UY37367A - Nuevos compuestos para uso en el tratamiento de una infección viral y composiciones de los mismos - Google Patents

Nuevos compuestos para uso en el tratamiento de una infección viral y composiciones de los mismos

Info

Publication number
UY37367A
UY37367A UY0001037367A UY37367A UY37367A UY 37367 A UY37367 A UY 37367A UY 0001037367 A UY0001037367 A UY 0001037367A UY 37367 A UY37367 A UY 37367A UY 37367 A UY37367 A UY 37367A
Authority
UY
Uruguay
Prior art keywords
treatment
viral infection
compositions
same
new compounds
Prior art date
Application number
UY0001037367A
Other languages
English (en)
Inventor
Dimitrios Stefanidis
J Henry Steven
William Rowe Charles
D Saito Roland
D Schroeder Scott
C Tse Winston
R Zhang Jennifer
Michael Graupe
O Link John
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59714166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY37367(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of UY37367A publication Critical patent/UY37367A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/08—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente descripción se refiere a un compuesto de Fórmula (Ia), (Ib), (IIa) y (IIb), Que son útiles en el tratamiento de una infección viral por Retroviridae incluyendo una infección causada por el virus del VIH.
UY0001037367A 2016-08-19 2017-08-17 Nuevos compuestos para uso en el tratamiento de una infección viral y composiciones de los mismos UY37367A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662377312P 2016-08-19 2016-08-19
US201762457555P 2017-02-10 2017-02-10

Publications (1)

Publication Number Publication Date
UY37367A true UY37367A (es) 2018-03-23

Family

ID=59714166

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037367A UY37367A (es) 2016-08-19 2017-08-17 Nuevos compuestos para uso en el tratamiento de una infección viral y composiciones de los mismos

Country Status (43)

