UA78014C2 - Macrocyclic peptides active against hepatitis c virus - Google Patents

Macrocyclic peptides active against hepatitis c virus Download PDF

Info

Publication number: UA78014C2
Authority: UA; Ukraine
Prior art keywords: compound; differs; acid; formula; pharmaceutical composition
Prior art date: 2002-01-30

Application number

UA20040807068A

Other languages

English (en)

Ukrainian (uk)

Inventor

Vida J Gorys

Original Assignee

Byoringer Inhelheim Canada Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-30

Filing date

2003-01-24

Publication date

2007-02-15

2003-01-24 Application filed by Byoringer Inhelheim Canada Ltd filed Critical Byoringer Inhelheim Canada Ltd

2007-02-15 Publication of UA78014C2 publication Critical patent/UA78014C2/uk

Links

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125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000012360 testing method Methods 0.000 description 1
CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical class CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical class C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
229960004559 theobromine Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
150000003585 thioureas Chemical class 0.000 description 1
NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
229960004231 thymalfasin Drugs 0.000 description 1
206010043778 thyroiditis Diseases 0.000 description 1
238000004448 titration Methods 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
230000009466 transformation Effects 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
238000001665 trituration Methods 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
229950002819 valtorcitabine Drugs 0.000 description 1
201000001862 viral hepatitis Diseases 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

UA20040807068A 2002-01-30 2003-01-24 Macrocyclic peptides active against hepatitis c virus UA78014C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA002369711A CA2369711A1 (en)	2002-01-30	2002-01-30	Macrocyclic peptides active against the hepatitis c virus
PCT/CA2003/000089 WO2003064455A2 (en)	2002-01-30	2003-01-24	Macrocyclic peptides active against the hepatitis c virus

Publications (1)

Publication Number	Publication Date
UA78014C2 true UA78014C2 (en)	2007-02-15

Family

ID=27626541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040807068A UA78014C2 (en)	2002-01-30	2003-01-24	Macrocyclic peptides active against hepatitis c virus

Country Status (26)

Country	Link
US (1)	US20030181363A1 (no)
EP (1)	EP1472278B1 (no)
JP (1)	JP4040578B2 (no)
KR (1)	KR20040077899A (no)
CN (1)	CN1639187A (no)
AR (1)	AR038330A1 (no)
AT (1)	ATE414098T1 (no)
BR (1)	BR0307297A (no)
CA (1)	CA2369711A1 (no)
DE (1)	DE60324660D1 (no)
EA (1)	EA007738B1 (no)
EC (1)	ECSP045243A (no)
ES (1)	ES2316718T3 (no)
HR (1)	HRP20040689A2 (no)
MX (1)	MXPA04007462A (no)
NO (1)	NO20043591L (no)
NZ (1)	NZ534929A (no)
PE (1)	PE20030818A1 (no)
PL (1)	PL371007A1 (no)
RS (1)	RS67004A (no)
SA (1)	SA03230569B1 (no)
TW (1)	TW200307692A (no)
UA (1)	UA78014C2 (no)
UY (1)	UY27630A1 (no)
WO (1)	WO2003064455A2 (no)
ZA (1)	ZA200405639B (no)

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2002
- 2002-01-30 CA CA002369711A patent/CA2369711A1/en not_active Abandoned
- 2002-12-17 US US10/320,978 patent/US20030181363A1/en not_active Abandoned
2003
- 2003-01-24 HR HR20040689A patent/HRP20040689A2/hr not_active Application Discontinuation
- 2003-01-24 KR KR10-2004-7011682A patent/KR20040077899A/ko not_active Ceased
- 2003-01-24 MX MXPA04007462A patent/MXPA04007462A/es unknown
- 2003-01-24 WO PCT/CA2003/000089 patent/WO2003064455A2/en not_active Ceased
- 2003-01-24 BR BR0307297-5A patent/BR0307297A/pt not_active IP Right Cessation
- 2003-01-24 NZ NZ534929A patent/NZ534929A/en unknown
- 2003-01-24 CN CNA038054841A patent/CN1639187A/zh active Pending
- 2003-01-24 UA UA20040807068A patent/UA78014C2/uk unknown
- 2003-01-24 PL PL03371007A patent/PL371007A1/xx not_active Application Discontinuation
- 2003-01-24 EP EP03700743A patent/EP1472278B1/en not_active Expired - Lifetime
- 2003-01-24 EA EA200400886A patent/EA007738B1/ru not_active IP Right Cessation
- 2003-01-24 RS YU67004A patent/RS67004A/sr unknown
- 2003-01-24 AT AT03700743T patent/ATE414098T1/de active
- 2003-01-24 ES ES03700743T patent/ES2316718T3/es not_active Expired - Lifetime
- 2003-01-24 DE DE60324660T patent/DE60324660D1/de not_active Expired - Lifetime
- 2003-01-24 JP JP2003564075A patent/JP4040578B2/ja not_active Expired - Fee Related
- 2003-01-28 TW TW092101813A patent/TW200307692A/zh unknown
- 2003-01-29 AR ARP030100252A patent/AR038330A1/es unknown
- 2003-01-29 PE PE2003000095A patent/PE20030818A1/es not_active Application Discontinuation
- 2003-01-29 UY UY27630A patent/UY27630A1/es not_active Application Discontinuation
- 2003-03-02 SA SA03230569A patent/SA03230569B1/ar unknown
2004
- 2004-07-15 ZA ZA200405639A patent/ZA200405639B/en unknown
- 2004-08-20 EC EC2004005243A patent/ECSP045243A/es unknown
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Also Published As

Publication number	Publication date
EA007738B1 (ru)	2006-12-29
PE20030818A1 (es)	2003-10-30
EP1472278A2 (en)	2004-11-03
CN1639187A (zh)	2005-07-13
ES2316718T3 (es)	2009-04-16
UY27630A1 (es)	2003-08-29
WO2003064455A3 (en)	2004-02-05
WO2003064455A2 (en)	2003-08-07
EP1472278B1 (en)	2008-11-12
JP2005524632A (ja)	2005-08-18
JP4040578B2 (ja)	2008-01-30
KR20040077899A (ko)	2004-09-07
HRP20040689A2 (en)	2005-06-30
US20030181363A1 (en)	2003-09-25
EA200400886A1 (ru)	2005-02-24
MXPA04007462A (es)	2005-07-13
TW200307692A (en)	2003-12-16
AR038330A1 (es)	2005-01-12
ZA200405639B (en)	2005-07-01
NO20043591L (no)	2004-08-27
CA2369711A1 (en)	2003-07-30
ATE414098T1 (de)	2008-11-15
BR0307297A (pt)	2004-12-21
ECSP045243A (es)	2004-09-28
DE60324660D1 (de)	2008-12-24
NZ534929A (en)	2006-08-31
PL371007A1 (en)	2005-06-13
SA03230569B1 (ar)	2007-03-05
RS67004A (sr)	2006-10-27

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