UA41362C2 - Тіазолідиндіони, спосіб їх отримання та лікарський засіб - Google Patents

Тіазолідиндіони, спосіб їх отримання та лікарський засіб

Info

Publication number
UA41362C2
UA41362C2 UA95114968A UA95114968A UA41362C2 UA 41362 C2 UA41362 C2 UA 41362C2 UA 95114968 A UA95114968 A UA 95114968A UA 95114968 A UA95114968 A UA 95114968A UA 41362 C2 UA41362 C2 UA 41362C2
Authority
UA
Ukraine
Prior art keywords
thiazolidindions
preparation
medicinal product
thiazolidindons
heteroatoms
Prior art date
Application number
UA95114968A
Other languages
English (en)
Russian (ru)
Inventor
Альфред Мертенс
Ханс-Петер ВОЛЬФФ
Петер ФРОЙНД
Original Assignee
Роше Діагностікс Гмбх
Роше Диагностикс Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Роше Діагностікс Гмбх, Роше Диагностикс Гмбх filed Critical Роше Діагностікс Гмбх
Publication of UA41362C2 publication Critical patent/UA41362C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Предметом цього винаходу є тіазолідиндіони, спосіб їх отримання і лікарські засоби, що містять їх. Тіазолідиндіони формули (I): в якій А означає карбоциклічне кільце з 5 або 6 атомами вуглецю або гетероциклічне кільце з 1 або 2 гетероатомами, причому гетероатоми означають кисень, азот або сірку, а гетероцикли, при необхідності, можуть нести на одному або декількох атомах азоту один атом кисню, В - -СН=СН-, -N=CH-, -СН=N-, W - СН2, О, СН(ОН) або СО, Х - S, О або NR2, причому залишок R2 є воднем, Y-N, R - нафтил, піридил, фурил, тієніл або фенил, при необхідності одно- або двозаміщений С1-Сз- алкілом, СFз, С1-Сз--алкокси, F, CI або бромом, R1 - водень або С1-С6-алкіл, і n = 2, а також їх таутомери, енантіомери, діастереомери і фізіологічно прийнятні солі.
UA95114968A 1993-05-25 1994-05-19 Тіазолідиндіони, спосіб їх отримання та лікарський засіб UA41362C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4317320A DE4317320A1 (de) 1993-05-25 1993-05-25 Neue Thiazolidindione und diese enthaltende Arzneimittel
PCT/EP1994/001619 WO1994027995A1 (de) 1993-05-25 1994-05-19 Neue thiazolidindione und diese enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
UA41362C2 true UA41362C2 (uk) 2001-09-17

Family

ID=6488833

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95114968A UA41362C2 (uk) 1993-05-25 1994-05-19 Тіазолідиндіони, спосіб їх отримання та лікарський засіб

Country Status (25)