Country Link
US (4) US10071985B2 (es)
EP (3) EP4265299A3 (es)
JP (6) JP6716785B2 (es)
KR (5) KR20250085838A (es)
CN (3) CN119462611A (es)
AU (5) AU2017312102B2 (es)
BR (2) BR112018071678B1 (es)
CA (1) CA3021227C (es)
CL (1) CL2019000415A1 (es)
CO (1) CO2019001379A2 (es)
CR (1) CR20190084A (es)
CY (2) CY1122296T1 (es)
DK (2) DK3347352T3 (es)
DO (1) DOP2019000033A (es)
EC (1) ECSP19011209A (es)
ES (2) ES2954514T3 (es)
FI (1) FI3597646T3 (es)
FR (1) FR22C1063I2 (es)
HK (1) HK1256904B (es)
HR (1) HRP20231018T1 (es)
HU (3) HUE063811T2 (es)
IL (1) IL264644B (es)
JO (2) JOP20180098A1 (es)
LT (3) LT3347352T (es)
LU (1) LUC00292I2 (es)
MA (2) MA50673A (es)
MX (1) MX369307B (es)
MY (1) MY191466A (es)
NL (1) NL301212I2 (es)
NO (1) NO2022059I1 (es)
NZ (1) NZ750706A (es)
PE (2) PE20211427A1 (es)
PH (2) PH12021552802A1 (es)
PL (2) PL3347352T3 (es)
PT (2) PT3347352T (es)
SA (1) SA519401123B1 (es)
SG (2) SG11201808944QA (es)
SI (2) SI3597646T1 (es)
TW (5) TW202138365A (es)
UA (1) UA121630C2 (es)
UY (1) UY37367A (es)
WO (1) WO2018035359A1 (es)
ZA (1) ZA201901430B (es)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2553449T3 (es) 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compuestos para el tratamiento de VIH
US10202353B2 (en) 2014-02-28 2019-02-12 Gilead Sciences, Inc. Therapeutic compounds
TW202138365A (zh) 2016-08-19 2021-10-16 美商基利科學股份有限公司 治療性化合物
TWI687415B (zh) * 2017-08-17 2020-03-11 美商基利科學股份有限公司 Hiv蛋白質膜抑制劑之固體形式
AR112412A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas de sal de colina de un inhibidor de la cápside del vih
CN111836805B (zh) 2018-02-15 2023-07-14 吉利德科学公司 吡啶衍生物及其用于治疗hiv感染的用途
TWI745652B (zh) 2018-02-16 2021-11-11 美商基利科學股份有限公司 用於製備有療效化合物之方法及中間物
US20210115061A1 (en) * 2018-06-21 2021-04-22 Drexel University Small-Molecule HIV-1 Capsid Protein Inhibitors and Methods Using Same
US11944611B2 (en) * 2018-07-16 2024-04-02 Gilead Sciences, Inc. Capsid inhibitors for the treatment of HIV
CN112789086A (zh) * 2018-08-09 2021-05-11 Viiv保健英国第五有限公司 人类免疫缺陷病毒复制的抑制剂
EP3849982A1 (en) 2018-09-14 2021-07-21 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
EP3853228A1 (en) 2018-09-20 2021-07-28 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
EP4234560A3 (en) * 2018-10-22 2023-09-13 Board of Regents of the University of Nebraska Antiviral prodrugs and nanoformulations thereof
US11541055B2 (en) 2018-10-24 2023-01-03 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
EP3870576B1 (en) 2018-10-24 2024-01-24 VIIV Healthcare UK (No.5) Limited Bezopyrazole derivatives as inhibitors of human immunodeficiency virus replication
JP7500555B2 (ja) 2018-10-25 2024-06-17 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤
US20210403465A1 (en) 2018-10-29 2021-12-30 VIIV Healthcare UK (No.5) Limited Quinazolinyl-indazole derivatives and their use as inhibitors of human immunodeficiency virus replication
US20210379071A1 (en) 2018-11-05 2021-12-09 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
WO2020095177A1 (en) 2018-11-05 2020-05-14 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
MX2021008751A (es) 2019-01-25 2021-11-12 Univ Brown Composiciones y metodos para tratar, prevenir o revertir la inflamacion y los trastornos asociados a la edad.
UY38559A (es) 2019-02-01 2020-07-31 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicación del virus de la inmunodeficiencia humana
IL286328B1 (en) 2019-03-22 2026-04-01 Gilead Sciences Inc Tricyclic bridging compounds of carbamoylpyridone and their pharmaceutical use
