ZA200401593B - Aerosolized decongestants for the treatment of sinusitis. - Google Patents

Aerosolized decongestants for the treatment of sinusitis. Download PDF

Info

Publication number: ZA200401593B
Authority: ZA; South Africa
Prior art keywords: composition; substance; treatment; agent; sinusitis
Prior art date: 2001-08-31

Application number

ZA200401593A

Other languages

English (en)

Inventor

Robert S Osbakken

Frederick T Leivo

Mary Anne Hale

James D Munk

Original Assignee

Sinuspharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-31

Filing date

2004-02-25

Publication date

2005-05-25

2004-02-25 Application filed by Sinuspharma Inc filed Critical Sinuspharma Inc

2005-05-25 Publication of ZA200401593B publication Critical patent/ZA200401593B/en

Links

201000009890 sinusitis Diseases 0.000 title claims description 102
238000011282 treatment Methods 0.000 title claims description 97
239000000850 decongestant Substances 0.000 title claims description 33
229940124581 decongestants Drugs 0.000 title description 18
239000000203 mixture Substances 0.000 claims description 207
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 77
238000009472 formulation Methods 0.000 claims description 63
239000002245 particle Substances 0.000 claims description 60
238000000034 method Methods 0.000 claims description 58
239000006199 nebulizer Substances 0.000 claims description 51
239000000126 substance Substances 0.000 claims description 50
239000003814 drug Substances 0.000 claims description 46
239000004094 surface-active agent Substances 0.000 claims description 43
239000003242 anti bacterial agent Substances 0.000 claims description 41
229940088710 antibiotic agent Drugs 0.000 claims description 36
239000003795 chemical substances by application Substances 0.000 claims description 35
239000011780 sodium chloride Substances 0.000 claims description 34
239000000739 antihistaminic agent Substances 0.000 claims description 31
206010020751 Hypersensitivity Diseases 0.000 claims description 23
239000004599 antimicrobial Substances 0.000 claims description 21
210000003630 histaminocyte Anatomy 0.000 claims description 21
230000007815 allergy Effects 0.000 claims description 18
230000002590 anti-leukotriene effect Effects 0.000 claims description 18
229940121375 antifungal agent Drugs 0.000 claims description 18
230000003637 steroidlike Effects 0.000 claims description 18
GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 17
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JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 claims description 17
210000003695 paranasal sinus Anatomy 0.000 claims description 17
230000008021 deposition Effects 0.000 claims description 16
230000001937 non-anti-biotic effect Effects 0.000 claims description 16
239000008194 pharmaceutical composition Substances 0.000 claims description 16
230000001387 anti-histamine Effects 0.000 claims description 15
229940121363 anti-inflammatory agent Drugs 0.000 claims description 15
239000002260 anti-inflammatory agent Substances 0.000 claims description 15
230000003110 anti-inflammatory effect Effects 0.000 claims description 15
230000002421 anti-septic effect Effects 0.000 claims description 15
-1 asternizole Chemical compound 0.000 claims description 15
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WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims description 12
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BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 5
YEEZWCHGZNKEEK-UHFFFAOYSA-N Zafirlukast Chemical compound COC1=CC(C(=O)NS(=O)(=O)C=2C(=CC=CC=2)C)=CC=C1CC(C1=C2)=CN(C)C1=CC=C2NC(=O)OC1CCCC1 YEEZWCHGZNKEEK-UHFFFAOYSA-N 0.000 claims description 5
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OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 claims description 5
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229930000680 A04AD01 - Scopolamine Natural products 0.000 claims description 4
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STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims description 4
ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 claims description 4
STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims description 4
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SEBMTIQKRHYNIT-UHFFFAOYSA-N azatadine Chemical compound C1CN(C)CCC1=C1C2=NC=CC=C2CCC2=CC=CC=C21 SEBMTIQKRHYNIT-UHFFFAOYSA-N 0.000 claims description 4
ZQDJSWUEGOYDGT-UHFFFAOYSA-N bromazine hydrochloride Chemical compound [Cl-].C=1C=C(Br)C=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 ZQDJSWUEGOYDGT-UHFFFAOYSA-N 0.000 claims description 4
229940068716 bromodiphenhydramine hydrochloride Drugs 0.000 claims description 4
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 4
239000000920 calcium hydroxide Substances 0.000 claims description 4
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JQEKDNLKIVGXAU-UHFFFAOYSA-L nedocromil sodium Chemical compound [Na+].[Na+].CCN1C(C([O-])=O)=CC(=O)C2=C1C(CCC)=C1OC(C([O-])=O)=CC(=O)C1=C2 JQEKDNLKIVGXAU-UHFFFAOYSA-L 0.000 description 1
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FJWLWIRHZOHPIY-UHFFFAOYSA-N potassium;hydroiodide Chemical compound [K].I FJWLWIRHZOHPIY-UHFFFAOYSA-N 0.000 description 1
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125000003396 thiol group Chemical group [H]S* 0.000 description 1
OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Dispersion Chemistry (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Immunology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200401593A 2001-08-31 2004-02-25 Aerosolized decongestants for the treatment of sinusitis. ZA200401593B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/942,959 US20020061281A1 (en)	1999-07-06	2001-08-31	Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis

