UA75402C2 - Use of pyrazoline derivative for the preparation of medicament for prevention or treatment of proliferative cellular diseases - Google Patents

Use of pyrazoline derivative for the preparation of medicament for prevention or treatment of proliferative cellular diseases Download PDF

Info

Publication number: UA75402C2
Authority: UA; Ukraine
Prior art keywords: trifluoromethyl; pyrazole; dihydro; methylsulfonylphenyl; methyl
Prior art date: 2001-04-06

Application number

UA2003119998A

Other languages

English (en)

Ukrainian (uk)

Inventor

Maria Rosa Cuberes-Altisent

Juana Maria Berrocal-Romero

Maria Montesar Contihoch-Yobet

Original Assignee

Del Dr Estebe S A Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-06

Filing date

2002-03-21

Publication date

2006-04-17

2002-03-21 Application filed by Del Dr Estebe S A Lab filed Critical Del Dr Estebe S A Lab

2006-04-17 Publication of UA75402C2 publication Critical patent/UA75402C2/uk

Links

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231100000135 cytotoxicity Toxicity 0.000 description 1
230000006378 damage Effects 0.000 description 1
230000034994 death Effects 0.000 description 1
230000003412 degenerative effect Effects 0.000 description 1
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000002900 effect on cell Effects 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
210000003038 endothelium Anatomy 0.000 description 1
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210000000416 exudates and transudate Anatomy 0.000 description 1
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210000002950 fibroblast Anatomy 0.000 description 1
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239000007789 gas Substances 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
231100000024 genotoxic Toxicity 0.000 description 1
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238000004128 high performance liquid chromatography Methods 0.000 description 1
230000028993 immune response Effects 0.000 description 1
230000007813 immunodeficiency Effects 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000004968 inflammatory condition Effects 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000000752 ionisation method Methods 0.000 description 1
PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 description 1
PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 description 1
239000002555 ionophore Substances 0.000 description 1
230000000236 ionophoric effect Effects 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
201000007270 liver cancer Diseases 0.000 description 1
208000014018 liver neoplasm Diseases 0.000 description 1
201000005202 lung cancer Diseases 0.000 description 1
208000020816 lung neoplasm Diseases 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
108020004999 messenger RNA Proteins 0.000 description 1
210000004688 microtubule Anatomy 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
239000011707 mineral Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
210000001616 monocyte Anatomy 0.000 description 1
201000006417 multiple sclerosis Diseases 0.000 description 1
208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
230000031990 negative regulation of inflammatory response Effects 0.000 description 1
210000005170 neoplastic cell Anatomy 0.000 description 1
210000000440 neutrophil Anatomy 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
201000002528 pancreatic cancer Diseases 0.000 description 1
208000008443 pancreatic carcinoma Diseases 0.000 description 1
230000009054 pathological process Effects 0.000 description 1
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235000011152 sodium sulphate Nutrition 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Oncology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

UA2003119998A 2001-04-06 2002-03-21 Use of pyrazoline derivative for the preparation of medicament for prevention or treatment of proliferative cellular diseases UA75402C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200100818A ES2174757B1 (es)	2001-04-06	2001-04-06	Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares.
PCT/ES2002/000137 WO2002080909A1 (fr)	2001-04-06	2002-03-21	Utilisation de derives de pyrazolines dans l'elaboration d'un medicament pour la prevention et/ou le traitement de maladies proliferatives cellulaires

Publications (1)

Publication Number	Publication Date
UA75402C2 true UA75402C2 (en)	2006-04-17

Family

ID=8497370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2003119998A UA75402C2 (en)	2001-04-06	2002-03-21	Use of pyrazoline derivative for the preparation of medicament for prevention or treatment of proliferative cellular diseases

Country Status (26)