EP3962603A1 (en) 2019-04-30 2022-03-09 ViiV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
RU2717101C1 (ru) 2019-06-03 2020-03-18 Андрей Александрович Иващенко Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения
KR102932817B1 (ko) * 2019-06-19 2026-03-04 비브 헬스케어 유케이 (넘버5) 리미티드 인간 면역결핍 바이러스 복제의 억제제로서의 피리도[2,3-d]피리미딘 유도체
JP2022551254A (ja) 2019-10-01 2022-12-08 ビーブ、ヘルスケア、ユーケー、（ナンバー５）、リミテッド ヒト免疫不全ウイルスの複製阻害剤
ES2974657T3 (es) 2019-10-01 2024-07-01 Viiv Healthcare Uk No 5 Ltd Derivados de n-substituido-6-oxo-1,6-dihidropirimidina-2-ilo como inhibidores de la replicación del virus de inmunodeficiencia humana
TW202128648A (zh) 2019-10-04 2021-08-01 英商Ｖｉｉｖ醫療保健英國(Ｎｏ 5)有限公司 人類免疫不全病毒複製之抑制劑
US20220370451A1 (en) 2019-10-08 2022-11-24 VIIV HEALTHCARE UK ( No. 5) LIMITED Inhibitors of human immunodeficiency virus replication
EP4643882A3 (en) 2019-11-26 2026-01-14 Gilead Sciences, Inc. Capsid inhibitors for the prevention of hiv
EP4066839A4 (en) 2019-11-28 2023-12-27 Shionogi & Co., Ltd PROPHYLACTIC AND THERAPEUTIC MEDICINAL PRODUCT FOR HIV INFECTIOUS DISEASES, CHARACTERIZED BY CONTAINING THE COMBINATION OF INTEGRAS INHIBITORS AND ANTI-HIV AGENTS
KR20220108086A (ko) * 2019-11-29 2022-08-02 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 융합된 피리딘 고리 유도체, 그것의 제조 방법, 및 그것의 제약학적 용도
CN113304166B (zh) * 2020-02-27 2022-10-14 河南真实生物科技有限公司 核苷类化合物在制备治疗冠状病毒感染性疾病的药物中的用途
KR20220151655A (ko) 2020-03-06 2022-11-15 비브 헬스케어 유케이 (넘버5) 리미티드 인간 면역결핍 바이러스 복제의 억제제
WO2021176367A1 (en) 2020-03-06 2021-09-10 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
CA3169348A1 (en) 2020-03-20 2021-09-23 Gilead Sciences, Inc. Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
US20230149408A1 (en) 2020-04-15 2023-05-18 Viiv Healthcare Uk (No. 5) Limited Inhibitors of human immunodeficiency virus replication
WO2021236944A1 (en) 2020-05-21 2021-11-25 Gilead Sciences, Inc. Pharmaceutical compositions comprising bictegravir
JP7520162B2 (ja) * 2020-06-25 2024-07-22 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖの治療のためのカプシド阻害剤
TW202406932A (zh) 2020-10-22 2024-02-16 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
JP7659628B2 (ja) 2020-11-11 2025-04-09 ギリアード サイエンシーズ， インコーポレイテッド ｇｐ１２０ ＣＤ４結合部位指向性抗体による治療に感受性のＨＩＶ患者を特定する方法
CN116801884B (zh) * 2021-01-25 2026-02-27 腾盛博药生物科技有限公司 使用腺苷衍生物和衣壳抑制剂的针对hiv的组合疗法
US20250320194A1 (en) * 2021-05-28 2025-10-16 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutically acceptable salt and crystal form of fused pyridine ring derivative and preparation method therefor
KR20230018690A (ko) 2021-07-30 2023-02-07 (주) 에빅스젠 둥근이질풀 추출물을 유효성분으로 포함하는, 바이러스성 질환 치료 및 개선용 조성물
KR20230019059A (ko) 2021-07-30 2023-02-07 (주) 에빅스젠 연전초 추출물을 유효성분으로 포함하는, 바이러스성 질환 완화 및 개선용 조성물
EP4415685A1 (en) * 2021-10-13 2024-08-21 ViiV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
WO2023102523A1 (en) 2021-12-03 2023-06-08 Gilead Sciences, Inc. Therapeutic compounds for hiv virus infection
PT4440702T (pt) 2021-12-03 2025-08-13 Gilead Sciences Inc Compostos terapêuticos para a infecção pelo vírus do hiv
JP7765637B2 (ja) * 2021-12-03 2025-11-06 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖウイルス感染症のための治療化合物
TWI856796B (zh) 2022-04-06 2024-09-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
EP4547659A1 (en) 2022-07-01 2025-05-07 Gilead Sciences, Inc. Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection
WO2024044477A1 (en) 2022-08-26 2024-02-29 Gilead Sciences, Inc. Dosing and scheduling regimen for broadly neutralizing antibodies
