ZA200007694B - EP4 receptor selective agonists in the treatment of osteoporosis. - Google Patents

EP4 receptor selective agonists in the treatment of osteoporosis.

Info

Publication number: ZA200007694B
Authority: ZA; South Africa
Prior art keywords: osteoporosis; treatment; selective agonists; receptor selective; receptor
Prior art date: 1999-12-22

Application number

ZA200007694A

Other languages

English (en)

Inventor

Kimberly O'keefe Cameron

Huazhu Ke

Bruce Allen Lefker

David Duane Thompson

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-22

Filing date

2000-12-20

Publication date

2002-06-20

2000-12-20 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2002-06-20 Publication of ZA200007694B publication Critical patent/ZA200007694B/xx

Links

208000001132 Osteoporosis Diseases 0.000 title 1
101150109738 Ptger4 gene Proteins 0.000 title 1
239000000556 agonist Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

ZA200007694A 1999-12-22 2000-12-20 EP4 receptor selective agonists in the treatment of osteoporosis. ZA200007694B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17135399P	1999-12-22	1999-12-22

Publications (1)

Publication Number	Publication Date
ZA200007694B true ZA200007694B (en)	2002-06-20

Family

ID=22623430

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200007694A ZA200007694B (en)	1999-12-22	2000-12-20	EP4 receptor selective agonists in the treatment of osteoporosis.

Country Status (36)

