UA74367C2 - ПОХІДНІ 4,5-ДИГІДРО-1Н-ПІРАЗОЛУ, ЩО ВИЯВЛЯЮТЬ АНТАГОНІСТИЧНУ АКТИВНІСТЬ ЩОДО СВ<sub>1</sub>, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЇЇ ВИГОТОВЛЕННЯ, СПОСІБ ЛІКУВАННЯ ЗАХВОРЮВАНЬ (ВАРІАНТИ) - Google Patents

ПОХІДНІ 4,5-ДИГІДРО-1Н-ПІРАЗОЛУ, ЩО ВИЯВЛЯЮТЬ АНТАГОНІСТИЧНУ АКТИВНІСТЬ ЩОДО СВ<sub>1</sub>, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЇЇ ВИГОТОВЛЕННЯ, СПОСІБ ЛІКУВАННЯ ЗАХВОРЮВАНЬ (ВАРІАНТИ)

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Publication number
UA74367C2
UA74367C2 UA2002108258A UA2002108258A UA74367C2 UA 74367 C2 UA74367 C2 UA 74367C2 UA 2002108258 A UA2002108258 A UA 2002108258A UA 2002108258 A UA2002108258 A UA 2002108258A UA 74367 C2 UA74367 C2 UA 74367C2
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UA
Ukraine
Prior art keywords
producing
dihydro
derivatives
revealing
pyrazole
Prior art date
Application number
UA2002108258A
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English (en)
Russian (ru)
Inventor
Йозефус Г.М. Ланге
Корнеліс Г. Крузе
Корнелис Г. Крузе
Якобус Тіпкер
Мартінус Т.М. Тулп
Фліт Бернард Ж. ван
Флит Бернард Ж. ван
Original Assignee
Сольве Фармас'Ютікалз Б.В.
Сольве Фармасьютикалз Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Сольве Фармас'Ютікалз Б.В., Сольве Фармасьютикалз Б.В. filed Critical Сольве Фармас'Ютікалз Б.В.
Publication of UA74367C2 publication Critical patent/UA74367C2/uk

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Винахід стосується групи нових похідних 4,5-дигідро-1Н-піразолу, які є могутніми антагоністами рецепторів Канабіс СВ1, формули (І) , (І) де R та R1 є однакові або різні групи, представлені фенілом, тієнілом або піридилом, які можуть бути заміщені 1, 2 або 3 замісниками Y, які можуть бути однаковими або різними, вибраними з: (С1-3)-алкіл- або алкокси, гідрокси, галоген, трифторметил, трифторметилтіо, трифторметокси, нітро, аміно, моно- або діалкіл(С1-2)-аміно, моно- або діалкіл (С1-2)-амідо, (С1-3)-алкілсульфоніл, диметилсульфамідо, С1-3-алкоксикарбоніл, карбоксил, трифторметилсульфоніл, ціано, карбамоїл, сульфамоїл та ацетилгрупи, або ж R та/або R1 представляють нафтил, R2 - водень, гідрокси, С1-3-алкокси, ацетилокси або пропіонілоксигрупу, Аа - одна з груп (і), (іі), (ііі), (iv), (v) , (i) , (ii) , (iii) , (iv) , (v) де R4 та R5, незалежно один від одного - водень або (С1-8) розгалужений або нерозгалужений алкіл, або (С3-8)-циклоалкіл, або R4 - ацетамід або диметиламін, або 2,2,2-трифторетил, або феніл, або піридил за умови, що R5 - водень, Bb - сульфоніл або карбоніл, R6 - водень або С1-3 нерозгалужений алкіл, R3 - бензил, феніл, триєніл або піридил, які можуть бути заміщені 1, 2 або 3 замісниками Y, що можуть бути однаковими або різними, або являє собою (C1-8) розгалужений або нерозгалужений алкіл або (С3-8)-циклоалкіл, або R3 - нафтил.
UA2002108258A 2000-03-23 2001-03-22 ПОХІДНІ 4,5-ДИГІДРО-1Н-ПІРАЗОЛУ, ЩО ВИЯВЛЯЮТЬ АНТАГОНІСТИЧНУ АКТИВНІСТЬ ЩОДО СВ<sub>1</sub>, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЇЇ ВИГОТОВЛЕННЯ, СПОСІБ ЛІКУВАННЯ ЗАХВОРЮВАНЬ (ВАРІАНТИ) UA74367C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00201032 2000-03-23
NL1014728 2000-03-23
PCT/EP2001/003247 WO2001070700A1 (en) 2000-03-23 2001-03-22 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity

Publications (1)

Publication Number Publication Date
UA74367C2 true UA74367C2 (uk) 2005-12-15

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ID=26072029

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UA2002108258A UA74367C2 (uk) 2000-03-23 2001-03-22 ПОХІДНІ 4,5-ДИГІДРО-1Н-ПІРАЗОЛУ, ЩО ВИЯВЛЯЮТЬ АНТАГОНІСТИЧНУ АКТИВНІСТЬ ЩОДО СВ<sub>1</sub>, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЇЇ ВИГОТОВЛЕННЯ, СПОСІБ ЛІКУВАННЯ ЗАХВОРЮВАНЬ (ВАРІАНТИ)

Country Status (26)

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US (1) US6476060B2 (uk)
EP (1) EP1268435B1 (uk)
JP (1) JP2004500401A (uk)
KR (1) KR100800277B1 (uk)
CN (1) CN1205188C (uk)
AT (1) ATE346047T1 (uk)
AU (2) AU4250101A (uk)
BR (1) BR0109457A (uk)
CA (1) CA2401832C (uk)
CY (1) CY1105967T1 (uk)
DE (1) DE60124685T2 (uk)
DK (1) DK1268435T3 (uk)
DZ (1) DZ3335A1 (uk)
ES (1) ES2272449T3 (uk)
HK (1) HK1052349B (uk)
HU (1) HUP0204519A3 (uk)
IL (2) IL151452A0 (uk)
MX (1) MXPA02009258A (uk)
NO (1) NO324173B1 (uk)
PL (1) PL208098B1 (uk)
PT (1) PT1268435E (uk)
RU (1) RU2245878C2 (uk)
SI (1) SI1268435T1 (uk)
SK (1) SK287074B6 (uk)
UA (1) UA74367C2 (uk)
WO (1) WO2001070700A1 (uk)

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