EP4598934A1 (en) 2022-10-04 2025-08-13 Gilead Sciences, Inc. 4'-thionucleoside analogues and their pharmaceutical use
KR20240061218A (ko) 2022-10-31 2024-05-08 주식회사 이보드 복합 단열재 및 제조방법
CR20250310A (es) 2023-01-30 2025-08-25 Merck Sharp & Dohme Llc Profármacos de inhibidores de la transcriptasa inversa de nucleósidos sustituidos en 4'
AR132464A1 (es) 2023-04-19 2025-07-02 Gilead Sciences Inc Régimen de dosificación de inhibidor de la cápside
AU2024281548A1 (en) 2023-05-31 2025-11-13 Gilead Sciences, Inc. Solid forms of compounds useful in the treatment of hiv
US20250011353A1 (en) 2023-05-31 2025-01-09 Gilead Sciences, Inc. Process of preparing hiv capsid inhibitor
EP4719608A1 (en) 2023-05-31 2026-04-08 Gilead Sciences, Inc. Quinazolinyl-indazole derivatives as therapeutic compounds for hiv
CN116675675A (zh) * 2023-06-05 2023-09-01 北京康立生医药技术开发有限公司 一种艾滋病治疗药物来那卡帕韦中间体化合物的制备方法
EP4727909A1 (en) 2023-06-15 2026-04-22 VIIV Healthcare UK (No.5) Limited Methods and intermediates for preparing compounds
KR20260046169A (ko) 2023-07-28 2026-04-06 길리애드 사이언시즈, 인코포레이티드 Hiv의 치료 및 예방을 위한 레나카파비르 주간 투여 레지먼
EP4531816B1 (en) 2023-08-15 2025-12-31 Gilead Sciences, Inc. PHARMACEUTICAL FORMULATIONS OF BICTEGRAVIR AND LENACAPAVIR
EP4529922A1 (en) 2023-09-29 2025-04-02 Gilead Sciences, Inc. Pharmaceutical formulations of bictegravir and lenacapavir
WO2025042394A1 (en) 2023-08-23 2025-02-27 Gilead Sciences, Inc. Dosing regimen of hiv capsid inhibitor
KR20250040288A (ko) 2023-09-15 2025-03-24 민영호 복합 단열재
TW202515549A (zh) 2023-10-11 2025-04-16 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
AU2024360779A1 (en) 2023-10-11 2026-04-16 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
CN122055369A (zh) 2023-10-11 2026-05-15 吉利德科学公司 桥连三环氨基甲酰基吡啶酮化合物及其用途
US20250230163A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Solid forms of hiv integrase inhibitors
US12594276B2 (en) 2024-02-05 2026-04-07 Viiv Healthcare Uk (No. 5) Limited Inhibitors of human immunodeficiency virus replication
US20250289822A1 (en) 2024-03-01 2025-09-18 Gilead Sciences, Inc. Solid forms of hiv integrase inhibitors
US20250296932A1 (en) 2024-03-01 2025-09-25 Gilead Sciences, Inc. Pharmaceutical compositions comprising hiv integrase inhibitors
US20250333424A1 (en) 2024-03-01 2025-10-30 Gilead Sciences, Inc. Antiviral compounds
WO2025240391A2 (en) 2024-05-14 2025-11-20 Gilead Sciences, Inc. Medical injections and related devices and methods
TW202604585A (zh) 2024-05-14 2026-02-01 美商基利科學股份有限公司 醫療注射及相關裝置及方法
WO2025240389A1 (en) 2024-05-14 2025-11-20 Gilead Sciences, Inc. Medical injections and related devices and methods
US20250367381A1 (en) 2024-05-14 2025-12-04 Gilead Sciences, Inc. Medical injections and related devices and methods
US20250367384A1 (en) 2024-05-14 2025-12-04 Gilead Sciences, Inc. Medical injections and related devices and methods
US20260007683A1 (en) 2024-06-14 2026-01-08 Gilead Sciences, Inc. Pharmaceutical compositions comprising hiv integrase inhibitors
WO2025264995A1 (en) * 2024-06-21 2025-12-26 Gilead Sciences, Inc. Formulations of an hiv capsid inhibitor
WO2026006521A1 (en) 2024-06-27 2026-01-02 Gilead Sciences, Inc. Oral tablet formulations
WO2026020086A1 (en) 2024-07-19 2026-01-22 Gilead Sciences, Inc. Methods and pharmaceutical formulations for treating viral infections
WO2026076265A1 (en) 2024-10-03 2026-04-09 Gilead Sciences, Inc. Combination therapy comprising bridged tricyclic carbamoylpyridone compounds and p-glycoprotein inhibitors