Country	Link
US (1)	US20040034082A1 (fr)
EP (2)	EP1516621A3 (fr)
JP (1)	JP4451599B2 (fr)
KR (1)	KR20040025912A (fr)
CN (2)	CN1299682C (fr)
AT (1)	ATE326966T1 (fr)
AU (1)	AU2002246152B2 (fr)
BR (1)	BR0208805A (fr)
CA (1)	CA2442974C (fr)
CY (1)	CY1105523T1 (fr)
DE (1)	DE60211681T2 (fr)
DK (1)	DK1384477T3 (fr)
ES (2)	ES2174757B1 (fr)
HU (1)	HUP0400918A3 (fr)
IL (1)	IL158269A0 (fr)
IS (1)	IS6973A (fr)
MA (1)	MA27019A1 (fr)
MX (1)	MXPA03009124A (fr)
NO (1)	NO20034470L (fr)
NZ (1)	NZ529304A (fr)
PL (1)	PL365220A1 (fr)
PT (1)	PT1384477E (fr)
RU (1)	RU2305545C2 (fr)
UA (1)	UA75402C2 (fr)
WO (1)	WO2002080909A1 (fr)
ZA (1)	ZA200308626B (fr)

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ES2238923B1 (es) *	2004-02-16	2006-11-01	Laboratorios Del Dr. Esteve, S.A.	Nuevos derivados pirazolinicos sustituidos.
KR20070044799A (ko) *	2004-02-16	2007-04-30	라보라토리오스 델 드라. 에스테브.에스.에이.	암 치료에 유용한 피라졸린 유도체
TW200533657A (en) *	2004-02-17	2005-10-16	Esteve Labor Dr	Substituted pyrazoline compounds, their preparation and use as medicaments
US7998996B2 (en)	2004-02-17	2011-08-16	Laboratorios Del Dr. Esteve S.A.	Substituted pyrazoline compounds for reducing triglycerides in blood
EP1637522A1 (fr) *	2004-09-16	2006-03-22	Laboratorios Del Dr. Esteve, S.A.	Composés de pyrazolines substituées pour réduire des triglycerides dans le sang
BRPI0507790A (pt) *	2004-02-17	2007-07-17	Esteve Labor Dr	composto de pirazolina substituìda, processo para a sua manufatura, medicamentos e seus usos
ES2327379B1 (es) *	2005-07-15	2010-05-28	Laboratorios Del Dr. Esteve, S.A.	Compuestos de pirazolina indolinsustituidos, su preparacion y su uso como medicamentos.
WO2007009707A2 (fr) *	2005-07-15	2007-01-25	Laboratorios Del Dr. Esteve, S.A.	Utilisation de composes a base de pyrazoline substitues pour le traitement de maladies liees a la coagulation
EP1749527A1 (fr) *	2005-07-15	2007-02-07	Laboratorios Del Dr. Esteve, S.A.	Utilisation des derivés du pyrazole pour le traitement du syndrome métabolique
EP1849784A1 (fr) *	2006-04-26	2007-10-31	Laboratorios Del Dr. Esteve, S.A.	Dérivés de la pyrazoline Indoline-substituée, leur préparation and utilisation comme médicaments
EP1743892A1 (fr) *	2005-07-15	2007-01-17	Laboratorios del Dr. Esteve S.A.	Composés pyrazoline substitués, leur préparation et utilisation comme médicaments
ES2334967B1 (es) *	2005-07-15	2010-10-21	Laboratorios Del Dr. Esteve, S.A.	Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre.
WO2007009699A2 (fr) *	2005-07-15	2007-01-25	Laboratorios Del Dr. Esteve, S.A	Utilisation de composes pyrazoliniques substitues et de leurs derives contre des affections associees au systeme des cannabinoides
WO2007009702A2 (fr) *	2005-07-15	2007-01-25	Laboratorios Del Dr. Esteve, S.A.	Composes de pyrazoline substitues, leur preparation et leur utilisation comme medicaments
EP1743889A1 (fr) *	2005-07-15	2007-01-17	Laboratorios del Dr. Esteve S.A.	Composés de pyrazolines substituées ayant une stereochimie predeterminèe pour réduire des triglycerides dans le sang
EP1743890A1 (fr)	2005-07-15	2007-01-17	Laboratorios Del Dr. Esteve, S.A.	Dérivés 4,5-dihydro-1H-pyrazole, leur, préparation et utilisation comme médicaments.
