UA76444C2 - Composition of biochemical compounds involved in bioenergy metabolism of cells and method of its use in prevention and therapy of diseases - Google Patents

Composition of biochemical compounds involved in bioenergy metabolism of cells and method of its use in prevention and therapy of diseases Download PDF

Info

Publication number: UA76444C2
Authority: UA; Ukraine
Prior art keywords: composition; deficiency; succinate; dehydrogenase; compounds
Prior art date: 2001-02-14

Application number

UA2003087690A

Other languages

English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-14

Filing date

2002-02-14

Publication date

2006-08-15

2002-02-14 Application filed filed Critical

2006-08-15 Publication of UA76444C2 publication Critical patent/UA76444C2/uk

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150000001875 compounds Chemical class 0.000 title claims abstract description 30
239000000203 mixture Substances 0.000 title claims abstract description 20
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238000000034 method Methods 0.000 title abstract description 9
230000002265 prevention Effects 0.000 title abstract description 9
238000002560 therapeutic procedure Methods 0.000 title abstract description 6
230000019522 cellular metabolic process Effects 0.000 title abstract description 4
230000007812 deficiency Effects 0.000 claims description 19
102000004190 Enzymes Human genes 0.000 claims description 10
108090000790 Enzymes Proteins 0.000 claims description 10
-1 I-malate Chemical compound 0.000 claims description 9
ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 claims description 8
ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 claims description 8
208000012902 Nervous system disease Diseases 0.000 claims description 8
208000025966 Neurological disease Diseases 0.000 claims description 8
NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims description 8
239000000126 substance Substances 0.000 claims description 8
150000003278 haem Chemical class 0.000 claims description 7
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
108700036912 Fumaric aciduria Proteins 0.000 claims description 6
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 6
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 6
ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims description 6
KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims description 5
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101710088194 Dehydrogenase Proteins 0.000 claims description 5
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KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims description 4
ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 4
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
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ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 4
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VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
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KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 3
LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 3
JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 3
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GTZCVFVGUGFEME-IWQZZHSRSA-N cis-aconitic acid Chemical compound OC(=O)C\C(C(O)=O)=C\C(O)=O GTZCVFVGUGFEME-IWQZZHSRSA-N 0.000 claims description 3
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FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 claims description 3
FVTCRASFADXXNN-UHFFFAOYSA-N flavin mononucleotide Natural products OP(=O)(O)OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-UHFFFAOYSA-N 0.000 claims description 3
ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical compound OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 claims description 3
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KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 claims description 3
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235000019157 thiamine Nutrition 0.000 claims description 3
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KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims description 3
GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 2
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XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 claims description 2
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CJHGHMBAPOLCBR-UHFFFAOYSA-F [Mo+4].S(=O)(=O)([O-])[O-].[Fe+2].[Cu+2].S(=O)(=O)([O-])[O-].S(=O)(=O)([O-])[O-].S(=O)(=O)([O-])[O-] Chemical compound [Mo+4].S(=O)(=O)([O-])[O-].[Fe+2].[Cu+2].S(=O)(=O)([O-])[O-].S(=O)(=O)([O-])[O-].S(=O)(=O)([O-])[O-] CJHGHMBAPOLCBR-UHFFFAOYSA-F 0.000 description 1
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235000014633 carbohydrates Nutrition 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
210000004413 cardiac myocyte Anatomy 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
210000000172 cytosol Anatomy 0.000 description 1
230000001086 cytosolic effect Effects 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
230000027721 electron transport chain Effects 0.000 description 1
230000037149 energy metabolism Effects 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
239000003248 enzyme activator Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
230000037406 food intake Effects 0.000 description 1
235000012631 food intake Nutrition 0.000 description 1
239000010437 gem Substances 0.000 description 1
230000009395 genetic defect Effects 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
235000012907 honey Nutrition 0.000 description 1
208000022368 idiopathic cardiomyopathy Diseases 0.000 description 1
230000037431 insertion Effects 0.000 description 1
238000003780 insertion Methods 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
210000003470 mitochondria Anatomy 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
210000000107 myocyte Anatomy 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
230000010627 oxidative phosphorylation Effects 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
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239000000758 substrate Substances 0.000 description 1
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238000003786 synthesis reaction Methods 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/415—Cytochromes
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Nutrition Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Immunology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

UA2003087690A 2001-02-14 2002-02-14 Composition of biochemical compounds involved in bioenergy metabolism of cells and method of its use in prevention and therapy of diseases UA76444C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26882501P	2001-02-14	2001-02-14
PCT/EP2002/001545 WO2002064129A2 (en)	2001-02-14	2002-02-14	Compositions of biochemical compounds involved in bioenergy metabolism of cells

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Publication Number	Publication Date
UA76444C2 true UA76444C2 (en)	2006-08-15

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UA2003087690A UA76444C2 (en)	2001-02-14	2002-02-14	Composition of biochemical compounds involved in bioenergy metabolism of cells and method of its use in prevention and therapy of diseases

Country Status (23)