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816570A (en) 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
AU651835B2 (en) 1990-06-13 1994-08-04 Arnold Glazier Phosphorous prodrugs
EP0481214B1 (en) 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US5935946A (en) 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
CN1291994C (zh) 2000-07-21 2006-12-27 吉里德科学公司 核苷酸膦酸酯类似物前药及其筛选和制备方法
ATE370943T1 (de) 2001-06-27 2007-09-15 Smithkline Beecham Corp Fluoropyrrolidine als dipeptidyl-peptidase inhibitoren
WO2003002530A2 (en) 2001-06-27 2003-01-09 Smithkline Beecham Corporation Pyrrolidines as dipeptidyl peptidase inhibitors
SI1441734T1 (sl) 2001-10-26 2007-08-31 Angeletti P Ist Richerche Bio Dihidropirimidin karboksamidni inhibitorji HIV-integraze
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
WO2004071448A2 (en) 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
PL1628685T3 (pl) 2003-04-25 2011-05-31 Gilead Sciences Inc Przeciwwirusowe analogi fosfonianowe
DE602005023224D1 (de) 2004-02-27 2010-10-07 Schering Corp Neuartige Verbindungen als Hemmer von Hepatitis C-Virus NS3-Serinprotease
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
US7429604B2 (en) 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
EP1778251B1 (en) 2004-07-27 2011-04-13 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti hiv agents
US8067587B2 (en) 2005-07-28 2011-11-29 Lenroc Company Process for the production of monoalkali metal cyanurates
AU2006279034A1 (en) 2005-08-05 2007-02-15 Astrazeneca Ab Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
EP1981854B1 (en) 2005-12-14 2011-06-01 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
ES2566481T3 (es) 2006-04-12 2016-04-13 Merck Sharp & Dohme Corp. Antagonistas del canal de calcio de tipo T de piridil amida
US7647464B2 (en) 2006-04-28 2010-01-12 At&T Intellectual Property, I,L.P. Methods, systems, and products for recording media to a restoration server
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US8124811B2 (en) 2007-03-20 2012-02-28 Allylix, Inc. Fragrance and methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one
EP2139883A4 (en) 2007-03-23 2011-06-22 Univ Massachusetts HIV-1 protease inhibitor
MX2009013830A (es) 2007-06-29 2010-03-01 Gilead Sciences Inc Compuestos antivirales.
US8426434B2 (en) 2007-07-12 2013-04-23 Tibotec Pharmaceuticals Ltd. Crystalline form of 4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile
AU2008277377B2 (en) 2007-07-19 2013-08-01 Msd Italia S.R.L. Macrocyclic compounds as antiviral agents
CA2701594C (en) 2007-10-24 2014-02-18 Merck Sharp & Dohme Corp. Heterocycle phenyl amide t-type calcium channel antagonists
US20100249176A1 (en) 2007-10-24 2010-09-30 Barrow James C Heterocycle amide t-type calcium channel antagonists
WO2009062285A1 (en) 2007-11-16 2009-05-22 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
EP2265601B1 (en) 2008-03-13 2012-02-01 Bristol-Myers Squibb Company Pyridazine derivatives as factor xia inhibitors
AU2009333559B2 (en) 2008-12-09 2015-03-12 Gilead Sciences, Inc. Modulators of toll-like receptors
EP2401286A4 (en) 2009-02-25 2012-09-26 Bigtec Private Ltd PROBES AND PRIMERS FOR DETECTION OF CHIKUNGUNYA
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US20110274648A1 (en) 2009-11-11 2011-11-10 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
WO2011094890A1 (en) 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
WO2011139637A1 (en) 2010-05-03 2011-11-10 Philadelphia Health & Education Corporation Small-molecule modulators of hiv-1 capsid stability and methods thereof
WO2011143772A1 (en) 2010-05-21 2011-11-24 Boehringer Ingelheim International Gmbh Inhibitors of hiv replication
AP2013006706A0 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc Napht-2-ylacetic acid derivatives to treat AIDS
PH12013500015A1 (en) 2010-07-02 2013-02-18 Gilead Sciences Inc 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds
