UA73080C2 - Amino-terminally truncated rantes as chemokine antagonists - Google Patents

Amino-terminally truncated rantes as chemokine antagonists Download PDF

Info

Publication number: UA73080C2
Authority: UA; Ukraine
Prior art keywords: amino; kamte5; cells; kamtez; truncated
Prior art date: 1997-09-29

Application number

UA2000042496A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-29

Filing date

1998-09-28

Publication date

2005-06-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8227408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA73080(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-09-28 Application filed by Applied Research Systems filed Critical Applied Research Systems

2005-06-15 Publication of UA73080C2 publication Critical patent/UA73080C2/uk

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Classifications

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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
AIDS & HIV (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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UA2000042496A 1997-09-29 1998-09-28 Amino-terminally truncated rantes as chemokine antagonists UA73080C2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP97116863A EP0906954A1 (en)	1997-09-29	1997-09-29	Amino-terminal truncated c-c chemokines as chemokine antagonist
EP98104216A EP0905241A1 (en)	1997-09-29	1998-03-10	Amino-terminally truncated c-c chemokines as chemokine antagonists
PCT/EP1998/006143 WO1999016877A1 (en)	1997-09-29	1998-09-28	Amino-terminally truncated rantes as chemokine antagonists

Publications (1)

Publication Number	Publication Date
UA73080C2 true UA73080C2 (en)	2005-06-15

Family

ID=8227408

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
UA2000042496A UA73080C2 (en)	1997-09-29	1998-09-28	Amino-terminally truncated rantes as chemokine antagonists
UA2000042499A UA73081C2 (en)	1997-09-29	1998-09-28	Amino-terminally truncated mcp-2 as chemokine antagonists

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
UA2000042499A UA73081C2 (en)	1997-09-29	1998-09-28	Amino-terminally truncated mcp-2 as chemokine antagonists

Country Status (28)

Country	Link
US (5)	US6977071B2 (pt)
EP (6)	EP0906954A1 (pt)
JP (2)	JP4230659B2 (pt)
KR (2)	KR100542934B1 (pt)
CN (3)	CN1145693C (pt)
AR (2)	AR013529A1 (pt)
AT (3)	ATE368742T1 (pt)
AU (2)	AU750341B2 (pt)
BG (2)	BG64679B1 (pt)
BR (2)	BR9812565A (pt)
CA (2)	CA2304827A1 (pt)
CY (1)	CY1110927T1 (pt)
CZ (2)	CZ299478B6 (pt)
DE (3)	DE69823218T2 (pt)
DK (3)	DK1439231T3 (pt)
EA (2)	EA003940B1 (pt)
EE (2)	EE200000151A (pt)
ES (3)	ES2215324T3 (pt)
HU (2)	HU226414B1 (pt)
IL (2)	IL135352A (pt)
NO (2)	NO20001584D0 (pt)
NZ (3)	NZ503235A (pt)
PL (2)	PL197569B1 (pt)
PT (3)	PT1021541E (pt)
SK (2)	SK286495B6 (pt)
UA (2)	UA73080C2 (pt)
WO (2)	WO1999016877A1 (pt)
ZA (2)	ZA988676B (pt)