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US (2)	US7056950B2 (cs)
EP (1)	EP1368017A2 (cs)
JP (1)	JP2004518712A (cs)
KR (1)	KR20020093906A (cs)
CN (1)	CN1457255A (cs)
AU (1)	AU2002250942B2 (cs)
BR (1)	BR0203902A (cs)
CA (1)	CA2401383A1 (cs)
CZ (1)	CZ20023935A3 (cs)
EE (1)	EE200200585A (cs)
HR (1)	HRP20020702A2 (cs)
HU (1)	HUP0302384A2 (cs)
IL (1)	IL151411A0 (cs)
MX (1)	MXPA02010149A (cs)
NO (1)	NO20024536L (cs)
NZ (1)	NZ528194A (cs)
PL (1)	PL363392A1 (cs)
RU (1)	RU2301665C2 (cs)
SK (1)	SK11252003A3 (cs)
TR (1)	TR200202175T1 (cs)
UA (1)	UA76444C2 (cs)
WO (1)	WO2002064129A2 (cs)
ZA (1)	ZA200207100B (cs)

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US9271983B2 (en)	2010-03-26	2016-03-01	Bioadatp, Llc	Composition for enhancing athletic performance
US8344032B2 (en) *	2010-03-26	2013-01-01	Kevin Meehan	Composition for enhancing athletic performance
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2002
- 2002-02-14 UA UA2003087690A patent/UA76444C2/uk unknown
- 2002-02-14 BR BR0203902-8A patent/BR0203902A/pt not_active IP Right Cessation
- 2002-02-14 EP EP02719835A patent/EP1368017A2/en not_active Withdrawn
- 2002-02-14 IL IL15141102A patent/IL151411A0/xx unknown
- 2002-02-14 CZ CZ20023935A patent/CZ20023935A3/cs unknown
- 2002-02-14 NZ NZ528194A patent/NZ528194A/en unknown
- 2002-02-14 JP JP2002563923A patent/JP2004518712A/ja active Pending
- 2002-02-14 AU AU2002250942A patent/AU2002250942B2/en not_active Ceased
- 2002-02-14 CN CN02800284A patent/CN1457255A/zh active Pending
- 2002-02-14 HR HR20020702A patent/HRP20020702A2/xx not_active Application Discontinuation
- 2002-02-14 WO PCT/EP2002/001545 patent/WO2002064129A2/en not_active Ceased
- 2002-02-14 PL PL02363392A patent/PL363392A1/xx unknown
- 2002-02-14 HU HU0302384A patent/HUP0302384A2/hu unknown
- 2002-02-14 TR TR2002/02175T patent/TR200202175T1/xx unknown
- 2002-02-14 US US10/077,283 patent/US7056950B2/en not_active Expired - Fee Related
- 2002-02-14 SK SK1125-2003A patent/SK11252003A3/sk not_active Application Discontinuation
- 2002-02-14 RU RU2003125179/15A patent/RU2301665C2/ru not_active IP Right Cessation
- 2002-02-14 EE EEP200200585A patent/EE200200585A/xx unknown
- 2002-02-14 CA CA002401383A patent/CA2401383A1/en not_active Abandoned
- 2002-02-14 MX MXPA02010149A patent/MXPA02010149A/es active IP Right Grant
- 2002-02-14 KR KR1020027013717A patent/KR20020093906A/ko not_active Ceased
- 2002-09-04 ZA ZA200207100A patent/ZA200207100B/en unknown
- 2002-09-20 NO NO20024536A patent/NO20024536L/no not_active Application Discontinuation
2006
- 2006-02-17 US US11/356,476 patent/US20060140925A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1368017A2 (en)	2003-12-10
KR20020093906A (ko)	2002-12-16
HUP0302384A2 (hu)	2003-10-28
MXPA02010149A (es)	2004-08-19
TR200202175T1 (tr)	2003-10-21
EE200200585A (et)	2004-04-15
CA2401383A1 (en)	2002-08-22
IL151411A0 (en)	2003-04-10
RU2301665C2 (ru)	2007-06-27
NO20024536D0 (no)	2002-09-20
WO2002064129A2 (en)	2002-08-22
SK11252003A3 (sk)	2003-12-02
JP2004518712A (ja)	2004-06-24
NO20024536L (no)	2002-09-20
PL363392A1 (en)	2004-11-15
BR0203902A (pt)	2003-01-28
CN1457255A (zh)	2003-11-19
WO2002064129A3 (en)	2003-05-08
US7056950B2 (en)	2006-06-06
ZA200207100B (en)	2003-09-04
NZ528194A (en)	2006-08-31
RU2003125179A (ru)	2005-01-20
CZ20023935A3 (cs)	2003-05-14
HRP20020702A2 (en)	2004-02-29
US20060140925A1 (en)	2006-06-29
AU2002250942B2 (en)	2007-04-26
US20020173546A1 (en)	2002-11-21

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UA76444C2 (en)	2006-08-15	Composition of biochemical compounds involved in bioenergy metabolism of cells and method of its use in prevention and therapy of diseases
Hertz et al.	2016	Glucose, lactate, β-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine–glutamate/GABA cycle
AU2002250942A1 (en)	2003-05-08	Compositions of biochemical compounds involved in bioenergy metabolism of cells
KR102057555B1 (ko)	2019-12-19	신부전 환자를 치료하기 위한 카복실산 혼합물
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CN104998264A (zh)	2015-10-28	治疗由过氧亚硝酸盐过度表达引起的哺乳动物疾病和创伤的方法和组合物
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