Country	Link
US (2)	US6737437B2 (fr)
EP (1)	EP1110949B1 (fr)
JP (1)	JP2001181210A (fr)
KR (1)	KR100419681B1 (fr)
CN (1)	CN1413190A (fr)
AP (2)	AP2001002357A0 (fr)
AT (1)	ATE250575T1 (fr)
AU (2)	AU1293101A (fr)
BG (1)	BG106882A (fr)
BR (1)	BR0016560A (fr)
CA (1)	CA2329678A1 (fr)
CO (1)	CO5251453A1 (fr)
CR (1)	CR6678A (fr)
CZ (1)	CZ20022048A3 (fr)
DE (1)	DE60005471T2 (fr)
DK (1)	DK1110949T3 (fr)
EA (1)	EA005293B1 (fr)
EE (1)	EE200200355A (fr)
ES (1)	ES2204458T3 (fr)
GE (1)	GEP20043203B (fr)
HR (1)	HRP20020537A2 (fr)
HU (1)	HUP0005001A3 (fr)
IL (1)	IL140325A0 (fr)
IS (1)	IS6388A (fr)
MA (1)	MA26852A1 (fr)
MX (1)	MXPA02006322A (fr)
NO (1)	NO20022925D0 (fr)
OA (1)	OA12117A (fr)
PE (1)	PE20010953A1 (fr)
PL (1)	PL356662A1 (fr)
PT (1)	PT1110949E (fr)
SK (1)	SK8552002A3 (fr)
TR (2)	TR200201643T2 (fr)
UA (1)	UA72293C2 (fr)
WO (1)	WO2001046140A1 (fr)
ZA (1)	ZA200007694B (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20010056060A1 (en) *	2000-02-07	2001-12-27	Cameron Kimberly O.	Treatment of osteoporsis with EP2/EP4 receptor selective agonists
PT1339678E (pt)	2000-11-27	2007-11-30	Pfizer Prod Inc	Agonistas selectivos do receptor ep4 no tratamento de osteoporose
ES2254726T3 (es) *	2001-07-16	2006-06-16	F. Hoffmann-La Roche Ag	Analogos de prostaglandina como agonistas receptores de ep4.
RU2296122C2 (ru)	2001-07-16	2007-03-27	Ф.Хоффманн-Ля Рош Аг	Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция
ES2360604T3 (es) *	2001-07-23	2011-06-07	Ono Pharmaceutical Co., Ltd.	Remedios para enfermedades con pérdida de masa osea que tienen como ingrediente activo agonistas de ep4.
NZ530885A (en) *	2001-07-23	2007-09-28	Ono Pharmaceutical Co	Remedies for diseases with bone mass loss having EP4 agonist as the active ingredient
JPWO2003041717A1 (ja) *	2001-11-12	2005-03-03	小野薬品工業株式会社	プロスタグランジン誘導体を有効成分とする局所投与用持続性フィルム状製剤
US20040204590A1 (en) *	2001-12-03	2004-10-14	Ogidigben Miller J.	Ep4 receptor agonist, compositions and methods thereof
US20040254230A1 (en) *	2001-12-03	2004-12-16	Ogidigben Miller J.	Method for treating ocular hypertension
DE60235198D1 (de) *	2001-12-20	2010-03-11	Merck Serono Sa Coinsins	Pyrrolidin-derivatie als prostaglandin-modulatoren
AU2003211574A1 (en)	2002-03-05	2003-09-16	Ono Pharmaceutical Co., Ltd.	8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
BR0308493A (pt) *	2002-03-18	2005-01-11	Pfizer Prod Inc	Uso de agonistas de receptor seletivo de ep4 para o tratamento da insuficiência hepática, perda de permeabilidade do canal arterial, glaucoma ou hipertensão ocular
AU2011202937B2 (en) *	2002-05-14	2012-06-07	Allergan, Inc.	8-azaprostaglandin analogs as agents for lowering intraocular pressure
US6573294B1 (en)	2002-05-14	2003-06-03	Allergan, Inc.	8-azaprostaglandin analogs as agents for lowering intraocular pressure
DE60334905D1 (de)	2002-06-06	2010-12-23	Merck Frosst Canada Ltd	1,5-disubstituierte pyrrolid-2-on-derivate zur verwendung als ep4 rezeptor agonisten zur behandlung von augenkrankheiten wie z.b. glaukom
US7419999B2 (en)	2002-06-10	2008-09-02	Applied Research Systems Ars Holding N.V.	Gamma lactams as prostaglandin agonists and use thereof
ES2584606T3 (es)	2002-10-10	2016-09-28	Ono Pharmaceutical Co., Ltd.	Microesferas que comprenden ONO-1301
CA2505127A1 (fr)	2002-11-08	2004-05-27	James B. Doherty	Compositions ophtalmiques pour traiter l'hypertension oculaire
US7196082B2 (en)	2002-11-08	2007-03-27	Merck & Co. Inc.	Ophthalmic compositions for treating ocular hypertension
US7053085B2 (en)	2003-03-26	2006-05-30	Merck & Co. Inc.	EP4 receptor agonist, compositions and methods thereof
RU2311409C2 (ru) *	2003-01-10	2007-11-27	Ф.Хоффманн-Ля Рош Аг	Производные 2-пиперидона в качестве агонистов простагландина
US7256211B1 (en)	2003-01-21	2007-08-14	Ono Pharmaceutical Co., Ltd.	8-azaprostaglandin derivatives and medical use thereof
ATE394372T1 (de)	2003-03-03	2008-05-15	Serono Lab	G-lactamderivate als prostaglandinagonisten
US6734206B1 (en)	2003-06-02	2004-05-11	Allergan, Inc.	3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure
US6734201B1 (en) *	2003-06-02	2004-05-11	Allergan, Inc.	8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents
US7179820B2 (en)	2003-06-06	2007-02-20	Allergan, Inc.	Piperidinyl prostaglandin E analogs
JP2006528154A (ja)	2003-07-18	2006-12-14	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	プロスタグランジン受容体のモジュレータとしてのヒドラジド誘導体
CN1845914A (zh)	2003-09-02	2006-10-11	默克公司	用于治疗眼压过高的眼用组合物
KR20060090801A (ko)	2003-09-04	2006-08-16	머크 앤드 캄파니 인코포레이티드	고안압증 치료용 안용 조성물
WO2005025568A1 (fr)	2003-09-04	2005-03-24	Merck & Co., Inc.	Compositions ophtalmiques pour traiter l'hypertension oculaire
WO2005027931A1 (fr) *	2003-09-19	2005-03-31	Pfizer Products Inc.	Compositions pharmaceutiques et methodes de traitement consistant en des associations d'un derive de la 2-alkylidene-19-nor-vitamine d et d'un agoniste selectif de ep2 ou ep4
WO2005080367A1 (fr)	2004-02-12	2005-09-01	Pharmagene Laboratories Limited	Agonistes des recepteurs ep2
CN1988903A (zh)	2004-07-20	2007-06-27	默克公司	用于治疗高眼压症的眼用组合物
ES2336933T3 (es)	2004-12-06	2010-04-19	Merck Serono Sa	Derivados de pirrolidin-2-ona para usar como antagonistas del receptor dp1.
US7531533B2 (en)	2005-01-27	2009-05-12	Asahi Kasei Pharma Corporation	6-Membered heterocyclic compound and use thereof
KR20080000647A (ko)	2005-04-28	2008-01-02	오노 야꾸힝 고교 가부시키가이샤	경피 흡수 제제
KR100686186B1 (ko) *	2005-06-13	2007-02-26	영진종합건설 주식회사	교량용 배수 구조물
CA2618486A1 (fr)	2005-08-09	2007-02-15	Asterand Uk Limited	Agonistes des recepteurs ep2
US8410171B2 (en)	2006-10-26	2013-04-02	Ono Pharmaceutical Co., Ltd.	Adhesive preparation
EP2094839B1 (fr)	2006-12-08	2020-02-05	University of Rochester	Expansion de cellules souches hématopoïétiques
EP2220057A4 (fr)	2007-11-14	2011-10-12	Cayman Chem Co	Analogues de prostaglandine e1 et e2 pour le traitement de diverses affections médicales
CA2738045C (fr)	2010-05-28	2019-02-19	Simon Fraser University	Composes conjugues, leurs procedes de fabrication et leurs utilisations
JP6052175B2 (ja)	2011-08-02	2016-12-27	小野薬品工業株式会社	左室拡張機能改善剤
CN107802623B (zh)	2012-07-19	2020-10-30	开曼化学股份有限公司	用于ep4介导的骨相关疾病和病症的二氟内酰胺组合物
EP2913047B1 (fr)	2012-10-29	2019-05-08	Cardio Incorporated	Agent thérapeutique spécifique de maladie pulmonaire
WO2014144610A1 (fr)	2013-03-15	2014-09-18	Cayman Chemical Company, Inc.	Composés lactames en tant qu'agonistes sélectifs du récepteur ep4 pour l'utilisation dans le traitement de maladies et d'états à médiation par ep4
EP3235817B1 (fr)	2013-03-15	2018-12-12	Cayman Chemical Company, Incorporated	Composés de lactamine en tant qu'agonistes sélectifs du récepteur ep4 destinés à être utilisés dans le traitement des maladies et affections transmises par l'ep4
JP2016527006A (ja)	2013-07-19	2016-09-08	ケイマンケミカルカンパニー，インコーポレーテッド	骨成長を促進するための方法、システム、及び組成物
AU2014305843B2 (en)	2013-08-09	2019-08-29	Ardelyx, Inc.	Compounds and methods for inhibiting phosphate transport
US9968716B2 (en)	2013-10-15	2018-05-15	Ono Pharmaceutical Co., Ltd.	Drug-eluting stent graft
CN107849072B (zh)	2015-06-12	2020-12-15	西蒙弗雷泽大学	酰胺连接的ep4激动剂-二膦酸盐化合物及其用途
EP4706758A3 (fr)	2019-05-21	2026-05-06	Ardelyx, Inc.	Procedes d'inhibition du transport de phosphate

