UA81365C2 - Ccr-2 antagonist salt, method for modulation of chemokine receptor activity, method for treating (variants) and pharmaceutical composition - Google Patents

Ccr-2 antagonist salt, method for modulation of chemokine receptor activity, method for treating (variants) and pharmaceutical composition Download PDF

Info

Publication number: UA81365C2
Authority: UA; Ukraine
Prior art keywords: solution; added; naphthyridine; trifluoromethyl; pyran
Prior art date: 2003-10-27

Application number

UAA200605772A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-27

Filing date

2004-10-25

Publication date

2007-12-25

2004-10-25 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2007-12-25 Publication of UA81365C2 publication Critical patent/UA81365C2/uk

Links

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239000002604 chemokine receptor CCR2 antagonist Substances 0.000 title 1
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AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
238000012856 packing Methods 0.000 description 1
WFRLANWAASSSFV-FPLPWBNLSA-N palmitoleoyl ethanolamide Chemical compound CCCCCC\C=C/CCCCCCCC(=O)NCCO WFRLANWAASSSFV-FPLPWBNLSA-N 0.000 description 1
XMGMFRIEKMMMSU-UHFFFAOYSA-N phenylmethylbenzene Chemical group C=1C=CC=CC=1[C]C1=CC=CC=C1 XMGMFRIEKMMMSU-UHFFFAOYSA-N 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000005086 pumping Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
PNGLEYLFMHGIQO-UHFFFAOYSA-M sodium;3-(n-ethyl-3-methoxyanilino)-2-hydroxypropane-1-sulfonate;dihydrate Chemical compound O.O.[Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC=CC(OC)=C1 PNGLEYLFMHGIQO-UHFFFAOYSA-M 0.000 description 1
241000894007 species Species 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
PTSJTHMUTXBBGJ-UHFFFAOYSA-N tert-butyl 4-oxopiperidine-3-carboxylate Chemical compound CC(C)(C)OC(=O)C1CNCCC1=O PTSJTHMUTXBBGJ-UHFFFAOYSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
238000004448 titration Methods 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
238000012546 transfer Methods 0.000 description 1
IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

UAA200605772A 2003-10-27 2004-10-25 Ccr-2 antagonist salt, method for modulation of chemokine receptor activity, method for treating (variants) and pharmaceutical composition UA81365C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US51473503P	2003-10-27	2003-10-27
PCT/US2004/035069 WO2005044264A1 (fr)	2003-10-27	2004-10-25	Sel antagoniste de ccr-2

Publications (1)

Publication Number	Publication Date
UA81365C2 true UA81365C2 (en)	2007-12-25

Family

ID=34572774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200605772A UA81365C2 (en)	2003-10-27	2004-10-25	Ccr-2 antagonist salt, method for modulation of chemokine receptor activity, method for treating (variants) and pharmaceutical composition

Country Status (21)

Country	Link
US (1)	US7473696B2 (fr)
EP (1)	EP1682135B1 (fr)
JP (1)	JP4542550B2 (fr)
KR (1)	KR20060101476A (fr)
CN (1)	CN1870998B (fr)
AT (1)	ATE517622T1 (fr)
AU (1)	AU2004287416C1 (fr)
BR (1)	BRPI0415836A (fr)
CA (1)	CA2543201C (fr)
CO (1)	CO5690606A2 (fr)
EC (1)	ECSP066524A (fr)
IL (1)	IL175009A0 (fr)
IS (1)	IS8400A (fr)
MA (1)	MA28104A1 (fr)
MX (1)	MXPA06004647A (fr)
NO (1)	NO20062377L (fr)
NZ (1)	NZ546447A (fr)
RU (1)	RU2317295C1 (fr)
UA (1)	UA81365C2 (fr)
WO (1)	WO2005044264A1 (fr)
ZA (1)	ZA200602752B (fr)