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US6989435B2 (en)	1997-09-11	2006-01-24	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7067117B1 (en)	1997-09-11	2006-06-27	Cambridge University Technical Services, Ltd.	Compounds and methods to inhibit or augment an inflammatory response
WO1999028474A2 (en) *	1997-12-01	1999-06-10	The Government Of The United States Of America, Represented By The Secretary Of Health And Human Services	Chemokine variants and methods of use
US7238711B1 (en)	1999-03-17	2007-07-03	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
EP1167527A1 (en) *	2000-06-22	2002-01-02	Euroscreen S.A.	Processed human chemokines PHC-1 and PHC-2
DE60030749T2 (de) *	1999-10-25	2007-09-20	Pharis Biotec Gmbh	Prozessiertes menschliches chemokin phc-1
WO2001036459A2 (en) *	1999-11-15	2001-05-25	Forssmann Wolf Georg	Novel use of hcc-2
CA2316405A1 (en) *	2000-05-26	2001-11-26	Ian Clark-Lewis	Modulation of inflammation by protease products
EP1176200A3 (de)	2000-06-20	2005-01-12	Switch Biotech Aktiengesellschaft	Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankung oder Wundheilung sowie ihre Verwendung zur Indentifizierung von pharmakologisch aktiven Substanzen
UA77950C2 (en) *	2000-10-04	2007-02-15	Applied Research Systems	Use of mutants of cc chemokines for treatment of multiple sclerosis
GB2373785A (en) *	2001-03-28	2002-10-02	Rega Inst For Medical Res	Truncating chemokines using dipeptidyl peptidase IV
EP1458756B1 (en)	2001-12-17	2009-01-28	Laboratoires Serono SA	Chemokine mutants acting as chemokine antagonists
WO2004104216A2 (en) *	2003-05-21	2004-12-02	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4)
DE102005049637A1 (de) *	2005-10-14	2007-04-26	Rheinisch-Westfälische Technische Hochschule Aachen	Antagonisten gegen die Interaktion von PF4 und RANTES
ES2453592T3 (es)	2007-08-02	2014-04-08	Novimmune Sa	Anticuerpos anti-RANTES y métodos de uso de los mismos
US20130053257A1 (en) *	2010-02-08	2013-02-28	Paul E. Oran	RANTES Multiplexed Assay, RANTES Variants Related to Disease, and RANTES Variants Related to Enzymatice Activity
CN102884194B (zh)	2010-03-11	2015-07-22	健康研究股份有限公司	含增强免疫应答的Fc融合蛋白的方法和组合物
TW201718851A (zh) *	2015-09-18	2017-06-01	通用醫院公司	具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途
WO2019229615A1 (en)	2018-05-28	2019-12-05	Université De Genève	Methods of inhibiting cerebral inflammation
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
US11402391B2 (en)	2020-12-21	2022-08-02	Incelldx, Inc.	Methods of treating a long-hauler subject for chronic COVID-19 by administering a CCR5 or CCL5 antagonist

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JPH01265099A (ja)	1987-10-08	1989-10-23	Stichting Rega Vzw	抗ｈｉｖ活性をもつ３’，−フルオロプリン−２’，３’−ジデオキシリボシド類
US5739103A (en) *	1993-11-12	1998-04-14	Dana-Farber Cancer Institute	Chemokine N-terminal deletion mutations
FI972433A0 (fi) *	1994-12-08	1997-06-06	Glaxo Group Ltd	Rantes-peptidi ja fragmentteja sekä tätä sisältäviä tulehduksen hoitoon soveltuvia koostumuksia
AU1532697A (en) *	1996-01-12	1997-08-01	Genetics Institute Inc.	Beta-chemokine, h1305 (mcp-2)
JP2000508527A (ja) *	1996-03-27	2000-07-11	アイコスコーポレイション	単球走化性タンパク質―５物質及び方法
FR2748938B1 (fr) *	1996-05-22	1998-07-31	Pasteur Institut	Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih
US6168784B1 (en) *	1997-09-03	2001-01-02	Gryphon Sciences	N-terminal modifications of RANTES and methods of use

