UA81243C2 - 1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, the use thereof for producing drugs, pharmaceutical preparation containing such derivatives - Google Patents

1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, the use thereof for producing drugs, pharmaceutical preparation containing such derivatives Download PDF

Info

Publication number: UA81243C2
Authority: UA; Ukraine
Prior art keywords: benzimidazol; oxy; group; methylphenyl; pyridinyl
Prior art date: 2002-02-15

Application number

UA20040907405A

Other languages

English (en)

Ukrainian (uk)

Inventor

Torsten Blume

Wolfgang Halfbrodt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-15

Filing date

2003-01-17

Publication date

2007-12-25

2003-01-17 Application filed filed Critical

2007-12-25 Publication of UA81243C2 publication Critical patent/UA81243C2/uk

Links

125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title claims abstract description 52
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229940079593 drug Drugs 0.000 title description 6
238000011282 treatment Methods 0.000 claims abstract description 17
150000001875 compounds Chemical class 0.000 claims description 127
WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 58
GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 claims description 58
FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 58
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 50
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 38
125000000217 alkyl group Chemical group 0.000 claims description 33
125000001424 substituent group Chemical group 0.000 claims description 26
210000000274 microglia Anatomy 0.000 claims description 25
-1 substituted -O Chemical class 0.000 claims description 25
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150000001412 amines Chemical class 0.000 description 7
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Transplantation (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

UA20040907405A 2002-02-15 2003-01-17 1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, the use thereof for producing drugs, pharmaceutical preparation containing such derivatives UA81243C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10207844A DE10207844A1 (de)	2002-02-15	2002-02-15	1-Phenyl-2-heteroaryl-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
PCT/EP2003/000462 WO2003068766A1 (de)	2002-02-15	2003-01-17	1-phenyl-2-heteroaryl-substituierte benzimidazolderivate, deren verwendung zur herstellung von arzneimitteln zur behandlung von immunologischen erkrankungen

Publications (1)

Publication Number	Publication Date
UA81243C2 true UA81243C2 (en)	2007-12-25

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ID=27674913

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040907405A UA81243C2 (en)	2002-02-15	2003-01-17	1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, the use thereof for producing drugs, pharmaceutical preparation containing such derivatives

Country Status (30)

Country	Link
EP (1)	EP1474415B1 (pl)
JP (1)	JP4739675B2 (pl)
KR (1)	KR101027556B1 (pl)
CN (1)	CN1317274C (pl)
AR (1)	AR038492A1 (pl)
AT (1)	ATE517881T1 (pl)
AU (1)	AU2003205624B2 (pl)
BR (1)	BR0307723A (pl)
CA (1)	CA2475780C (pl)
CR (1)	CR7442A (pl)
CY (1)	CY1113230T1 (pl)
DE (1)	DE10207844A1 (pl)
DK (1)	DK1474415T3 (pl)
EC (1)	ECSP045296A (pl)
ES (1)	ES2369662T3 (pl)
IL (1)	IL163431A (pl)
MX (1)	MXPA04007949A (pl)
NO (1)	NO329667B1 (pl)
NZ (1)	NZ534660A (pl)
PE (1)	PE20030941A1 (pl)
PL (1)	PL216233B1 (pl)
PT (1)	PT1474415E (pl)
RS (1)	RS51831B (pl)
RU (1)	RU2325384C2 (pl)
SI (1)	SI1474415T1 (pl)
TW (1)	TWI328583B (pl)
UA (1)	UA81243C2 (pl)
UY (1)	UY27661A1 (pl)
WO (1)	WO2003068766A1 (pl)
ZA (1)	ZA200407381B (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1497266T1 (sl)	2002-03-27	2008-10-31	Glaxo Group Ltd	Derivati kinolina in njihova uporaba kot ligandi 5-ht6
CN1787817B (zh) *	2003-05-19	2011-09-07	Irm责任有限公司	免疫抑制剂化合物及组合物
WO2014044611A1 (en)	2012-09-20	2014-03-27	Bayer Pharma Aktiengesellschaft	1-aryl-2-heteroaryl benzimidazoles for the induction of neuronal regeneration

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4430502A (en) *	1982-08-13	1984-02-07	The Upjohn Company	Pyridinyl substituted benzimidazoles and quinoxalines
EP0520200B1 (en) *	1991-06-24	1998-02-18	Neurosearch A/S	Imidazole compounds, their preparation and use
DE4129603A1 (de) *	1991-09-06	1993-03-11	Thomae Gmbh Dr K	Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4330959A1 (de) *	1993-09-09	1995-03-16	Schering Ag	Neue Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
IL132575A0 (en) *	1997-05-01	2001-03-19	Nissan Chemical Ind Ltd	Benzimidazole derivative
WO2001021634A1 (en) *	1999-09-21	2001-03-29	Lion Bioscience Ag	Benzimidazole derivatives and combinatorial libraries thereof
US7115645B2 (en) *	2000-01-14	2006-10-03	Schering Aktiengesellschaft	1,2 diarylbenzimidazoles and their pharmaceutical use
NZ519326A (en) *	2000-01-14	2005-02-25	Schering Ag	1,2-diarylbenzimidazoles for treating diseases that are associated with a microglia activation
DE10207843A1 (de) *	2002-02-15	2003-09-04	Schering Ag	Mikrolia-Inhibitoren zur Unterbrechung von Interleukin 12 und IFN-gamma vermittelten Immunreaktionen