EP1749525A1 (fr) *	2005-07-15	2007-02-07	Laboratorios Del Dr. Esteve, S.A.	Combination de pyrazoline substitués et de médicaments contre la dépendance
WO2007009701A2 (fr) *	2005-07-15	2007-01-25	Laboratorios Del Dr. Esteve, S.A.	Utilisation de composes pyrazoliniques substitues pour traiter des facteurs de risque cardiovasculaires imputables a des troubles du metabolisme ou de l'alimentation
WO2007009693A1 (fr) *	2005-07-15	2007-01-25	Laboratorios Del Dr.Esteve, S.A	Combinaison d'un compose pyrazolinique substitue et medicament utilise pour des troubles en lien avec les aliments
EP1849776A1 (fr) *	2006-04-26	2007-10-31	Laboratorios Del Dr. Esteve, S.A.	Dérivés de la pyrazoline azépane- ou azocane-substituées, leur préparation et utilisation comme médicaments
EP1746090A1 (fr) *	2005-07-15	2007-01-24	Laboratorios del Dr. Esteve S.A.	Composés de pyrazolines substituées ayant une stereochimie predeterminèe pour réduire des triglycerides dans le sang
WO2007009700A2 (fr) *	2005-07-15	2007-01-25	Laboratorios Del Dr. Esteve, S.A.	Utilisation de composes pyrazoliniques substitues pour le traitement de parametres des lipides du syndrome metabolique
EP1743637A1 (fr) *	2005-07-15	2007-01-17	Laboratorios Del Dr. Esteve, S.A.	Utilisation des derivés du pyrazole seuls ou en combinaison pour le traitement du syndrome métabolique
EP1743643A1 (fr) *	2005-07-15	2007-01-17	Laboratorios Del Dr. Esteve, S.A.	Nouvelles formulations de composés à base de pyrazoline
ES2326724B1 (es) *	2005-07-15	2010-05-11	Laboratorios Del Dr. Esteve, S.A.	Nuevas formulaciones de compuestos de pirazolina sustituidos.
US7897589B2 (en)	2005-07-15	2011-03-01	Laboratorios Del Dr. Esteve, S.A.	Substituted pyrazoline compounds, their preparation and use as medicaments
ES2326725B1 (es) *	2005-07-15	2010-05-11	Laboratorios Del Dr. Esteve, S.A.	Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos alimentarios, que incluyen la obesidad o el sindrome metabolico en pacientes con diabetes desarrollada.
EP1749526A1 (fr) *	2005-07-15	2007-02-07	Laboratorios Del Dr. Esteve, S.A.	Utilisation des derivés de la pyrazoline pour le traitement des troubles alimentaires, comme l'obesité ou le syndrome métabolique chez les patients diabetiques
EP1743636A1 (fr) *	2005-07-15	2007-01-17	Laboratorios Del Dr. Esteve, S.A.	Combinaison d'une pyrazoline substituée avec un agent utilisé contre les dérangements alimentaires
EP1743639A1 (fr) *	2005-07-15	2007-01-17	Laboratorios Del Dr. Esteve, S.A.	Utilisation des derivés de la pyrazoline pour le traitement des troubles liées à la coagulation
WO2007009691A2 (fr) *	2005-07-15	2007-01-25	Laboratorios Del Dr. Esteve, S.A.	Combinaison de substances active s
EP1743642A1 (fr) *	2005-07-15	2007-01-17	Laboratorios Del Dr. Esteve, S.A.	Utilisation de composés à base de pyrazoline pour le traitement des maladies associées avec le système cannabinoïde
KR101457637B1 (ko) *	2012-10-24	2014-11-20	건국대학교 산학협력단	디히드로피라졸카르보티오아미드 유도체 및 그 제법 및 그 유도체를 포함하는 항암제 조성물
CN103664785A (zh) *	2013-11-04	2014-03-26	南京大学	一类新颖的二氢吡唑磺胺衍生物的合成及在抗癌药物中的应用
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KR100796851B1 (ko) *	1999-06-16	2008-01-22	템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션	사이클록시게나아제-2의 억제제로서 1-(4-설파밀아릴)-3-치환형-5-아릴-2-피라졸린