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AR045875A1 (es) *	2003-10-27	2005-11-16	Merck & Co Inc	Procedimiento para la preparacion del antagonista ccr-2
KR20080052683A (ko)	2003-12-18	2008-06-11	인사이트 코포레이션	케모킨 수용체의 조절제로서의3-사이클로알킬아미노피롤리딘 유도체
BRPI0510665A (pt)	2004-05-11	2007-12-04	Incyte Corp	3-(4-heteroarilcicloexilamino) ciclopentano-carboxiamidas como moduladores de receptores de quimiocinas
GB0413605D0 (en) *	2004-06-17	2004-07-21	Addex Pharmaceuticals Sa	Novel compounds
MXPA06014672A (es)	2004-06-28	2007-03-26	Incyte Corp	3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas.
WO2006004741A2 (fr)	2004-06-28	2006-01-12	Incyte Corporation	3-aminocyclopentanecarboxamides utilises en tant que modulateurs des recepteurs des chimiokines
CN101534824A (zh)	2006-11-17	2009-09-16	艾博特公司	作为化学活素受体拮抗剂的氨基吡咯烷
US20090076065A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched mk-0812
US7741327B2 (en)	2008-04-16	2010-06-22	Hoffmann-La Roche Inc.	Pyrrolidinone glucokinase activators
US8178689B2 (en)	2010-06-17	2012-05-15	Hoffman-La Roche Inc.	Tricyclic compounds
WO2012125663A2 (fr) *	2011-03-17	2012-09-20	Merck Sharp & Dohme Corp.	Dérivés d'amino cyclopentane substitués par cyclohexane en tant qu'antagonistes utiles de ccr2
WO2013149376A1 (fr)	2012-04-02	2013-10-10	Abbott Laboratories	Antagonistes de récepteurs de chimiokines
HK1216233A1 (zh)	2013-02-28	2016-10-28	参天制药株式会社	含有四氢吡喃基氨基环戊基羰基四氢吡啶并吡啶衍生物作为有效成分的眼後段疾病的预防或治疗剂
DK3297438T3 (da)	2015-05-21	2022-01-17	Chemocentryx Inc	Ccr2-modulatorer
CA3293051A1 (en)	2017-09-25	2026-03-02	Chemocentryx, Inc.	Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
CN112105353B (zh)	2018-01-08	2024-04-19	凯莫森特里克斯股份有限公司	Ccr2拮抗剂治疗实体瘤的方法
US20190269664A1 (en)	2018-01-08	2019-09-05	Chemocentryx, Inc.	Methods of treating solid tumors with ccr2 antagonists
CN112341350A (zh) *	2020-10-19	2021-02-09	江苏威奇达药业有限公司	酶法拆分γ-内酰胺后副产物的处理方法

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AR045875A1 (es) *	2003-10-27	2005-11-16	Merck & Co Inc	Procedimiento para la preparacion del antagonista ccr-2

2004
- 2004-10-25 MX MXPA06004647A patent/MXPA06004647A/es active IP Right Grant
- 2004-10-25 RU RU2006118352/04A patent/RU2317295C1/ru not_active IP Right Cessation
- 2004-10-25 CA CA2543201A patent/CA2543201C/fr not_active Expired - Fee Related
- 2004-10-25 NZ NZ546447A patent/NZ546447A/en unknown
- 2004-10-25 US US10/577,584 patent/US7473696B2/en not_active Expired - Fee Related
- 2004-10-25 WO PCT/US2004/035069 patent/WO2005044264A1/fr not_active Ceased
- 2004-10-25 BR BRPI0415836-9A patent/BRPI0415836A/pt not_active IP Right Cessation
- 2004-10-25 UA UAA200605772A patent/UA81365C2/uk unknown
- 2004-10-25 JP JP2006538125A patent/JP4542550B2/ja not_active Expired - Fee Related
- 2004-10-25 EP EP04796120A patent/EP1682135B1/fr not_active Expired - Lifetime
- 2004-10-25 AT AT04796120T patent/ATE517622T1/de not_active IP Right Cessation
- 2004-10-25 AU AU2004287416A patent/AU2004287416C1/en not_active Ceased
- 2004-10-25 CN CN2004800315947A patent/CN1870998B/zh not_active Expired - Fee Related
- 2004-10-25 KR KR1020067008066A patent/KR20060101476A/ko not_active Ceased
2006
- 2006-04-04 ZA ZA200602752A patent/ZA200602752B/xx unknown
- 2006-04-06 IS IS8400A patent/IS8400A/is unknown
- 2006-04-20 IL IL175009A patent/IL175009A0/en unknown
- 2006-04-24 MA MA28957A patent/MA28104A1/fr unknown
- 2006-04-25 CO CO06039063A patent/CO5690606A2/es unknown
- 2006-04-26 EC EC2006006524A patent/ECSP066524A/es unknown
- 2006-05-24 NO NO20062377A patent/NO20062377L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2004287416C1 (en)	2010-09-09
EP1682135A1 (fr)	2006-07-26
RU2317295C1 (ru)	2008-02-20
EP1682135B1 (fr)	2011-07-27
KR20060101476A (ko)	2006-09-25
ATE517622T1 (de)	2011-08-15
BRPI0415836A (pt)	2007-01-02
IS8400A (is)	2006-04-06
JP2007509940A (ja)	2007-04-19
AU2004287416B2 (en)	2009-11-19
ZA200602752B (en)	2007-08-29
EP1682135A4 (fr)	2009-11-25
JP4542550B2 (ja)	2010-09-15
CN1870998B (zh)	2010-10-20
NO20062377L (no)	2006-05-24
CA2543201C (fr)	2010-12-21
CO5690606A2 (es)	2006-10-31
MXPA06004647A (es)	2006-06-27
WO2005044264A1 (fr)	2005-05-19
NZ546447A (en)	2009-02-28
IL175009A0 (en)	2006-08-20
US7473696B2 (en)	2009-01-06
ECSP066524A (es)	2006-10-10
US20070135474A1 (en)	2007-06-14
AU2004287416A1 (en)	2005-05-19
MA28104A1 (fr)	2006-08-01
CA2543201A1 (fr)	2005-05-19
CN1870998A (zh)	2006-11-29

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