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR897566A (fr)	1942-08-28	1945-03-26	Bopp & Reuther Gmbh	Machine à rotors
US3528961A (en)	1966-08-16	1970-09-15	Allied Chem	Monoazo dyes from e-caprolactam
US3780095A (en)	1970-04-08	1973-12-18	Byk Gulden Lomberg Chem Fab	Acylated anilino-carboxylic acids and their salts
US3987091A (en)	1973-04-12	1976-10-19	Merck & Co., Inc.	11,12-secoprostaglandins
US4033996A (en)	1973-04-25	1977-07-05	Merck & Co., Inc.	8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins
SE7414770L (fr)	1973-12-13	1975-06-16	Merck & Co Inc
DK366475A (da)	1974-08-30	1976-03-01	Merck & Co Inc	Fremgangsmade til fremstilling af aryloxy- eller arylthioholdige secoprostaglandiner
US4055596A (en)	1974-09-13	1977-10-25	Merck & Co., Inc.	11,12-Seco-prostaglandins
US3991106A (en)	1974-09-13	1976-11-09	Merck & Co., Inc.	16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins
US4113873A (en)	1975-04-26	1978-09-12	Tanabe Seiyaku Co. Ltd.	8-azaprostanoic acid derivatives
DE2528664A1 (de) *	1975-06-27	1977-01-13	Hoechst Ag	Pyrrolidone und verfahren zu ihrer herstellung
IL49325A (en)	1976-03-31	1979-11-30	Labaz	8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them
DE2619638A1 (de)	1976-05-04	1977-11-17	Hoechst Ag	Pyrrolidone und verfahren zu ihrer herstellung
US4177346A (en)	1976-08-06	1979-12-04	Pfizer Inc.	1,5-Disubstituted-2-pyrrolidones
US4175203A (en)	1976-12-17	1979-11-20	Merck & Co., Inc.	Interphenylene 11,12-secoprostaglandins
US4243678A (en)	1977-12-30	1981-01-06	Byk Gulden Lomberg Chemische Fabrik Gmbh	Acylhydrocarbylaminoalkanoic acids, compositions and uses
DE3000377A1 (de)	1980-01-07	1981-07-09	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3042482A1 (de)	1980-11-11	1982-06-24	A. Nattermann & Cie GmbH, 5000 Köln	N-benzoyl- (omega) -anilinoalkancarbonsaeuren, -salze und -ester, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3266360D1 (en)	1981-06-16	1985-10-24	Choay Sa	Medicines containing as active ingredients compounds of the arylbenzenesulfonamide-type, and processes for their preparation
AU6427596A (en) *	1992-04-14	1996-10-31	Alfred Maximillian Stessl	A boat hull
TW383306B (en)	1992-12-22	2000-03-01	Lilly Co Eli	New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
ES2303341T3 (es) *	1996-12-20	2008-08-01	Pfizer Inc.	Prevencion y tratamiento de trastorno del esqueleto con agonistas de la prostaglandina e2 selectivos del subtipo de receptor ep2.
GB2330307A (en) *	1998-02-07	1999-04-21	Glaxo Group Ltd	EP4 Receptor antagonists as bone resorption inhibitors
WO2000021542A1 (fr) *	1998-10-15	2000-04-20	Merck & Co., Inc.	Methodes de stimulation de la formation osseuse
JP2002527393A (ja) *	1998-10-15	2002-08-27	メルクエンドカムパニーインコーポレーテッド	骨吸収阻害方法

