UA62996C2 - 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines - Google Patents

6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines Download PDF

Info

Publication number: UA62996C2
Authority: UA; Ukraine
Prior art keywords: amino; aminocyclohexyl; dihydrochloride; cyclopentylpurine; trans
Prior art date: 1998-02-26

Application number

UA2000095500A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Aventic Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-26

Filing date

1999-02-18

Publication date

2004-01-15

1999-02-18 Application filed by Aventic Pharmaceuticals Inc filed Critical Aventic Pharmaceuticals Inc

2004-01-15 Publication of UA62996C2 publication Critical patent/UA62996C2/uk

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YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 1
238000010257 thawing Methods 0.000 description 1
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125000001544 thienyl group Chemical group 0.000 description 1
FKKJJPMGAWGYPN-UHFFFAOYSA-N thiophen-2-ylmethanamine Chemical compound NCC1=CC=CS1 FKKJJPMGAWGYPN-UHFFFAOYSA-N 0.000 description 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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239000002341 toxic gas Substances 0.000 description 1
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125000004306 triazinyl group Chemical group 0.000 description 1
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ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
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208000009540 villous adenoma Diseases 0.000 description 1
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HOFQVRTUGATRFI-XQKSVPLYSA-N vinblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 HOFQVRTUGATRFI-XQKSVPLYSA-N 0.000 description 1
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OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Oncology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

UA2000095500A 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines UA62996C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3238198A	1998-02-26	1998-02-26
PCT/US1999/003451 WO1999043676A2 (fr)	1998-02-26	1999-02-18	2-[trans-(4- aminocyclohexyl) amino]purines 6,9-disubstituees

Publications (1)

Publication Number	Publication Date
UA62996C2 true UA62996C2 (en)	2004-01-15

Family

ID=21864658

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2000095500A UA62996C2 (en)	1998-02-26	1999-02-18	6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines

Country Status (30)

Country	Link
EP (1)	EP1056745B1 (fr)
JP (1)	JP2002504553A (fr)
KR (1)	KR100568658B1 (fr)
CN (1)	CN1128149C (fr)
AP (1)	AP1258A (fr)
AR (1)	AR019822A1 (fr)
AT (1)	ATE269332T1 (fr)
AU (1)	AU748178B2 (fr)
BR (1)	BR9908325A (fr)
CA (1)	CA2320448C (fr)
CZ (1)	CZ291604B6 (fr)
DE (1)	DE69918062T2 (fr)
DK (1)	DK1056745T3 (fr)
EE (1)	EE04315B1 (fr)
ES (1)	ES2219038T3 (fr)
HU (1)	HUP0100931A3 (fr)
IL (2)	IL138044A0 (fr)
NO (1)	NO20004281L (fr)
NZ (1)	NZ506234A (fr)
OA (1)	OA11480A (fr)
PL (1)	PL344021A1 (fr)
PT (1)	PT1056745E (fr)
RU (1)	RU2191777C2 (fr)
SI (1)	SI1056745T1 (fr)
SK (1)	SK12912000A3 (fr)
TR (1)	TR200002482T2 (fr)
TW (1)	TW541308B (fr)
UA (1)	UA62996C2 (fr)
WO (1)	WO1999043676A2 (fr)
ZA (1)	ZA991548B (fr)

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RU2681081C2 (ru) *	2007-10-05	2019-03-04	Верастэм, Инк.	Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ, и способ лечения пролиферативных заболеваний