CN102464654B (zh) 2010-11-12 2016-01-13 上海泓博智源医药技术有限公司 抗病毒化合物
SMT201700325T1 (it) 2011-03-23 2017-09-07 Trevena Inc Ligandi del recettore degli oppioidi e metodi per l’uso e la produzione dei medesimi
UA111841C2 (uk) 2011-04-21 2016-06-24 Гіліад Сайєнсіз, Інк. Сполуки бензотіазолу та їх фармацевтичне застосування
ES2553449T3 (es) * 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compuestos para el tratamiento de VIH
CN102863512B (zh) 2011-07-07 2016-04-20 上海泓博智源医药技术有限公司 抗病毒化合物
CN110343135A (zh) 2011-08-16 2019-10-18 吉利德科学公司 替诺福韦艾拉酚胺(tenofovir alafenamide)半反丁烯二酸盐
WO2013091096A1 (en) 2011-12-20 2013-06-27 Boehringer Ingelheim International Gmbh Condensed triclyclic compounds as inhibitors of hiv replication
US9096586B2 (en) 2012-04-20 2015-08-04 Gilead Sciences, Inc. Therapeutic compounds
GB201213087D0 (en) 2012-07-24 2012-09-05 Medical Res Council Inhibition of HIV-1 infection
US9447134B2 (en) 2012-08-17 2016-09-20 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
CA2893843C (en) 2012-12-21 2018-09-04 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
HK1214817A1 (en) 2012-12-27 2016-08-05 Japan Tobacco Inc. Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as hiv integrase inhibitor
TW201443037A (zh) 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
CA2896244C (en) 2013-01-09 2017-07-04 Gilead Sciences, Inc. 5-membered heteroaryls and their use as antiviral agents
US9012441B2 (en) 2013-01-09 2015-04-21 Gilead Sciences, Inc. Therapeutic compounds
EP2769722A1 (en) 2013-02-22 2014-08-27 Ruprecht-Karls-Universität Heidelberg Compounds for use in inhibiting HIV capsid assembly
US20140296266A1 (en) 2013-03-01 2014-10-02 Gilead Sciences, Inc. Therapeutic compounds
TWI694071B (zh) * 2013-03-01 2020-05-21 美商基利科學股份有限公司 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物
GB201312991D0 (en) 2013-07-19 2013-09-04 Isis Innovation Process
EP3060554A1 (en) 2013-10-24 2016-08-31 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US10202353B2 (en) 2014-02-28 2019-02-12 Gilead Sciences, Inc. Therapeutic compounds
WO2015130966A1 (en) 2014-02-28 2015-09-03 Gilead Sciences, Inc. Antiviral agents
US9873680B2 (en) 2014-08-29 2018-01-23 Gilead Sciences, Inc. Therapeutic compounds
US9855230B2 (en) 2014-09-09 2018-01-02 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
TW202237569A (zh) 2014-12-24 2022-10-01 美商基利科學股份有限公司 喹唑啉化合物
ES2735087T3 (es) 2014-12-24 2019-12-16 Gilead Sciences Inc Compuestos de pirimidina fusionados para el tratamiento de VIH
BR112017022605A2 (pt) 2015-04-23 2018-07-17 Viiv Healthcare Uk No 5 Ltd ?composto, composição, e, método para tratamento de infecção por hiv?.
BR112017022544A2 (pt) 2015-04-23 2018-07-10 Viiv Healthcare Uk No 5 Ltd ?composto, composição, e, método para tratamento de infecção por hiv?.
KR20220129667A (ko) * 2015-07-06 2022-09-23 길리애드 사이언시즈, 인코포레이티드 Cot 조정제 및 그의 사용 방법
US10171985B1 (en) 2015-07-22 2019-01-01 Ginko LLC Method and apparatus for data sharing
TW202138365A (zh) 2016-08-19 2021-10-16 美商基利科學股份有限公司 治療性化合物
AR110922A1 (es) 2017-02-06 2019-05-15 Gilead Sciences Inc Compuestos inhibidores del vih
TW201906834A (zh) 2017-05-02 2019-02-16 英商Viiv醫療保健英國(No.5)有限公司 人類免疫不全病毒複製之抑制劑
TWI687415B (zh) * 2017-08-17 2020-03-11 美商基利科學股份有限公司 Hiv蛋白質膜抑制劑之固體形式
AR112412A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas de sal de colina de un inhibidor de la cápside del vih
CN111836805B (zh) 2018-02-15 2023-07-14 吉利德科学公司 吡啶衍生物及其用于治疗hiv感染的用途
TWI745652B (zh) 2018-02-16 2021-11-11 美商基利科學股份有限公司 用於製備有療效化合物之方法及中間物
US10911396B2 (en) 2018-06-28 2021-02-02 Paypal, Inc. Mid-tier messaging system
US11944611B2 (en) 2018-07-16 2024-04-02 Gilead Sciences, Inc. Capsid inhibitors for the treatment of HIV
EP4643882A3 (en) 2019-11-26 2026-01-14 Gilead Sciences, Inc. Capsid inhibitors for the prevention of hiv
JP7520162B2 (ja) 2020-06-25 2024-07-22 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖの治療のためのカプシド阻害剤