2000
- 2000-11-20 AP APAP/P/2001/002357A patent/AP2001002357A0/en unknown
- 2000-11-20 HR HRP20020537 patent/HRP20020537A2/hr not_active Application Discontinuation
- 2000-11-20 UA UA2002065186A patent/UA72293C2/uk unknown
- 2000-11-20 AP APAP/P/2002/002555A patent/AP2002002555A0/en unknown
- 2000-11-20 OA OA1200200177A patent/OA12117A/en unknown
- 2000-11-20 BR BR0016560-3A patent/BR0016560A/pt not_active IP Right Cessation
- 2000-11-20 WO PCT/IB2000/001711 patent/WO2001046140A1/fr not_active Ceased
- 2000-11-20 MX MXPA02006322A patent/MXPA02006322A/es active IP Right Grant
- 2000-11-20 AU AU12931/01A patent/AU1293101A/en not_active Abandoned
- 2000-11-20 PL PL00356662A patent/PL356662A1/xx not_active Application Discontinuation
- 2000-11-20 CN CN00817566A patent/CN1413190A/zh active Pending
- 2000-11-20 CZ CZ20022048A patent/CZ20022048A3/cs unknown
- 2000-11-20 GE GEAP20006502A patent/GEP20043203B/en unknown
- 2000-11-20 EE EEP200200355A patent/EE200200355A/xx unknown
- 2000-11-20 EA EA200200505A patent/EA005293B1/ru not_active IP Right Cessation
- 2000-11-20 SK SK855-2002A patent/SK8552002A3/sk unknown
- 2000-11-20 TR TR2002/01643T patent/TR200201643T2/xx unknown
- 2000-12-11 TR TR2003/01841T patent/TR200301841T4/xx unknown
- 2000-12-11 PT PT00311034T patent/PT1110949E/pt unknown
- 2000-12-11 ES ES00311034T patent/ES2204458T3/es not_active Expired - Lifetime
- 2000-12-11 DE DE60005471T patent/DE60005471T2/de not_active Expired - Fee Related
- 2000-12-11 AT AT00311034T patent/ATE250575T1/de not_active IP Right Cessation
- 2000-12-11 EP EP00311034A patent/EP1110949B1/fr not_active Expired - Lifetime
- 2000-12-11 DK DK00311034T patent/DK1110949T3/da active
- 2000-12-14 IL IL14032500A patent/IL140325A0/xx unknown
- 2000-12-15 US US09/738,670 patent/US6737437B2/en not_active Expired - Fee Related
- 2000-12-19 PE PE2000001368A patent/PE20010953A1/es not_active Application Discontinuation
- 2000-12-19 KR KR10-2000-0078214A patent/KR100419681B1/ko not_active Expired - Fee Related
- 2000-12-20 ZA ZA200007694A patent/ZA200007694B/xx unknown
- 2000-12-20 CA CA002329678A patent/CA2329678A1/fr not_active Abandoned
- 2000-12-20 AU AU72393/00A patent/AU763983B2/en not_active Ceased
- 2000-12-21 HU HU0005001A patent/HUP0005001A3/hu unknown
- 2000-12-22 CO CO00097391A patent/CO5251453A1/es not_active Application Discontinuation
- 2000-12-22 JP JP2000390594A patent/JP2001181210A/ja not_active Ceased
2001
- 2001-11-16 US US09/991,585 patent/US6642266B2/en not_active Expired - Fee Related
2002
- 2002-05-17 IS IS6388A patent/IS6388A/is unknown
- 2002-06-12 CR CR6678A patent/CR6678A/es not_active Application Discontinuation
- 2002-06-13 MA MA26686A patent/MA26852A1/fr unknown
- 2002-06-18 NO NO20022925A patent/NO20022925D0/no not_active Application Discontinuation
- 2002-06-28 BG BG106882A patent/BG106882A/xx unknown