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US6627633B2 (en) *	1999-03-17	2003-09-30	Albany Molecular Research, Inc.	6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
IL150594A0 (en) *	2000-01-07	2003-02-12	Ustav Ex Botan Adademie Ved Ce	Purine derivatives, process for their preparation and use
YU54202A (sh)	2000-01-18	2006-01-16	Agouron Pharmaceuticals Inc.	Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es)	2000-01-21	2003-12-11	Inc Agouron Pharmaceuticals	Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) *	2000-03-22	2003-11-28	Centre Nat Rech Scient	Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
MXPA02010222A (es)	2000-04-18	2003-05-23	Agouron Pharma	Pirazoles para inhibir proteina cinasa.
WO2002012250A2 (fr)	2000-08-09	2002-02-14	Agouron Pharmaceuticals, Inc.	Composes pyrazole-thiazole, compositions pharmaceutiques les contenant, et leurs procedes d'utilisation pour inhiber les kinases cyclino-dependantes
DE60110802T2 (de)	2000-08-18	2005-10-06	Agouron Pharmaceuticals, Inc., San Diego	Heterozyklische-hydroximino-fluorene und ihre verwendung zur inhibierung von proteinkinasen
GB0117075D0 (en) *	2000-10-31	2001-09-05	Aventis Pharm Prod Inc	Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
DK1377579T3 (da) *	2000-10-31	2009-08-31	Aventis Pharma Inc	Acyl- og sulfonylderivater af 6,9-disubstitueret-2(trans-1,4-diaminocyklohexyl)puriner og deres anvendelse som antiproliferative midler
US6756374B2 (en)	2001-01-22	2004-06-29	Hoffmann-La Roche Inc.	Diaminothiazoles having antiproliferative activity
DE60205376T2 (de)	2001-06-27	2006-04-06	Cyclacel Ltd.	2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten
US6812232B2 (en)	2001-09-11	2004-11-02	Amr Technology, Inc.	Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en)	2001-09-11	2003-12-23	Albany Molecular Research, Inc.	Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
GB0219052D0 (en)	2002-08-15	2002-09-25	Cyclacel Ltd	New puring derivatives
GB0219054D0 (en)	2002-08-15	2002-09-25	Cyclacel Ltd	New purine derivatives
US20060135445A1 (en) *	2003-02-04	2006-06-22	Kabushiki Kaisha Yakult Honsha	Breast cancer-resistant protein inhibitor
US7211576B2 (en)	2004-04-20	2007-05-01	Hoffmann-La Roche Inc.	Diaminothiazoles
RU2462246C2 (ru) *	2006-03-30	2012-09-27	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Способы получения функционального белка из днк, имеющей нонсенс-мутацию, и лечения нарушений, ассоциированных с ней
CN102241646B (zh) *	2010-05-14	2014-04-09	中国人民解放军军事医学科学院毒物药物研究所	己烯酮类化合物及其医药用途
US9493464B2 (en)	2012-02-29	2016-11-15	The Scripps Research Institute	Wee1 degradation inhibitors
US9879014B2 (en)	2013-07-12	2018-01-30	Kyoto University	Method for screening substance capable of inhibiting abnormal splicing causative of onset or progress of disease
CA2973949C (fr)	2015-01-16	2023-07-11	The General Hospital Corporation	Composes pour ameliorer l'epissage de l'arnm
CN107903274A (zh) *	2017-12-28	2018-04-13	窦玉玲	一种胺类化合物及其在抗肿瘤药物中的应用
US20220251085A1 (en) *	2019-07-21	2022-08-11	University Of Virginia Patent Foundation	Cysteine binding compositions and methods of use thereof
WO2024105159A1 (fr) *	2022-11-16	2024-05-23	University Of Zurich	Ligands des lecteurs d'arn m6a

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AU7296896A (en) *	1995-11-01	1997-05-22	Novartis Ag	Purine derivatives and processes for their preparation
FR2741881B1 (fr) *	1995-12-01	1999-07-30	Centre Nat Rech Scient	Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques

1999
- 1999-02-18 TR TR2000/02482T patent/TR200002482T2/xx unknown
- 1999-02-18 CA CA002320448A patent/CA2320448C/fr not_active Expired - Fee Related
- 1999-02-18 UA UA2000095500A patent/UA62996C2/uk unknown
- 1999-02-18 RU RU2000124409/04A patent/RU2191777C2/ru active
- 1999-02-18 SK SK1291-2000A patent/SK12912000A3/sk unknown
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- 1999-02-18 DE DE69918062T patent/DE69918062T2/de not_active Expired - Fee Related
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- 1999-02-18 JP JP2000533431A patent/JP2002504553A/ja active Pending
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- 1999-02-18 BR BR9908325-6A patent/BR9908325A/pt not_active IP Right Cessation
- 1999-02-18 NZ NZ506234A patent/NZ506234A/en active IP Right Revival
- 1999-02-18 EP EP99936074A patent/EP1056745B1/fr not_active Expired - Lifetime
- 1999-02-18 WO PCT/US1999/003451 patent/WO1999043676A2/fr not_active Ceased
- 1999-02-18 ES ES99936074T patent/ES2219038T3/es not_active Expired - Lifetime
- 1999-02-18 EE EEP200000501A patent/EE04315B1/xx not_active IP Right Cessation
- 1999-02-18 KR KR1020007009421A patent/KR100568658B1/ko not_active Expired - Fee Related
- 1999-02-18 PT PT99936074T patent/PT1056745E/pt unknown
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- 1999-02-18 CN CN99803395A patent/CN1128149C/zh not_active Expired - Fee Related
- 1999-02-18 AT AT99936074T patent/ATE269332T1/de not_active IP Right Cessation
- 1999-02-24 TW TW088102781A patent/TW541308B/zh not_active IP Right Cessation
- 1999-02-25 AR ARP990100782A patent/AR019822A1/es active IP Right Grant
- 1999-02-25 ZA ZA9901548A patent/ZA991548B/xx unknown
2000
- 2000-08-23 IL IL138044A patent/IL138044A/en not_active IP Right Cessation
- 2000-08-25 NO NO20004281A patent/NO20004281L/no not_active Application Discontinuation
- 2000-08-25 OA OA1200000234A patent/OA11480A/en unknown

