	DK2001876T3 (zh)
HR (1)	HRP20110590T1 (zh)
IL (1)	IL193690A (zh)
MA (1)	MA30284B1 (zh)
MX (1)	MX2008011165A (zh)
MY (1)	MY145633A (zh)
NZ (1)	NZ570764A (zh)
PE (1)	PE20071311A1 (zh)
PL (1)	PL2001876T3 (zh)
PT (1)	PT2001876E (zh)
RU (1)	RU2423362C2 (zh)
SI (1)	SI2001876T1 (zh)
TW (1)	TWI379832B (zh)
WO (1)	WO2007103187A2 (zh)

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TWI409067B (zh)	2007-02-28	2013-09-21	Theravance Inc	８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) *	2007-07-20	2013-11-21	Theravance Inc	製備ｍｕ類鴉片受體拮抗劑之中間物的方法
WO2009029257A1 (en) *	2007-08-27	2009-03-05	Theravance, Inc.	Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists
US7902221B2 (en) *	2007-08-27	2011-03-08	Theravance, Inc.	Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh)	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
WO2009029253A1 (en) *	2007-08-27	2009-03-05	Theravance, Inc.	Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
BR112012006069A8 (pt) *	2009-09-18	2017-10-10	Adolor Corp	Método para tratar ou prevenir constipação induzida e disfunção intestinal induzida por opióide em um humano, e, uso de uma quantidade terapeuticamente efetiva de composto
US20120122928A1 (en)	2010-08-11	2012-05-17	Bayer Cropscience Ag	Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
EP2423210A1 (de)	2010-08-25	2012-02-29	Bayer CropScience AG	Heteroarylpiperidin- und -piperazinderivate als Fungizide
US8759527B2 (en)	2010-08-25	2014-06-24	Bayer Cropscience Ag	Heteroarylpiperidine and -piperazine derivatives as fungicides
BR112013010497B1 (pt)	2010-10-27	2018-07-17	Bayer Intellectual Property Gmbh	derivados de heteroaril - piperidina e - piperazina enquanto fungicidas, composição os compreendendo, bem como processo para a produção de composições para controle de fungos fitopatogênicos nocivos e método para controle de fungos fitopatogênicos nocivos
JP5703009B2 (ja) *	2010-12-16	2015-04-15	住友精化株式会社	スルホン化合物、スルホン化合物の製造方法、および電気化学デバイス用電解液
BR112013019667B1 (pt)	2011-02-01	2019-07-02	Bayer Intellectual Property Gmbh	Compostos derivados de heteroaril-piperidina e -piperazina, seus usos, composição, processos de produção de compostos e de composições, método para o controle de fungos fitopatogênicos prejudiciais
ES2661849T3 (es)	2011-09-15	2018-04-04	Bayer Intellectual Property Gmbh	Piperidinpirazoles como fungicidas
ES2647442T3 (es)	2011-12-27	2017-12-21	Bayer Intellectual Property Gmbh	Compuestos intermedios para la preparación de derivados de heteroarilpiperidina y de heteroarilpiperazina como fungicidas
EP3082816B1 (en)	2013-12-20	2019-03-20	Indivior UK Limited	Intranasal naloxone compositions and methods of making and using same
WO2016161069A1 (en)	2015-04-02	2016-10-06	Theravance Biopharma R&D Ip, Llc	Combination dosage form of a mu opioid receptor antagonist and an opioid agent
JP2021512952A (ja)	2018-02-05	2021-05-20	アルカームス・インコーポレイテッド	疼痛の処置のための化合物
US20230416243A1 (en) *	2020-11-06	2023-12-28	Actinogen Medical Limited	Process for Preparing Heterocyclic Methanone Compounds and AZA-Bicyclo Intermediates Thereof

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JP2010509227A (ja)	2006-11-07	2010-03-25	ネクターセラピューティックスエイエル，コーポレイション	オピオイド作動薬およびオピオイド拮抗薬の用量形態および同時投与
TWI409067B (zh) *	2007-02-28	2013-09-21	Theravance Inc	８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh)	2007-07-20	2013-11-21	Theravance Inc	製備ｍｕ類鴉片受體拮抗劑之中間物的方法
WO2009029257A1 (en)	2007-08-27	2009-03-05	Theravance, Inc.	Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists
TWI423801B (zh)	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
WO2009029253A1 (en)	2007-08-27	2009-03-05	Theravance, Inc.	Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
US7902221B2 (en) *	2007-08-27	2011-03-08	Theravance, Inc.	Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