Also Published As

Publication number	Publication date
BG106882A (en)	2003-02-28
TR200201643T2 (tr)	2002-11-21
IL140325A0 (en)	2002-02-10
DK1110949T3 (da)	2003-11-24
MA26852A1 (fr)	2004-12-20
HRP20020537A2 (en)	2004-12-31
EA005293B1 (ru)	2004-12-30
AP2001002357A0 (en)	2001-12-31
BR0016560A (pt)	2002-09-10
CZ20022048A3 (cs)	2004-03-17
HUP0005001A3 (en)	2002-01-28
AP2002002555A0 (en)	2002-06-30
DE60005471D1 (de)	2003-10-30
PT1110949E (pt)	2003-12-31
HU0005001D0 (fr)	2001-02-28
EP1110949A1 (fr)	2001-06-27
OA12117A (en)	2006-05-04
US20020040149A1 (en)	2002-04-04
DE60005471T2 (de)	2004-04-22
NO20022925L (no)	2002-06-18
GEP20043203B (en)	2004-03-25
CO5251453A1 (es)	2003-02-28
IS6388A (is)	2002-05-17
PE20010953A1 (es)	2001-09-25
AU1293101A (en)	2001-07-03
EP1110949B1 (fr)	2003-09-24
AU7239300A (en)	2001-06-28
KR20010067415A (ko)	2001-07-12
MXPA02006322A (es)	2002-12-13
US6737437B2 (en)	2004-05-18
UA72293C2 (en)	2005-02-15
WO2001046140A1 (fr)	2001-06-28
CR6678A (es)	2004-01-14
CA2329678A1 (fr)	2001-06-22
AU763983B2 (en)	2003-08-07
US20010047105A1 (en)	2001-11-29
NO20022925D0 (no)	2002-06-18
HUP0005001A2 (hu)	2001-12-28
US6642266B2 (en)	2003-11-04
TR200301841T4 (tr)	2004-01-21
KR100419681B1 (ko)	2004-02-21
ES2204458T3 (es)	2004-05-01
JP2001181210A (ja)	2001-07-03
PL356662A1 (en)	2004-06-28
SK8552002A3 (en)	2003-09-11
EA200200505A1 (ru)	2002-12-26
CN1413190A (zh)	2003-04-23
EE200200355A (et)	2003-10-15
ATE250575T1 (de)	2003-10-15

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