WO2007134077A3 - Neurogenèse induite par le récepteur 5ht - Google Patents

Neurogenèse induite par le récepteur 5ht Download PDF

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Publication number
WO2007134077A3
WO2007134077A3 PCT/US2007/068503 US2007068503W WO2007134077A3 WO 2007134077 A3 WO2007134077 A3 WO 2007134077A3 US 2007068503 W US2007068503 W US 2007068503W WO 2007134077 A3 WO2007134077 A3 WO 2007134077A3
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WO
WIPO (PCT)
Prior art keywords
receptor mediated
neurogenesis
mediated neurogenesis
stimulate
stimulating
Prior art date
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Ceased
Application number
PCT/US2007/068503
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English (en)
Other versions
WO2007134077A2 (fr
Inventor
Carrolee Barlow
Todd A Carter
Andrew Morse
Kai Treuner
Kym I Lorrain
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Braincells Inc
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Braincells Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Braincells Inc filed Critical Braincells Inc
Priority to AU2007249435A priority Critical patent/AU2007249435A1/en
Priority to JP2009510152A priority patent/JP2009536667A/ja
Priority to EP07762023A priority patent/EP2026813A2/fr
Priority to MX2008014320A priority patent/MX2008014320A/es
Priority to CA002651862A priority patent/CA2651862A1/fr
Publication of WO2007134077A2 publication Critical patent/WO2007134077A2/fr
Publication of WO2007134077A3 publication Critical patent/WO2007134077A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention porte sur des méthodes de traitement de maladies et d'états affectant le système nerveux central et périphérique, ces méthodes de traitement visant à stimuler ou accroître la neurogenèse. L'invention porte également sur des compositions et des méthodes basées sur l'utilisation d'un agent de 5HTR, éventuellement en combinaison avec un ou plusierus autres agents neurogènes, pour stimuler ou activer la formation de nouvelles cellules nerveuses.
PCT/US2007/068503 2006-05-09 2007-05-08 Neurogenèse induite par le récepteur 5ht Ceased WO2007134077A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2007249435A AU2007249435A1 (en) 2006-05-09 2007-05-08 5 HT receptor mediated neurogenesis
JP2009510152A JP2009536667A (ja) 2006-05-09 2007-05-08 ５ｈｔ受容体介在性の神経新生
EP07762023A EP2026813A2 (fr) 2006-05-09 2007-05-08 Neurogenèse induite par le récepteur 5ht
MX2008014320A MX2008014320A (es) 2006-05-09 2007-05-08 Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
CA002651862A CA2651862A1 (fr) 2006-05-09 2007-05-08 Neurogenese induite par le recepteur 5ht

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US74687806P 2006-05-09 2006-05-09
US60/746,878 2006-05-09
US80543606P 2006-06-21 2006-06-21
US60/805,436 2006-06-21
US88242906P 2006-12-28 2006-12-28
US60/882,429 2006-12-28

Publications (2)

Publication Number Publication Date
WO2007134077A2 WO2007134077A2 (fr) 2007-11-22
WO2007134077A3 true WO2007134077A3 (fr) 2008-01-03

Family

ID=38582011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/068503 Ceased WO2007134077A2 (fr) 2006-05-09 2007-05-08 Neurogenèse induite par le récepteur 5ht

Country Status (7)

Country Link
US (2) US7678808B2 (fr)
EP (1) EP2026813A2 (fr)
JP (1) JP2009536667A (fr)
AU (1) AU2007249435A1 (fr)
CA (1) CA2651862A1 (fr)
MX (1) MX2008014320A (fr)
WO (1) WO2007134077A2 (fr)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006269231A1 (en) * 2005-07-08 2007-01-18 Braincells, Inc. Methods for identifying agents and conditions that modulate neurogenesis
GB0515090D0 (en) * 2005-07-22 2005-08-31 Birmingham Res & Dev Ltd Novel epilepsy treatment
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20090197823A1 (en) * 2006-05-09 2009-08-06 Braincells, Inc. Aliskiren modulation of neurogenesis
WO2007134077A2 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenèse induite par le récepteur 5ht
AU2007299726A1 (en) * 2006-09-22 2008-03-27 Braincells, Inc. Combination comprising an HMG-COA reductase inhibitor and a second neurogenic agent for treating a nervous system disorder and increasing neurogenesis
WO2008083204A2 (fr) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation de la neurogenèse par des ligands mélatoninergiques
US20080171750A1 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation Of Neurogenesis With Use of Modafinil
WO2008097861A2 (fr) * 2007-02-02 2008-08-14 Braincells, Inc. Modulation d'une neurogénèse avec des biguanides et des agents gsk3-ss
EP2167065A1 (fr) * 2007-06-18 2010-03-31 The General Hospital Corporation Thérapie par combinaison pour la dépression
EP2065038A1 (fr) 2007-11-30 2009-06-03 Pharnext Nouvelles approches thérapeutiques pour traiter la maladie de Charcot-Marie-Tooth
DK3260118T3 (da) 2008-10-16 2021-04-19 Univ Johns Hopkins Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
US20100298397A1 (en) * 2009-05-19 2010-11-25 Singh Nikhilesh N Method of treatment of obsessive compulsive disorder with ondansetron
EP2263665A1 (fr) 2009-06-02 2010-12-22 Pharnext Nouvelles compositions pour traiter le CMT et troubles associés
US9393241B2 (en) 2009-06-02 2016-07-19 Pharnext Compositions for treating CMT and related disorders
EA202092673A3 (ru) * 2010-02-09 2021-05-31 Дзе Джонс Хопкинс Юниверсити Способы и композиции для улучшения когнитивной функции
CN102058600A (zh) * 2010-12-27 2011-05-18 天津医科大学总医院 莫沙必利在制备治疗癫痫药物中的应用
US9193710B2 (en) 2011-08-29 2015-11-24 Sanford-Burnham Medical Research Institute Benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof
NZ700474A (en) * 2012-04-18 2016-10-28 Contera Pharma Aps Orally available pharmaceutical formulation suitable for improved management of movement disorders
ITMI20120913A1 (it) * 2012-05-28 2013-11-29 Nicoletta Maxia Uso della n-acetil-5-metossitriptamina o suoi analoghi per favorire il meccanismo di impianto dell' embrione, e relative composizioni e mezzi di coltura
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2014144663A1 (fr) 2013-03-15 2014-09-18 The Johns Hopkins University Procédés et compositions pour améliorer la fonction cognitive
EP2986158A1 (fr) 2013-03-15 2016-02-24 Abbott Laboratories Procédés de maintien et d'amélioration de la fonction musculaire
AU2014228512A1 (en) 2013-03-15 2015-10-01 Agenebio, Inc. Methods and compositions for improving cognitive function
AU2014276856B2 (en) 2013-06-05 2018-11-15 Pharnext Stable oral solutions for combined API
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
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