Publications (1)

Publication Number	Publication Date
ZA200401593B true ZA200401593B (en)	2005-05-25

Family

ID=25478882

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200401593A ZA200401593B (en)	2001-08-31	2004-02-25	Aerosolized decongestants for the treatment of sinusitis.

Country Status (10)

Country	Link
US (2)	US20020061281A1 (fr)
EP (1)	EP1420760A2 (fr)
JP (1)	JP2005508314A (fr)
AU (1)	AU2002361918B2 (fr)
CA (1)	CA2456904A1 (fr)
HU (1)	HUP0600332A2 (fr)
IL (1)	IL160187A0 (fr)
MX (1)	MXPA04001763A (fr)
WO (1)	WO2003020219A2 (fr)
ZA (1)	ZA200401593B (fr)

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- 2001-08-31 US US09/942,959 patent/US20020061281A1/en not_active Abandoned
2002
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- 2002-08-28 AU AU2002361918A patent/AU2002361918B2/en not_active Ceased
- 2002-08-28 CA CA002456904A patent/CA2456904A1/fr not_active Abandoned
- 2002-08-28 MX MXPA04001763A patent/MXPA04001763A/es active IP Right Grant
- 2002-08-28 IL IL16018702A patent/IL160187A0/xx unknown
- 2002-08-28 HU HU0600332A patent/HUP0600332A2/hu unknown
- 2002-08-28 JP JP2003524533A patent/JP2005508314A/ja active Pending
- 2002-08-28 WO PCT/US2002/027868 patent/WO2003020219A2/fr not_active Ceased
2004
- 2004-02-25 ZA ZA200401593A patent/ZA200401593B/en unknown
- 2004-04-29 US US10/835,872 patent/US20040204399A1/en not_active Abandoned

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Publication number	Publication date
WO2003020219A3 (fr)	2003-09-25
US20020061281A1 (en)	2002-05-23
MXPA04001763A (es)	2004-05-31
CA2456904A1 (fr)	2003-03-13
WO2003020219B1 (fr)	2004-05-06
JP2005508314A (ja)	2005-03-31
HUP0600332A2 (en)	2007-02-28
WO2003020219A2 (fr)	2003-03-13
EP1420760A2 (fr)	2004-05-26
IL160187A0 (en)	2004-07-25
AU2002361918B2 (en)	2007-03-01
US20040204399A1 (en)	2004-10-14

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AU2002361918A1 (en)	2003-06-05	Aerosolized decongestants for the treatment of sinusitis
AU779077B2 (en)	2005-01-06	Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US20090221541A1 (en)	2009-09-03	Pharmaceutical formulations
US20070202050A1 (en)	2007-08-30	Pharmaceutical Formulations
TR201820559T4 (tr)	2019-01-21	Azelastin içeren kompozisyonlar ve bunların kullanım metotları.
US20100144610A1 (en)	2010-06-10	Pharmaceutical formulations
MX2007001561A (es)	2007-04-16	Formulacion farmaceutica que comprende pleconaril para tratamiento de enfermedades de vias aereas.
JP2011520894A (ja)	2011-07-21	鼻性鼻炎の治療に使用するための組換えヒトｃｃ１０およびその組成物
US20210386748A1 (en)	2021-12-16	Non-infective nasal symptom management compositions and methods
JP2002161032A (ja)	2002-06-04	粘膜適用組成物
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