UA117565C2 - Модифікований олігонуклеотид - Google Patents

Модифікований олігонуклеотид

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Publication number
UA117565C2
UA117565C2 UAA201502834A UAA201502834A UA117565C2 UA 117565 C2 UA117565 C2 UA 117565C2 UA A201502834 A UAA201502834 A UA A201502834A UA A201502834 A UAA201502834 A UA A201502834A UA 117565 C2 UA117565 C2 UA 117565C2
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UA
Ukraine
Prior art keywords
ligands
producing
methods
rig
novel rig
Prior art date
Application number
UAA201502834A
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English (en)
Inventor
ден Боорн Джаспер ван
Янош Людвіг
Крістіне Шуберт-Вагнер
Original Assignee
Райніше Фрідріх-Вільхельмс-Універсітет Бонн
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Application filed by Райніше Фрідріх-Вільхельмс-Універсітет Бонн filed Critical Райніше Фрідріх-Вільхельмс-Універсітет Бонн
Publication of UA117565C2 publication Critical patent/UA117565C2/uk

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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3513—Protein; Peptide
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    • C12N2310/3527—Other alkyl chain
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
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  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • Electric Propulsion And Braking For Vehicles (AREA)

Abstract

Винахід належить до трифосфатмодифікованих олігонуклеотидів, які можуть діяти як ліганди RIG-I, а також до фармацевтичної композиції, що їх містить.
UAA201502834A 2012-09-27 2013-09-26 Модифікований олігонуклеотид UA117565C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12186444.1A EP2712870A1 (en) 2012-09-27 2012-09-27 Novel RIG-I ligands and methods for producing them
PCT/EP2013/070117 WO2014049079A1 (en) 2012-09-27 2013-09-26 Novel rig-i ligands and methods for producing them

Publications (1)

Publication Number Publication Date
UA117565C2 true UA117565C2 (uk) 2018-08-27

Family

ID=46940404

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201502834A UA117565C2 (uk) 2012-09-27 2013-09-26 Модифікований олігонуклеотид

Country Status (32)

Country Link
US (3) US10059943B2 (uk)
EP (5) EP2712870A1 (uk)
JP (1) JP6313768B2 (uk)
KR (1) KR102182479B1 (uk)
CN (2) CN106279300B (uk)
AU (2) AU2013322620C1 (uk)
BR (2) BR122019023887B1 (uk)
CA (1) CA2885564C (uk)
CL (1) CL2015000752A1 (uk)
CY (1) CY1120660T1 (uk)
DK (1) DK2903997T3 (uk)
EA (2) EA028707B1 (uk)
ES (1) ES2679373T3 (uk)
HK (1) HK1214602A1 (uk)
HR (1) HRP20181114T1 (uk)
HU (1) HUE038811T2 (uk)
IL (1) IL237794B (uk)
LT (1) LT2903997T (uk)
MX (1) MX2015003787A (uk)
NZ (2) NZ706443A (uk)
PH (1) PH12015500644A1 (uk)
PL (1) PL2903997T3 (uk)
PT (1) PT2903997T (uk)
RS (1) RS57609B1 (uk)
SA (2) SA517380700B1 (uk)
SG (3) SG10201912308SA (uk)
SI (1) SI2903997T1 (uk)
TN (1) TN2015000104A1 (uk)
TR (1) TR201810231T4 (uk)
UA (1) UA117565C2 (uk)
WO (1) WO2014049079A1 (uk)
ZA (1) ZA201501718B (uk)

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SI2056845T1 (en) 2006-08-08 2018-02-28 Rheinische Friedrich-Wilhelms-Universitaet Bonn STRUCTURE AND USE 5 'PHOSPHATE OF OLIGONUCLEOTES
EP2297323A1 (en) 2008-05-21 2011-03-23 Hartmann, Gunther 5' triphosphate oligonucleotide with blunt end and uses thereof
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
US9861574B2 (en) * 2013-04-09 2018-01-09 Duke University 2-fluoro-modified RNAs as immunostimulators
DE102015008536A1 (de) 2015-07-02 2017-01-05 Rheinische Friedrich-Wilhelms-Universität Bonn Diskontinuierliche Oligonukleotid-Liganden
US11382966B2 (en) 2017-03-24 2022-07-12 Rigontec Gmbh Method for designing RIG-I ligands
EP3607063A4 (en) 2017-04-03 2021-01-13 Duke University COMPOSITIONS AND METHODS FOR DIFFERENTIAL INDUCTION OF CELLULAR DEATH AND INTERFERON EXPRESSION
JP7366057B2 (ja) 2018-04-19 2023-10-20 チェックメイト ファーマシューティカルズ， インコーポレイテッド 合成ｒｉｇ－ｉ様受容体アゴニスト
EP3781687A4 (en) 2018-04-20 2022-02-09 Merck Sharp & Dohme Corp. NEW RIG-I SUBSTITUTED AGONISTS: COMPOSITIONS AND METHODS THEREOF
EP3790970A1 (en) 2018-05-07 2021-03-17 Alnylam Pharmaceuticals Inc. Extrahepatic delivery
CN113453669B (zh) * 2019-02-22 2024-01-16 雷莫内克斯生物制药有限公司 用于免疫活性或用于预防或治疗癌症的药物组合物
EP3990635A1 (en) 2019-06-27 2022-05-04 Rigontec GmbH Design method for optimized rig-i ligands
WO2021237067A1 (en) * 2020-05-22 2021-11-25 President And Fellows Of Harvard College Interferon- inducing oligonucleotide duplexes and methods of use
IL309662A (en) 2021-07-02 2024-02-01 Univ Yale Compositions and methods for treating cancers
EP4395832A1 (en) 2021-08-31 2024-07-10 Yale University Compositions and methods for treating cancers
JP2025507840A (ja) 2022-03-03 2025-03-21 イエール ユニバーシティ ヒト化３ｅ１０抗体、そのバリアント、及び抗原結合断片
WO2025088117A1 (en) * 2023-10-25 2025-05-01 Rheinische Friedrich-Wilhelms-Universität Bonn Ribonucleic acid construct capable of inducing an immune response, as well as pharmaceutical composition and kit comprising same
WO2025158069A1 (en) 2024-01-25 2025-07-31 Rheinische Friedrich-Wilhelms-Universität Bonn CONSTRUCT COMPRISING mRNA-STRAND AND RETINOIC ACID-INDUCIBLE GENE I (RIG-I)-LIGAND(S), PHARMACEUTICAL COMPOSITION AND KIT COMPRISING THE SAME
WO2026039779A1 (en) 2024-08-15 2026-02-19 Yale University Humanized 3e10 antibodies and antigen binding fragments optimized for rad51 binding
WO2026047025A1 (en) 2024-08-27 2026-03-05 Rheinische Friedrich-Wilhelms-Universität Bonn Photocontrollable conjugate, pharmaceutical composition and kit comprising the same, and uses thereof

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