1997
- 1997-09-29 EP EP97116863A patent/EP0906954A1/en not_active Withdrawn
- 1997-12-19 EP EP97122471A patent/EP0905240A1/en not_active Withdrawn
1998
- 1998-03-10 EP EP98104216A patent/EP0905241A1/en not_active Withdrawn
- 1998-09-22 ZA ZA9808676A patent/ZA988676B/xx unknown
- 1998-09-22 ZA ZA9808675A patent/ZA988675B/xx unknown
- 1998-09-28 SK SK451-2000A patent/SK286495B6/sk not_active IP Right Cessation
- 1998-09-28 AU AU97474/98A patent/AU750341B2/en not_active Ceased
- 1998-09-28 EP EP98947553A patent/EP1021541B1/en not_active Expired - Lifetime
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- 1998-09-28 HU HU0003563A patent/HU226468B1/hu not_active IP Right Cessation
- 1998-09-28 CA CA002305017A patent/CA2305017A1/en not_active Abandoned
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- 1998-09-28 KR KR1020007003019A patent/KR100560275B1/ko not_active Expired - Fee Related
- 1998-09-28 DE DE69823218T patent/DE69823218T2/de not_active Expired - Lifetime
- 1998-09-28 UA UA2000042496A patent/UA73080C2/uk unknown
- 1998-09-28 PT PT98947553T patent/PT1021541E/pt unknown
- 1998-09-28 BR BR9812565-6A patent/BR9812565A/pt not_active Application Discontinuation
- 1998-09-28 WO PCT/EP1998/006143 patent/WO1999016877A1/en not_active Ceased
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- 1998-09-28 UA UA2000042499A patent/UA73081C2/uk unknown
- 1998-09-28 EA EA200000379A patent/EA003940B1/ru not_active IP Right Cessation
- 1998-09-28 PT PT98951476T patent/PT1019507E/pt unknown
- 1998-09-28 AT AT04007579T patent/ATE368742T1/de active
- 1998-09-28 CN CNB988095696A patent/CN1145693C/zh not_active Expired - Fee Related
- 1998-09-28 NZ NZ503234A patent/NZ503234A/en unknown
- 1998-09-28 AR ARP980104820A patent/AR013529A1/es active IP Right Grant
- 1998-09-28 PL PL339559A patent/PL197569B1/pl not_active IP Right Cessation
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- 1998-09-28 AT AT98947553T patent/ATE264390T1/de active
- 1998-09-28 DK DK98947553T patent/DK1021541T3/da active
- 1998-09-28 DE DE69822856T patent/DE69822856T2/de not_active Expired - Lifetime
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- 1998-09-28 JP JP2000513946A patent/JP4230659B2/ja not_active Expired - Fee Related
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- 1998-09-28 BR BR9812394-7A patent/BR9812394A/pt not_active Application Discontinuation
- 1998-09-28 CN CNB031492991A patent/CN1233415C/zh not_active Expired - Fee Related
- 1998-09-28 DK DK98951476T patent/DK1019507T3/da active
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2000
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- 2000-03-22 BG BG104267A patent/BG64757B1/bg unknown
- 2000-03-27 NO NO20001584A patent/NO20001584D0/no not_active Application Discontinuation
- 2000-03-28 NO NO20001609A patent/NO20001609D0/no unknown
- 2000-03-28 US US09/537,858 patent/US6977071B2/en not_active Expired - Fee Related
- 2000-03-28 US US09/537,859 patent/US6905676B2/en not_active Expired - Fee Related
- 2000-03-29 IL IL135352A patent/IL135352A/en not_active IP Right Cessation
- 2000-03-29 IL IL135351A patent/IL135351A/en not_active IP Right Cessation
2005
- 2005-03-07 US US11/072,454 patent/US7326411B2/en not_active Expired - Fee Related
- 2005-05-06 US US11/123,089 patent/US7338653B2/en not_active Expired - Fee Related
- 2005-05-18 US US11/131,221 patent/US20050220790A1/en not_active Abandoned
2007
- 2007-10-08 CY CY20071101290T patent/CY1110927T1/el unknown