Also Published As

Publication number Publication date
MA42795A (fr) 2019-07-03
MA50673A (fr) 2020-08-05
BR112018071678A2 (pt) 2019-02-19
AU2020202331C1 (en) 2021-08-26
FR22C1063I2 (fr) 2023-12-15
NZ791323A (en) 2025-03-28
TW202342449A (zh) 2023-11-01
JP2021008516A (ja) 2021-01-28
MX369307B (es) 2019-11-05
LT3347352T (lt) 2019-08-12
DK3597646T3 (da) 2023-09-04
CN109890808A (zh) 2019-06-14
AU2025271141A1 (en) 2025-12-18
AU2021221855B2 (en) 2023-08-31
CL2019000415A1 (es) 2019-06-21
DOP2019000033A (es) 2019-03-15
KR20240070646A (ko) 2024-05-21
LUC00292I2 (es) 2025-05-12
ECSP19011209A (es) 2019-02-28
AU2017312102A1 (en) 2019-03-07
UA121630C2 (es) 2020-06-25
TWI664966B (zh) 2019-07-11
CN111793061A (zh) 2020-10-20
KR102180740B1 (ko) 2020-11-20
CA3021227C (en) 2020-11-03
EP3347352A1 (en) 2018-07-18
CR20190084A (es) 2019-05-02
CN111793061B (zh) 2024-11-26
EP3597646B1 (en) 2023-06-21
CA3021227A1 (en) 2018-02-22
JP2019528280A (ja) 2019-10-10
JP2024170471A (ja) 2024-12-10
NZ791314A (en) 2025-03-28
AU2023271739B2 (en) 2025-08-21
LTPA2023501I1 (es) 2023-02-10
US20200262815A1 (en) 2020-08-20
US11993583B2 (en) 2024-05-28
HRP20231018T1 (hr) 2023-12-08
LTC3347352I2 (es) 2024-10-10
DK3347352T3 (da) 2019-08-26
US20180370950A1 (en) 2018-12-27
NZ763251A (en) 2025-02-28
CY1122296T1 (el) 2021-01-27
AU2023271739A1 (en) 2023-12-14
PL3597646T3 (pl) 2023-12-11
TWI715944B (zh) 2021-01-11
CO2019001379A2 (es) 2019-02-19
AU2020202331A1 (en) 2020-04-23
JP2026074095A (ja) 2026-05-01
SI3597646T1 (sl) 2023-10-30
HUS2200053I1 (hu) 2023-01-28
KR20230011471A (ko) 2023-01-20
EP4265299A3 (en) 2024-01-17
NO2022059I1 (no) 2022-12-16
HUE045137T2 (hu) 2019-12-30
KR20200131351A (ko) 2020-11-23
KR20250085838A (ko) 2025-06-12
SI3347352T1 (sl) 2019-08-30
AU2020202331B2 (en) 2021-05-27
TWI853404B (zh) 2024-08-21
EP4265299A2 (en) 2023-10-25
SG10201912535VA (en) 2020-02-27
BR122020001791B1 (pt) 2022-01-25
PH12019500335A1 (en) 2019-11-11
TW202504608A (zh) 2025-02-01
EP3597646A1 (en) 2020-01-22
EP3347352B1 (en) 2019-07-03
JOP20180123A1 (ar) 2019-01-30
US20180051005A1 (en) 2018-02-22
JP2023011754A (ja) 2023-01-24
CY2022039I1 (el) 2023-01-27
KR20190039431A (ko) 2019-04-11
MA42795B1 (fr) 2019-08-30
ES2746374T3 (es) 2020-03-05
PT3347352T (pt) 2019-09-24
TW202138365A (zh) 2021-10-16
LT3597646T (lt) 2023-09-25
CN119462611A (zh) 2025-02-18
NL301212I2 (nl) 2023-04-06
IL264644B (en) 2019-09-26
SA519401123B1 (ar) 2022-11-09
BR112018071678B1 (pt) 2021-01-26
JP2020111592A (ja) 2020-07-27
PL3347352T3 (pl) 2019-12-31
US20240376077A1 (en) 2024-11-14
JP6716785B2 (ja) 2020-07-01
CN109890808B (zh) 2020-08-07
AU2017312102B2 (en) 2020-03-05
WO2018035359A1 (en) 2018-02-22
ZA201901430B (en) 2021-09-29
US10071985B2 (en) 2018-09-11
JOP20180098A1 (ar) 2018-02-19
SG11201808944QA (en) 2018-11-29
NL301212I1 (es) 2023-01-12
FR22C1063I1 (fr) 2023-02-03
PH12021552802A1 (en) 2022-07-04
US10654827B2 (en) 2020-05-19
HK1256904B (en) 2020-07-17
PT3597646T (pt) 2023-09-11
NZ750706A (en) 2020-07-31
PE20190910A1 (es) 2019-06-26
CY2022039I2 (el) 2023-01-27
MY191466A (en) 2022-06-28
TW201922711A (zh) 2019-06-16
ES2954514T3 (es) 2023-11-22
FI3597646T3 (fi) 2023-09-07
MX2018012905A (es) 2019-01-30
HUE063811T2 (hu) 2024-02-28
TW201811327A (zh) 2018-04-01
PE20211427A1 (es) 2021-08-03
AU2021221855A1 (en) 2021-09-23