2002
- 2002-02-15 DE DE10207844A patent/DE10207844A1/de not_active Ceased
2003
- 2003-01-17 SI SI200332061T patent/SI1474415T1/sl unknown
- 2003-01-17 ES ES03702464T patent/ES2369662T3/es not_active Expired - Lifetime
- 2003-01-17 JP JP2003567893A patent/JP4739675B2/ja not_active Expired - Fee Related
- 2003-01-17 PT PT03702464T patent/PT1474415E/pt unknown
- 2003-01-17 UA UA20040907405A patent/UA81243C2/uk unknown
- 2003-01-17 NZ NZ534660A patent/NZ534660A/en not_active IP Right Cessation
- 2003-01-17 RU RU2004127678/04A patent/RU2325384C2/ru not_active IP Right Cessation
- 2003-01-17 CA CA2475780A patent/CA2475780C/en not_active Expired - Fee Related
- 2003-01-17 AT AT03702464T patent/ATE517881T1/de active
- 2003-01-17 DK DK03702464.3T patent/DK1474415T3/da active
- 2003-01-17 EP EP03702464A patent/EP1474415B1/de not_active Expired - Lifetime
- 2003-01-17 CN CNB038039974A patent/CN1317274C/zh not_active Expired - Fee Related
- 2003-01-17 AU AU2003205624A patent/AU2003205624B2/en not_active Ceased
- 2003-01-17 MX MXPA04007949A patent/MXPA04007949A/es active IP Right Grant
- 2003-01-17 BR BR0307723-3A patent/BR0307723A/pt not_active IP Right Cessation
- 2003-01-17 RS YU71404A patent/RS51831B/sr unknown
- 2003-01-17 WO PCT/EP2003/000462 patent/WO2003068766A1/de not_active Ceased
- 2003-01-17 PL PL371269A patent/PL216233B1/pl unknown
- 2003-01-17 KR KR1020047012576A patent/KR101027556B1/ko not_active Expired - Fee Related
- 2003-01-31 PE PE2003000110A patent/PE20030941A1/es not_active Application Discontinuation
- 2003-02-11 UY UY27661A patent/UY27661A1/es not_active Application Discontinuation
- 2003-02-12 AR ARP030100437A patent/AR038492A1/es not_active Application Discontinuation
- 2003-02-14 TW TW092103073A patent/TWI328583B/zh not_active IP Right Cessation
2004
- 2004-08-10 IL IL163431A patent/IL163431A/en not_active IP Right Cessation
- 2004-09-01 CR CR7442A patent/CR7442A/es not_active Application Discontinuation
- 2004-09-14 NO NO20043841A patent/NO329667B1/no not_active IP Right Cessation
- 2004-09-14 EC EC2004005296A patent/ECSP045296A/es unknown
- 2004-09-14 ZA ZA2004/07381A patent/ZA200407381B/en unknown
2011
- 2011-10-26 CY CY20111101016T patent/CY1113230T1/el unknown

Also Published As

Publication number	Publication date
PL216233B1 (pl)	2014-03-31
AU2003205624A1 (en)	2003-09-04
CA2475780A1 (en)	2003-08-21
TWI328583B (en)	2010-08-11
RU2004127678A (ru)	2005-07-10
WO2003068766A1 (de)	2003-08-21
EP1474415A1 (de)	2004-11-10
CA2475780C (en)	2011-08-02
CY1113230T1 (el)	2016-04-13
UY27661A1 (es)	2003-09-30
DK1474415T3 (da)	2011-11-21
PL371269A1 (pl)	2005-06-13
JP2005521686A (ja)	2005-07-21
TW200303307A (en)	2003-09-01
SI1474415T1 (sl)	2011-12-30
CN1317274C (zh)	2007-05-23
ZA200407381B (en)	2005-11-30
MXPA04007949A (es)	2004-11-26
RU2325384C2 (ru)	2008-05-27
RS51831B (sr)	2012-02-29
RS71404A (sr)	2006-10-27
BR0307723A (pt)	2005-01-25
AR038492A1 (es)	2005-01-19
ATE517881T1 (de)	2011-08-15
EP1474415B1 (de)	2011-07-27
JP4739675B2 (ja)	2011-08-03
NO20043841L (no)	2004-11-12
PT1474415E (pt)	2011-10-13
CR7442A (es)	2006-02-06
KR20040081795A (ko)	2004-09-22
ECSP045296A (es)	2004-10-26
KR101027556B1 (ko)	2011-04-06
NO329667B1 (no)	2010-11-29
CN1633429A (zh)	2005-06-29
DE10207844A1 (de)	2003-09-04
AU2003205624B2 (en)	2009-08-27
ES2369662T3 (es)	2011-12-02
NZ534660A (en)	2006-02-24
IL163431A (en)	2010-11-30
PE20030941A1 (es)	2004-01-17

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