Country Link
US (1) US5599826A (uk)
EP (1) EP0700397B1 (uk)
JP (1) JP3162721B2 (uk)
KR (1) KR100243783B1 (uk)
CN (1) CN1040324C (uk)
AT (1) ATE223409T1 (uk)
AU (1) AU682699B2 (uk)
CA (1) CA2163028C (uk)
CL (1) CL2004001167A1 (uk)
CY (1) CY2415B1 (uk)
CZ (1) CZ285927B6 (uk)
DE (2) DE4317320A1 (uk)
DK (1) DK0700397T3 (uk)
ES (1) ES2180581T3 (uk)
FI (1) FI955685A7 (uk)
HU (1) HU217065B (uk)
NO (1) NO307832B1 (uk)
NZ (1) NZ267410A (uk)
PL (1) PL180046B1 (uk)
PT (1) PT700397E (uk)
RO (1) RO114328B1 (uk)
RU (1) RU2122002C1 (uk)
SK (1) SK282618B6 (uk)
UA (1) UA41362C2 (uk)
WO (1) WO1994027995A1 (uk)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07138258A (ja) * 1993-11-16 1995-05-30 Taiho Yakuhin Kogyo Kk チアゾリジンジオン誘導体又はその塩
EP0848004B1 (en) * 1995-07-31 2003-04-02 Shionogi & Co., Ltd. Pyrrolidine derivatives having phospholipase a2 inhibitory activity
JPH09176162A (ja) * 1995-12-22 1997-07-08 Toubishi Yakuhin Kogyo Kk チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物
DE19619819A1 (de) * 1996-05-16 1997-11-20 Boehringer Mannheim Gmbh Neue Thiazolidindione, Verfahren zu ihrer Herstellung und diese enthaltenden Arzneimittel
DE19711617A1 (de) * 1997-03-20 1998-09-24 Boehringer Mannheim Gmbh Neue Thiazolidindione, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE19711616A1 (de) * 1997-03-20 1998-09-24 Boehringer Mannheim Gmbh Verbessertes Verfahren zur Herstellung von Thiazolidindionen
US6028088A (en) * 1998-10-30 2000-02-22 The University Of Mississippi Flavonoid derivatives
GB9824893D0 (en) * 1998-11-12 1999-01-06 Smithkline Beckman Corp Novel method of treatment
AU1740900A (en) * 1998-11-20 2000-06-13 Genentech Inc. Method of inhibiting angiogenesis
DE60026404T2 (de) 1999-08-02 2006-10-19 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Benzothiophen-Derivaten
US6531609B2 (en) 2000-04-14 2003-03-11 Hoffmann-La Roche Inc. Process for the preparation of thiazolidinedione derivatives
EP1283830B1 (en) * 2000-05-08 2008-06-18 F. Hoffmann-La Roche Ag Para-amine substituted phenylamide glucokinase activators
YU96602A (sh) 2000-06-27 2005-03-15 F.Hoffmann-La Roche Ag. Postupak za spravljanje smeše
EP1726586A1 (en) * 2000-12-25 2006-11-29 Ono Pharmaceutical Co., Ltd. Dihydronaphthalene derivative compounds and agent comprising the derivative as active ingredient
EP1392296A1 (en) * 2001-04-06 2004-03-03 F. Hoffmann-La Roche Ag Thiazolidinediones alone or in conbination with other therapeutic agents for inhibiting or reducing tumour growth
PT1392295E (pt) 2001-05-15 2006-09-29 Hoffmann La Roche Derivados de oxazole substituidos por acidos carboxilicos para serem utilizados como activadores de rapp alfa e gama no tratamento de diabetes
JP2003040877A (ja) * 2001-07-24 2003-02-13 Sumika Fine Chemicals Co Ltd ５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
AU2003249879B2 (en) * 2002-07-03 2008-12-18 F. Hoffmann-La Roche Ag Oxazole derivatives and their use as insulin sensitizers
ATE483699T1 (de) * 2002-08-30 2010-10-15 Hoffmann La Roche Neue 2-arylthiazolverbindungen als ppar-alpha und gamma agonisten
ATE345340T1 (de) * 2002-09-12 2006-12-15 Hoffmann La Roche N-substituierte-1h-indol-5-propansäure verbindungen als ppar-agonisten zur behandlung von diabetis
BR0316556A (pt) * 2002-11-25 2005-10-04 Hoffmann La Roche Compostos, processo para a preparação de um composto, composição farmacêutica que compreende esse composto, sua utilização e método para o tratamento e/ou profilaxia de enfermidades que são moduladas por agonistas ppar(alfa) e/ou ppary
MXPA05013732A (es) 2003-06-26 2006-03-08 Hoffmann La Roche Proceso para preparacion de sensibilizador de insulina y compuesto intermediario del mismo.
CN101693202B (zh) * 2009-10-21 2011-04-20 沧州那瑞化学科技有限公司 盐酸吡咯列酮关键中间体加氢反应催化剂及加氢反应方法
US20150004144A1 (en) 2011-12-02 2015-01-01 The General Hospital Corporation Differentiation into brown adipocytes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
WO1986007056A1 (en) * 1985-05-21 1986-12-04 Pfizer Inc. Hypoglycemic thiazolidinediones
GB8713861D0 (en) * 1987-06-13 1987-07-15 Beecham Group Plc Compounds
EP0374149B1 (en) * 1988-03-04 1994-04-20 Kurt H. Volk, Incorporated Direct mail article with mailable reply card
HU217432B (hu) * 1988-03-08 2000-01-28 Pfizer Inc. Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények
CA2086606A1 (en) * 1990-07-03 1992-01-04 Kunihiro Niigata Bisheterocyclic compound
FR2688220A1 (fr) * 1992-03-06 1993-09-10 Adir Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
US5599826A (en) 1997-02-04
FI955685L (fi) 1995-11-24
HUT75099A (en) 1997-04-28
HU217065B (hu) 1999-11-29
PL180046B1 (en) 2000-12-29
RU2122002C1 (ru) 1998-11-20
PL311752A1 (en) 1996-03-18
KR960702460A (ko) 1996-04-27
CZ285927B6 (cs) 1999-11-17
HU9503376D0 (en) 1996-01-29
KR100243783B1 (ko) 2000-03-02
CA2163028A1 (en) 1994-12-08
EP0700397A1 (de) 1996-03-13
PT700397E (pt) 2002-12-31
NO307832B1 (no) 2000-06-05
JP3162721B2 (ja) 2001-05-08
DK0700397T3 (da) 2003-01-06
AU682699B2 (en) 1997-10-16
NZ267410A (en) 1996-12-20
CY2415B1 (en) 2004-11-12
CL2004001167A1 (es) 2005-05-20
DE59410181D1 (de) 2002-10-10
EP0700397B1 (de) 2002-09-04
SK146195A3 (en) 1996-06-05
RO114328B1 (ro) 1999-03-30
CN1124488A (zh) 1996-06-12
CZ299995A3 (en) 1996-03-13
FI955685A0 (fi) 1995-11-24
ES2180581T3 (es) 2003-02-16
WO1994027995A1 (de) 1994-12-08
DE4317320A1 (de) 1994-12-01
JPH08510456A (ja) 1996-11-05
ATE223409T1 (de) 2002-09-15
CA2163028C (en) 2003-11-25
NO954762D0 (no) 1995-11-24
CN1040324C (zh) 1998-10-21
SK282618B6 (sk) 2002-10-08
AU6970494A (en) 1994-12-20
FI955685A7 (fi) 1995-11-24
NO954762L (no) 1995-11-24

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