2007
- 2007-02-07 MY MYPI20070176A patent/MY145633A/en unknown
- 2007-02-26 TW TW096106339A patent/TWI379832B/zh active
- 2007-02-28 PL PL07752111T patent/PL2001876T3/pl unknown
- 2007-02-28 CA CA2646409A patent/CA2646409C/en active Active
- 2007-02-28 SI SI200730691T patent/SI2001876T1/sl unknown
- 2007-02-28 KR KR1020087024027A patent/KR101376479B1/ko active Active
- 2007-02-28 JP JP2008557405A patent/JP5086280B2/ja active Active
- 2007-02-28 RU RU2008138875/04A patent/RU2423362C2/ru active
- 2007-02-28 PE PE2007000212A patent/PE20071311A1/es active IP Right Grant
- 2007-02-28 AU AU2007224213A patent/AU2007224213B2/en active Active
- 2007-02-28 NZ NZ570764A patent/NZ570764A/en not_active IP Right Cessation
- 2007-02-28 EP EP07752111A patent/EP2001876B1/en active Active
- 2007-02-28 DK DK07752111.0T patent/DK2001876T3/da active
- 2007-02-28 MX MX2008011165A patent/MX2008011165A/es active IP Right Grant
- 2007-02-28 WO PCT/US2007/005388 patent/WO2007103187A2/en not_active Ceased
- 2007-02-28 BR BRPI0708490A patent/BRPI0708490B8/pt not_active IP Right Cessation
- 2007-02-28 US US11/711,961 patent/US7622508B2/en active Active
- 2007-02-28 AR ARP070100835A patent/AR059690A1/es active IP Right Grant
- 2007-02-28 HR HR20110590T patent/HRP20110590T1/hr unknown
- 2007-02-28 AT AT07752111T patent/ATE509928T1/de active
- 2007-02-28 PT PT07752111T patent/PT2001876E/pt unknown
2008
- 2008-08-26 IL IL193690A patent/IL193690A/en active IP Right Grant
- 2008-09-17 MA MA31246A patent/MA30284B1/fr unknown
2009
- 2009-10-14 US US12/578,715 patent/US8263618B2/en active Active
2011
- 2011-08-09 CY CY20111100762T patent/CY1111747T1/el unknown
2012
- 2012-06-20 US US13/527,942 patent/US8664242B2/en active Active
- 2012-08-01 JP JP2012171119A patent/JP2012211193A/ja not_active Withdrawn
2014
- 2014-01-15 US US14/156,014 patent/US8927573B2/en active Active
- 2014-11-06 US US14/534,798 patent/US9206172B2/en active Active
2015
- 2015-10-29 US US14/926,225 patent/US9663509B2/en active Active
2017
- 2017-04-25 US US15/496,269 patent/US10081626B2/en active Active
2018
- 2018-08-16 US US15/998,823 patent/US10377751B2/en active Active
2019
- 2019-06-24 US US16/449,857 patent/US10745394B2/en active Active
2020
- 2020-07-07 US US16/922,414 patent/US11548887B2/en active Active
2022
- 2022-12-09 US US18/078,891 patent/US20230183232A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US8664242B2 (en)	2014-03-04
SI2001876T1 (sl)	2011-09-30
HK1125935A1 (zh)	2009-08-21
MA30284B1 (fr)	2009-03-02
BRPI0708490B8 (pt)	2021-05-25
US7622508B2 (en)	2009-11-24
US20160176863A1 (en)	2016-06-23
WO2007103187A2 (en)	2007-09-13
US9206172B2 (en)	2015-12-08
US20140288112A1 (en)	2014-09-25
DK2001876T3 (da)	2011-08-29
EP2001876A2 (en)	2008-12-17
EP2001876B1 (en)	2011-05-18
US20170349578A1 (en)	2017-12-07
AU2007224213B2 (en)	2012-06-14
US10745394B2 (en)	2020-08-18
US10377751B2 (en)	2019-08-13
RU2423362C2 (ru)	2011-07-10
BRPI0708490A2 (pt)	2011-05-31
RU2008138875A (ru)	2010-04-10
KR20080100282A (ko)	2008-11-14
PT2001876E (pt)	2011-08-18
BRPI0708490B1 (pt)	2019-07-30
PL2001876T3 (pl)	2011-10-31
JP2012211193A (ja)	2012-11-01
MX2008011165A (es)	2008-09-15
US20150291579A1 (en)	2015-10-15
US20100035921A1 (en)	2010-02-11
US20190119267A1 (en)	2019-04-25
US10081626B2 (en)	2018-09-25
CA2646409A1 (en)	2007-09-13
NZ570764A (en)	2011-08-26
US9663509B2 (en)	2017-05-30
PE20071311A1 (es)	2007-12-29
US8263618B2 (en)	2012-09-11
US20190308966A1 (en)	2019-10-10
US20130158060A1 (en)	2013-06-20
AR059690A1 (es)	2008-04-23
HRP20110590T1 (hr)	2011-09-30
CA2646409C (en)	2015-11-10
IL193690A (en)	2013-02-28
JP5086280B2 (ja)	2012-11-28
US20070219278A1 (en)	2007-09-20
TWI379832B (en)	2012-12-21
IL193690A0 (en)	2009-08-03
KR101376479B1 (ko)	2014-03-27
CY1111747T1 (el)	2015-10-07
JP2009528371A (ja)	2009-08-06
US11548887B2 (en)	2023-01-10
MY145633A (en)	2012-03-15
ATE509928T1 (de)	2011-06-15
US20210024515A1 (en)	2021-01-28
AU2007224213A1 (en)	2007-09-13
US20230183232A1 (en)	2023-06-15
US8927573B2 (en)	2015-01-06
WO2007103187A3 (en)	2007-11-01

Publication	Publication Date	Title
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