Also Published As

Publication number	Publication date
EP1019507B1 (en)	2004-03-31
PL339559A1 (en)	2000-12-18
CZ299478B6 (cs)	2008-08-06
JP2001518296A (ja)	2001-10-16
EA200000379A1 (ru)	2000-10-30
DE69838188T2 (de)	2007-11-22
SK4512000A3 (en)	2000-09-12
KR100542934B1 (ko)	2006-01-11
CN1148447C (zh)	2004-05-05
SK4502000A3 (en)	2000-09-12
KR100560275B1 (ko)	2006-03-10
AR013528A1 (es)	2000-12-27
CN1233415C (zh)	2005-12-28
EP1021541A1 (en)	2000-07-26
AU750341B2 (en)	2002-07-18
EA003942B1 (ru)	2003-10-30
DK1439231T3 (da)	2007-11-05
CN1490049A (zh)	2004-04-21
EA003940B1 (ru)	2003-10-30
EP1439231A2 (en)	2004-07-21
EA200000378A1 (ru)	2000-10-30
AU9442098A (en)	1999-04-23
SK286495B6 (sk)	2008-11-06
ZA988676B (en)	1999-12-03
PT1439231E (pt)	2007-08-20
AU750606B2 (en)	2002-07-25
BG64679B1 (bg)	2005-11-30
BG104267A (en)	2000-11-30
DE69822856T2 (de)	2004-08-19
CN1271386A (zh)	2000-10-25
HU226414B1 (en)	2008-11-28
SK286439B6 (sk)	2008-10-07
ES2215324T3 (es)	2004-10-01
US7326411B2 (en)	2008-02-05
BG104266A (en)	2000-11-30
CA2304827A1 (en)	1999-04-08
ZA988675B (en)	1999-11-24
NO20001584L (no)	2000-03-27
NO20001584D0 (no)	2000-03-27
EE200000151A (et)	2001-02-15
HK1062637A1 (en)	2004-11-19
CZ299479B6 (cs)	2008-08-06
ES2218860T3 (es)	2004-11-16
IL135351A (en)	2006-08-20
ES2287601T3 (es)	2007-12-16
US20050201977A1 (en)	2005-09-15
JP4233214B2 (ja)	2009-03-04
HK1032426A1 (en)	2001-07-20
NZ516027A (en)	2003-05-30
DE69822856D1 (de)	2004-05-06
US20050164936A1 (en)	2005-07-28
IL135352A (en)	2006-08-20
EP0906954A1 (en)	1999-04-07
NZ503235A (en)	2002-08-28
PT1021541E (pt)	2004-07-30
PL197569B1 (pl)	2008-04-30
EP1439231A3 (en)	2004-12-22
HUP0003563A3 (en)	2005-11-28
DK1021541T3 (da)	2004-08-02
HK1032425A1 (en)	2001-07-20
ATE264390T1 (de)	2004-04-15
CA2305017A1 (en)	1999-04-08
AR013529A1 (es)	2000-12-27
JP4230659B2 (ja)	2009-02-25
CN1145693C (zh)	2004-04-14
US6977071B2 (en)	2005-12-20
KR20010024213A (ko)	2001-03-26
PL339545A1 (en)	2000-12-18
JP2001518297A (ja)	2001-10-16
EP1439231B1 (en)	2007-08-01
KR20010024214A (ko)	2001-03-26
US20030119148A1 (en)	2003-06-26
US20050220790A1 (en)	2005-10-06
UA73081C2 (en)	2005-06-15
HUP0003505A2 (hu)	2001-02-28
DK1019507T3 (da)	2004-07-19
AU9747498A (en)	1999-04-23
DE69823218T2 (de)	2004-08-26
EP0905240A1 (en)	1999-03-31
WO1999016877A1 (en)	1999-04-08
EP0905241A1 (en)	1999-03-31
US20030124677A1 (en)	2003-07-03
BR9812394A (pt)	2000-09-12
BR9812565A (pt)	2000-08-01
CZ20001147A3 (cs)	2000-09-13
HUP0003563A2 (hu)	2001-02-28
HU226468B1 (en)	2008-12-29
CY1110927T1 (el)	2015-06-10
EP1021541B1 (en)	2004-04-14
US7338653B2 (en)	2008-03-04
HUP0003505A3 (en)	2005-11-28
BG64757B1 (bg)	2006-02-28
DE69823218D1 (de)	2004-05-19
PT1019507E (pt)	2004-06-30
WO1999016876A1 (en)	1999-04-08
ATE368742T1 (de)	2007-08-15
NO20001609L (no)	2000-03-28
US6905676B2 (en)	2005-06-14
ATE263242T1 (de)	2004-04-15
NO20001609D0 (no)	2000-03-28
EP1019507A1 (en)	2000-07-19
NZ503234A (en)	2002-06-28
CZ20001146A3 (cs)	2000-09-13
CN1271385A (zh)	2000-10-25
PL196427B1 (pl)	2008-01-31
DE69838188D1 (de)	2007-09-13
EE200000152A (et)	2001-02-15

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