2001
- 2001-04-06 ES ES200100818A patent/ES2174757B1/es not_active Expired - Fee Related
2002
- 2002-03-21 DE DE60211681T patent/DE60211681T2/de not_active Expired - Lifetime
- 2002-03-21 BR BR0208805-3A patent/BR0208805A/pt not_active IP Right Cessation
- 2002-03-21 PT PT02714233T patent/PT1384477E/pt unknown
- 2002-03-21 ES ES02714233T patent/ES2264723T3/es not_active Expired - Lifetime
- 2002-03-21 PL PL02365220A patent/PL365220A1/xx not_active Application Discontinuation
- 2002-03-21 CA CA2442974A patent/CA2442974C/fr not_active Expired - Fee Related
- 2002-03-21 CN CNB028098935A patent/CN1299682C/zh not_active Expired - Fee Related
- 2002-03-21 MX MXPA03009124A patent/MXPA03009124A/es active IP Right Grant
- 2002-03-21 JP JP2002578948A patent/JP4451599B2/ja not_active Expired - Fee Related
- 2002-03-21 HU HU0400918A patent/HUP0400918A3/hu unknown
- 2002-03-21 WO PCT/ES2002/000137 patent/WO2002080909A1/fr not_active Ceased
- 2002-03-21 ZA ZA200308626A patent/ZA200308626B/en unknown
- 2002-03-21 AT AT02714233T patent/ATE326966T1/de not_active IP Right Cessation
- 2002-03-21 RU RU2003132457/15A patent/RU2305545C2/ru not_active IP Right Cessation
- 2002-03-21 EP EP04030751A patent/EP1516621A3/fr not_active Withdrawn
- 2002-03-21 UA UA2003119998A patent/UA75402C2/uk unknown
- 2002-03-21 DK DK02714233T patent/DK1384477T3/da active
- 2002-03-21 IL IL15826902A patent/IL158269A0/xx unknown
- 2002-03-21 CN CNA2005100713090A patent/CN1698602A/zh active Pending
- 2002-03-21 NZ NZ529304A patent/NZ529304A/en unknown
- 2002-03-21 US US10/312,193 patent/US20040034082A1/en not_active Abandoned
- 2002-03-21 AU AU2002246152A patent/AU2002246152B2/en not_active Ceased
- 2002-03-21 EP EP02714233A patent/EP1384477B1/fr not_active Expired - Lifetime
- 2002-03-21 KR KR10-2003-7013062A patent/KR20040025912A/ko not_active Ceased
2003
- 2003-10-03 IS IS6973A patent/IS6973A/is unknown
- 2003-10-06 NO NO20034470A patent/NO20034470L/no not_active Application Discontinuation
- 2003-11-05 MA MA27382A patent/MA27019A1/fr unknown
2006
- 2006-08-03 CY CY20061101088T patent/CY1105523T1/el unknown

Also Published As

Publication number	Publication date
DK1384477T3 (da)	2006-08-21
AU2002246152B2 (en)	2007-05-31
ATE326966T1 (de)	2006-06-15
ES2174757A1 (es)	2002-11-01
KR20040025912A (ko)	2004-03-26
CN1698602A (zh)	2005-11-23
CY1105523T1 (el)	2010-07-28
US20040034082A1 (en)	2004-02-19
EP1516621A3 (fr)	2005-05-04
HK1067311A1 (en)	2005-04-08
MA27019A1 (fr)	2004-12-20
IS6973A (is)	2003-10-03
CN1299682C (zh)	2007-02-14
JP2004525166A (ja)	2004-08-19
NZ529304A (en)	2006-02-24
CA2442974A1 (fr)	2002-10-17
EP1384477A1 (fr)	2004-01-28
WO2002080909A1 (fr)	2002-10-17
PT1384477E (pt)	2006-09-29
HUP0400918A2 (hu)	2004-07-28
ES2174757B1 (es)	2003-11-01
CA2442974C (fr)	2010-02-23
JP4451599B2 (ja)	2010-04-14
DE60211681D1 (de)	2006-06-29
IL158269A0 (en)	2004-05-12
NO20034470L (no)	2003-12-05
EP1384477B1 (fr)	2006-05-24
RU2003132457A (ru)	2005-04-10
CN1509171A (zh)	2004-06-30
MXPA03009124A (es)	2005-04-11
PL365220A1 (en)	2004-12-27
HUP0400918A3 (en)	2004-10-28
NO20034470D0 (no)	2003-10-06
DE60211681T2 (de)	2007-05-16
EP1516621A2 (fr)	2005-03-23
ES2264723T3 (es)	2007-01-16
ZA200308626B (en)	2004-11-05
BR0208805A (pt)	2004-07-13
RU2305545C2 (ru)	2007-09-10

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