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2681081C2 (ru) *	2007-10-05	2019-03-04	Верастэм, Инк.	Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ, и способ лечения пролиферативных заболеваний

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Publication number	Publication date
ZA991548B (en)	1999-08-26
SK12912000A3 (sk)	2001-08-06
NO20004281D0 (no)	2000-08-25
CA2320448C (fr)	2005-02-01
WO1999043676A2 (fr)	1999-09-02
PL344021A1 (en)	2001-09-24
CA2320448A1 (fr)	1999-09-02
ES2219038T3 (es)	2004-11-16
AP1258A (en)	2004-03-15
PT1056745E (pt)	2004-09-30
CZ20003106A3 (cs)	2000-12-13
IL138044A (en)	2006-04-10
AR019822A1 (es)	2002-03-20
DE69918062D1 (de)	2004-07-22
ATE269332T1 (de)	2004-07-15
IL138044A0 (en)	2001-10-31
EP1056745A2 (fr)	2000-12-06
TW541308B (en)	2003-07-11
EE04315B1 (et)	2004-06-15
OA11480A (en)	2004-05-05
HK1030948A1 (en)	2001-05-25
CN1291983A (zh)	2001-04-18
DK1056745T3 (da)	2004-10-25
BR9908325A (pt)	2000-11-07
CN1128149C (zh)	2003-11-19
EP1056745B1 (fr)	2004-06-16
SI1056745T1 (en)	2004-12-31
AU748178B2 (en)	2002-05-30
HUP0100931A3 (en)	2002-08-28
AU3299099A (en)	1999-09-15
WO1999043676A3 (fr)	1999-10-21
AP2000001923A0 (en)	2000-09-30
DE69918062T2 (de)	2005-06-02
TR200002482T2 (tr)	2002-10-21
KR100568658B1 (ko)	2006-04-07
CZ291604B6 (cs)	2003-04-16
KR20010041315A (ko)	2001-05-15
RU2191777C2 (ru)	2002-10-27
JP2002504553A (ja)	2002-02-12
NO20004281L (no)	2000-10-18
EE200000501A (et)	2002-02-15
HUP0100931A2 (hu)	2002-04-29
NZ506234A (en)	2003-05-30

Publication	Publication Date	Title
UA62996C2 (en)	2004-01-15	6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines
US6413974B1 (en)	2002-07-02	6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
EP3867251B1 (fr)	2022-09-07	Inhibiteurs de kras g12c
AU747151B2 (en)	2002-05-09	6,9-disubstituted 2-(trans-(4-aminocyclohexyl) amino) purines
ES2716732T3 (es)	2019-06-14	Inhibidor de quinasa Aurora A
AU2016245864C1 (en)	2021-09-09	Substituted quinazoline compounds and methods of use thereof
JP5385268B2 (ja)	2014-01-08	インドリン−２−オンおよびアザ−インドリン−２−オン
AU2015280138B2 (en)	2018-06-14	Phosphatidylinositol 3-kinase inhibitors
CA2656290A1 (fr)	2008-01-10	Procedes d'utilisation de modulateurs de kinase igf1r et abl
KR20100014720A (ko)	2010-02-10	단백질 키나아제의 조절제로서 (ｓ)-2-아미노-1-(4-클로로페닐)-1-[4-(1ｈ-피라졸-4-일)-페닐]-에탄올을 포함하는 조성물
CN104119321B (zh)	2017-09-08	二氢吲哚酮衍生物的二马来酸盐及其多晶型物
WO2012092288A2 (fr)	2012-07-05	Compositions et procédés d'utilisation des formes cristallines d'analogues de wortmannine
US6642231B2 (en)	2003-11-04	6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
MXPA00008376A (en)	2002-07-25	6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines
HK1030948B (en)	2004-12-10	6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
CN120289432A (zh)	2025-07-11	一种具有极光激酶b和表皮生长因子受体双重抑制作用的喹啉类化合物及用途
HK40048861A (en)	2021-12-10	Kras g12c inhibitors
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HK1030949A1 (en)	2001-05-25	6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino]purines
HK1030949B (en)	2004-03-19	6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino]purines

UA62996C2 - 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines - Google Patents

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