Similar Documents

Publication Publication Date Title
CO2019001379A2 (es) Compuestos terapéuticos útiles para el tratamiento profiláctico o terapéutico de una infección por el virus del vih .
CR20160241A (es) Nuevas dihidroquinolizinonas para el tratamiento y profilaxis de la infección por virus de la hepatitis b
UY35362A (es) Compuestos terapéuticos
CO2020012824A2 (es) Compuestos de 4-aminoisoindolina-1,3-diona sustituidos y su uso para el tratamiento de linfoma
MX2017001862A (es) Nuevas piridazonas y triazinonas para el tratamiento y la profilaxis de infeccion por virus de hepatitis b.
CR20160337A (es) Nuevas heteroarildihidropirimidinas 6-fusionadas para el tratamiento y la profilaxis de la infección por virus de la hepatitis b
CO7170160A2 (es) Nuevas 6-aminoacido-heteroarildihidropirimidinas para el tratamiento y profilaxis de la infección del virus de la hepatitis b
CL2015001864A1 (es) Compuestos derivados de espiropirido[1,2-a]pirazina sustituidos, como inhibidores de la integrasa del vih; composicion farmaceutica que los comprende; y su uso para la profilaxis o el tratamiento de una infeccion por vih.
UY37710A (es) Inhibidores de la replicación del virus de la inmunodeficiencia humana
CO2019005534A2 (es) Compuestos de heterociclo tetracíclicos útiles como inhibidores de la integrasa del vih
CL2017001191A1 (es) Compuestos derivados de carbamoilpiridona policíclicos; composición farmacéutica que los comprende; y su uso para el tratamiento de una infección de vih en un humano que tiene o se encuentra en riesgo de tener la infección.
CL2016000493A1 (es) Inhibidores de polimerasa hcv.
CL2014003634A1 (es) Inhibidores del virus de la hepatitis c
CU20170089A7 (es) Derivados de quinazolina utilizados para tratar el vih
MX2018000280A (es) Oxiesteroles y metodos de uso de los mismos.
UY35263A (es) Compuestos terapéuticos
MX2016003199A (es) Compuestos de azapiridona y usos de los mismos.
DOP2016000336A (es) Derivados de isoindolina para uso en el tratamiento de una infeccion viral
MX2019009212A (es) Analogos de atazanavir (atv) para tratar infecciones por virus de inmunodeficiencia humana (vih).
MX2018008772A (es) Formulaciones/composiciones que comprenden un inhibidor de btk.
MX2017011655A (es) Compuestos de aza-piridona y usos de estos.
MX2022008062A (es) Uso del agonista fxr para el tratamiento de una infeccion por el virus de la hepatitis d.
AR109364A1 (es) Compuestos antivirales
AR111017A1 (es) Sal hemisulfato de un compuesto nucleotídico para el tratamiento del virus de la hepatitis c

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20230626